15 Dec 2017
Ipamorelin - basic information
As it turned out information on such a "peptide" product, like Ipamorelin, on our vast spaces is still very small, and what is, is traditionally replete with legends and myths. Therefore, in this article, we will try to understand what is Ipamorelin, what are its properties, and how to correctly take this peptide.
Ipamorelin is the release of growth hormone peptide. Ghrelin mimetic. The mechanism of its action is the same as in GHRP 6, GHRP 2, Hexarelin. He, as well as his "brethren", transmits a signal to the growth hormone cell about GH secretion by connecting to a specific ghrelin receptor GHS-R.
Ipamorelin "saw the world" in the distant 1998. This peptide was "invented" by replacing the Alanine-Tryptophan GHRP fragment with the Aib-His-D-2-Nal fragment, where His is histidine and D-2-Nal is the dextro form of 2-naphthylamine. But, the most interesting is Aib, which is nothing else than Gamma-aminobutyric acid (GABA) (Why is it interesting ?, more about this later).
Ipamorelin - the main effects
By binding to the GHS-R receptor, Ipamorelin sends a signal to the somatotropic pituitary cell, thereby stimulating GH secretion. Comparing the potential of Ipamorelin in terms of GHRP secretion with GHRP 6, GHRP 2 and Hexarelin using the same dosages, it is possible to build a kind of "rating", where Hexarelin will lead the list, since it simulates the largest release of GR; GHRP 2 will be in 2nd place; Well, an honorable third place will be shared by GHRP 6 and Ipamorelin. Many, of course, can "grimace" and say that Ipamorelin is a 3rd grade slag, but this is far from the case. In fact, Hexarelin differs from Ipamorelin in about 10-15 ng / ml by the secretion of GH. Why "about", because with non-abortion use, rely on the analysis of different people follows with a certain error, as you know, the results of the tests may depend on a number of factors, such as age, food intake, quality of the drug, etc.
As for the release of GH, it also has a "pulse" character, where the duration of the "pulse" is about 3 hours with a maximum value of 30-35 ng / ml.
Side effects of Ipamorelin
To such I will refer all the phenomena not related to the stimulation of GH secretion. Considering the group releasing growth hormone peptides, we have traditionally attributed these products the ability to influence the stimulation of the secretion of not only GH, but also the secretion of prolactin and cortisol. In addition, it is quite common for us to have a feeling of hunger when using these peptides. But Ipamorelin, due to its structure, goes beyond these stereotypes, and does not cause a feeling of hunger, and it is not capable of exerting any influence on lactotrophs (responsible for the secretion of prolactin) and on eosinophilic cells (responsible for the secretion of ACTH). It is for this "selectivity" that this product is generally called "selective", since it is now established that it acts only on the somatotropic cell. But do not forget that abuse (excess dosages) can lead to both loss of sensitivity of the growth hormone cell, as well as to fluid retention in the body. These "pobochki" in principle are unlikely, but knowing the maximalist views of many "peptide adherents" mention them yet will not be superfluous.
An interesting property of Ipamorelin is the ability to increase (extend) the phase of slow sleep, which promotes a deeper sleep and as a consequence of additional secretion of growth hormone, although in some cases of practical use it has been observed that Ipamorelin can cause drowsiness after injection.
In addition, considering this product, it is also necessary to indicate not quite the "traditional" side effects that happened to "meet" in practice. At me, for example, after an evening injection the next day (approximately closer to noon) there were "easy" headaches. Morning injection from daily headache helped. Also, there are cases when a person after a night's application very well slept, and after a morning injection again "cut down". After removing the morning injection, the person again "came back to normal." In addition, one of the "peptide users" I respected shared very interesting information about his reaction to the use of Ipamorelin, namely, the appearance of a "tingling" sensation in the fingers after injection. Also quite curious was the fact that the level of PH saliva (set on indicator paper) changes after applying Ipa. There is also information about the smoothing of small wrinkles after applying Ipamorelin.
Research has not established the effect of Ipamorelin on insulin secretion in humans. But, I note that in 2004 an interesting experiment was conducted during which scientists from the United Arab Emirates found that Ipamorelin is nevertheless capable of stimulating insulin secretion in rats (normal and rats with diabetes).
I knowingly drew your attention to this interesting element in the amino acid chain. The fact is that "deep sleep" is just the result of the "work" of gamma-aminobutyric acid, which additionally also has an added bonus, in the form of stimulation of GH secretion, and is also capable of causing a slight sedative effect, a little calming after a mental and emotional Excitation.
After preparing a solution based on water for injection, Ipamorelin (depending on the quality) is able to "live" in the refrigerator about 2x3 weeks (maximum 1 month). Theoretically, it is possible to prolong the degradation period by preparing a solution based on the "saline solution" of sodium chloride, but in practice I was not able to carry out such an experiment (which, of course, does not mean that saline is worse than water for injections).
Prospects for using Ipamorelin (what to expect?)
Speaking about what to expect, and what not to dream about, it should be recalled that any effects from peptides can not be separated from the effects caused in the body by the growth hormone. I will not clone the advertising slogans of many sellers and resources, but will focus only on specific "effects" from the monthly application of Ipamorelin. To such I will refer to the improvement of concentration, the best "recovery" of the body after stress (training by itself, as well as stress at work), significant improvement in sleep, restoration of joints and ligaments, light cosmetic effect (smoothing of fine wrinkles, although perhaps this is due to The fact that you smile less). Biceps in 50 cm increase unfortunately was not possible, and to reduce the percentage of fat from 40% to 2% is also not realistic, but the restoration of natural GH secretion and an increase in the concentration of IGF binding protein of the third type (which falls as a result of the use of aac) Significant (though not entirely tangible) pluses of Ipamorelin.
Here, too, Ipamorelin does not differ from its "classmates". 1 μg / kg is the optimal dosage, but, to my great regret, this dosage has recently become less effective due to the deterioration in the quality of the products offered. Therefore, I will not criticize and agree with the opinion of some peptide "users" who say that for Ipamorelin the dosage should be raised higher, for example, up to 1.5-2 μg / kg. I will say frankly, "that", that I happened to try more and more and more and more disappointing lately and that "at least" it would be good to sleep 2-3 mkg / kg and "happiness" was not very long, because . The peptide somewhere in 1 week degraded.
Prospects for use on drying
On the prospects of using Ipamorelin in sports, you are more or less (in general terms), I think, understood, but I would like to talk about using this product in the period of fighting fat. If you are planning to choose which peeling to dry, then it's best to look towards Ipamorelin. There are several reasons. Ipa does not cause a feeling of hunger, which is already "aggravated" during the diet. Also, because of its light sedative effect, Ipa will help to "soften" the tides of unreasonable aggression (well, or increased temper), which are sometimes rolled on hard diets (for example, on "carbohydrate"). Well, by itself "drying" with GR (stimulated by Ipamorelin) will be much more productive than drying without GR.
Ipamorelin can be safely combined with somatoliberin and its analogues. A good "bunch" in terms of stimulating GH secretion will be Ipamorelin + CJC-1295. Also, if there is a desire, you can "connect" