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Olanzapine

23 Jan 2018

Olanzapine- antipsychotic drug (atypical antipsychotic), structurally and similarly to clozapine. It is used to treat schizophrenia and bipolar affective disorder. Has a wide range of psychopharmacological effects and has antidepressant effect.

Olanzapine

Trade names: Olanzapine, Normiton, Olanex, Parnasan, Zalasta, Ziprexa, Egolansa

It is also produced in combination with fluoxetine called Symbiax for the treatment of bipolar depressive episodes and resistant depression.

In preclinical studies, the affinity of olanzapine for serotonin 5-HT2A, 5-HT2C, 5-HT3, 5-HT6, dopamine D1, D2, D3, D4 and D5, muscarinic (1..5), adrenergic α1 and histamine H1 receptors has been established. In experimental studies, the presence of antagonism of olanzapine with respect to serotonin receptors, dopamine and cholinergic receptors has been revealed. In vivo and in vitro, olanzapine has more pronounced affinity and activity with respect to 5-HT2 compared to D2 receptors.

According to electrophysiological studies, olanzapine selectively decreases the excitability of mesolimbic dopaminergic neurons, and at the same time has a negligible effect on the striatal neural pathways involved in the regulation of motor functions. Olanzapine reduces the conditioned protective reflex (a test characterizing antipsychotic activity) at doses lower than the doses causing catalepsy (a disorder reflecting a side effect on the motor function). In contrast to the "typical" antipsychotics, olanzapine enhances the anti-anxiety effect during the anxiolytic test.

Two placebo-controlled and two out of three comparative controlled trials involving 2,900 schizophrenic patients showed that olanzapine provides statistically significant reduction in the short term as productive (including delusions, hallucinations) and negative disorders. Data on the effect of different doses of olanzapine on negative symptoms are not completely consistent; perhaps the reduction in severity of negative disorders is explained by the action of olanzapine on secondary negative symptoms (eg, caused by drug parkinsonism or psychosis), rather than by direct action on primary negative symptoms.

According to the meta-analysis, olanzapine is superior to haloperidol in the likelihood of success of therapy, improvement in the severity of mental disorders, and a decrease in the severity of productive and negative disorders. According to some studies, olanzapine is superior to haloperidol in its effect on cognitive function, in other studies no difference was found. Studies show that relapses with olanzapine are significantly less frequent than when taking haloperidol.

Indications

~ treatment of exacerbations; supportive and long-term anti-relapse therapy for schizophrenia and other psychotic disorders with marked productive (including delirium, hallucinations, automatism) and / or negative symptoms (including emotional flattening, decreased social activity, impoverishment of speech) and symptomatic accompanying affective disorders;

~ Treatment of acute manic or mixed seizures in bipolar affective disorder. can be used to treat stimulant psychoses.

At the beginning of treatment, especially when choosing a dosage, it is necessary to observe: extrapyramidal side effects, orthostatic hypotension and reflex tachycardia, drowsiness, weight gain, hyperglycemia and hyperlipoproteinemia are possible. The risk of orthostatic hypotension increases with combined use of olanzapine with benzodiazepines. Drowsiness at the beginning of treatment develops often, so it is better to take the drug at night.

Caution should be given to patients with a reduced number of leukocytes and / or neutrophils, due to various causes; with signs of oppression / toxic damage to bone marrow function under the influence of drugs in the anamnesis; with oppression of bone marrow function due to concomitant disease, radiotherapy or chemotherapy in history; with hypereosinophilia or myeloproliferative disease. In clinical studies, the use of olanzapine in patients with clozapine-dependent neutropenia or agranulocytosis in a history was not accompanied by relapses of these disorders.

When olanzapine is prescribed for the first time, it is necessary to evaluate the probability of weight gain by the patient, taking into account his body mass index, anamnesis, the general clinical feeling of propensity to fullness - pastness, friability. Observing the patient taking olanzapine, it is important to consider the main principle of weight gain control: seven percent of the initial increase in body weight is an absolute contraindication to the further use of the drug.

For the prevention of obesity and its complications (in particular, diabetes mellitus) it is necessary:

~ Monitor before taking antipsychotics and during their intake of body weight and body mass index, fasting glucose (or hemoglobin A1c) and lipid levels in the blood plasma. The fasting glucose level should not exceed 126 mg / dl, hemoglobin A1c - not exceed 6.1%. To detect hyperglycemia, it is also desirable to measure not only the fasting glucose level, but also the level 2 hours after taking glucose. In patients with risk factors (family history, overweight), monitoring of glucose levels should be carried out every 2-4 months. All patients are also advised to measure blood pressure before starting therapy and during therapy.

~ Dose of antipsychotic to build up slowly, which allows you to partially prevent weight gain. In this case, the first weeks of neuroleptic therapy are especially important, since it is much easier to prevent weight gain than to decrease it in the future.

~ Treat attentively to the lifestyle and diet of the patient. It is necessary that food is as low as possible in terms of calories, and the way of life is much more active. In this diet and exercise require careful dosing. ~ It is recommended to reduce intake of saturated fats and cholesterol, increased consumption of fibrous food. Smoking is also recommended.

~ If significant weight gain is seen, refer the patient to a dietician and a physiotherapist.

~ When taking high doses of neuroleptic - a cautious approach to its combination with other diabetogenic drugs (beta-adrenoblockers, glucocorticoids, protease inhibitors, thiazide diuretics).

To prevent the development of life-threatening conditions associated with diabetes (acidosis and coma), it is necessary to recognize early and begin treatment of developing diabetes. Psychiatrists with olanzapine therapy should be wary of such symptoms of diabetes as weight loss, drowsiness, thirst, polyuria, if necessary, provide the patient with an endocrinologist's advice.

With the use of olanzapine, malignant neuroleptic syndrome, a potentially lethal symptom complex, whose clinical manifestations include a significant increase in body temperature, rigidity of the musculature, changes in mental status, and autonomic disorders (unstable pulse or arterial pressure, tachycardia, cardiac arrhythmia, increased sweating) may develop.

