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Phenotropil Pharmacology

02 Jul 2018

Phenylpiracetam - Nootropic drug. Has expressed posed anti-amnesic action activates the integrative activity of the brain, helps memory consolidation, improves concentration and mental performance, facilitates learning processes, accelerates the transfer of information between the hemispheres of the brain, increases resistance brain tissue to hypoxia and toxic effects, possesses anticonvulsant activity and anxiolytic activity, regulates the processes of activation and inhibition of CNS, improves mood.

Phenotropil has a positive effect on metabolic processes and blood circulation of the brain, stimulates redox processes, increases the energy potential of the body through the utilization of glucose, improves regional blood flow in ischemic areas of the brain. Increases the content of noradrenaline, dopamine and serotonin in the brain.

Does not affect levels of GABA, is not associated with GABAA - and GABA-receptors, has no significant impact on the spontaneous bioelectrical activity of the brain.

Phenotropil has no effect on the respiratory and cardiovascular systems. It has a weak diuretic effect. Has anorexic activity in exchange application.

Phenotropil has a moderately activating effect on motor reactions, increases physical performance, has a pronounced antagonism against the cataleptic action of neuroleptics, reduces the severity of the hypnotic action of ethanol and hexenal.

Stimulating effect of Phenotropil prevails in the ideational sphere. Moderate psychoactive effect of the drug is combined with anxiolitic activity. Phenotropil improves mood, has analgesic effect, increasing pain threshold.

Phenotropil stimulates the production of antibodies in response to the introduction of antigen, indicating its immunostimulatory properties, but at the same time does not cause the development of hypersensitivity reactions of immediate type and does not change the allergic inflammatory reaction of the skin caused by the introduction of foreign protein.

In the course of application of Phenotropil does not develop drug dependence and tolerance. When the drug was canceled, there was no development of withdrawal syndrome.

The action of Phenotropil is manifested after a single dose, which is important when using the drug in extreme conditions.


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Best Nootropics for a Beginner

18 Jun 2018

The topic of nootropics is relatively new, so it took time to accumulate practical experience and feedback.

We remind you that you all have your head on your shoulders, you know your organisms and we do not call for anything and read the pancake contraindications before taking any substances.

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Here you have 2 working patterns:

Piracetam + Lecithin + Vitamins

Yes, Yes, Yes! The well-advertised scheme.

Its main advantage: Availability

These substances can be found in most pharmacies sachanski the slain of the village.

What benefit:

+ Better memory

This is a controversial parameter, depending on what to consider as memory. But I immediately picked up my notes on the first nootropic courses from piracetam and improving memory indirectly mentioned quite often.

+ Efficiency

It is not the effect of stimulation, but the ability to do the job. Sometimes it happens that the brain if begins to blunt. Here you did a presentation or sat at work and after 2 hours begins to fade, and in the evening there is no intellectual work to do unreal. The maximum to watch the film but is light and not drama. So, on this course, the time of intellectual burnout will come later than usual.

+ Creative

Nootropics are also nootropics that alter brain function through neurotransmitters or other mechanisms. In fact, with the same piracetam, lecithin and vitamins, the brain is debugged, improved. Personally, I noticed an improvement in creativity, non-standard thinking, not like curcumin with piperine, but it was obvious. So, if you have long wanted to try hallucinogen microdoses only to change the thinking and views, but scary try nootropics.

Caffeine

Option even cheaper than the first scheme. Recommend taking caffeine tablets or capsules 100-200 mg. Sold online and in stores of sports nutrition.

Why? The fact is that you can not accurately determine the percentage of caffeine and other substances in a Cup of coffee. This is possible in the energy sector, but they are already expensive and with a mountain of sugar, which is bad.

If you think that caffeine puts you to sleep, then there are 2 options: drank not pure caffeine, but just coffee, or received a large dose of caffeine.

That is why, remember, the optimal working dosage of caffeine, which is probably 80% of people-100 mg!

Caffeine works well on its own, but even better when combined with L-Theanine or Eleutherococcus infusion. This is also not the most expensive supplements, so it is optional.

