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Actovegin solution for injections

19 Jul 2018

"What is Actovegin?"

"How to use Actovegin?"
Such questions are asked to us by readers in their letters.

Actovegin solution for injections

Actovegin is an antihypoxic, i.e. a drug that improves oxygen delivery to tissues. Due to the ability to increase metabolism in tissue cells, the latter effectively absorb glucose and oxygen. Thanks to injections of Actovegin, the energy of the cell is improved, especially with ischemia and hypoxia. Clinical studies have shown that the maximum effect of Actovegin in ampoules occurs in 2-6 hours.

Actovegin in ampoules is effective in patients with such concomitant diseases as renal or hepatic insufficiency. Also, ampoule Actovegin is used in patients of advanced age and newborns, in patients with type 2 diabetes with diabetic polyneuropathy. Actovegin is used in neurology, endocrinology, cardiology, etc.

Actovegin in ampoules / Instruction

Description / Actovegin in ampoules
Transparent solution in glass ampoules. Weak yellow solution.

Composition / Actovegin in ampoules
The main substance: dry deproteinized calf blood calves. Auxiliary components: sodium chloride, water for injections, glucose anhydrous.

Indications for use of Actovegin in ampoules / Instruction
1. Vascular and metabolic disorders of the brain (ischemic stroke, cerebral insufficiency, encephalopathy, craniocerebral trauma).

2. Peripheral vascular disorders, as well as their consequences.
Diabetic polyneuropathy, radiation neuropathy, arterial angiopathy.

3. Actovegin in ampoules is used for poorly healing wounds, as well as in the following cases:
bedsores, ulcers of different etiology, burns (chemical and thermal lesions of the nervous tissue, skin, mucous membranes), radiation damage to mucous membranes and skin.

Contraindications / Actovegin in ampoules
Individual allergic intolerance to injections of Actovegin and similar medicines. For infusion solutions - heart failure in the stage of decompensation, oliguria, pulmonary edema, fluid retention in the body, anuria.
For those suffering from diabetes it is very important to take into account the concentration of glucose in the solution for infusions of Actovegin with dextrose.

Way of application of Actovegin parenteral / Instruction
Actovegin is used intravenously, intramuscularly or intraarterially in ampoules of 10-20 ml or as an infusion with Actovegin, and then - 5 ml IV or IM daily or several times a week. In / m - enter no more than 5ml, because the solution is hypertonic.
With the introduction of Actovegin in the form of infusions - 10-50 ml are diluted in 200-300 ml of sodium chloride or 5% of glucose.

Dosage of Actovegin in ampoules / Instruction

Disorders of blood circulation and metabolism: first injections of ampoules of Actovegin IV in 10 ml every day for two weeks, then iv 5-10 ml several times a day for four weeks. Stroke ischemic: 20-50ml solution of Actovegin in 200-300 ml of the base solution, applied daily or several times within two to three weeks.

Arterial angiopathy: 20-50 ml of Actovegin in 200-300 ml of the basic r-ra, in / a or / in a daily or several times a week (approximately, for four weeks).

Burns of different etiology: iv in 10 ml of Actovegin or in / m of 5 ml of Actovegin daily or several times a day.

A solution of Actovegin for IV or IV administration / Instruction
Enter Actovegin from 250 ml per day in / in or in / a to 500 ml. The speed is approx. 2 ml / min. Usually prescribe 10-20 injections of Actovegin.

Disorders of the metabolism and circulation of the brain: intravenously 250-500 ml / day (for two weeks), then 250 ml several times a week (at least four weeks).

Actovegin with ischemic stroke: in / in 250-500 ml of Actovegin apply daily or several times a week (for two to three weeks).

Arterial angiopathy: iv or 250 ml of Actovegin daily or several times a week (four weeks).

Actovegin with ulcers, burns: in / in 250ml daily or several times a week.

Radiation damage to the skin, mucous membranes: intravenously 250 ml - 1 day before the start of radiotherapy and two weeks - after the end of therapy.

Additional Instructions for Use of Actovegin / Instruction
1. When administering Actovegin in / m, do not exceed the dose in 5 ml of the solution, t. it is hypertonic (concentrated).
2. It is always necessary to carry out a trial reaction of Actovegin (2 ml of solution) in connection with possible anaphylactic reactions.
3. The solution of Actovegin is compatible with solutions of sodium chloride and 5% glucose solution. It is not recommended to mix with other solutions.

Side effects of Actovegin / Instruction
Actovegin is usually well tolerated, rarely allergic reactions occur, anaphylactic shock.
Side effects of Actovegin may manifest themselves in a variety of ways:
1. Immune system: rash, itching, skin hyperemia, urticaria, increased sweating, swelling of the mucous membranes and skin, angioedema edema, chills, fever.
2. Nervous system: headache, agitation, weakness, tremor, paresthesia, fainting.
3. Musculoskeletal system: pain in the joints, lower back, muscles.
4. Digestive tract: pain in epigastrium, diarrhea, nausea, vomiting.
5. Cardiovascular system: tachycardia, dyspnea, pain in the heart, acrocyanosis, arterial hypertension or hypotension, pallor of the skin.
6. Respiratory system: asthma attack, sore throat, rapid breathing, difficulty swallowing, tightening in the chest.
7. Possible reactions at the site of administration of Actovegin.

Actovegin during pregnancy and lactation
The use of the drug Actovegin during pregnancy is only for the purpose of the attending physician and under his supervision according to vital indications (for example, with pathological pregnancy, which you can also learn here).

Children: Actovegin, according to the instruction, is not used in pediatrics (because of lack of evidence base). But in practice Actovegin is used in exceptional cases (according to vital indications).

Actovegin is compatible with a variety of drugs.
Transport management with the use of Actovegin
There are no studies of the effect of Actovegin on the reaction rate when driving vehicles. However, one should consider the possibility of negative effects of Actovegin on the nervous system.

Overdose: cases of an overdose of Actovegin are unknown.


Phenotropil Buy

19 Jul 2018

Phenotropil buy - a drug that has nootropic, psycho-stimulating effect. Such influence allows to widely use the drug Phenotropil buy in cognitive and other neurological disorders, in sports (bodybuilding) and for weight loss. The active substance of the medicine has a pronounced complex effect on the body, which requires strict adherence to dosages and methods of application, which includes this instruction manual. Current prices and reviews of patients, as well as losing weight, and doctors, as well as possible substitutes (analogues) of Phenotropil buy in Russia will supplement the data on the drug.

The active ingredient is a chemical compound called Phenyl-oxo-pyrrolidinyl-acetamide (other names are Fonturacetam, Phenylpiracetam). One dose contains 100 mg of this component.

Phenotropil buy

Other ingredients: starches, Ca salts, lactose.

Pharmachologic effect of Phenotropil Buy
Phenotropil buy is a remedy that is the representative of the pharmacological group of nootropic drugs and stimulants intended for the treatment of neurological and other disorders according to the list of indications for use approved by the instruction for use.