In comparative studies lasting more than 6 weeks, treatment with olanzapine was significantly less likely to be accompanied by the development of tardive dyskinesia (an irreversible neurological side effect) than the use of haloperidol. However, it is still necessary to consider the risk of this side effect with prolonged therapy with neuroleptics. When developing signs of tardive dyskinesia, it is recommended to reduce the dose or to cancel olanzapine. Symptoms of tardive dyskinesia may increase or manifest


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Clozapine

22 Jan 2018

Clozapine is an antipsychotic drug (neuroleptic). Historically, this is the first atypical antipsychotic (started in 1971, approved by the FDA in 1989). Unlike other antipsychotics, it usually does not cause extrapyramidal disorders, and also has high efficacy against productive disorders that are resistant to other neuroleptics, but should be used under the strict supervision of a physician due to possible effects on the cellular composition of the blood. Common name - azaleptin

Trade names: Azaleptin, Leponex, Azaleprol, Klozasten, Clozaril, Alemoxane, Azapine, Azaleptol, Azalepticon, Skizoril.

clozapine

Clozapine was historically the first representative of the class of so-called "atypical antipsychotics," that is, antipsychotics that differ from the traditional low probability of extrapyramidal side effects, better tolerability and less influence on the secretion of prolactin.

Clozapine was synthesized in the 1960s. After the death of 8 out of 16 patients in Finland who developed agranulocytosis with clozapine in the 1970s, this drug was banned in the US and many other countries, but in some countries it continued to be used. In 1990, he was re-sold in the United States after finding that he was effective for schizophrenic psychoses resistant to therapy and less inclined to cause side effects characteristic for antipsychotics in general.

According to its chemical structure, it is a tricyclic compound having similarities to tricyclic antidepressants and partially to benzodiazepine tranquilizers.

Clozapine is in some ways "the most atypical", atypical of atypical antipsychotics, because it rarely causes extrapyramidal disorders throughout the range of clinically applicable doses, than other atypical antipsychotics such as risperidone, olanzapine (ziprex) and even quetiapine (seroquel), which at high doses approach properties of traditional neuroleptics and can cause dose-dependent extrapyramidal disorders.

Clozapine has a strong antipsychotic, moderate antimanic and moderate tricyclic-like (associated with the effect on re-uptake of monoamines) antidepressant activity in combination with pronounced hypnotic, sedative and anti-anxiety action. It blocks various subtypes of dopamine (D1, D2, D3, D4, D5), serotonin (5-HT1A, 5-HT2A, 5-HT1C), muscarinic (M1, M2, M3, M5), histamine (H1) and adreno- ( α1, α2) receptors; has the properties of agonism to M4-receptors.

Self-antidepressant effect (blockade of monoamines re-uptake) in clozapine begins to occur at doses of the order of 150-200 mg / day, lower than the doses that have a pronounced antipsychotic effect (300-600 mg / day), but higher than the doses at which begins to manifest nonspecific anti-anxiety, hypnotics and sedation (25-50 mg or more, depending on the degree of excitation and anxiety).

In connection with very strong anti-anxiety activity, clozapine shows special selectivity for acute depersonalization syndrome, quickly, strongly and selectively eliminating the sharply emerging depersonalization and derealization in patients with depression. The efficacy of clozapine for chronic depersonalization is much lower, but it is also very significant.

Does not cause a strong general oppression, like chlorpromazine and other aliphatic phenothiazines.

Clinical improvement with clozapine therapy in individuals with schizophrenia is much more common than with typical antipsychotics. It is characterized by high efficiency in relation to productive symptoms, including those resistant to the action of other neuroleptics. Effective at the risk of suicide, persistent hostility and aggressiveness. With regard to cognitive impairment, the results of clinical trials produced conflicting results: clozapine improved in one measure, in others it did not affect cognitive impairment, or even worsened. There is evidence that clozapine can cause symptoms of obsessive-compulsive disorder in patients with schizophrenia due to its pronounced antiserotonergic effect.

A low proportion of extrapyramidal disorders (0-20%), absence of late dyskinesias are associated with agonistic effects on dopamine D2 receptors in the mesocortical region of the brain with simultaneous suppression of dopaminergic activity in the mesolimbic pathway. Central muscle-relaxing effects are associated with the effect of the drug on GABA receptors.

Indications

For no indication, the drug can not be used as a first-line agent in connection with the frequent (1-2%) development of a terrible and sometimes deadly complication - granulocytopenia, up to agranulocytosis and aplastic anemia.

Clozapine is indicated in patient resistance to other antipsychotics (if at least two traditional antipsychotics taken in the usual dosage over a long period of time do not improve the clinical or subjective state), as well as the occurrence of severe side effects, mainly extrapyramidal, in the treatment other neuroleptics. It is necessary to guarantee the implementation of appropriate medical and control measures, which determine the need for a material and technical base for blood control and special training of medical personnel.

In antipsychotic doses (300-600 mg / day) are used for hallucinatory-delusional, catatonic-gabeferic, catatonic-hallucinatory states and states of psychomotor agitation in schizophrenia, with manic syndrome in the bipolar affective disorder. In some cases, the drug is effective in resistance to treatment with other antipsychotics (neuroleptics).

In small doses (12.5-25-50 mg / day), the drug is often used as a hypnotic, sedative and anti-anxiety for insomnia and sleep disorders of various origins, with anxiety, neuroses, anxious and agitated depression, depressions with depersonalization. It is also used in cases of psychopathy in excited patients, with aggressiveness, dysphoria, affective fluctuations and disorders.

In antidepressant doses (150-200 mg / day and above) it is sometimes used as an independent antidepressant in endogenous depressions, primarily with depersonalization syndrome, anxiety, agitation, agitation, severe insomnia or accompanied by psychosis.

Frequent use of clozapine to achieve sedation and as a hypnotic is subject to criticism in highly authoritative sources as not consistent with its main profile of indications for use in therapy. It is noted that clozapine in many cases is appointed without sufficient reason and not for the intended purpose, without taking into account the risk / benefit ratio.

With an overdose of clozapine, depression of consciousness can develop until the development of coma, as well as symptoms associated with holinoliticheskim action (tachycardia, delirium), epileptic seizures, respiratory depression, extrapyramidal disorders. When taking a dose exceeding 2500 mg, there is a risk of death.


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Neurotransmitter acetylcholine improves memory and concentration of attention

17 Jan 2018

Acetylcholine can be considered the most important neurotransmitter involved in the process of remembering information. This highly chemically active substance is an ester of choline and acetic acid. It contributes to the fact that information is quickly and unhindered transmitted from the senses to the main control center - the brain.

Unfortunately, with age, less acetylcholine is synthesized in the human brain. As a result of this, scientists believe, forgetfulness, problems with concentration of attention, difficulties in the selection of necessary words.

Meclofenoxate and choline serve as a basis for good brain activity. In order to improve memory in a short time and keep it clear for a long time, the famous researcher of brain activity, professor of the University of Hyssin, Wilfried Dimpfel, recommends that the concentration of the main neurotransmitter, acetylcholine, be purposefully stabilized. This can be achieved by taking choline preparations. Choline is a natural building block for the synthesis of acetylcholine molecules.

It is even better to build your own food in such a way as to ensure sufficient natural intake of choline in the body with natural food. A large amount of choline contains cabbage (especially cauliflower and broccoli), eggs, peanuts, fish, meat, hard cheese varieties, liver, milk and wheat sprouts. In addition to choline for the synthesis of acetylcholine, vitamins such as pantothenic acid (vitamin B3), folic acid, vitamins B12 and B1 are needed. Just in the elderly, as well as in people suffering from bowel disease, there is a shortage of B vitamins.

The scientists also place great hopes on deanol (meclofenoxate) - in a scientific environment known as dimethylaminoethanol (Dimethylaminoethanol) or abbreviated DMAE. With a lack of acetylcholine in the body, it can be re-synthesized in the required amount from deanol. Some medical research has proved the positive effect of this substance on brain function.

In one experiment, conducted over a period of 3 months, a group of people with memory problems and concentration of attention took medications containing deanol and choline. At the end of the experiment, problems with concentration disappeared in 84% of the subjects, memory improved in 75% of the participants in the experiment.

In addition, supplying your body with all the necessary substances for building neurotransmitter molecules by substances, do not forget that the synthesis of acetylcholine (and hence memory improvement) will occur only if the brain is actively involved, receiving sufficient information for thought and remembering. Do not be lazy to load your memory, giving it food for thought.

And one more aspect of the problem of memorization. For intensive activity, brain cells require continuous intake of energy and nutrients, which is ensured by the flow of blood. Poor blood supply leads to rapid fatigue, headache and drowsiness. So do not be lazy at least 30 minutes a day to devote to intense physical training. Only all three factors - proper nutrition, physical and intellectual loads, - in aggregate will help to significantly improve memory and keep it to a very old age.


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Tablets for Memory

16 Jan 2018

Memory is one of the higher functions of the brain, which is influenced from outside. The main varieties of this integrative brain activity are immediate, short-term (part of the operational) and long-term memory. Memory disorders can occur both in cases of vascular pathologies in conditions of chronic oxygen starvation of the cortex, and in bacterial or viral infections, parasitic infestations, under the influence of anesthesia, hypnotics, with various intoxications, including nakrokoticheskih, alcohol and tobacco. Separately there are traumatic brain injuries, tumors and epilepsy, in which memory is disturbed significantly. Memory loss can concern both events that occurred before a certain moment (trauma), and capture the present period of time. There is also a violation, in which there is a good memory for the old facts, and the fallout concerns fresh information (this type is typical for vascular dementia in the elderly). Often, memory impairments are of a non-structured nature and relate to the difficulties of memorization.

tablets for memory

There are electoral defects. For example, the inability to memorize dates or persons. Such deviations are hardly noticeable to others, but they can bring a lot of inconveniences in everyday life to those who suffer from them.

Since there is a wide range of diseases and functional conditions for memory disorders, it makes sense to consult a doctor in all cases when memory disorders are fixed by the patient himself or his relatives. This will make it possible to understand in due time the true causes of what is happening and not to miss the conditions that threaten not only complete loss of memory, but also life.

To diagnose memory disorders, patients undergo special testing from a neurologist or psychiatrist.

Tablets used to treat memory disorders, the so-called, mnemotropic drugs.

1. Cholinesterase blockers. Donezyl hydrochloride (aricept), galantamine (dilated), rivastigmine (exelon). Drugs interfere with the cleavage of acetylcholine, which facilitates the transmission of a nerve impulse in the brain cells, improves memory.

2. Pyrrolidine derivatives or ratsetamy: phenylpyrazetam (phenotropil), pyracetam (nootropil, lucetam, vinpocetin, oikamid, pyrabene), aloracetam, brivaracetam, aniracetam (draganol), dupracetam, dorracetam, dimiracetam, imaracetam, nebrasetam, noopept, nefiracetam, fazoracetam, pramiracetam, rolziratsetam, rolipram, seletracetam. Activates glutamate receptors that are adjacent to acetylcholine and potentiate their action.

3. Derivatives of precursors of acetylcholine (dimethylaminoethanol) -aclumate deanol (noctolin, clerel, deanol), meclofenoxate (anilux, lucidryl, cerutil, acephene). Increase the content of acetylcholine, responsible for improving nerve conduction.

4. Vitamins of group B. Pyridoxine derivatives (pyrithinol, encephabol, energy, pyriditol). Thiamin (B1) potentiates memory, smooths out the effects of anesthesia. Niacin, nicotinic acid (B3) increases the efficiency of the brain. Cyanocobalamin (B12) improves neuromuscular transmission, prevents the development of Alzheimer's disease (milgamma).

5. Gamma-aminobutyric acid (aminalon), its derivatives and analogues: gamma-amine-beta-phenylbutyric acid hydrochloride (phenibut), nicotinoyl-gamma-aminobutyric acid (picamylon), gapontenic acid (pantocalcin, pantogam). It provides removal of unnecessary excitation in the brain, increases the resistance of neurocytes to hypoxia, regulates the transportation and utilization of sugar, enhances protein synthesis, acting as a protector for cells.

6. Neuropeptides with analogues: semax, vasopressin, selank, oxytocin, tiroliberin, noopept. Memories are influenced by individual parts of the molecules of neuropeptides, changing the postsynaptic effect of acetylcholine and increasing the activation of nerve cells.

