Best deal of the week
DR. DOPING

Blog

Logo DR. DOPING

Speech therapist tips

13 Apr 2018

If you want to the speech of your baby was smooth, clear, expressive and beautiful, listen to the advice of a speech therapist:

1) Say it yourself expressively and correctly, do not let yourself speak quickly, too loudly, incorrectly uttering sounds. Be an example of the right speech for your child;

2) Everyone has heard about the dangers of a pacifier. She really can do much harm to the baby, if he often and for a long time keeps it in his mouth. The nipple can provoke the formation of a high palate, which distorts the pronunciation of sounds. In addition, the dummy simply prevents the child from talking;

3) Do not imitate the so-called autonomous (child) speech of the baby. Talk with the baby in a normal language - and he will soon realize that it is more correct.
If the child stubbornly does not want to talk, although he knows how, refuse to understand his gestures and facial expressions. Only respond when the child uses speech.

4) If the child does not correctly pronounce sounds and words, do not scold him and do not make harsh remarks. So you can achieve complete rejection of the child from communication.


Logo DR. DOPING

Anti-Nootropics. How to make a person stupid?

12 Apr 2018

You are used to analyzing nootropics and other topics related to improving the quality of life, the quality of the intellect. But today we will go from the opposite. We will analyze the most popular ways of temporary deterioration of intellectual abilities!

Cortexin, cerebrolysin buy

At the beginning
- A huge request to take the release with some humor.

- Most substances are expected in medium-high doses. In the low, it does not do much harm.

Anti-nootropics:

Alcohol
Let's start with a simple and understandable to everyone! Everyone knows that alcohol significantly changes human behavior. The effect of alcohol extends to the neurotransmitters GABA, Dopamine and Serotonin. With a significant increase in these substances, there is some effect of stupor and a growing sense of self-importance.

As a substance, alcohol itself is present initially in our body, and therefore is not an alien compound. The whole question is in the dosage of pure ethyl alcohol. So, 10 g for women and 20 for men are even considered useful, that is, 20-40 g of vodka can be called nootropic. Of course, with an irregular reception.

But who can stop after the first glass? Practice shows that the willpower of people is weak, so further - more. Add here the rate of withdrawal of alcohol from the blood, an average of 7 grams per hour and the speed of the maximum effects in 20-40 minutes, it turns out the situation "Drink and not drunk, you want more!". In an hour this person will lose tens of% of his IQ) What is not an anti-nootrops ?!)))

Cholinolytics
The most direct and coarse effect of stupor! These are substances that reduce acetylcholine. But nootropics often increase it on the contrary. A sharp decrease in this neurotransmitter leads to: confusion, nausea, thirst for water, slight hallucinations and poor eyesight.

Popular anticholinergics are: cyclodol, atropine, scopolamine, dicycloverin from trigan-d.

Perhaps you've heard in the movies or maybe from acquaintances about the so-called "truth serum", about a substance that can erase memory for several hours or days. And it's not a failure in memory as from alcohol. Everything is much more serious.

The substance that is capable of this - Scopolamine, just from the group of anticholinergics. With a high dosage of this substance, the person has a block of protection, he speaks the truth easier, memory becomes worse, and overall health is terrible. At too high a dose - death. And as we have said repeatedly, all the poison and the entire medicine, depending on the dosage. Even scopolamine in small doses is used in medicine.

Neuroleptics
Created for killing first of all dopamine. Often given to mentally ill people, their neuroleptics lead to a norm, are used in medical practice, if a shift has started due to the use of narcotic psychostimulants, Tipo Amphetamine. Substances do not treat the disorder, but stop the symptoms.

Popular antipsychotics: Aminazine and Haloperidol.
When the permissible dosage is exceeded or when used by healthy people, depressive states develop, inhibition appears, prolactin increases. There is no stupidity here, but the effect of turning into a plant. You think slowly, move slowly and speak slowly and all against the background of a complete lack of positive. The problem is also in a large half-life, in short, they act up to several days.

Oxytocin
A soft, kind and easy way to reduce the intellect. There is no tin as from anticholinergics or antipsychotics. In the release of oxytocin, we generally gave a study of its similarity to Ecstasy, but without dependence.

In the world, Oxytocin is called a "molecule of morality", in subjects under oxytocin, empathy, empathy and empathy sharply increase. It's easier to communicate with people, less aggression. But where is dullness you ask? It is complex and manifests itself in some kind of credulity, infalty, and a slight memory impairment. Therefore I said that it is a soft and kind substance.

In the studies used for application to the skin, hair or when instilled in the nose. 10-15 units of substance. In one pharmacy ampoule 5 units. And yes, in medicine this substance is for the stimulation of childbirth, so you can not be pregnant! On the other hand, pregnant women are given intramuscularly, but it is better to be safe. Oxytocin increases even in a man when he becomes a parent.