Different directions of the mechanisms of the action of the device allow complex influence on different processes in the brain. The drug Phenotropil buy differs in such directions of pharmacological effects and actions (according to the data of the manual Vidal):

activation of the brain;
memory stimulation;
improvement of mental activity;
increase learning;
increase the stability of brain tissue to lack of oxygen;
strengthening the resistance of the brain to damage by toxic substances;
anticonvulsant activity, which allows you to prescribe the drug for epilepsy and seizures;
optimization of inhibition and excitation in the brain;
improvement of mood;
acceleration of metabolism in the body, which makes it possible to use the drug, including obesity;
Anorexigenic activity, directed to decrease of appetite. This effect allows to prescribe the drug in the complex treatment of excess weight;
Increase of energy possibilities of the organism due to activation of glucose utilization processes;
increase in concentration in the brain of active substances - Dopamine, Noradrenaline, Serotonin;
strengthening of working capacity, physical endurance. Due to this action, the drug is often prescribed to athletes;
helps to reduce sensitivity to pain;
increased resistance to stress, fatigue, movement restrictions;
improvement of vision;
increased blood circulation in the brain and limbs;
immunostimulating activity.

Phenotropil buy - Indications for use
Phenotropil buy is used for such diseases:

neurological disorders associated with circulatory disorders in the blood vessels;
diseases caused by impaired metabolism in the brain;
decreased cognitive function;
disorders of the motor sphere;
depression. Phenotropil buy includes the properties of antidepressants that do not have a negative effect on the body;
disorders accompanied by lethargy and apathy;
seizures of different etiologies;
obesity due to changes in metabolism, as well as of alimentary-constitutional genesis;
prevention of oxygen starvation of the brain;
prevention of depletion and decreased activity in difficult living and working conditions (athletes do not have doping;
normalization of biorhythms;
symptoms of alcoholism or other manifestations in narcology, having a neurological character.

Phenotropil buy is characterized by a large range of indications for use against a background of high safety.

Phenotropil buy Contraindications
Phenotropil buy has a high level of safety for the body, despite a wide range of activities. Among the contraindications to the use of the drug in describing the studies can be identified only allergy to any components.

Phenotropil buy is not used in the treatment of children under 18 years of age.

Instructions for use
The drug may only be taken orally after a meal. To drink at least 150 ml of water.

The average therapeutic dosage of Phenotropil buy for an adult (according to the manufacturer's annotation), including for improving memory, is from 100 to 150 mg per dose.

When administering a dose of up to 100 mg of Phenotropil buy, the entire amount of the drug is taken at a time. If necessary, take a dose of more than 100 mg intake scheme involves dividing the daily dosage by 2 times - in the morning (before lunch) and in the evening (after dinner).

Duration of admission depends on the patient's condition and is 14 days - 3 months. Most often, Phenotropil buy is used for one month. It is permissible to repeat the course of treatment 30 days after the end of the previous one.

Important! In order to increase the patient's ability to work, Phenotropil is prescribed 1-2 tablets in the morning. Duration of admission for athletes is 3 days, for the rest of patients - 14 days.

Usage of Phenotropil buy for weight loss
In order to reduce weight, the drug is used only in combination with other methods, which include exercise and proper diet. In most cases, it is recommended that you take 1-2 tablets in the morning (preferably after a full breakfast). The duration of therapy should be from 1 to 2 months. Phenotropil buy is not used to reduce body weight in obese people caused by serious internal (diabetes mellitus) or congenital pathologies.

Select the course of treatment should only a doctor who will choose the optimal dose and duration of use of Phenotropil buy. The drug has no toxic effects, it does not develop addiction in patients, even in the case of prolonged use. In the process of treatment, it is important to regularly monitor blood glucose levels to prevent sudden changes in the indicators that have a negative effect on the body.

Interaction with other medicines
Phenotropil buy leads to an increase in the effectiveness of such drugs in the case of their compatibility:

stimulators of nervous activity (coffee);
nootropic drugs.

It is important to take into account such compatibility features and adjust the dose of these drugs.

Phenotropil with alcohol

Ethanol has a negative effect on the psyche and the state of the nervous system. For this reason, during the period of treatment with Phenotropil buy it is important to exclude its interaction in alcohol. Between Phenotropil and alcohol, if they are compatible, a decrease in the effectiveness of the drug and a general deterioration in the patient's condition may develop.

Analogues of Phenotropil buy
Similar drugs on which you can replace Phenotropil are as follows:

Fonturacetam (part of the drug Fenotropil);

Phenotropil differs from these drugs only by the manufacturer. Efficacy for all means is proven.

There are medicines showing similar actions, but differing in chemical composition. These include the following:

Cytikolins (Ceraxon, Neurooxon, Somazina);
aminobutyric acid (in the composition of Aminalon);
Glycine is a Russian analogue (synonym) of Fentropil (cheap, domestic);
Pyracetam (Nootropil, Lucetam);
Hopantenic acid;
Pikamilon - analog (Russian), which is cheaper;
Pramiracetam (Pramistar);
Fenibut (Noobut, Noofen);
Pyrithinol (Encephabol);
Vinpocetine (Cavinton);
means with a combined composition - Kombintropil, Omaron, Fezam (Cinnarizine and Pyracetam), Gamalate (amino acids).


Instruction to Actovegin. Indications for use. Prevention and treatment

19 Jul 2018

What is Actovegin?

Actovegin is a deproteinized drug from the blood of young calves.
It includes low molecular weight peptides and amino acid derivatives.

ÀÒC (Anatomico-Therapeutically-Chemical) classification system (international system of classification of medicines): (B06AB) Blood preparations other

buy actovegin

Composition and form of release

Actovegin exists today in the form of tablets, a solution for intramuscular and intravenous infusion, in the form of a gel, ointment, cream.

Tablets (round form) Actovegin: 200 mg of the drug.

A solution of Actovegin for injections
1ml contains 40 mg of the drug in sterile water.
10% (20%) solution for infusion. 250 ml contains 25 ml (50 ml) of the preparation (corresponding to 1 g and 2 g of dry weight) in sterile water. Excipient: sodium chloride.
10% solution for infusion with glucose. 250 ml contains 25 ml of the preparation in sterile water (corresponding to 1 mg of dry weight). Excipient: glucose anhydride.

Actovegin 5% ointment. 1g ointment consists of a drug equal to 2 mg of dry weight.
Excipients: preservatives propyl parahydroxybenzoate and methyl parahydroxybenzoate.

Actovegin 5% cream. 1 g of cream consists of a preparation equal to 2 mg of dry weight. Excipient: preservative benzalkonium chloride.

Actovegin 20% gel (often talk about "jelly"). 1 g of gel consists of a preparation equal to 8 mg of dry weight. Excipients: preservatives methyl parahydroxybenzoate and propyl parahydroxybenzoate.

Actovegin 20% eye gel. 1 g of the eye gel consists of a preparation corresponding to 8 mg of dry weight (in sterile water). Excipients: sorbitol, thiomersal sodium carboxymethylcellulose.