7. Cerebrovascular drugs (tanakan).

8. Amino acids: biotreidine, glycine, glutamic acid, picamilon, gopantenic acid. Mediators that excite the central nervous system.

9. Polypeptides: cerebrolysin, cortexin, celebrex, cerebramine. These are chains of amino acids that work similarly to them. Simultaneously improve the blood supply to the brain.

10. Antioxidants: vitamin C (ascorbic acid), alpha-tocopherol (Vitamin C), mexidol (oxymethylethylpyridine succinate). Decrease the level of lipid peroxidation, stabilize the membranes of neurocytes.

11. Adamantane derivatives: mefexamid (timodine, perineuron, mefexadin), adamantin bromophenylamine (memantine, inertast, bromantine), adrafine (olimpone), tonibral, ciprodenate (actebral), bifimelan, pyrisudanol (mentis, nanox), deminol, linopyridine. These drugs increase the content of choline in the brain (in synapses), accelerating the transmission of the nerve impulse, the synthesis of phospholipids in the brain. Also, under the influence of drugs, the content of lipofuscin, which is the pigment of aging, decreases in the brain cells.

12. Combined preparations. Combine the mnemotropic properties of its components. Melatonin-apic (pyridoxine plus melatonin), inotropin (melatonin plus aminalon), pituitary (aminalon plus pyracetam), fesam (cinnarizine plus pyracetam), orocetam (oric acid plus pyracetam), thiocetam (tiotriazoline plus pyracetam).

The drugs of the above groups should be prescribed according to strict indications after a detailed examination by a specialist.

To date, a huge number of different studies have been conducted, during which it has been proved that the mnemotropic medications do not affect the healthy brain so that the memory improves significantly. Therefore, it is not advisable to use the drugs of this group for students and students, as well as adult able-bodied population, in order to increase the concentration of attention and increase the assimilation of new material without the presence of neurological deficit symptoms.

Medications are appropriate during recovery from cerebral hemorrhages, craniocerebral trauma, in the treatment of chronic cerebrovascular disorders and Alzheimer's disease, and other senile dementias.


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Faq for the most popular course of peptides for muscle mass ghrp2 and cjc1295

12 Jan 2018

How to take peptides GHRP-6 and CJC-1295?

So, suppose that you ordered a course of peptides GHRP-6 + CJC-1295, which can additionally be completed with special capsules Ginseng Kianpi Pill.

ghrp2 cjc1295

The duration of the course is 1 month, a certain number of vials are included in the kit: ghrp2 or ghrp-6 - 4 bottles, cjc1295 - 5 bottles, ginseng cup - 1 can (60 capsules). Dosages are calculated individually, based on your weight. But still, there are some common guidelines. For example, the dosage of peptides may not vary by a person's weight of 75-100 kg.

Dosage of ghrp 2, cjc1295, Ginseng

GHRP should be set at 1-2 mcg per kg of body weight, cf. 1295 - put 1 mcg per kg of body weight, ginseng cap - is used at the rate of 2 capsules per day, one in the morning, the other in the evening. Dosages of peptides may vary. Based on your individual characteristics. For example, some people grow with the smallest dosages of peptides, while others, on the contrary, need a high dose. Standard dosages of peptides were given above. We are forced to state the fact that if you take any of their GHRP-6 in a dosage of 1 μg, and dissolve any of the pharmacy solvents, this will lead to the death of the peptide, until its full use. Therefore, a single dosage of GHRP should not be less than 150 μg at a time, 3 times a day. CJC-1295 is not recommended to use less than 100 μg at a time. Dissolve the peptides best 2 ml of water for injection or another pharmacy solvent.

Consider the dosage of 90 kg a man

Ghrp2 is put 2 μg per 1 kg of weight, that is, 180 μg, cjc1295 - 1 μg per 1 kg of weight, - 100 μg (rounded), ginseng cap also 2 capsules per day. Put peptides ghrp and scs1295 should be 3 times a day for 10-15 minutes before meals, with an interval of 6-8 hours between injections. You can put two peptides in one syringe to reduce the number of injections, it's okay that they mix. Thus, for a 90 kg male, the daily dose of gyrp is 2 to 540 μg, and the 1295 to 300 μg.

ghrp2 insulin syringe

How to calculate the dose of peptides on an insulin syringe?

Likely now, there is a question, and how to calculate these mkg on insulin, how many awakens divisions of 180 mcg ghrp or 100 szhs1295, this is done very simply. Peptides are diluted with 2 cubes of water (2 complete insulin syringes). Consider the example of rxpn2. The vials are 5 mg of active ingredient, that is 5,000 μg, we dilute them with 2 cubes of water, that is, 200 units (2 complete insulin syringes) on the insulin. We make a proportion, and find out that in 1 unit of an insulin syringe on a scale of 100 - 25 μg peptide ghrp, to get 180 μg peptide should be typed 7 units on an insulin syringe.

Insulin needles should preferably be purchased with bright orange caps, which are abundantly sold in the pharmacy - BD Micro fine. Approximate cost of 10 pieces is 150 rubles. There are different markings on syringes, we recommend 2 types, the first one is a 1 ml syringe with a scale of u100, the second is a 0.5 cc syringe with a scale of 10 to 50 units.

The best soluble for peptides is water for injections, which costs about 30 rubles per pack. If you have tender skin and you are afraid of pain and bruising, at the injection sites, we recommend diluting the bottles with peptides novocaine. It is with the help of it, after injecting peptides, you practically do not feel anything.


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Faq for the most popular course of peptides Frag hgh 176 191 for weight loss

11 Jan 2018

Frag hgh 176-191 instruction for use

For drying, the best peptide is a peptide - frag hgh176-191. There are many questions on the use of this peptide, in this article I will try to decompose everything in detail.

hgh 176-191 buy

Dosage of frag hgh 176-191

Put this peptide should be from the following calculation, if a person weighs 100 kg, then his dose is 1000 mcg, divided into 3 doses. That is, a dosage of 10 μg per kg. As practice has shown, it is at such dosages that the peptide really works and there are excellent results on fat burning. For girls weighing 60-80 kg, it is not recommended to lower the dosage less than 800 mcg per day.

