Active ingredient: Desipramine (desipramine)
Analogs: Pertofran, Petilil.
Desipramine is an antidepressant belonging to the tricyclic class. Its action is based on the inhibition of the reuptake of neurotransmitters, primarily norepinephrine by neurons of the brain. Promotes stimulation of psychomotor activity, improves motivation and thus does not exert a more or less pronounced sedative effect, which makes it possible to use it in the morning hours. In addition, of all the tricyclic antidepressants, desipramine is least likely to cause side effects.
Thus, even people with a slightly increased sensitivity to tricycles can take it. Very effective for the removal of long-lasting stupid pains, as well as pain that resulted from burns. The drug has shown effectiveness in the treatment of depression, it significantly improves mood, normalizes sleep and appetite, and returns interest to life. In addition, Norpramine (desipramine) is completely addictive.
Indications for use:
- treatment of endogenous depressions and neuroses;
- as an analgesic for cancer patients, as well as migraines;
- treatment of peripheral neuropathy syndrome (trigeminal neuralgia, postherpetic neuralgia, diabetic neuropathy);
- treatment of enuresis;
- treatment of anorexia;
- treatment of impaired concentration;
- treatment of phobias, increased anxiety, attacks of fear.
Contraindications: It is forbidden to take the drug for acute alcohol intoxication, as well as intoxication with sleeping pills, analgesics and psychotropic drugs. Desipramine should not be taken concomitantly with MAO inhibitors (until at least 2 weeks after their last intake), people with delusions, angle-closure glaucoma, dysuria, and an acute phase of myocardial infarction. In addition, this antidepressant should not be taken in patients with severe impairment of kidney and liver function, hypersensitivity to the drug, and mothers during lactation.
Dosage and administration: The starting dose for the treatment of pain syndromes is 50-100 mg / day orally (at a rate of 1-2 mg / kg). The drug is taken both in the morning and at bedtime. In order to achieve the desired effect, the dose can be increased by 25-50 mg every 3-4 weeks. The maintenance dose is 50-200 mg / day (calculation of 1-4 mg / kg). If treatment of diabetic neuropathy is required, large doses of the drug are not excluded. When the first appearance of undesirable effects should be reduced dosage.
The starting dose for treatment of depression is 75-100 mg / day (it makes sense to divide into several receptions), supporting - 50-300 mg / day. Intramuscular administration is possible.
With stable positive dynamics, dosage should be reduced to a minimum. As a rule, this is enough to ensure a full recovery.
For elderly patients, as well as patients with impaired renal function / liver function, the dosage should be reduced by one-third or one-half. In this case, the total amount of the drug consumed per day should not exceed 300 mg.
Side effects: The most common of these are blurred vision, disorder of accommodation, dry mouth, constipation, fatigue, dizziness, headaches, mood changes, agitation, internal anxiety, weight gain, vomiting, nausea, increased appetite, increased dairy glands. In general, side effects and contraindications are similar to the drug Amitriptyline.