Pharmacological action of Actovegin
Regardless of the state of the body, Actovegin promotes positive changes in energy processes in tissue cells: the accumulation of oxygen and glucose increases. Transportation of oxygen and glucose to the cell is increasing, intracellular utilization is increasing. This process accelerates the metabolism of adenosine triphosphate, which increases the energy processes of anabolism and metabolism. The result is increased blood supply.
To date, there is no evidence of a decrease in the pharmacological effect in patients with renal or hepatic insufficiency, in patients with advanced age or newborns.

Indications for use of Actovegin / instruction
- Violations (vascular and metabolic) of the brain (stroke, craniocerebral injury, encephalopathy).
- Peripheral vascular changes (violations of the venous and arterial blood circulation), as well as the consequences of these disorders (diabetic, arterial angiopathy, trophic ulcers, caused by such serious diseases as venous insufficiency and concomitant thrombophlebitis, obliterating endarteritis).
- Wounds (sores and burns of different origin, bedsores, damage to the conjunctiva and cornea, in preparation for skin transplantation).
- Treatment (as well as prevention) of complications, in oncology, as a result of radiation therapy (lesions of mucous membranes, skin and nervous tissue).

Actovegin - Dosing and Administration / Instruction
The clinical picture, the severity of the disease dictate the way the doctor uses and the dose for treating a particular disease.

Parenteral / Instruction:
Actovegin for injection. Initially, prescribe 5-20 ml per day in / in or in / a. Then continue treatment iv or intramuscularly by administering 2-5 ml of Actovegin 1x a day or several times a week.
A solution of Actovegin for injections is acceptable to combine with sodium chloride solution, as well as with 5% glucose solution!

Actovegin for infusion. 250 ml per day in / in or / a (or a week several times). The initial dose of the solution of Actovegin is allowed up to 500 ml. The rate is 2 ml / min.
Assign 10-20 infusions per course of treatment.

No other medications can be added to the infusion solution !!!

Oral / Instruction: 3 r. per day for 2 tablets of Actovegin. Take before meals with a small amount of water.

Locally / Instruction: Ointment, cream, gel Actovegin.
To accelerate epithelization after therapeutic treatment, the ointment of Actovegin is applied a thin layer on the skin.
As a means of preventing decubitus, ointment is applied to the corresponding area of the skin.
As a means of preventing radiation damage to the skin, it is necessary to apply Actovegin ointment after irradiation or in between sessions.

Cream Actovegin / instruction - used to heal simple wounds and wounds with secretions. Use Actovegin cream as after treatment with Actovegin gel, and for the prevention of decubitus and radiation damage to the skin.

Gel (jelly) Actovegin / instruction - used for treatment, cleansing of open ulcers, wounds.
Burns and radiation damage: the gel is applied in a thin layer.
Ulcers: the gel is applied in a thick layer, on top of which put a compress with 5% ointment Actovegin. The bandage is changed 1x a day. If the ulcers become very wet, then the bandage is changed several times a day.

Eye gel / instructions. 1 drop is squeezed directly into the affected eye several times a day.

Actovegin Contraindications
Individual intolerance of Actovegin or drugs of this group, as well as cardiac decompensated failure, pulmonary edema, oliguria, anuria.

Actovegin Side effects
Actovegin is usually well tolerated by patients.
The cases of individual intolerance to Actovegin are quite rare and are limited to a minor allergy, which is treated with antihistamines. Therefore, if the attending physician prescribes treatment with the drug Actovegin, you can apply it without fear.

Actovegin Overdose
Cases of an overdose of Actovegin are unknown.

The use of Actovegin during pregnancy and lactation
The use of Actovegin is possible under the supervision of the attending physician.
In case of risk of miscarriage (from the sixteenth to the twenty-fourth week) Actovegin is used in complex treatment to prevent hypoxic damage to the fetal organs (due to lack of oxygen).
Apply Actovegin during pregnancy and for such indications as systemic diseases and insulin-dependent diabetes mellitus, which have been abortions in women in the past and the threat of abortion in the present, with placental insufficiency.

Actovegin for Children
It is undesirable to prescribe Actovegin to children. But in medical practice, in very severe cases, Actovegin is used in the complex treatment of children. At the same time, all possible risks must be evaluated.

Atovegin’s Compatibility
Actovegin is compatible with a variety of drugs.
The ability to influence the reaction speed when driving or working with other machinery:
does not affect.
Shelf life:
3 years or 5 years (read the instructions on the packaging). Do not use after the expiration date.
Storage conditions:
Tablets should be stored at room temperature (18 ° C-25 ° C), out of the reach of children.
Solutions for injection / infusion - in a place protected from light and inaccessible to children (at a temperature of no higher than 25 °): open the ampoule - do not store in the refrigerator, use the drug immediately after opening the ampoule.


Phenylpiracetam and alcohol

19 Jul 2018

Many people who take medications, sitting down at a festive table and drinking a few drinks of strong alcohol, begin to be tormented by the question: is it possible to take medicines and alcoholic beverages together?

phenylpiracetam and alcohol

There is a huge list of drugs that are strictly not recommended to be used together with alcoholic beverages, this method can lead to numerous complications or chronic diseases. But there are medications that can be taken together with alcohol, one of them is considered to be Phenylpiracetam.

Phenylpiracetam - what is the popularity of the drug
This drug belongs to the category of neurostomiators nootropic action, it has a positive effect on the regulation processes occurring in the brain. It stimulates memory, concentrates attention, improves eyesight and general condition of the body. The person taking Phenylpiracetam feels a surge of strength and good mood.

The drug was developed in Russia and was intended for use in extreme situations arising in space. Having passed approbation and proved its consistency in the future, it was used in the sports environment, many Russian athletes accepted it in the period of preparation for the competition, in order to increase endurance and achieve better results. Currently, Phenylpiracetam appeared in mass sale and quickly gained popularity. There is an opinion that Phenylpiracetam is perfectly compatible with alcohol and they can be consumed simultaneously.

When the recommended use of Phenylpiracetam
The drug has virtually no contraindications, there are no serious limitations in the application. The exception is the age of children and the presence of severe chronic diseases (kidney and liver diseases, cardiovascular diseases). The medicine is prescribed in the following cases:

- The emergence of depressive states.
- Complex treatment of alcoholism.
- Treatment of circulatory disorders in the brain.
- The onset of seizures.
- Application in complex therapy for the detection of vascular pathologies.
- With stressful conditions and memory impairment.
- To reduce excess weight and to remove puffiness.
- To activate metabolic processes in the body and increase immunity.

Reception is carried out in the morning and afternoon, after meals. The daily intake and duration of the course treatment is prescribed by the doctor. Course treatment lasts from a month to three. The drug is not addictive.

Compatibility of Phenylpiracetam and alcohol
Phenylpiracetam is indicated for use in the treatment of alcoholism. Influencing the processes taking place in the cerebral cortex, it significantly reduces the effect of alcoholic beverages on humans. Phenylpiracetam, taken with alcohol, blocks intoxication and greatly reduces the possibility of a morning hangover.