How to calculate the dosage of the peptide for weight loss frag hgh176-191?

The first step is to know that the peptide is in the amount of 2 mg of the active ingredient in one vial, that is, 2,000 μg. Accordingly, we take an insulin syringe, where there is a division of U100, we collect 2 cubes of water into the bottle, and we find out that in one unit of an insulin syringe 10 μg of peptide is obtained. Accordingly, to allow a dose of 300 μg of peptide to be calculated, we must dial u30 in the insulin.

At what time to take the peptide frag hgh 176-191?

This peptide is taken three times a day at intervals of 6-8 hours. To put frag hgh 176-191 is recommended three times a day, in between meals, so that the injection is done on an empty stomach. There is one more little recommendation. The evening dose of the peptide should be greater than the morning and daytime. For example, for a man weighing 100 kg, the dose of peptide fragment xxx should be distributed as follows - 300 morning, 300 day, 400 evening. The ideal time to perform injections of the fat-burning peptide - in the morning on an empty stomach, before or immediately after training, at night just before bedtime.

What can be combined (combined) peptide frag hgh176-191?

Fragment xxx 176-191 is an excellent fat burner, but it does not grow muscle by itself. If you want to see fattened and tightened muscles under the fat layer, then we recommend combining peptide fragment hgh 176-191 with cjc 1295 or if your goal is to enhance the effect of hgh 176-191, and also get a beautiful tan, then the best combination hgh 176-191 will be with melanotan 2.

CJC-1295 will make your muscles bigger and more embossed, which will improve the overall appearance of your body, after weight-loss. Recently, the rate of peptides for weight loss frag hgh 176-191 + ipamorelin is gaining momentum. It is about this bunch of peptides that we hear the best reviews.

The length of the course on slimming frag hgh176-191 and what can you expect after it?

As practice has shown, the most optimal drying time with peptide hgh 176-191 is a period of 1-2 months. Then the peptide starts to work more weakly. For the course to work out the most successfully, it is necessary to train, combine power and aerobic loads, and diet is also mandatory.

It should be understood that the peptide is not a magic pill, you can not just take it and wait until you get the body of Apollo. In the course of consultations, it is possible to develop a training program and a diet for you free of charge, when ordering a fat-burning course. With good training and nutrition for an average man weighing 100 kg, it is possible to throw off 5-10 kg of excess weight (the individual tolerance of the peptide plays here), a girl weighing 70 kg can easily weigh 62-63 kg a month, without any kickbacks, provided that the regime and training are maintained.

insulin syringe hgh frag

Of working moments. Question answer.

The course of peptides hgh frag 176-191 + ipamorelin.

Customer: Hello! I turned to you on the advice of a friend. I would like to buy from you preparations for fat burning. What could you advise? I want to please you, fat is more than enough and you have to burn a lot. I will wait for an answer.

Administration: Hello! I would advise you the course of the fragment xxx together with the peptide ipamorelin. What is your weight and height? What physical activity?

Client: Height 164, and the weight is very strong and now 88. It is quite active and + I go to the hall for 2-3 hours there. And more? What is it and how to take it?

Administration: For fat burning, you can try peptides. Your course will consist of two preparations, namely the fragment hgh together with the peptide ipamorelin.

Both peptides contain 2 mg of active ingredient, that is, 2,000 μg.

The dosage of hgh 176-191 per your weight will be 1,000 micrograms per day. The daily dose of ipamorelin is 300 mcg per day. Both peptides should be taken three times a day. On empty stomach. Between meals.

An approximate schedule for the reception of peptides for fat burning:

9:00 Porridge on milk.

11:00 - injection of peptides.

13:00 - dinner of fruit.

14-16: 00 - time for training.

16:30 - food intake, for example boiled fish.

18:00 - an injection of peptides.

20:00 - dinner, last meal. For example, low-fat cottage cheese, with yogurt. Or just cottage cheese.

22:00 - an injection of peptides.

It is permissible to collect two peptides in one syringe, to reduce the number of peptide injections. But after a set of two peptides, it is not recommended to keep them long in an insulin syringe, it is better to perform the injection as soon as possible.

As already mentioned. You need to take peptides three times a day. In the following way. Frag hgh 300 μg morning, 300 lunch, 400 night. Ipamoreline 100 morning, 100 day, 100 night.

How to calculate the dosage of peptides on an insulin syringe?

Brew the bottles 2 cubes of water for injection. Accordingly, in 2 cubes of water, that is, 200 units will be 2 mg of the active substance of the peptide, that is 2,000 μg. Significantly 200 units = 2 000 μg. We shorten and clarify that 1 unit on an insulin syringe equals 10 μg of the active substance of the peptide. That is, to collect 300 μg frag hgh 176-191, 30 units of solution should be injected into the insulin syringe, and 200 μg of ipamorelin = 20 units on the insulin syringe.

Course duration, from 1 to 2 months. Take the average value, mc need to burn a lot, a month and a half = 6 weeks = 42 days.

If hgh frag 176-191 diurnal 1000 micrograms, then 42,000 μg of active substance will be required for 42 days, respectively. In one bottle 2 000 mkg, that is all 21 bottles of 2 mg are needed.

Ipamorelin daily is 300, that is, for the entire course, 9,000 μg of peptide is needed. In 1 vial also 2 000 mkg, respectively, 5 vials of ipamorelin will be required. Diet and exercise during the course are also important.

Course of peptides: hgh 176-191 + melanotan 2 (for a girl of medium weight).

Now another course of peptides for weight loss is gaining popularity - hgh 176-191 + Melanotan 2. The feature of this kit is faster weight loss, as well as an excellent tan skin, after the skin is finished. Both peptides perfectly match with each other, which explains the high effectiveness of the course as a whole.

Let's touch on the question of how to properly prepare peptides for use

1. Make bottles 2 cubes of water for injection.

2. In the morning you take 250 μg, that is 25 yeins on an insulin syringe.

3. At lunchtime also 250 mcg.

4. At night 300 mcg, that is, 30 units. And just before bedtime, a prick of 10 units of chalk! (from it can vomit!)

Or another option:

1. Prick of the fragment xxx 25 units. After 10 minutes, a prick of 5 units of melanotane (this is approximately 350 μg).

2. At lunch, a fragment of xxx is 250 units.

3. In the evening, also 300 μg hgh176-191, and after 10 minutes 5 units of melanotane.

Which option to choose? Both are good! To be honest, I prefer the second option. From mt2 could be no appetite, so do not particularly eat, respectively, weight loss will be more fun and faster. Also, to achieve sunburn, it is recommended to go to the solarium 2-3 times a week for 5-8 minutes. Sunburn will be like after the resort.


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Peptides and growth hormone - what to choose?

10 Jan 2018

From beginning athletes such a question can be heard especially often. Indeed, what contributes to the best results - stimulation of the secretion of growth hormone or injection directly GH? Which option is better for the ratio of price and quality? We will try to answer this difficult question.

Cost, availability of growth hormone and peptides, sale

The cost of growth hormone is significantly higher than that of peptides. It is a more complex substance for production, besides GR is used in medicine, it is subject to certification. Growth hormone is legal, but its sale is regulated legislatively. The price for a course of growth hormone can reach and exceed $1500 (all depends on the duration of the course and the price of the specific drug). Cheap growth hormone should cause you fear: the market is flooded with fakes, which are not just ineffective, they are dangerous. And if the price is too low, do not hesitate to ask the seller questions and carefully study the packaging for signs of counterfeit.

Peptides are much cheaper, and their turnover is not regulated. Their full course will cost a about $700 and then in those cases when a very powerful effect is needed. Beginners can suffice and a noticeably smaller amount. However, there are many counterfeit peptides. In addition, peptides are extremely sensitive to storage conditions: bodybuilders write that sometimes one day in the light outside the refrigerator is enough for the peptide to lose at least half of its efficiency. Therefore, the seller of peptides should be selected very carefully, because some unscrupulous store owners do not pay due attention to the storage of drugs.

Effect for muscle mass and fat burning

Reviews of growth hormone and peptides give priority to the results of the increase in pure muscle mass is GH. More practical experience of using growth hormone in bodybuilding has been accumulated, the most effective combinations and reception schemes have been known for a long time already. So growth hormone for muscle mass is recognized as effective. "Before and after" growth hormone so far look more impressive. With peptides, however, experiments continue. They devoted less clinical research, this is a new word in sports and bodybuilding. Therefore, many, especially beginners, are faced with the fact that the result of using peptides does not meet expectations. In defense of peptides, it should be said that there have already been accumulated feedback and data convincing that with competent combination, the effect on the body composition can be no worse than that of growth hormone. However, this requires a thoughtful approach, a competently designed course and its strict observance.

The mechanism of action and possible side effects

Growth hormone is a ready-made drug that is injected into the body "as is" and replaces its own GR, produced by the pituitary gland. Peptides also stimulate the production of endogenous hormone. In the first case, the body's own function can be inhibited, and in the second case, it only grows stronger. This is the fundamental difference. Unlike GH, peptides do not affect the functions of the pancreas and thyroid gland, can not cause hyperplasia of internal organs, the body does not produce antibodies to them.

Peptides are also not determined by doping control, while growth hormone is doping in the classical sense. What should I choose? You decide! But whatever you decide, in our store you can always quickly and conveniently order growth hormone with a guarantee of quality and originality of the drug, as well as effective peptides.


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The benefits of growth hormone and harm. HGH Growth Hormone Dosing and Side Effects

09 Jan 2018

Let's look at such a popular in bodybuilding drug, like growth hormone, from all sides. After all, he has not only undoubted advantages. Like any pharmacological agent, GH can lead to side effects. But what is more important - a powerful anabolic effect or risks? After reading this article, each athlete will be able to make his choice.

The Advantages and Benefits of Growth Hormone

The benefits of GR are incredible - there is not a lot of sports nutrition, peptides, or even anabolic steroids.

Muscle growth (anabolic effect) and inhibition of muscle destruction (anti-catabolic effect)

Reducing the fat layer, improving energy use and changing the energy balance towards the use of fats

Rapid healing of wounds, injuries, burns

Effect of rejuvenation

Repeated growth of internal organs, with age atrophy

Growth of bones (up to 26 years) and / or their strengthening and improved salinity

Increased blood glucose levels Improved immune system performance

Possible harm and side effects of growth hormone. How to eliminate side effects?

Tunnel syndrome - pain, numbness in the hands and sometimes feet. The effect is eliminated after lowering the dosage

Swelling and fluid accumulation. This is also necessary to increase the volume of muscles and their elasticity. Minimized by reducing the amount of salt in the diet and excluding alcoholic beverages.

Increase in pressure. To eliminate, you can reduce the dose or start taking antihypertensive drugs.

Decreased thyroid function. It is solved by the administration of thyroxine, which also increases the fat burning effect. After the course ends, the function is restored automatically.

Hyperglycemia. You can take insulin (this will also increase anabolism) or drugs to stimulate the pancreas.

Acromegaly. Do not occur if used correctly.

Hypertrophy of internal organs. It develops only when applied for more than six months.

In some reviews of the growth hormone, he is credited with side effects, which he is not able to induce. For example, an enlarged abdomen has no scientific confirmation. This is possible in theory only when combining GH with steroids and consuming very large amounts of food. Also, growth hormone does not affect testosterone, libido and sexual function in any way, unlike steroids. Growth hormone for men is absolutely safe in terms of intimate sphere. There is also the view that GH causes tumors that have already refuted the studies. It can only provoke the rapid development of already existing tumors (before the start of the growth hormone it is worthwhile to undergo screening to exclude the development of such processes).

Bottom Line

The development of significant side effects with the use of recommended doses of growth hormone is impossible. Minor side effects are easily eliminated, often without additional medications. Therefore, in general, it can be argued that GR is a safe drug. According to bodybuilders, 88% of those taking GH believe it to be an effective drug. 86% noted a really noticeable fat burning and a gain in muscle mass. The increase in power indicators was noted by 79%. At the same time, more than 80% of respondents very easily tolerated injections of growth hormone. Any side effects were noticed only by 23% of athletes who resort to moderate doses of the hormone. And the main obstacle to receiving them is not risk, but a happy high price of growth hormone.