What benefit:

+ Productivity

In the first scheme was the performance, in the case of caffeine, he hours to 3 to enable turbo mode in your body. Yes, such that will grow efficiency per unit of time. 100 mg of caffeine is a super underrated nootropic.

+ Energy

With such a nootropic, it is easy to engage in both highly active and monotonous activities. Everything will go faster. It is difficult to sleep, it is difficult to practice meditation, so the extreme reception for 8 hours before sleep.

+ Mood / Motivation

Yes, caffeine significantly improves mood through communication with dopamine receptors. There is no question of severe depression, but if the mood is rotten and there is no desire to do something again, 100 mg of caffeine).

Addition

From the very first issues on the site was very clear message: Nootropics-are assistants! They're not gonna load up your head. They are like a more powerful Internet, it makes sense if you use it, surf or download files. Otherwise, nootropics make no sense. The parish won't be like drugs. Except that caffeine will cheer up, but what to do with cheerfulness-you decide!

buy cerebrolysin

Result:

Piracetam + Lecithin + Vitamins = Memory/Performance/Creativity

Optimal nootropic course for a beginner!

Caffeine will give motivation and productivity.

Consider it a turbo mode.

Well, if you took write your review!) And I hope the issue as usual was helpful and interesting! Good luck and see you soon!


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New tips for bio-haker to retarding aging - Metformin

15 Jun 2018

Decided to "update the drugs" and added Metformin prolonged action. For a healthy person, you need to drink 500 mg per day, and prolong, in order to eliminate side effects for the gastrointestinal tract.

Metformin

Consumed this drug after eating, better after Breakfast.

It is recommended to add 500 mg of taurine (amino acid) to the drug.

Personally, I've added INTENSIVE walk BEFORE and AFTER work. If you can't walk before work, walk at lunch and after work. It is important to walk fast and at least 35-45 minutes.

How Metformin prolongs life by reducing mortality in humans ?

✔ Metformin rejuvenates the brain

✔Metformin suppresses chronic inflammation (one of the causes of aging)

✔ Metformin inhibits protein glycation (another cause of aging)

✔ Metformin prevents the development of chronic heart failure.

✔ Metformin improves cardiac function

✔ Metformin inhibits atherosclerosis of vessels regardless of cholesterol metabolism

✔ Metformin prevents many types of cancer

✔ Metformin reduces frailty in old age

✔ Metformin prolongs life through mitohormesis in animals and humans

How Metformin prolongs life by reducing mortality in humans?

✔p.s. It is worth considering that it is necessary to use everything that affects the inhibition of aging - whether it is a diet, sleep or physical activity, as aging is a multifactorial process.


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Ways to increase the secretion of growth hormone in the body

13 Jun 2018

Growth hormone is one of the main anabolic hormones in the human body. Under his influence, muscles grow faster and fat is burned. The development of this hormone is influenced by multiple factors. Scientifically proven that it is possible to enhance the synthesis of growth hormone in the body of an athlete 3-5 times, without resorting to hormonal stimulants.

hgh peptides

Drugs that stimulate the production of growth hormone

- GHRP-2 and GHRP-6 are the most potent stimulants of growth hormone, an increase in concentration is 7-15 times.

- Baclofen - this drug is identical to the action of Gaba, but it provides a stronger effect.

Sports nutrition, increasing the synthesis of growth hormone

  • Protein
  • Arginine
  • Glutamine
  • Creatine
According to the latest scientific experiments, these nutritional supplements affect the synthesis of growth hormone in the body of an athlete, increasing its level. So, for example, creatine increases the production of insulin-like growth factor (IGF-1).

In the sports nutrition market, there are also products aimed at stimulating the production of growth hormone by combining certain food additives. These products increase the level of somatotropin by 2-4 times.

In addition, the level of growth hormone increases:
  • Physical exercise
  • Healthy sleep
  • Correct diet


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Insulin-like growth factor (IGF-1) and its role in bodybuilding

08 Jun 2018

Insulin-like growth factor (IGF-1) is a biologically active protein that is formed in the liver and muscles. He acts as an intermediary of the action of growth hormone.

This factor has many varieties, the best of which is the mechanical growth factor.

I must say that no serious scientific studies on the effect of insulin-like growth factor on the athlete's body have been conducted. However, preparations based on it are very expensive.

Action IGF-1
It has been scientifically proven that the insulin-like growth factor does not in any way affect the increase in the athlete's strength. Its main advantage is that it stimulates hyperplasia of muscle fibers, which is a particularly important effect for mature athletes.

The best actions of this factor are manifested when performing a special training program and a special diet. Optimal multi-rehearsal training with a short rest time between approaches, for example, pumping. With regards to nutrition, a protein diet with a rather large amount of carbohydrates in the diet is needed here.

IGF-1 also has a very useful property - fat burning. In addition, it is capable of smoothing nutritional deficiencies, such as a lack of protein, an excess of carbohydrates or an inadequate calorie intake. Recent scientific tests have shown that insulin-like growth factor has a stronger fat burning effect than artificial growth hormone, which is based on a completely different principle of work. Hence, it can be concluded that combining the course of somatotropin and IGF-1 will make fat burning more effective.

Dosage IGF-1
The optimal dose of insulin-like growth factor is 100 mg per day. Such a volume is ideal for athletes of any level. Higher dosages are not recommended, however, as are low dosages. IGF-1 should be taken only by injection. Local injections can accelerate the growth of specific muscles, and the systemic ones are best used to combat subcutaneous fat.

The recommended number of injections are 2-4 injections per week. Daily tricks are not only irrational, but harmful to the body.

Side effects
The negative effects of IGF-1, oddly enough, result from its advantages. For example, a significant anabolic effect, along with muscle growth, can accelerate the growth of various tumors that are present in the body. And this is the development of serious pathologies.

Another side effect is the effect on the heart. On the one hand, IGF-1 promotes the restoration of the heart muscle. On the other hand, it can lead to an increase in myocardial oxygen demand. Thus, as a minimum, shortness of breath during exercise is assured.

In general, I must say that the influence of insulin-like growth factor on the bodybuilding organism has not yet been fully studied. Therefore, it is too early to talk about concrete results and compatibility with anabolic steroids.


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Drugs that increase the production of growth hormone in the body

01 Jun 2018

Growth hormone has long been used in professional bodybuilding as a means of recruiting muscle relief. Thanks to such properties as suppression of catabolism, acceleration of muscle growth and splitting of adipose tissue, there is no safer and more effective analogue to this hormone.

recombinant human growth hormone

In this article, we will analyze the list of pharmaceutical preparations that increase the synthesis of growth hormone in the body.

The most potent stimulators of growth hormone are peptides, namely:

  • GHRP-2
  • GHRP-6
  • GRF (1-29)
  • CJC-1295
  • Ipamorelin
  • HGH Frag (176-191)
Next are the following drugs:

Clopheline and moxonidine are the most potent activators of growth hormone from available pharmacological agents.
Baclofen - is similar in effect to Gaba, but it differs better than the ability to penetrate the brain.

With regard to sports nutrition, the best growth hormone boosters present on the market are able to increase the concentration of growth hormone in the body 2-4 times. Such sports nutrition products include:
  • Fountain Of Youth HGH Complete
  • Applied Nutriceuticals HGH Up
  • Universal GH Max
  • Nutritional supplements based on arginine and glutamine


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What doping do you use?

31 May 2018

The five most potent types of doping.

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Scandals associated with the use of banned drugs, occur almost monthly, but something we miss the ears. This time around the doping story does not work at all desire. Another scandal broke out a week before the start of the Olympic Games in Sochi, and it was involved in Russian biathletes. In general, in the world of doping, Russia, alas, was on the "front line". It does not take a year for our athletes not to light up in the doping scandals - the percentage of negative samples in Russian athletes is kept at a beyond the level. So this year has just begun, and already there was the "Yefimova case", now "the case of Yuryeva and Staryh" ...

In general, all this doping history is still coming from the USSR, when many coaches and doctors built their careers on what stuffed sportsmen with all sorts of drugs. Some can not stop until now. Gradually formed a list of the most popular drugs. We are trying to figure out which of them are now in the course, what kinds of sports are used and what they actually give.