The compatibility of Phenylpiracetam with the use of alcohol is used by many people. Morning intake of one pill guarantees that during the festive feast a person will remain sober and will not suffer from hangover syndrome the next day.
Good compatibility of Phenylpiracetam and alcoholic beverages allows not to interrupt complex treatment if a celebration or a festive event is planned. Tablets can be drunk on the same day as alcoholic beverages, but it is worthwhile to delimit them in time. The best option - taking alcohol after 6-7 hours after taking Phenylpiracetam.

Systematic drug and alcohol intake

The absence of unfortunate consequences and even the improvement of the condition from one-time joint medication with alcohol should not create a false impression. Continuous use of alcohol on the background of course treatment with Phenylpiracetam can lead to sad consequences.

Systematic treatment with Phenylpiracetam helps to activate the metabolic processes of the body, and alcohol, which constantly enters the blood, will be perfectly absorbed by the brain cells, they will quickly absorb toxins, after a while, mass destruction of cells is possible. This condition is called apoptosis.

The process of neuronal death is irreversible and fleeting, the consequences include:
- Gradual loss of memory.
- Inability to think abstractly.
- Decreased visual and auditory activity.
- Depletion of speech.
Frequent use of medicines and alcoholic beverages not only will not lead to a decrease in the degree of intoxication, but also significantly worsen the general state of the body. Phenylpiracetam together with alcohol can be taken only in isolated cases. Specialists noted that the negative consequences from the joint intake of the drug and alcoholic beverages are possible even with a single use. In rare cases, this combination can cause a strong lethargy, a state of drowsiness or extreme excitement, which turns into anger. The constant interaction of drugs and alcohol has an extremely negative impact on overall well-being.

A single dose of Phenylpiracetam together with alcohol will not harm the body, it should only be delineated by time. The systematic use of alcoholic beverages against the background of course treatment can lead to severe consequences.


Actovegin for children

19 Jul 2018

Actovegin - injections, pills, ointment and gel - for children. Intravenous or intramuscular?

Actovegin and Children: CNS
Many parents, not having medical education, read on the Internet various diagnoses and try to ascribe them to their child. Immediately say that this path will not lead anywhere: you need to consult with specialists, and only then you can and need to look for information for yourself, in order to better understand the situation and how to deal with it.

Most often in young children there are neurological diseases associated with a complicated mother's pregnancy and / or difficult births.

actovegin pills for children

Drug Actovegin is one of the most popular drugs used in this complex situation.
According to the global statistics (medical), CNS lesions in children occupy one of the leading places in the general pathology of the organism, since the brain is very sensitive to oxygen starvation.
During the period of perinatal development, the baby's brain is often affected by the pathology of pregnancy. Especially acute is the problem in premature infants. In the absence of competent and timely treatment, such children are often at risk of disability.

So do Actovegin prescribe pregnant women for pathological pregnancy?
We respond positively: yes, prescribe Actovegin to pregnant women with poor blood circulation in the placenta, when there is a real threat to the fetus (a detachment of the fetal egg is possible).
Assign to pregnant and with the threat of miscarriage, and with diabetes of a pregnant woman.
Duration of treatment, as well as the number of courses of Actovegin are appointed individually by a doctor.

Treatment with Actovegin: intramuscular (no more than 5 ml) or intravenous (the initial dose is not more than 10-20 ml).

The intramuscular method of administering Actovegin (less effective and more painful) is used, as a rule, in the event that there is no possibility of intravenous injection of Actovegin!

Why did we start the conversation in this article with the problem of pregnancy pathology? Because it has a direct relationship to children: to what they will be born and grow up (healthy or sick).

Let us dwell on the use of Actovegin in newborns and infants with CNS lesions as a result of complications in the perinatal period.
Regurgitation and vomiting in children of the first months of life is a serious problem. Many specialists in their works write that these manifestations are the result of hypoxic involvement of the child's CNS in the perinatal period. Such children become "hostages" of campaigns on gastroenterologists. They often change mixtures, change probiotics and prebiotics. But, as a rule, in 65% -90% of cases everything turns out to be unsuccessful. Parents and doctors associate the hyperexcitability of the child with intestinal dysbiosis, and children's neurologists are often limited to Pantogam and massage.

In his article "The use of Actovegin in newborns and infants with PPNS," the authors LA Khoroshkina and V.V. Dulinets describe the experience of treating such children in the maternity hospital N.1 in Omsk. They describe the results of clinical trials. The authors write that in 98% of cases such children had a hypoxic lesion of the central nervous system (CNS) in the perinatal period. As a result of the complex treatment with other drugs (also improving the cellular metabolism), which included intramuscular injection of Actovegin, the state of children improved, and there was an obvious therapeutic effect. And there were no side effects of Actovegin: the medicine was well tolerated by children.

In the treatment of children with vomiting and regurgitation parenteral route of administration of Actovegin is preferred, although in general the treatment of children with Actovegin is preferable in tableted form.

When parenteral administration of Actovegin (bypassing the gastrointestinal tract), children are usually given intramuscular injections or intravenous infusions in the case of PPNS (perinatal damage to the nervous system).

According to the instructions to the drug Actovegin, dosage of administration of Actovegin to children is as follows:
Newborns are prescribed in a dose of 0.4-0.5 ml / kg 1 time per day IM or IV; children aged 1-3 years - in a dose of 0.4-0.5 ml / kg once a day IM or IV; 3-6 years - 0,25-0,4 ml / kg once a day in / m or in / in;
Children from 6 to 12 years of age are prescribed 5-10 ml per day;
and children over 12 years old - 10-15 ml per day.

For non-severe forms of PPNS, Actovegin is prescribed by a pediatric neurologist in the form of tablets (1 tablet per day).

Treatment with Actovegin is performed on an outpatient basis (Actovegin as part of complex therapy).
Children's neurologists use Actovegin when children are lagging behind in neuropsychological development, with a backlog in their studies.
Actovegin acts quite slowly, but in the complex treatment can achieve therapeutic success.

In severe forms of PPNS parenteral treatment is performed in a hospital.
Treatment is also complex.

Before the introduction of Actovegin, children are given a test for the medicine (for an allergic reaction)!

The injection of Actovegin is quite painful, so the children of Aktovegin are combined with Novokain (after the skin test).

Being basically a hood from calf blood, Actovegin has, therefore, a physiological basis, therefore, in principle, it is a fairly safe medication, which has found wide application in practice.

Apply Actovegin and in the treatment of head trauma (craniocerebral injury), which is not uncommon in children. But it is necessary to watch how the child is suffering with Actovegin treatment, at least in the first days (skin reaction, presence of fever and other reactions.).
In case of side effects, treatment with Actovegin is immediately canceled, replaced with other drugs.
Although side effects from therapy with Actovegin are rare, nevertheless individual intolerance of the drug is possible.
Before starting therapy, you should also read the contraindications to the use of Actovegin.

In previous articles on the blog All about Actovegin you will read that Actovegin is not indicated for use in pediatric practice. And this really corresponds to the instructions to the drug Actovegin, as there is not enough evidence for its use in children.
However, in practice, Actovegin is used in hospitals and at home.
In most cases, its use is without complications: Actovegin is well tolerated by patients.
Nevertheless, before the therapy Actovegin, the doctor should be thoroughly informed about all the diseases of the child.

As a rule, Actovegin in children is used in very difficult situations, when it is assumed that the therapeutic effect of treatment with Actovegin can exceed the possible risks.
These are diseases such as acute disorders of cerebral circulation, TBI, metabolic processes, etc.

Actovegin is also available in the form of an ointment, gel, eye gel. And we highly recommend having it in your home medicine cabinet.

Usually both ointment and gel Actovegin are well tolerated by both adults and children (they are used for burns, wounds, abrasions).
Neither ointment nor gel Actovegin contain toxic components. But a local reaction is possible in the form of burning, itching, so before using them in children, we advise you to consult a doctor.

Actovegin - prescription medication: independent treatment of children (without medical appointment) is unacceptable!


Actovegin - Treatment of astenia

18 Jul 2018

Dystonia. Causes of the disease. Treatment with Actovegin

Dystonia is a pathological condition that can be a symptom in a wide variety of organic diseases. Fortunately, the astenia in most cases has no connection with any serious disease. Another name for this disease is "neurocirculatory dystonia." If we try to explain this disease in two or three words, we should emphasize the following: vegeto-vascular dystonia is a violation "between the cerebral cortex and subcortical structures". And the manifestations VSD can be very diverse.

What is the role of astenia in the vital activity of the body?
Being in the brain and spinal cord, the autonomic nervous system regulates the activity of internal organs, etc.

Actovegin astenia

What can provoke this disease, which is found in a large number of patients who seek help from doctors (it is estimated - from a third to two-thirds of patients)?
The reasons can be very diverse: it can be the constitution of the person himself, and a variety of external factors, such as family, climate, the overall cultural development of a person, prolonged and often recurring stresses, chronic fatigue, violations of the working and rest regime, etc. .

A well-known scientist, academician AM Vein, who studied the autonomic nervous system, wrote that the cause of astenia in acute or chronic stress. And most scientists and practitioners agree with this statement. Wayne.

The insidiousness of this pathology also lies in the fact that the astenia can affect a person of any age (from early childhood to menopause) and can have a huge variety of manifestations: hypotension / hypertension, tachycardia / brachycardia, fear and anxiety, dysfunction of the digestive system, dizziness, chilliness hands and feet and more.

Although the first signs of astenia may appear already in childhood, and especially in adolescence, it should be noted that most often the disease manifests itself in people of the most active age (from twenty to forty-five years). And in women - more often than men. Hormonal reorganization of the body (in adolescence, with menopause in women) or hereditary predisposition can also be an impetus to the emergence of astenia.

The way of treatment astenia
Treatment astenia is complex, which can include medicines, physical education, work and rest, spa treatment, vitamin therapy, etc.
If you feel unwell, the patient should not listen to any advice from friends and girlfriends, and boldly go to the doctor who will give the referral for the tests, and then - if necessary - refer them to different specialists: the neurologist, the oculist, the endocrinologist, the ENT - and if necessary will - to a psychiatrist or psychotherapist at the reception.
Do not be afraid of psychiatrists: psychiatry has long ceased to be an instrument in the hands of punitive authorities. If there is no confidence in the treatment prescribed by the doctor, several specialists can be consulted.
The main thing is a correctly diagnosed diagnosis, as well as your own belief in the success of treatment. Own optimistic perception of life, a purposeful desire to conquer fear and all kinds of phobias - if properly and timely prescribed treatment - will help if you do not get rid of this disease forever, then achieve a stable remission.

The main symptoms with astenia: neurasthenia, depression; phobias; anxiety and excitement for every trifle, palpitations, dizziness, etc.

Drug therapy astenia can be very diverse. These can be medicines such as Glycine, Cinnarizine (Stugeron), Leonurus, Cerebrolysin, Ceraxon, Actovegin and other medications.

What can help Actovegin in a complex of measures aimed at eliminating the symptoms of the disease astenia?
In the complex treatment of astenia, drugs are used that improve cerebral circulation, since often astenia is a sign of cerebrovascular insufficiency, which is especially characteristic for middle-aged patients.
One of these medicines, which improve the energy metabolism of brain cells, is Actovegin.

Actovegin is administered intravenously by drip or by intramuscular injection. After the parenteral course of therapy with Actovegin, the patient can be transferred to the tablet form of Actovegin.
About dosages of Actovegin, the methods of treatment with Actovegin can be read here. The duration of therapy with Actovegin can be determined only by the attending physician, based on the severity of the disease, the age of the patient.

In addition, antioxidants are also used in complex treatment of astenia. One of these drugs used in the treatment of vegetovascular dystonia is Mexidol.

Symptomatic treatment of all types of astenia is diverse. For success in therapy of the astenia, it is very important that a diagnosis is made in time (already at the initial stage of this difficultly diagnosed disease) and immediately treatment started.



18 Jul 2018

Nootropic preparation.

Preparation: FENOTROPIL
The active substance of the drug: non appropriate
Encoding ATX: N06BX Nootropic drug

Fenotropil racetam

Pharmacological action of Fenotropil
Fenotropil - Nootropic preparation. By the mechanism of action is a neuromodulator, it acts on the majority of neurotransmitter systems of the brain. Has a pronounced antiamnestic effect, activates the integrative activity of the brain, promotes memory consolidation, improves concentration and mental activity, facilitates learning processes, accelerates the transfer of information between the cerebral hemispheres, increases the resistance of brain tissue to hypoxia and toxic effects, has anticonvulsant action and anxiolytic activity , regulates the processes of activation and inhibition of the central nervous system, improves mood.

Fenotropil has a positive effect on the metabolic processes and blood circulation of the brain, stimulates redox processes, increases the energy potential of the body through the utilization of glucose, improves regional blood flow in the ischemic areas of the brain. Increases the content of norepinephrine, dopamine and serotonin in the brain.

Does not affect the level of GABA, does not bind to GABAA- and GABAB receptors, does not have a significant effect on spontaneous bioelectrical activity of the brain.

Fenotropil has no effect on respiratory and cardiovascular systems. Has a weakly diuretic effect. Possesses anorexigenic activity in course use.

Fenotropil has a moderately activating effect on motor reactions, improves physical performance, has a pronounced antagonism with respect to the catalepsy effect of neuroleptics, reduces the severity of the hypnotics of ethanol and hexenal.
Psycho-stimulating effect of phenothropylate predominates in the ideator sphere. Moderate psychoactivating effect of the drug is combined with anxiolytic activity. Fenotropil improves mood, analgesic effect, raising the threshold of pain sensitivity.

Fenotropil has an adaptogenic effect, increasing the body's resistance to stress in conditions of increased mental and physical loads, fatigue, hypokinesia and immobilization, at low temperatures.

Against the background of the use of Fenotropil noted improvement in vision (increased acuity, brightness and fields of vision).

Fenotropil improves the blood supply of the lower extremities.