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The use of growth hormone: how to apply, where to shot growth hormone?

28 Dec 2017

So, you are a happy owner of a course or GR package. Congratulations! What to do next, how to properly take growth hormone? Read the detailed instructions!

What is required for growth hormone injections

Insulin syringes for 100 units (100UI) for injections - do not confuse the unit of the drug with the divisions!

Sterile or bactericidal water for dilution. Sterile can be bought in a pharmacy, bactericidal - you can order from us (at the drugstore they sell it on prescription). Some manufacturers put water and syringes right in the package (eg, Dzhintropin).

For reconstitution of drugs - syringes with a long needle. Wadded disks and alcohol or alcohol wipes for skin treatment and ampoules.

How to properly grow growth hormone

For breeding, use only bactericidal or sterile water for injection. If the diluted drug should be stored for more than 24 hours, bactericidal water is preferable.

Do not pour water directly onto the powder. Hold the syringe so that water flows down the wall of the ampoule or vial.

Do not shake or shake the dissolved hormone! This will reduce its effectiveness. To completely dissolve the drug, slowly and gently rotate the ampoule.

The usual dosage for breeding is 1-2ml of water for injections per ampoule.

How to calculate the dosage of growth hormone?

It is very simple: the number of International Units (UI, ME, Ud) of growth hormone is indicated directly on the vial. Let's say there are 10 in the bottle, and you need 5 units of hormone for a single injection.

If you used 2 ml of water for breeding, you need to collect a full insulin syringe. If you used 1 ml of water - then up to half.

Injection of Growth Hormone: Instruction

Where to stab? The best place for subcutaneous injection is the abdominal region 8 cm from the navel. It is necessary to get into the layer between the skin and the muscles. Experiencedly find the points where the injection is painless (there are very "sick" places).

Periodically change the injection site, since GH can cause lipodystrophy - local destruction of the fat layer at the point of injection.

How? Hold the syringe at an angle of 45 degrees with respect to the skin. Slowly inject the drug and hold the syringe for 5-10 seconds to prevent leakage.

Do injections only with clean hands. Before using, the neck of the ampoule should be wiped with an alcoholic napkin or alcohol. It is not superfluous to wipe and the injection site, although with the use of insulin syringes it is not necessary.

Do not allow air bubbles to enter the syringe.

Useful tips and precautions for growth hormone pricks

Do injections on an empty stomach and do not eat for at least 40 minutes after the injection. This will ensure maximum effect from each injection.

4 hours - a minimum break between injections.

Diary of injections or application-calendar in the phone will help not forget what and when to work.

Morning injections should be done immediately after awakening. This will stop the catabolic processes in the body. The second prick is best done immediately after training or fart sleep.

In the diet should be a high amount of protein - at least 2-3 grams per 1 kg of weight per day, and a minimum of simple carbohydrates.

How to store growth hormone

Protect from sunlight, temperature extremes, do not allow heating or freezing.

The ready solution should be stored in the refrigerator on the top shelf or in the door (temperature mode 2-8 degrees).

The shelf life of dry growth hormone is 2 years. Quick effect and sporting achievements! Follow the instructions and the GR courses will only benefit you.


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Ipamorelin - basic information

27 Dec 2017

As it turned out, information on such a "peptide" product as Ipamorelin is quite small in our areas, and what is, is traditionally replete with legends and myths. Therefore, in this article we will try to understand what is Ipamorelin, what are its properties, and how to correctly take this peptide.

Buy ipamorelin

Ipamorelin is the release of growth hormone peptide. Ghrelin mimetic. The mechanism of its action is the same as in GHRP 6, GHRP 2, Hexarelin. He, as well as his "brethren", transmits the signal to the growth hormone cell for GH secretion by combining with the specific ghrelin receptor GHS-R.

Ipamorelin "saw the world" in the distant 1998. This peptide was "invented" by replacing the Alanine-Tryptophan GHRP fragment with the Aib-His-D-2-Nal fragment, where His is histidine and D-2-Nal is the dextro form of 2-naphthylamine. But, the most interesting is Aib, which is nothing else than Gamma-aminobutyric acid (GABA) (Why is it interesting ?, more on this later).

Ipamorelin - the main effects

By binding to the GHS-R receptor, Ipamorelin sends a signal to the somatotropic pituitary cell, thereby stimulating GH secretion. Comparing the potential of Ipamorelin in terms of GHRP secretion with GHRP 6, GHRP 2 and Hexarelin using the same dosages, it is possible to build a kind of "rating", where Hexarelin will lead the list, since it simulates the largest release of GR; GHRP 2 will be in 2nd place; well, and honorable third place will be shared by GHRP 6 and Ipamorelin. Many, of course, can "grimace" and say that Ipamorelin is a 3rd grade slag, but this is far from the case. In fact, Hexarelin differs from Ipamorelin in about 10-15 ng / ml for GH secretion. Why "about", because with non-abortion use, rely on the analysis of different people follows with a certain error, as you know, the results of tests can depend on a number of factors, such as age, food intake, drug quality, etc.

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With regard to the release of GH, it also has a "pulse" character, where the duration of the "pulse" is about 3 hours at a maximum value of 30-35 ng / ml.

Side effects of Ipamorelin

To those, I will take all the phenomena that are not related to the stimulation of GH secretion. Considering the group of releasing growth hormone peptides, we have traditionally attributed these products the ability to influence the stimulation of the secretion of not only GH, but also the secretion of prolactin and cortisol. In addition, it is quite usual for us to have a feeling of hunger when using these peptides. But Ipamorelin, due to its structure, goes beyond these stereotypes, and does not cause a feeling of hunger, and it is not capable of exerting any influence on lactotrophs (responsible for the secretion of prolactin) and on eosinophilic cells (responsible for the secretion of ACTH). It is for this "selectivity" that this product is usually called "selective", since it is now established that it affects only the growth cell. But do not forget that abuse (excess dosages) can lead to both a loss of sensitiveness of the somatotropic cell, as well as to the fluid retention of the body. These "pobochki" in principle are unlikely, but knowing the maximalist views of many "peptide adherents" mention them yet will not be superfluous.