1.Erythropoietin EPO
Let's start with the dope, in the use of which Catherine Yuryeva and Irina Starykh are suspected. Erythropoietin is a hormone that stimulates the formation of erythrocytes from late progenitor cells and increases the yield of reticulocytes from the bone marrow, depending on the consumption of oxygen. Erythropoietin - a kind of copy of the natural kidney hormone. After he gets into the blood, he activates the process of ripening of red blood cells.

History of appearance
The drug appeared in 1983, it was invented by American specialists. Almost immediately he was in the sport. But due to the fact that erythropoietin practically copied the natural hormone, it could not be caught. Only in the early 2000s in the French laboratory Chateau-Malabry found a way. After that, the tests of old samples were sent and almost all the famous cyclers of the past were caught using EPO. Nevertheless, then new types of EPO appeared. In particular, CERA, which was widely used by riders, but, since 2007, have learned to identify him. All this led to a whole stream of disqualifications for cyclists.

Physiological role
Erythropoietin (EPO) increases the amount of hemoglobin in the blood, so blood can carry more oxygen in the body, which improves endurance.

Scope of application
Cyclic sports: cycling, cross country skiing, biathlon, swimming, speed skating.

The loudest scandals
In 2001, at the home world championship in cross-country skiing on the use of EPO, almost all the starry Finnish team was caught - Mika Myllyul, Jari Isometasa, Virpi Kuitunen.
A year later at the Olympic Games in Salt Lake City, our turn came - the victims of the checks were Larissa Lazutina and Olga Danilova.

In 2008, the Tour de France was immediately captured by 4 people, in their blood was found a new kind of EPO - CERA. Disqualifications were awarded to the overall standings Bernhard Kohl, as well as the winners of the individual stages Stefan Schumacher, Riccardo Ricco and Leonardo Piepoli. The results of the race were revised.

Also on the application of CERA was caught a two-time world champion, a runner at 1500 and 5000 meters Rashid Ramzi. Olympic champion, he was only a few days, one of the samples taken from him at the Games in Beijing, showed the presence of blood doping.

The previous biathlon scandal involving Akhatova, Yaroshenko and Yuryeva also did not do without mentioning the EPO.

2.Anabolic steroids (testosterone, stanozolol, nandrolone, methenolone, OSTARIN)
At its core, anabolics are pharmacological drugs that mimic the effect of the male sex hormone testosterone and dihydrotestosterone. Anabolic steroids accelerate the synthesis of protein inside cells, which leads to severe hypertrophy of muscle tissue (in general, this process is called anabolism).

History of appearance
Back in the 30s of the last century, scientists learned to artificially reproduce testosterone. Then, in the 1940s, the anabolic actions of testosterone began to improve in the USSR and the country of the Eastern bloc. Until now, it is believed that track and field records established in the 80s by athletes from the former USSR countries, as well as the GDR were established with the help of steroids.
On the threshold of centuries the American laboratory BALCO tried to improve anabolic steroids, created tetrahydro-testosterone.

Physiological role
Due to the use of steroids, there is a significant increase in muscle mass (5-10 kg per month), strength indicators, endurance, production of erythrocytes increase, bone tissue strengthens, fat reserves decrease.

In principle, it is still believed that steroids are the most effective type of doping, but the trouble is that they learned to recognize it easily.

Scope of application
Track and field athletics (sprint, throwing, long jumps), weightlifting, swimming, cross-country skiing.

The loudest scandals
Scandals associated with the use of steroids pond a dime. I'll just name a few names: Ben Johnson, Carl Lewis, Marion Jones, Tim Montgomery, Frank Luc, Anfisa Reztsova, Irina Korzhanenko, Nadezhda Ostapchuk, Irina Sergeeva. The list can stretch over several dozen pages ...

3.Diuretics (chlortalidone, acetazolamide, triamterine, furosemide)
Diuretics are diuretics that are often used to remove excess fluid from the body in order to give relief to the muscles. Usually used before competitions, as the effect is rather short. Diuretics can be taken during the steroid cycle, since anabolic steroids cause excessive accumulation of fluid. Intensive urination helps to remove from the body of other dopes or mask their use by significantly reducing the density of urine.