Fenotropil stimulates the production of antibodies in response to antigen administration, which indicates its immunostimulatory properties, but at the same time does not cause immediate-type hypersensitivity reactions and does not change the allergic skin inflammatory reaction caused by the introduction of a foreign protein.

In the course of the use of Fenotropil, drug dependence and tolerance do not develop. When the drug was withdrawn, there was no development of withdrawal syndrome.

The action of Fenotropil appears after a single dose, which is important when using the drug in extreme conditions.

Fenotropil - Indications for use:
- Diseases of the central nervous system of various genesis, especially diseases of vascular genesis or associated with impaired metabolic processes in the brain and intoxication (in particular, in posttraumatic states and chronic cerebrovascular insufficiency), accompanied by impaired intellectual and mnestic functions, decreased motor activity;

- neurotic states, manifested by lethargy, increased exhaustion, decreased psychomotor activity, impaired attention, memory impairment;

- Violations of learning processes;

- Depression of mild and moderate severity;

- psycho-organic syndromes, manifested by intellectual-mnestic disorders and apatiko-abulic symptoms, as well as flaccid states in schizophrenia;

- convulsive conditions;

- obesity (alimentary-constitutional genesis);

- Prevention of hypoxia, increased resistance to stress;

- correction of the functional state of the organism in extreme conditions of professional activity with the purpose of preventing the development of fatigue and increasing mental and physical performance;

- correction of daily biorhythm, regulation of the cycle "sleep-wakefulness";

- chronic alcoholism (in order to reduce the symptoms of asthenia, depression, intellectual-mnestic disorders).

Fenotropil Dosage and route of administration.
Dosage is set individually.

The average single dose is 100-200 mg, the average daily dose is 200-300 mg. The maximum daily dose is 750 mg. Multiplicity of admission - 1-2 times / day.

A daily dose of more than 100 mg is recommended to be divided into 2 divided doses. Duration of treatment - from 2 weeks to 3 months. The average course of treatment is 30 days. If necessary, appoint a second course of treatment in a month.

To improve performance, 100-200 mg 1 time / day in the morning for 2 weeks (for athletes - for 3 days).
In case of alimentary-constitutional obesity, 100-200 mg 1 time / day in the morning for 30-60 days.

Fenotropil is taken orally after a meal.

It is not recommended to take Fenotropil after 15 hours.

Special instructions for the use of Fenotropil.
Caution should be given to the drug Fenotropil to patients with severe organic lesions of the liver and kidneys, severe course of arterial hypertension, with severe atherosclerosis; patients with panic attacks, acute psychotic conditions accompanied by psychomotor agitation (as possible aggravation of anxiety, panic, hallucinations and delusions); patients prone to allergic reactions to nootropic drugs of the pyrrolidone group.

It should be borne in mind that with excessive psychoemotional exhaustion on the background of chronic stress and fatigue, chronic insomnia, a single dose of Fenotropil in the first day can cause a sharp need for sleep. Such patients in outpatient settings are advised to start taking the drug on non-working days.

Use in Pediatrics
Fentotropil is not recommended for children due to the lack of clinical data on the use of the drug in children.


Actovegin - unique drug

18 Jul 2018

One of the leading causes of morbidity and mortality worldwide is cerebrovascular pathology (up to 50 percent of all cardiovascular pathologies). Effective treatment and diagnosis of pathology is the foundation for the treatment of major diseases in geriatrics. Metabolic changes in nerve cells have long been the goal of targeted pharmacological effects.

aktovegin buy

Actovegin is the most commonly used medication of this type. It is connected with the concept of neurometabolic pharmacotherapy. Different areas of medicine use Actovegin with success - therapy, neurology, endocrinology, surgery. Such a huge success of Actovegin is the result of a special mechanism of action.

Let's try to understand the features of the mechanism of action of Actovegin.
A practicing physician of clinical neurology has an extensive selection of medications for neurotransmitter and vasotropic action that can successfully solve problems of correction of neurotransmitter imbalance and regulation of cerebral blood flow. Nevertheless, the third most important part of the strategy of treating central nervous system diseases - neurometabolism - is a problematic link.

Actovegin is popular not only in the field of neurology, but also in all clinical practice due to its three main merits:
a) high efficiency;
c) a wide range of pharmacological effects;
(c) Security.
The basic mechanism of action of the drug Actovegin is to improve aerobic metabolism due to improved supply and consumption of glucose. This helps to activate the formation of ATP and establish an energy metabolism in hypoxia, as well as normalize the metabolism and action of the cell.

All this is due to the following features of the action of Actovegin:
Actovegin improves the use of oxygen by neurons, and also promotes the formation of adenosine triphosphate.
Actovegin helps the formation of the most important neurotransmitter of the central nervous system - acetylcholine.
Actovegin improves the flow of glucose through the blood-brain barrier.

Actovegin is a kind of comprehensive bioenergy stabilizer of cellular metabolism. This is what distinguishes Actovegin from other nootropic and vasotropic drugs, which affect only a certain component energy supply of the cell or several components, rather than the whole process.

Actovegin is also a powerful antioxidant, acting as a result of the start of the main enzyme of the internal antioxidant system.

Actovegin promotes intracellular transport of glucose, acting like insulin, but without affecting the receptors of the pancreas, which is important in the presence of insulin resistance. At the same time, according to the force of action, Actovegin is weaker than insulin only twice.
Actovegin inhibits the progress of angiopathy in diabetics of the first type, and also increases the intensity of lipolysis.

Actovegin improves the adaptation of neurons, increases transport and oxygen consumption not only by neurons, but also by cells of various body systems.

Actovegin affects the cells of the myocardium and liver.

Thus, Actovegin is a unique drug that has found application in clinical practice, primarily in neurology (discalcular encephalopathy, vascular dementia, stroke, alcoholic neuropathy, diabetic neuropathy and angiopathy, radiculitis, vertebral hernia and osteochondrosis, craniocerebral trauma, brain injuries).

Actovegin also has a preventive effect, which helps prevent the occurrence of metabolic disorders characterized by cognitive and psycho-emotional symptoms.
The use of Actovegin helps in the successful treatment.

Actovegin is a safe drug, side effects have not been observed, allergic reactions are exceptions (in most cases, when the original is not used, but a fake), and that is important:
Actovegin is compatible with many drugs.

Actovegin is used in therapy not only for adults (including pregnant women), but also for the treatment of children.

Actovegin is also used in veterinary medicine. Apply Actovegin and in sports.

Actovegin is available both in a solution for intravenous infusions, and in injections, tablets, in the form of a gel, cream and ointment.

Actovegin is one of the most progressive pharmacological drugs used in various fields of medicine: in endocrinology, neurology, cardiology, gynecology, gastroenterology (here), rheumatology and dermatology, etc ..

Sometimes readers in their letters ask whether Actovegin can provoke dementia. Very authoritative authors of scientific research completely refute such unsubstantiated rumors.

I would like to stop here on what issue: on the issue of actovegin's effectiveness. Does Actovegin help?