An interesting property of Ipamorelin is the ability to prolong the phase of slow sleep, which contributes to a deeper sleep and as a consequence of additional secretion of growth hormone, although in some cases of practical use it has been observed that Ipamorelin can cause drowsiness after injection.

In addition, considering this product, it should also indicate not quite the "traditional" side effects that happened to "meet" in practice. At me, for example, after an evening injection the next day (approximately closer to noon) there were "easy" headaches. Morning injection from daily headaches helped. Also, there are cases when a person after a night's application very well slept, and after a morning injection again "cut down". Removing the morning injection man again "bounced back." In addition, one of the "peptide users" that I respected shared very interesting information about his reaction to the use of Ipamorelin, namely, the appearance of a "tingling" sensation in the fingers after injection. Also quite curious was the fact that the level of PH saliva (set on indicator paper) changes after applying Ipa. There is also information about the smoothing of small wrinkles after applying Ipamorelin.

Insulin

Research has not established the effect of Ipamorelin on insulin secretion in humans. But, I note that in 2004 an interesting experiment was conducted during which scientists from the UAE found that Ipamorelin is nevertheless able to stimulate insulin secretion in rats (normal and rats with diabetes).

GABA

I knowingly drew your attention to this interesting element in the amino acid chain. The fact is that "deep sleep" is just the result of the "work" of gamma-aminobutyric acid, which additionally also has an additional bonus, in the form of stimulation of GH secretion, and is also capable of causing a slight sedation, calming down after a mental and emotional excitation.

Degradation

After preparing a solution based on water for injection, Ipamorelin (depending on the quality) is able to "live" in the refrigerator for about 2x3 weeks (maximum 1 month). Theoretically, the degradation period can be prolonged by preparing a solution based on the sodium chloride solution, but in practice I did not manage to conduct such an experiment (which, of course, does not mean that saline is worse than water for injections).

Prospects for using Ipamorelin (what to expect?)

Speaking about what to expect, and what not to dream about, it should be recalled that any effects from peptides can not be separated from the effects caused in the body by the growth hormone. I will not clone the advertising slogans of many sellers and resources, but I will focus only on specific "effects" from the monthly application of Ipamorelin. To such I will refer to the improvement of concentration, the best "recovery" of the body after stress (training by itself, as well as stress at work), significant improvement in sleep, restoration of joints and ligaments, light cosmetic effect (smoothing of fine wrinkles, although perhaps this is due to the fact that you smile less). Biceps in 50 cm increase unfortunately failed, and to reduce the percentage of fat from 40% to 2% is also not realistic, but the restoration of natural GH secretion and an increase in the concentration of IGF binding protein of the third type (which falls as a result of the use of aac) is quite significant (though not entirely tangible) pluses Ipamorelin'a.

Ipamorelin Dosages

Here, too, Ipamorelin does not differ from its "classmates". 1 μg / kg is the optimal dosage, but, to my great regret, this dosage has recently become less effective due to the deterioration in the quality of the products offered. Therefore, I will not criticize and agree with the opinion of some peptide "users" who say that for Ipamorelin'a dosage should be raised higher, for example, up to 1.5-2 mcg / kg. I will say frankly, "that", that I happened to try more and more and more and more disappointing lately and that "at least" it would be good to sleep 2-3 mkg / kg and "happiness" was not very long, because . peptide somewhere in 1 week degraded.

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Prospects Ipamorelin for use on fat loss

On the prospects of using Ipamorelin in sports, you are already more or less (in general terms), I think, understood, but I would like to talk about the use of this product in the period of fighting fat. If you are planning to choose which peeling to dry, then it's best to look towards Ipamorelin. There are several reasons. Ipa does not cause a feeling of hunger, which is already "aggravated" during a diet. Also, because of its light sedative effect, Ipa will help to "soften" the tides of unreasonable aggression (well, or increased temper), which sometimes roll on hard diets (for example, on "carbohydrate"). Well, by itself, "drying" with GR (stimulated by Ipamorelin) will be much more productive than drying without GR.

Combination of Ipamorelin

Ipamorelin can be safely combined with somatoliberin and its analogues. A good "bundle" in terms of stimulating the secretion of GR will be Ipamorelin + CJC-1295. Also, if there is a desire, you can "connect" Ipamorelin with Tesamorelin. Combining Ipa with other ghrelin mimetics is also possible, but from a practical point of view it is better not to do it at the same time, but at different times of the day, for example morning, day GHRP, and evening Ipamorelin.

Also, because of the lack of influence on the secretion of insulin, Ipamorelin can be used during the application of HGH Frag 176-191 without risking "suppressing" the action of the undesired insulin. With MGF (and its more advanced forms), as well as with Peg MGF (simple, pegellated and Long form), Ipamorelin is also normally combined without suppressing (as in principle and without amplifying) the effects of these growth factors.

If you want to choose what to be stabbed by the time of "AAS homeopathy" and PCT, then the most normal option is Ipamorelin (and on PCT so even more), as, as you already remember, Ipa does not stimulate cortisol and prolactin, and also increases concentration of IGFBP-3, thereby maximizing the benefits of IGF-1.

Doping control

This question is increasingly worried about the minds of athletes who turned their attention to peptides. The answer is "scorching or not scorching" peptides on the DC is very simple - "scorching" but in the case of mass spectrometry after separation of the sample by liquid chromatography. And in this connection there is a counter question, "but do you apply this method to the DC for your competitions?". If "yes", then it is desirable for an athlete to stop using both Ipamorelin and other releasing peptides and somatoliberin analogues at least one day before DC.

Here is such a selective ghrelin mimetic, releasing growth hormone peptide Ipamorelin. As you can see, this is quite a promising product. But, as we have, any budding project can be ruined by poor quality, and even by an absolutely inadequate price. Absolutely absurd is also the sale of Ipamorelin'a weighing 10 mg, since degradation occurs quite fast, and besides, to measure the normal dosage in a solution with a large concentration of peptide (after all, the liquid in the bottle is placed at a maximum of 3.5 ml) is not very easy . It turns out some strange savings. In general, discarding these ridiculous misunderstandings, in my opinion, Ipamorelin deserves attention, and it has to be in the arsenal of many athletes. As a safe, but very effective tool for improving physical performance.


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