History of appearance
In sports, diuretics appeared almost immediately after anabolic steroids came into use.

Physiological role
They help to quickly reduce body weight, improve the appearance of athletes. Dehydration helps to give the musculature of the stressed forms.

Scope of application
Rhythmic gymnastics, figure skating, athletics, weightlifting.

The loudest scandals
Most often, diuretics are used to hide the use of steroids. At the Olympics in Seoul, the Bulgarian national team won 4 gold and 1 bronze medals. However, after her representatives Mitko Grablev and Angel Genchev were caught using diuretics, the whole weightlifting team was withdrawn from the Olympics. Two Hungarian weightlifters were also caught using similar diuretics.

Quite often athletes manage to prove that the use of diuretics was not conscious, they can enter into nutritional supplements. Lately, the Olympic champion Cesar Sielo Filho and the Jamaican runner Veronica Campbell-Brown managed to "slip" from the disqualification.

4.Transfusion of blood and its components (blood transfusion) and autohemotransfusion

Blood transfusion is a transfusion, a special case of transfusion, in which the blood or its components are transfused from the donor to the recipient biological fluid.
Autohemotransfusion - transfusion to the recipient of his own blood.

History of appearance
It is difficult to say when the first time athletes resorted to autohemotransfusion, but in 1985 all kinds of transfusions were banned. It happened after the American cyclers at the Olympics in Los Angeles publicly confessed to a transfusion. The first cases of detection of such a trick after its official ban were identified already in the 2000s, after which WADA insisted on the introduction of biological passports. The system of the passport of the blood is based on its regular collection in athletes and the analysis of blood parameters: hemoglobin, erythrocytes and reticulocytes. An increase in the level of blood cells and hemoglobin leads to an increase in the function of transport of oxygen from the blood to the muscles, and consequently, to an increase in working capacity.

Often, the increase in the level of red blood cells and hemoglobin is associated with various types of transfusions.

Physiological role
Autohemotransfusion accelerates the delivery of oxygen to the muscles, thereby increasing their productivity.

Scope of application
Cycling, athletics, cross country skiing.

The loudest scandals
The first on blood transfusion was caught the Olympic champion 2000 in the race with a separate start American Tyler Hamilton.

Olympic champion of London Kazakhstan cyclist Alexander Vinokurov at the Tour de France in 2007 was also caught on blood transfusion and disqualified for 2 years. According to the experts of the Châteaune-Malabry laboratory, where the analysis of the doping test was conducted, Vinokurov's blood transfusion was performed on July 21, the same day when the 13th stage was won. In this regard, Alexander and the whole team of Astana (at the request of the leadership of the Tour de France), left the French grand tour.

5. Stimulants of mental activity (cocaine, ephedrine, ecstasy and amphetamines)
In acute conditions, stimulants rapidly change the functional indices of brain activity (activate the bioelectrical activity of the brain, change conditioned reflexes, etc.), increase endurance to physical work. In conditions of clinical use, they have a rapidly onset stimulating effect, are widely used in practice for the treatment of diseases accompanied by drowsiness, lethargy, apathy, asthenia, depression. Increasing the functionality of athletes under the influence of stimulants is largely due to the blockade of physiological regulators, the boundaries of the mobilization of functional reserves.

History of appearance
Different kinds of stimulants appeared in sports at different times. In particular, ephedrine appeared on the horizon in the late 70-ies of the last century.

Physiological role
These drugs increase vitality, reduce fatigue, stimulating an increase in training time or performance at competitions.

Scope of application
Absolutely any kind of sport - from boxing to rhythmic gymnastics.

The loudest scandals
At the Olympics in 1976 in Innsbruck in the body of the Soviet skier Galina Kulakova was found ephedrine. True, Kulakov was removed for only 1 race, as it was proved that ephedrine was found in her body due to the use of a nasal spray. This disqualification was the first in the history of disqualification for the use of prohibited drugs in competitions skiers at the Olympics.

In 1994, the famous Diego Maradona was disqualified for 15 months for the use of ephedrine in the World Cup.

On the use of ephedrine and pseudoephedrine, the famous American athlete Carl Lewis came across, but he was never disqualified, and he managed to convince everyone that the cough medicine was at fault ...

In 2011, on the use of ephedrine was caught Ukrainian biathlete Oksana Khvostenko.


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Peptides GHRP-6 and their use in bodybuilding

30 May 2018

GHRP-6 is a peptide that promotes the synthesis of growth hormone. Initially, this drug was invented for the treatment of people suffering from a deficiency of growth hormone in the body, but over time it has become quite popular among the representatives of power sports (including bodybuilding).

GHRP-6

By its structure and properties, GHRP-6 is similar to GHRP-2 - the main difference is that GHRP-2 enhances appetite, and also increases the concentration of prolactin and cortisol. Despite some differences, these peptides may well be used together - in this case there will be a synergistic effect (mutual enhancement of each other's properties). This was confirmed by scientific experiments that showed that the maximum level of growth hormone in the blood of an athlete was observed with simultaneous reception of GHRP-2 and GHRP-6.

GHRP-6 can be taken in a variety of ways - under the skin, ingestion, under the tongue, but the most popular method is intramuscular injection.

His popularity in bodybuilding this drug was due to the fact that he helped to increase endurance, and also to increase the relief of muscles.

Basic Properties of GHRP-6

  • Increasing strength
  • Muscle growth
  • Burning of subcutaneous fat
  • Strengthening immunity
  • Strengthening bones
  • Anti-inflammatory action
  • Protection of the liver
Since GHRP-6 leads to an increase in the secretion of growth hormone, its properties are similar to those of growth hormone.

According to the research, the drug GHRP-6 significantly increased the concentration of growth hormone within 30 minutes after administration. Elevated levels of growth hormone were observed within 3-4 hours after injection, then dropped to the initial value.

How to take GHRP-6?
The optimal dose of GHRP-6 is 1 μg per 1 kg of body weight. With the use of lower standards, the increase in production of growth hormone decreases. When using higher dosages, an additional increase in the concentration of growth hormone is not observed.

The total duration of the course should not exceed 4-8 weeks. It was proved that long courses (up to 16 weeks) led to tolerance of the organism, reducing the effectiveness of GHRP-6. The optimal break between the courses is 1-2 weeks.

The problem of reducing the sensitivity of the body to GHRP-6 is effectively solved by the additional administration of CJC-1295.

Combination with other drugs
The effectiveness of GHRP-6 can be significantly increased by combining it with the use of other drugs:

  • CJC-1295 - is the best combination to date, enhancing the effect of GHRP-6 six-fold
  • GHRP-2 - increases the efficiency of the course by an average of 2 times
  • Insulin - increases the effectiveness of the course by 30-40%
  • Arginine - increases the effectiveness of the course by 10-20%
  • Glutamine
  • GABA
Side Effects of GHRP-6
In the course of numerous studies of side effects or pathological changes in the body from taking GHRP-6 was not found. In addition, GHRP-6 helped improve the protective properties of the body. When using super-large dosages (more than 600 μg per day and higher), an increased production of prolactin and cortisol is observed.

At the injection site, a burning sensation can be observed, which completely disappears within 10-15 minutes.


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Peptides of GHRP-2 and their effect on muscle growth

29 May 2018

Peptides of GHRP-2 and their effect on muscle growth

The GHRP-2 stimulator is by far the most effective drug that increases the production of growth hormone. Its peculiarity is that it is able to penetrate through the vessels of the oral cavity and directly enter the bloodstream, bypassing the liver. I study the effects of GHRP-2 on the human body, it was found that it stimulates the pituitary gland, which in turn raises the production of growth hormone 7-15 times. At the same time other additives based on amino acids can increase its secretion only 2-3 times.

ghrp-2

GHRP-2 is a peptide consisting of 6 consecutive amino acids. It was first discovered at the end of the last century. This stimulator of growth hormone (somatotropin) has a small molecular weight, due to which it easily penetrates the mucous membrane of the oral cavity. The effectiveness of this method of GHRP-2 has been proved by numerous scientific studies.

For example, in 1997, the results of scientific research published in the popular Journal of Endocrinology and Metabolism showed that the use of GHRP-2 increases the secretion of growth hormone in both adults and children.

Effects of GHRP-2
Stimulation of somatotropin (growth hormone);
Improving appetite;
Reduced fat mass and increased muscle;
Strengthening of bones;
Decreased cholesterol;
Protection of the liver;
Anti-inflammatory effect.

How to take GHRP-2?
According to scientific studies, the increase in secretion of growth hormone directly depends on the volume of application of GHRP-2 and does not depend on sex, age or other factors.

Those engaged in bodybuilding, is recommended to take GHRP-2 at a dosage of 50-100 mg per 1 kg of body weight. Thus, the average dosage for an athlete is 2.5-10 mg. It must be said that the sports nutrition manufacturers nowhere indicate GHRP-2 a share in its supplements, which may mean that they use a lower dosage, which will not have the desired effect.

Additives based on GHRP-2 can be combined with other sports nutrition products, such as arginine, GABA, glutamine. This will lead to an even greater increase in the production of growth hormone. In addition, this combination is completely safe for health.

GHRP-2 Side Effects
Numerous scientific studies have shown complete safety and no side effects when taking supplements based on GHRP-2. This stimulant has undergone clinical trials and observations for 30 years, so negative impact in the future is also ruled out.


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Peptide GRF (1-29) (Sermorelin, Sermoreline) and its use in bodybuilding

28 May 2018

Peptide GRF (1-29) (Sermorelin, Sermoreline) and its use in bodybuilding

GRF (1-29) is a peptide hormone of the GHRH class, which increases the synthesis of growth hormone in the body. This peptide, most often, is sold under the trademark Sermorelin (Sermorelin).

Sermorelin

Features of Sermorelin GRF (1-29)

The main feature of GRF (1-29) is a very fast half-life in the body, which is only a few minutes (5-10). For this reason, the classical forms of GRF (1-29) provide a weak increase in the concentration of growth hormone and, accordingly, have low efficiency.

The exception is GRF (1-29) Mod - tetrasubstituted or modified GRF (1-29). Its feature is the additional 4 amino acids included in its composition and providing a half-life of about 30 minutes. This provides a longer lasting effect and significantly better stimulation of growth hormone production in the body.

GRF (1-29) and CJC-1295
Very often GRF (1-29) and CJC-1295 DAC confuse each other, however, having similarities in structure, they differ significantly in action. Thus, CJC-1295 DAC is a modified peptide of the GHRH type, which contains the amino acid lysine, which is bound to the molecule Drug Affinity Complex (DAC). This combination allows the CJC-1295 DAC to have a half-life of 1-2 weeks, which is much more convenient, since it allows injections only a couple of times a week (instead of 1-3 times a day).

Dosages and course GRF (1-29) Sermorelin (Sermorelin)
The optimal dosage of GRF (1-29) Mod is 100-200 μg, taken 1-3 times a day in the form of subcutaneous or intramuscular injections. The total duration of the course is 6-12 weeks.

The optimum is the combination of GRF (1-29) with the reception of peptides like GHRP in the following course:

Serrorelin GRF (1-29) - 100-200 mcg;
GHRP-6 or GHRP-2 - 100 μg;
Peptides must be dissolved in 1-2 ml of water and administered 1-3 times a day;
The optimal time of reception: 15 minutes before meals, immediately after training and before bedtime.

How to make a solution of GRF (1-29)?
Take the vial and cool it to room temperature;
Add the necessary amount of water for injection (the addition of water should be carried out by draining it along the wall of the bottle);
Stir the resulting composition (do not shake or shake, but use circular rotational movements);
The resulting composition can be stored in the refrigerator without freezing for 8-10 days (with the use of bacteriostatic water - up to 30 days).

Important! Tetra-substituted (modified) GRF (1-29) Mod is best dissolved only in bacteriostatic water.


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