Actovegin and Evidence-Based Medicine
You will meet on the Internet many articles on the lack of evidence base for Actovegin, ie. it is a question of that there are no studies of the efficacy and safety of Actovegin.

And it's all written about a drug that is very well known to doctors.

Yes, the exact mechanism of action of Actovegin is still unclear and has not been fully understood.

However, it would be unfair not to notice that a number of experiments on the mechanism of Actovegin have been carried out in recent years and a number of effects of this drug have been accurately established (insulin-like activity, neuroprotective properties ...).

Experimental experiments have shown that in Actovegin, extraordinary opportunities exist for the therapy of pathologies, which are accompanied by ischemia, hypoxia and oxidative stress.

Today, Actovegin is widely used in the complex therapy of encephalopathies, in the treatment of patients after a stroke and patients with diabetes mellitus (in the case of diabetic polyneuropathy - a frequent and extremely dangerous complication of diabetes, often resulting in gangrene of the extremities).

Actovegin is used in practice for more than thirty years: longer than the term "evidence-based medicine" itself.

If you follow the fact that there is no evidence base for Actovegin, then there may be a situation where the possibilities for treatment as a whole will be reduced, because a lot of drugs can be added to the list of drugs that did not pass "independent studies on GCP rules".

Here is what an authoritative specialist writes about this (Kulikov A.Yu., Associate Professor of the Department of Drug Supply Organization ...): "40% of medicines on the Russian market ... have no evidence base." However, this does not mean that such a sin is not found among a number of foreign manufacturers.

Archie Cochran and his colleagues have done a great job in the last decade: around the world today - a dozen Cochran centers. They made a significant contribution to what is today called "evidence-based medicine."

We hope that further study of Actovegin will be continued:
Today there are more than two dozen countries where this drug has found application.


Buy Phenylpiracetam

17 Jul 2018

Buy Phenylpiracetam is one of the most effective nootropic drugs available on the market today. This is a relatively new nootropic drug from the family of pyracetam derivatives, which is a modification of the original preparation Piracetam. The difference between Buy Phenylpiracetam and pyracetam is that its activity is 30-60 times higher, it has neuroprotective properties and increases physical efficiency. For all these reasons, phenylpira - cetam is increasingly becoming the drug of choice among nootropics.

buy phenylpiracetam

Phenylpyracetam (RS) -2- (2-oxo-4-phenylpyrrolidin-1-yl) -acetamide), also known as Carphedon or Fentropil, was developed in Russia in 1983. It was created as a nootropic remedy, and also as a means to increase physical endurance. Buy Phenylpiracetam was synthesized from Piracetam by adding a phenyl group to the substance. Buy Phenylpiracetam has long been popular in the east, and only recently has become popular in the west. Its effects are described as increasing concentration of attention, as well as improving memory and learning. There is a stimulation and improvement of locomotor activity, which increases physical efficiency. For this reason, Buy Phenylpiracetam has been included in the list of banned drugs by many sports organizations, including the Olympic Committee.

The structure of phenylpiracetam is a pyracetam with a phenyl group attached to it. This feature significantly increases its bioavailability and increases the efficiency 30-60 times compared to piracetam. The addition of a phenyl group affects these properties in two ways:

High efficiency and more pronounced effects are achieved due to the ability of the molecule to penetrate more easily through the blood-brain barrier.

Stimulant effects are more pronounced due to their similarity to phenylethylamines, such as Adderol. In comparison with other pyracetamines, phenylpiracetam is quite effective and has high bioavailability even when administered orally. Its half-life in humans is 3-5 hours.

Efficiency. Is Buy Phenylpiracetam better than piracetam?
There is ample evidence that Buy Phenylpiracetam, like other piracetam drugs, is effective in slowing the progression and symptoms of cognitive impairment. In some of these studies, piracetam was used for more than one month, and its positive effects were due only to the effect on organic causes of cognitive impairment (dementia and stroke) rather than to traumatic brain damage.

There is only one study in rats, in which there was an improvement in cognitive ability in relatively healthy individuals, and this study only describes the effectiveness of the R-isomer (the racemic mixture that is most commonly found on the market has no similar effect). It is impossible to exclude the cognitive improving effect of Buy Phenylpiracetam in young individuals. Presumably, it differs from the psychostimulating effect (which is noted equally when using the said racemic mixture and the R isomer). The R-isomer appears to be more active than the S-isomer when using phenylpiracetam for conventional purposes (for psychostimulation and enhancement of learning), while the racemic mixture (most commonly sold) is effective for increasing cognitive abilities, but it is not known, whether it has a nootropic effect in adolescents.

Buy Phenylpiracetam Dosage
The recommended dosage is 100-250 mg. Recommendations: Buy Phenylpiracetam is soluble in water. Do not use during pregnancy and lactation. Side effects - very rarely allergic reactions. Before use, consult a specialist.

Buy Phenylpiracetam has 100% bioavailability for oral administration, rapidly absorbed through the gastrointestinal tract and other organs. After entering the bloodstream, it easily penetrates the blood-brain barrier. 60% of the drug is excreted in the urine, the rest is through the biliary tract. Metabolism occurs with the formation of 3-hydroxycarphedon and 4-hydroxycarphedon. Buy Phenylpyracetam begins to act 1 hour after the administration, its half-life is 3-5 hours.

Buy Phenylpiracetam has the properties of a neuromodulator. It has a significant effect on the cholinergic and glutamatergic system. It binds to acetylcholine and glutamate receptors. Buy Phenylpiracetam also increases the level of dopamine and norepinephrine in the brain, which can explain its stimulating effect and the ability to cheer up.

On the direct mechanism of action of Buy Phenylpiracetam is known as little as other piracetamas. It is known that it increases the density of NDMA-glutamate receptors in the hippocampus. It is believed that Buy Phenylpiracetam is also able to stimulate nicotinic cholinergic receptors of the cerebral cortex and D3-dopamine receptors of the striatum.

The ability of Buy Phenylpiracetam to affect physical performance was noted. Despite the fact that phenylpiracetam has a stimulating effect, no direct effect on the cardiovascular and respiratory systems was detected. It was noted that phenylpiracetam is able to reduce the pain threshold, as well as the ability to adapt to stress. It is believed that phenylpyracetam promotes modulation of locomotor activity in the brain.

Side effects of buy Phenylpiracetam
Buy Phenylpiracetam has the same side effects and risks as most other piracetamines. These include: headache, nausea, irritability and problems with the gastrointestinal tract. Insomnia can occur due to the stimulating effect of the drug. This side effect can be avoided by reducing the dosage of the drug or correcting the time of its administration, since it has a fairly short half-life.

Over time, Buy Phenylpiracetam is addictive, which develops faster than other pyracetamines. It is believed that the drug does not cause dependence, but there is information about the occurrence of dependence. In general, this drug is not recommended for daily use, as with long-term use, it loses its nootropic properties. Buy Phenylpiracetam rarely causes dependence and can be considered relatively safe with proper application.

There are no reports of fatal or severe cases when phenylpyra- cetamine interacts with other drugs. No cases of an overdose of phenylpyricetam were observed. It can be considered safe with the use of recommended dosages. Do not exceed the recommended dosage, and before starting reception should consult with a specialist. Hypersensitivity to the drug may develop, so you should start taking small doses.

Like other pyracetamines, Buy Phenylpiracetam rarely causes side effects when administered at the recommended dosages. If you have a headache, you might want to increase your choline intake, which is often recommended when taking piracetam drugs.


Phenylpiracetam Carphedon

16 Jul 2018

Phenylpiracetam Carphedon (internationally called Fonturacetam, chemical - 4-phenylpyricetam) is a drug with nootropic effect, besides it has psychostimulating, anticonvulsant, antihypoxic and antihypertensive properties. It has an adaptogenic effect under various stress models. 

Phenylpiracetam carphedon

Phenylpiracetam Carphedon prevents overloading of higher nervous activity during information overloads in experiments in higher animals, normalizes the daily biorhythm of the indicators of the sympathoadrenal system. It is a chemically improved formula of pyracetam.

Phenylpiracetam Carphedon in sport
Phenylpiracetam Carphedon has a clear activating effect, and therefore was listed in the list of banned substances by the World Anti-Doping Agency. So in 2006, Russian biathlete Olga Pyleva was disqualified for 2 years. In August 2008, another Russian athlete (run with obstacles) Roman Usov was disqualified.

According to the experience of using in sports, it is safe to say that this is one of the few drugs whose effect is really felt. Already on the second or third day of admission, there is a marked increase in endurance, physical activity and strength. It is recommended to take 3-7 days before the competition, in a dose of 200-500 mg per day. When recruiting muscle mass is undesirable, as phenotropic moderately reduces appetite and promotes weight loss.

It is worth noting that Phenylpiracetam Carphedon is extremely effective for increasing mental activity during preparation for exams or other heavy mental activity. Significantly reduces the need for sleep, improves the assimilation and processing of information. For these purposes is adopted by the instruction.

Phenylpiracetam Carphedon pharmachologic effect
Phenylpiracetam Carphedon - Nootropic drug, has a pronounced antiamnestic effect, has a direct activating effect on the integrative activity of the brain, promotes memory consolidation, improves concentration and mental activity, facilitates the learning process, increases the speed of information transfer between the cerebral hemispheres, increases the resistance of brain tissue to hypoxia and toxic impacts. It also has anticonvulsant and anxiolytic effects, regulates the processes of activation and inhibition of the central nervous system, improves mood. It has a positive effect on the metabolic processes and blood circulation of the brain, improves the regional blood flow in ischemic areas of the brain, stimulates redox processes, increases the energy potential of the organism due to better utilization of glucose. Increases the concentration of norepinephrine, dopamine and serotonin in the brain, does not affect the content of GABA, binds neither to GABAa nor to GABAb receptors, does not have a significant effect on spontaneous bioelectrical activity of the brain. Does not affect the respiratory and cardiovascular systems, shows an unexpressed diuretic effect, Phenylpiracetam Carphedon has anorexigenic activity in course use. The stimulating effect of the drug is manifested in the ability to exert a pronounced effect on motor reactions, in increasing physical performance, in pronounced antagonism to the catalepytic action of neuroleptics, and in the weakening of the expression of the hypnotic action of ethanol and hexenal. Phenylpiracetam Carphedon - psychostimulating action prevails in the ideatorial sphere. Has some analgesic effect, increasing the threshold of pain sensitivity. Phenylpiracetam Carphedon - adaptogenic action is manifested in increasing the body's resistance to stress in conditions of excessive mental and physical stress, fatigue, hypokinesia and immobilization, at low temperatures. Against the background of taking the drug, there is an increase in visual acuity, brightness and visual fields. Phenylpiracetam Carphedon improves blood circulation of the lower extremities. Stimulates the production of antibodies in response to the introduction of antigen, at the same time does not promote the development of immediate type hypersensitivity and does not change the skin allergic reaction caused by the introduction of a foreign protein. With the course application does not develop drug dependence, tolerance, withdrawal syndrome. The effect is manifested even when taking a single dose. Does not have a teratogenic, mutagenic, carcinogenic and embryotoxic effect. The toxicity of the drug is low, the lethal dose is 800 mg / kg.

Phenylpiracetam Carphedon Indications
CNS diseases associated with vascular diseases and metabolic disorders in the brain, intoxication (including post-traumatic conditions, chronic cerebrovascular insufficiency), accompanied by deterioration of intellectual-mnestic functions, decreased motor activity. Neurotic conditions manifested by lethargy, increased exhaustion, decreased psychomotor activity, impaired attention, memory impairment. Violation of the learning process. Depression of mild and moderate severity. Psycho-organic syndromes, manifested by intellectual-mnestic disorders and apatiko-bulimic phenomena; apatic conditions at a schizophrenia. Convulsive syndrome. Obesity (alimentary-constitutional genesis). Prevention of hypoxia, increased resistance to stress, correction of the functional state of the organism in extreme conditions of professional activity with the goal of preventing the development of fatigue and increasing mental and physical performance, correcting the daily biorhythm, inversion of the "sleep-wake" cycle. Chronic alcoholism (in order to reduce the phenomena of asthenia, depression, intellectual-mnestic disorders).

Phenylpiracetam Carphedon Contraindications
Hypersensitivity, pregnancy, lactation, children's age.C with caution. Heavy organic diseases of the liver and kidneys, severe arterial hypertension, atherosclerosis, panic attacks in the anamnesis, acute psychotic conditions that occur with psychomotor agitation (risk of worsening anxiety, panic, hallucinations and delirium), allergic reactions to drugs from the group of pyrrolidone.

Phenylpiracetam Carphedon Side effects
Insomnia (in case of taking the drug later than 15 hours). In the first 1-3 days: psychomotor agitation, hyperemia of the skin, sensation of heat, increased AD. Overdose. Treatment is symptomatic.

Phenylpiracetam Carphedon Dosing and Administration
Inside, right after eating. The average single dose is 150 mg (100-250 mg), the average daily dose is 250 mg (200-300 mg), the maximum daily dose is 750 mg. The daily dose is divided into 2 divided doses. Duration of treatment - from 2 weeks to 3 months. The average duration of treatment is 30 days. If necessary, a second course is possible after 1 month. To improve performance - 100-200 mg once in the morning for 2 weeks (for athletes - 3 days). Alimentary-constitutional obesity: 100-200 mg once a day in the morning hours for 30-60 days.

Phenylpiracetam Carphedon special instructions
It is not recommended to take the drug after 15 hours. In case of excessive psychoemotional exhaustion against the background of chronic stress and fatigue, chronic insomnia, a single dose of the drug in the first day can cause a sharp need for sleep, therefore it is recommended for patients on out-patient treatment to start treatment on non-working days.

Phenylpiracetam Carphedon Interaction
Strengthens the action of drugs, stimulating the central nervous system, nootropic drugs and antidepressants.
ATTENTION!!!! Phenylpiracetam Carphedon Included in the list of substances WADA as banned in the competition period!

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