Bottom line:

Here are the substances that can stupefy a person:

- Alcohol, the most famous way of getting into an altered state

- Cholinolytics, in the literal sense of "antinotropy", the most severe and merciless

- Neuroleptics, slow down thoughts and body, develop depresnyak

- Oxytocin, light variant. Kindness, sociality, memory loss.

Remember that the effects are directly proportional to the dosage! Even a microdose of anticholinergic can improve well-being and intelligence in some settings.

Well, I hope you liked the release! Write your antinotopes) Good luck and see you soon


Logo DR. DOPING

Cortexin - Nootropics from the Brain of Animals

11 Apr 2018

Neuropeptide nootropic - Cortexin.

Cortexin effects

Recall that this group of neuropeptides can be attributed and Semax with Selank and Noopept and Cerebrolysin / Cerebrolysate.

This group of nootropics is often criticized for a poor evidence base, and it really is. In general, nootropics have a weak base for the treatment of some kind of intellectual disturbance. We did the issue on this subject "Hayter's Nootropics" and its essence is that the brain is extremely complicated, and there is no such tablet to work on all the memory mechanisms and improve it, as an example. In this case, no one cancels the principle of work of each nootropic.

Imagine the brain as auto, and each nootropic as an auto element. And say, if you know for sure that the wheel is punched, the nootropus X patches it, and the nootropic Y dips fuel, but the car will still be with the punctured wheel, although the nootropic Y also had a positive effect.

Neuroprotective effect
Or the effect of protecting the nerve cells. It is known that with age the number of nerve cells decreases, and although they are capable of recovery, neurogenesis, the rate of dying goes faster. Often, closer to old age, this leads to intellectual disabilities. One of the ways of such apoptosis - the death of nerve cells, is the activity of so-called caspases. Cortexin is able to inhibit or turn off certain caspases, which is best preserved by neurons.

Yes, apparently it was difficult!) More clearly, under cortexin, all that kills nerve cells - will kill less. This includes the effects of alcohol and other drugs, senile changes, and other negative effects on the brain.

Even in conditions with a lack of oxygen, cortexin is able to maintain an optimal working state, so it can help in sports.

Neurogenesis
This is the second main effect that all neuropeptides are famous for. Means the creation of new nerve cells through stimulation in the cerebral cortex of the transcription of neurotrophins (NGF, BDNF). Consider brain renewal. Which is extremely effective if there are any brain injuries. And in ordinary life, visiting new places, new activities, physical training also improve neurogenesis. In short, this is a useful effect for any person.

Anti-stress action
In at least 2 studies, there was a change in the level of cortisol, one of the main stress hormones. More precisely, if the level is too high, it decreases. Therefore, you feel less nervous.

There was another mention that Cortexin can increase serotonin. The main antidepressant neurotransmitter. There is no direct connection with stress, but there is one type of depression, this can also be attributed to stress.

Other Action
Data on the positive effects in the treatment of the effects of chronic alcoholism.

A study of neurasthenia in adolescent girls showed an improvement in 80% of cases, although without a placebo group.

A recent study in 2018 showed an excellent combination of Memantine and Cortexin and a significant improvement in intellectual function in patients with ischemia.

Effects of Cortexin
This is a more subjective point, from personal experience and feedback on the network:

- Striving for novelty

An unusual effect, manifested in a great desire to hammer the information. And do not just turn the tape, but rather read books, learn languages or programs, attend courses. It seems that the degree of interest in any case is increased by several points.

- Humanity

At first I wanted to write rationality, but this is not a crude logic. Strongly growing and emotionality, empathy. In this case, there is a similar phenibut effect of less aggression and relaxation. So emotions are not in the negative side.

- Dreams

Sometimes they even fret, it's all too realistic. And after awakening, a few more seconds are needed to return to the familiar reality.

- Reduction of animal motivation

This is both a bad and good effect, less concerned with the instinct of "Dominate, Conquer, Humiliate." Less motivation for sports and parties for the whole night, more to the intellect and to the quality of social contacts, rather than quantity.

For the sake of justice, I will immediately inform you that these effects can also be attributed to Cerebrolysin, Selank and Noopept (in descending order) so that the detective does not wake up in you and does not look for advertising for something specific.

The Cortexin course
The substance has a few contraindications and side effects, read the instructions.

It is used intramuscularly / intravenously. And yes, if you are not under the supervision of a doctor, then no intravenous infusion, this is very dangerous!

There's still a way to prepare the solution!

Usually a course or every day of 10 mg intramuscularly, or every other day. Total injections 10. In the gluteus muscle. If you decide - be sure to read how to do the injections in order to avoid getting into the vessel. Effects appear immediately, but more noticeable by the end of the course and after it.

Outcome:
- Cortexin is a neuropeptide, similar to other nootropics from the same group.

- Works as a neuroprotector, increases neurogenesis, antistress effect. At least, there are studies on these items.

- In medicine it is used for a number of diseases, mainly associated with ischemia, stroke and encephalopathy.

- Subjective effects: the desire for novelty, dreams and reduction of animal motivation.

- The course consists of injections of 10 mg per day

Well, the substance is unusual and interesting! If used - tell us what and how, confirm or deny the information!


Logo DR. DOPING

Cerebrolysin

10 Apr 2018

A drug of the brain of pigs, positioned by the manufacturer as a medicine. It refers to nootropic drugs, complex drugs with neurotrophic activity, is proposed for use in the treatment of patients with various neurological diseases, such as ischemic and hemorrhagic strokes, vascular dementia, including Alzheimer's disease. It is a complex of low molecular weight peptides obtained by enzymatic cleavage of purified porcine brain substance proteins. The active fraction is represented by peptides whose molecular weight does not exceed 10,000 daltons. In connection with the complex nature of cerebrolysin, the exact mechanism of its action remains unknown.

Cerebrolysin

- Active ingredient: hydrolyzate brain pig.
- Dosage form: injection.

The drug has been produced and studied since the early 1970s, is the main product of the Austrian pharmaceutical company EVER Neuro Pharma, which besides this drug produces a drug intended for the treatment of Parkinson's disease, and nutritional supplements. The international name of the drug is absent.

According to the authoritative organization Cochrane Collaboration in randomized clinical trials of cerebrolysin, no improvement in the status of patients from taking the drug has been reported. Based on the results of a double-blind, randomized, placebo-controlled study in 2011, patients with mild to moderate vascular dementia demonstrated that patients who received Cerebrolysin as a supplement to acetylsalicylic acid therapy experienced significant improvements in all primary outcome parameters compared to baseline level and with the same parameters in the placebo group. Main conclusions: can be recommended for inclusion in regional forms of treatment for patients with vascular dementia.

For more than 40 years, cerebrolysin has been widely used in Russia and CIS countries. For many years (since 1992) is on the government's list of vital and essential medicines.

In the United States, the Food and Drug Administration (FDA) is not registered, but has the status of a new drug approved by the FDA for private clinical use.

Pharmacodynamics
The composition of the drug includes low-molecular biologically active neuropeptides, which are able to penetrate the blood-brain barrier and to go directly to the nerve cells. The drug has an organ-specific multimodal effect on the brain.

~ Neurotrophic activity ~
The drug has proven neurotrophic activity, similar to the action of natural factors of neuronal growth, but manifested in conditions of peripheral administration. It has the effect of neurotrophic stimulation of neurons of the peripheral and central nervous system.

~ Metabolic regulation ~
Increases the efficiency of aerobic energy metabolism of the brain, improves intracellular protein synthesis in the developing and aging brain.

~ Neuroprotection ~
It protects neurons from damaging effects of lactic acidosis, prevents the formation of free radicals, improves survival and prevents the death of neurons in conditions of hypoxia and ischemia, reduces the damaging neurotoxic effect of excitatory amino acids (glutamate).

~ Functional neuromodulation ~
Has a positive effect on violations of cognitive functions and memory processes.

Indications: disorders of the central nervous system: traumatic brain and spinal cord injuries, ischemic stroke, Alzheimer's disease, chronic cerebrovascular insufficiency, mental retardation in children, hyperactivity and attention deficit in children, dementia syndrome of various genesis.

Contraindications: status epilepticus, acute renal failure, individual intolerance of the drug.

Efficiency mark:
A randomized controlled study of the safety of cerebrolysin, conducted at the Christian-Doppler Hospital in Salzburg, with neuroprotective treatment of patients with acute cerebrovascular accident showed that the drug is safe and well tolerated in patients with acute stroke. The results, despite the small sample size, indicate a potential effect of treatment with cerebrolysin in acute stroke.

In 2007, a meta-analysis of the effectiveness of cerebrolysin in the treatment of Alzheimer's disease was conducted at the Department of Pharmacology and Biostatistics of Shanghai Jiaotong University Medical College. Six randomized, double-blind, placebo-controlled clinical trials were examined using standard meta-analysis methods. The analysis found that cerebrolysin can significantly improve the overall condition of patients with mild and moderate Alzheimer's disease. The effectiveness of the action of cerebrolysin on cognitive functions requires further study.

A multi-center, randomized, placebo-controlled, double-blind clinical study of cerebrolysin in 2011 after the stroke did not show a difference in the final outcome of treatment with cerebrolysin compared with placebo in the treatment of ischemic stroke. However, after the stratification of the results of the severity of the patients' condition, a decrease in mortality was observed for 90 days after the stroke by 10% compared to the control group (mortality in the placebo group was 20.2%, in the cerebrolysin group 10.5 %). This result should be confirmed by further clinical studies.


Logo DR. DOPING

Delayed Speech Development

04 Apr 2018

Delayed speech development (PID) and delayed psycho-speech development (PID) are not independent diseases, but only certain symptoms. At the same time, the prevalence of this diagnosis has recently become an epidemic.

We list the main:

- A child at 4 months emotionally does not respond to gestures of adults and does not come alive when his mother addresses him.

- In 8-9 months he does not babble (he does not repeat ba-ba-ba, pa-pa-ta, etc. of combinations), in a year is extremely quiet and almost does not make sounds.

- In a year and a half he does not speak and does not understand simple words, for example, "mom" or "dad", names of surrounding objects. He can not fulfill simple requests like "go here", "sit down".

- In two years he uses only a few separate words and does not try to repeat new words.

- In 2.5 years in the active vocabulary less than 20 words and word-of-mouth. Does not know the names of the surrounding objects and body parts. It can not, at the request, show a familiar object or bring something. He does not know how to write phrases from two words (for example, "give water").

- A three-year-old is hardly understood even by his relatives. He does not say simple sentences, does not understand simple explanations or stories about events in the past or the future.

"At three, he talks too fast, swallowing the words." Or, on the contrary, very slowly, stretching them, although there is no such speech at home.

- In three years he speaks mostly phrases from cartoons and books, but does not build his own proposals. Mirror repeats what adults say to him, even to the point.

If the child has a delay in speech development, then his mental development is violated, and by the age of 5 the diagnosis usually changes to another: the delay of psycho-speech development.

As a rule, the delay in verbal and psycho-speech development is a consequence of brain, central nervous system, genetic or mental disorders. But why they arise, and most importantly, why more often in recent times, classical medicine can not explain.

As a therapy, medications are most often prescribed, which improve metabolic processes in brain cells, microcirculation of blood and impulses in nerve fibers. Such drugs as cortexin, actovegin, coguitum, neuromultivitis, lecithin, really contribute to the restoration of normal functioning of the central and peripheral nervous system.

Often, magnetotherapy, electroreflexotherapy is used to restore certain areas of the brain responsible for mental and speech development. Sometimes unconventional methods are also connected: hippotherapy (treatment with horse riding and training with horses), dolphin therapy.

An important role is played by the work of the defectologist (psychologist), which is aimed at raising the child's mental development level. Art therapy (treatment with the help of drawing), musterapy (treatment with the help of music), subject-sensory therapy can be used in this case: in the cerebral cortex the center of speech and the center of manual motility are located close, and with the development of fine manual motility, the development of the speech center . And, of course, you need to work with a speech therapist.

Complex treatment of a neurologist, speech therapist and psychologist, as a rule, helps to significantly improve the basic indicators of speech and mental development in general. Nevertheless, classical methods do not reveal and, accordingly, do not eliminate a number of initial violations that lead to speech underdevelopment. In other words, these methods are not enough.

According to studies conducted under the guidance of the Institute of Osteopathy, speech disorders in children are accompanied in 100% of cases and, most likely, result from structural damage to the skull and spine.

These injuries most often cause problems during pregnancy and childbirth: premature, prolonged or rapid delivery, a long anhydrous period during labor, birth asphyxia, birth trauma. And, probably, it is the spread of various methods of stimulation in childbirth and the popularity of cesarean section, even without medical indications, that cause the growth of the number of speech development delays.

However, the reasons can be and others: domestic, sports traumas, sometimes even an easy cuff can cause a number of infringements in work of a brain of the child. The result is the same: different areas of the brain start to work incorrectly or not actively. Delays in speech and mental development mean that the sites responsible for speech and intellect have suffered.

And here it is important to know: structural, mechanical damage to the skull and spine can not simply be eliminated with medication, psychotherapy or logopedic work. They can be corrected only physically, manually. This is what osteopathy is doing - human mechanics.

An osteopathic physician, when examined, identifies the affected child as a result of genera or other causes of the zone and acts on them, restoring their correct position and restoring their freedom of movement. As a rule, these are the zones that are most injured in the process of childbirth, namely: 1-2 cervical vertebra, cervico-thoracic spine, occipital-temporal sutures, intraosseous injuries of the occipital bone, main seam in the skull.

As a result, the function of the bone, nervous system and blood supply is restored. Normal blood microcirculation and metabolism in brain cells. As a result, brain nutrition is improved, its work is normalized, behavior and speech are changed. In my practice, the effectiveness of osteopathic treatment with a delay in speech and mental development is 70%. There is also documented statistics.

The Institute of Osteopathy conducted a study of children diagnosed with "dysarthria" - a general hypoplasia of speech. Half of the children (control group) underwent classical treatment with a neurologist, speech therapist and psychologist, and half (experimental) with a speech therapist and an osteopath. After three months, a comprehensive examination showed: osteopathic treatment was more effective than medication.

In the experimental group receiving osteopathic treatment, all the indices were better: emotional excitement decreased in 78% of the children (56% in the control group), restlessness in 61% (45% in the control group), speech impairment in 89% (72% in the control group).

Absolutely in all children of the osteopathic group, the independent speech and the state of the speech apparatus improved (in comparison with 94% and 78% of the children in the control group).

Psycho-speech development improved in 72% (61% in the control group), intelligence increased in 56% (45% in the control group), attention was strengthened in 45% (33% in the control group).

At the same time, in children, who were treated with osteopaths, naturally, the number of disorders at the level of the body structures decreased. This allows us to hope that in the future their development will be more harmonious.


Logo DR. DOPING

At what age can children be given Cogitum? How to take? Possible contraindications.

03 Apr 2018

Parents are usually alarmed by the need to take any medication by their child, especially if it is caused by nervous disorders. The drug Cogitum for children is used strictly according to indications, despite the relative safety of the components.

The composition with a pleasant banana flavor, distinguished by its impressive cost, has been actively used for almost half a century with a general tonic purpose and for obtaining more narrowly specialized effects. It should be taken into account that, despite the promise of numerous positive results, it is strictly forbidden to use the drug without the appointment of a specialist, its impact on the child's body can be unpredictable.

The active substance of the drug and the principle of its action Cogitum is a medicament intended for restoring the work of the nervous system.

The active substance is a synthetic analogue of aspartic acid. This product is contained in the human body, especially its quantity in the structure of the brain. The chemical compound takes an active part in the synthesis of DNA and RNA, controls carbohydrate metabolism. Under its influence, the processes of excitation and inhibition of the central nervous system are optimized. The work of an important department of the child's body becomes more stable and productive. In addition to the main component, the product includes fructose, drinking water, preservative and flavor, which gives the product a banana smell.

Tip: It is noteworthy that it is the additional components most often observed immune response in children prone to allergic reactions. In the event of such consequences, it is not necessary to completely abandon the profile treatment, it is only necessary to choose a suitable analogue based on the same active component.

The drug instruction states that it is able to cope with neuroses, mild depression, increased fatigue, mood swings and other functional asthenic conditions that adversely affect the life of a modern person. Cogitum for children is used as part of complex therapy in the following cases:

  • Obvious delay in speech, motor, emotional and mental development, suspicion of these states.
  • Manifestations of the consequences of perinatal damage to the nervous system.
  • Children's cerebral palsy and some forms of hydrocephalus leading to a neurological deficit.
  • Delays in the physical and functional stages of development.
  • Confirmed or unspecified mental retardation.
  • Increased fatigue after a previous viral disease, persisting for a long time.
  • Some neurotic disorders.
  • Depressive signs of a short-term type.
  • Disorders of mental development and adaptation.

Cogutum can be prescribed as an independent drug in cases of craniocerebral trauma, elimination of the consequences of neuroinfections. Sometimes it is used in periods of increased emotional, mental and physical exertion. The main contraindication to the use of the composition is the intolerance of its components.

The instruction recomend not to use the treatment for children less than 7 years, but experts themselves often violate this prohibition.

Today Kogitum is prescribed even to infants. Detailed instructions for the use of the drug The drug is taken internally, the doses are set by a specialist. Most often it looks like this:

Children under the age of 7 years are given no more than 5 ml per day, reception is carried out in the morning hours. The kid should receive no more than 125 mg of the active ingredient.

Children aged 7 to 10 years are shown to give 1 ampoule (250 mg of active substance) once a day, in the morning.

For children aged 10 to 18 years, 2 ampoules (500 mg of active substance) are shown once a day, in the morning.

The duration of the treatment course is 3-4 weeks. To exit therapy, a gradual dose reduction is not required. If, for some reason, one drug intake was missed, it is not necessary to compensate, it is simply skipped. If necessary, therapy can be interrupted at any time without negative consequences. Children usually like the banana flavor of the product, but if necessary, it can be diluted in water. To take the medicine, the ampoule is opened on one side, turned over over the cup and opened on the other side.

In case of intolerance of the components of the composition, the child may experience an allergic reaction with all symptoms characteristic of the condition. Other types of side effects were not fixed. The development of the pharmacological industry has led to the fact that today there are many analogues of the base product, which also relieve fatigue and other types of ailments. Among the most common and in demand are: Dr. Thiess, Kudesan, tincture of ginseng, Cortexin, Multi Tubs, Centrum, Notta, Novo-Passit, sedatives.

Product Reviews are the most controversial. Some parents note the rapid development of positive changes in the state of the child, others argue that there are no improvements. In any case, the therapeutic effect should not be expected after the first medication. There will be no jumps in the state, the psychological mood of the child will change gradually. It is worth considering that, for all its safety, Cogitum remains a potent drug. Before the beginning of therapy it is recommended to consult with several specialists who will calculate all the variants of the development of events, select the optimal dosages and additional medications. Violating recommendations and adjusting them at your own discretion is strictly prohibited.


Logo DR. DOPING

Adamantyl bromophenylamine- trade name Ladasten

02 Apr 2018

A drug, a psychostimulant, an anxiolytic, an immunotropic drug.

Pharmachologic effect

- Enhanced synthesis and Ca2 + -dependent processes of dopamine release. The ability of the drug to enhance the synthesis of dopamine de novo fundamentally differentiates the drug from typical psychostimulants. Due to the increased synthesis of dopamine, with the treatment with adamantyl bromophenylamine there is no depletion of the neuronal reserves of catecholamines.

- Restoration of stress-depleted GABA-receptors and a decrease in the expression of the gene encoding the GABA GAT-3 carrier protein synthesis. GAT-3 is one of the isoforms of the GABA transfer protein, which reuptakes GABA from the synaptic cleft. By reducing the expression of the gene that codes for the synthesis of this protein, the GABA content in the synaptic cleft is increased, which increases the GABA-transmission and is a factor in increasing the binding of the ligands to the GABA-benzodiazepine-chloronophore complex.

- Antiradical action: reduces the activity of excessively elevated processes of lipid peroxidation, contributes to the preservation of the integrity and barrier function of cellular and mitochondrial membranes.

Indications

Asthenic conditions of various genesis, including somatic diseases and after the transferred infectious diseases.

Neurasthenia.

From the side of the central nervous system: there can be signs of excessive activation and a disorder of falling asleep.

From the cardiovascular system: development or aggravation of heart failure, orthostatic hypotension; hypertension, rarely - arrhythmia, tachycardia.

Other: allergic reactions (with increased individual sensitivity to the drug).

Adamantyl bromophenylamine belongs to the group of so-called actoprotectors - drugs of different groups, which increase the body's defenses. Adamantibromphenylamine was developed by Soviet military physicians as a means of increasing overall immunity, endurance of a person. It was found that the drug also has a psychostimulating effect. In addition, he disguises the use of steroids: all standard doping procedures that the IOC practiced turned out to be ineffective against adamantyl bromophenylamine. 


Logo DR. DOPING

Cogitum France and Cogitum Portugal. Are these different medications?

30 Mar 2018

It is often possible to meet the question: the French Ņogitum of the firm Sanofi and the Portuguese Cogitum company Korangi are different things?

Let's compare the compositions and understand - whether only the names of the preparations are consonant or indeed it is a question of the same drug with the same active substance.

Composition of the Portuguese Coguitum

175 mg of N-acetylaminosuccinic acid (250 mg of potassium salt),

1000 mg of levulose *,

15 mg of methyl parahydroxybenzoate *,

7 mg of banana flavor *

10 ml of purified water q.s.

DDR not set

Composition of the French Cogitum:

Sanofi company

Name of the product Trade name: Kogitum.

Chemical name: potassium N-acetylaminosuccinate

Dosage form Solution for oral administration.

The composition of 10 ml of the solution contains:

active substance: potassium acetylaminosuccinate 250 mg;

Excipients:

fructose 1000 mg,

methylparahydroxybenzoate 15 mg,

flavoring banana 7 mg,

water purified to 10 ml.

Pharmacotherapeutic group: tonic.

ATX Code: N06BX.

Description Transparent light yellow solution with the smell of a banana.

Let's compare the active substances. In Portuguese: N-acetylaminosuccinic acid (250 mg potassium salt) is the main component.

French: 250mg of potassium acetylamino succinate is the main component.

Acetylaminosuccinic acid (the dicalcium salt of N-acetylaminosuccinate) is a synthetic analog of aspartic acid (a non-essential amino acid); as a result, their chemical properties, as well as the mechanisms of biological action, do not differ. Moreover, aspartic acid, rather than acetylaminosuccinate (N-acetylaminosuccinic acid) was previously indicated as the active substance of the drug.

Acetylaminosuccinic acid (Cogitum, Sanofi Aventis, France) is not a food additive, does not refer to biologically active additives or "orthomolecular" complexes. Acetylamino-succinic acid is officially registered in Russia as a prescription drug. This drug belongs to the pharmacological group "Toning agents and adaptogenes", which allows you to extrapolate to the described drug the basic general characteristics of these drugs. In accordance with the existing definition, these are "herbal preparations (native or in the form of pure active substances) that have a low specific generalizing effect on the functions of the central nervous system, endocrine regulation, metabolic processes and increasing the adaptation of the organism to unfavorable conditions".

As a result, we can put an equal sign between the terms used: both here and there it is said about the N-acetylaminosuccinic acid contained in the two-potassium salt in the same volumes on the ampoule.

Other components: these are auxiliary elements (including sweeteners) that practically coincide in both compositions and do not affect the pharmacological effect.

You can safely say - both drugs are identical in composition and volume of ampoules. Only one insignificant difference: it is a 20 ampoule in the Portuguese cogitum instead of 30 ampoules in the French coguitum (now withdrawn from production or re-registered).


Logo DR. DOPING

Atomoxetinum (Atomoxetinum) - Strattera

26 Mar 2018

A drug intended for the treatment of attention deficit hyperactivity disorder (ADD, ADHD). By the mechanism of action, atomoxetine is an inhibitor of norepinephrine reuptake (indirect sympathomimetic of the central action).

Atomoxetine is approved by the US Food and Drug Administration for the treatment of attention deficit / hyperactivity disorder in children, adolescents and adults. Its effectiveness has not been investigated in children under 6 years. Unlike psychostimulants traditionally prescribed for ADHD, atomoxetine is not a narcotic and does not have the inherent potential for abuse. In clinical trials, it has been shown that atomoxetine is able to provide a stable 24-hour monitoring of ADHD symptoms in both adults and children.

Atomoxetine is also used to treat treatment-resistant depression as an independent remedy or as part of a comprehensive treatment with SSRIs or other drugs.

The therapeutic effects of atomoxetine develop gradually over at least one week. The duration of the course use of the drug should be 6-8 weeks before the decision on its level of effectiveness. Many patients with ADHD, whose disease can not be corrected by psychostimulants, respond to treatment with atomoxetine. Atomoxetine is also more preferred in patients with a variety of mental disorders, those who do not tolerate psychostimulants well, as well as patients with substance abuse in the anamnesis. Psychostimulants based on amphetamine (mixed salts of amphetamine and dextroamphetamine), pure dextroamphetamine, lisdexamphetamine, etc.) are not recommended for use in patients suffering from nervous disorders (such as facial tics, spasms, etc.). In such cases, atomoxetine is the best choice.

Atomoxetine potently and highly selectively inhibits the proteins of the presynaptic membrane carrying out the re-uptake of norepinephrine, serotonin and dopamine. The binding constants (Ki) are 5, 77 and 1451 nM, respectively. In studies of tissue microdialysis, it has been shown that atomoxetine triply increases levels of norepinephrine and dopamine in the prefrontal cortex, but does not alter the level of dopamine in the striatum and adjacent nucleus. Also, atomoxetine in therapeutic doses acts as an NMDA receptor antagonist. The role of such antagonism in the therapeutic profile of atomoxetine has yet to be clarified, however, fresh sources of literature imply that the dysfunction of the glutamatergic system may play a role in the etiology and pathogenesis of ADHD.

Atomoxetine does not have a clinically significant affinity for serotonin, acetylcholine and adrenergic receptors.

Side effects include dry mouth, fatigue, irritability, nausea, decreased appetite, constipation, dizziness, sweating, upset urination, sexual problems, decreased libido, urinary retention, weight changes, slower growth in children, increased heart rate and blood pressure, aggressiveness, mania, hypomania.

Atomoxetine was initially studied as a drug for the treatment of depression, but did not show a favorable risk / benefit ratio in clinical trials. Subsequently, the manufacturing company Eli Lilly and Company examined the atomomxetine for the treatment of ADHD. Many patients observe a pronounced antidepressant effect of atomoxetine (when used with other antidepressants).

The efficacy of atomoxetine in the treatment of psychogenic overeating was investigated. The average dose of atomoxetine was 106 mg / day. The study showed that "the use of atomoxetine was associated with a significantly higher rate of reduction in episodes of overeating, weight loss and BMI." The authors of the study concluded that atomoxetine can be effective in the short-term treatment of psychogenic overeating.


Logo DR. DOPING

Fenibut - Phenibutum

20 Mar 2018

Phenibut (γ-amino-β-phenylbutyric acid) is an anxiolytic and nootropic agent, a β-phenyl derivative of the γ-aminobutyric acid neurotransmitter.

Fenibut - Phenibutum buy online

Trade names: Bifren, Noobut, Noofen, Fenibut, Anvifen

Phenibut was synthesized in the Leningrad Pedagogical Institute. Herzen Professor V. V. Perekalin. The study of clinical and pharmacological properties of phenibut was carried out in the laboratory of psychopharmacology of the Leningrad Scientific Research Institute. VM Bekhtereva senior researcher R. A. Khaunina.

At one time, Phenibut was among the medicines, which are necessarily included in the cosmonaut's first-aid kit. Conventional tranquilizers badly lowered the high level of astronaut stress, because in addition to calming effect, they also had a relaxing effect. With the reception of the Phenibut, the cosmonauts' working capacity remained at the same level.

In 1975, the phenybut preparation was included in the first aid kit of cosmonauts participating in the experimental flight "Soyuz" - "Apollo".

By chemical structure, phenobut can be regarded as a phenyl derivative of GABA, and also as a derivative of phenylethylamine.

Phenibut has elements of nootropic activity, has a tranquilizing effect, reduces tension, anxiety, improves sleep; prolongs and intensifies the effect of sleeping pills, narcotic, neuroleptic substances and psychostimulants.

Apply Phenibutum in asthenic and anxiety-neurotic states, anxiety, anxiety, fear, insomnia, and also as a sedative before surgical interventions.

Assign also with Meniere's disease, dizziness associated with dysfunction of the vestibular apparatus, for the prevention of motion sickness.

Children are prescribed for stuttering and tics.

There is evidence of an increase in the effect of antiparkinsonian drugs (due to the presence of a dopaminopositive component) under the influence of Phenibutum.

With the use of phenibut in children under 10 years of age who suffer from stuttering, speech impairment can occur, and a change in the picture of the electroencephalogram, including the appearance of sharp wave peaks, is possible. This drug should be given to children with extreme caution.

Indications:
Asthenic and anxiety-neurotic states, anxiety, anxiety, fears, insomnia, and also as a sedative before surgical intervention. A distinctive feature is the pronounced effect in the treatment of dizziness.

A direct effect on GABA-ergic receptors facilitates GABA-mediated transmission of nerve impulses in the CNS. Improves the functional state of the brain due to the normalization of tissue metabolism and the influence on cerebral circulation (increases the volume and linear speed of the cerebral blood flow, reduces the resistance of the cerebral vessels, improves microcirculation, has antiaggregant effect), also has a tranquilizing, psychostimulating, antiaggregant and antioxidant effect. Helps reduce or disappear feelings of anxiety, tension, anxiety and fear, normalize sleep, does not have an anticonvulsant effect, but enhances the effect of anticonvulsant drugs. Does not affect cholino- and adrenergic receptors. It prolongs the latent period and shortens the duration and severity of nystagmus. Reduces the manifestations of asthenia and vasovegetative symptoms (including headache, a feeling of heaviness in the head, sleep disturbance, irritability, emotional lability), increases mental performance. It improves psychological indicators (attention, memory, speed and accuracy of sensory-motor reactions). At the course reception increases physical and mental efficiency, improves memory, normalizes sleep; improves the condition of patients with motor and speech disorders. In patients with asthenia, from the first days of therapy, feeling better, increasing interest and initiative (motivation of activity) without sedation or arousal. In the appointment after severe craniocerebral trauma increases the number of mitochondria in the perifocal areas and improves the course of bioenergetic processes in the brain. With neurogenic lesions of the heart and stomach normalizes the processes of lipid peroxidation. In elderly people does not cause congestion and excessive lethargy, a relaxing aftereffect is most often absent. Improves microcirculation in the tissues of the eye, reduces the inhibitory effect of ethanol on the central nervous system. The drug is low-toxic, does not cause allergic action, does not have teratogenic, embryotoxic and carcinogenic properties.

Metabolized in the liver - 80-95%, metabolites are not pharmacologically active. Do not cumulate. After 3 hours begins to be secreted by the kidneys, while the concentration in the brain tissue does not decrease and it is found in the brain for another 6 hours. About 5% is excreted by the kidneys unchanged, partly with bile.

Side effects:
Usually well tolerated. At the first reception possible drowsiness, with an overdose - pronounced drowsiness, nausea, vomiting; increased irritability, agitation, anxiety, dizziness, allergic reactions.
With prolonged use, it is necessary to monitor the liver function and the peripheral blood picture. It is necessary to refrain from potentially dangerous activities requiring increased attention. It is not effective at the expressed phenomena of motion sickness ("indomitable" vomiting, dizziness, etc.).

Phenibut should not be combined with alcohol.


Someone from the United Arab Emirates - just purchased the goods:
Encephabol suspension 80mg/5ml 200ml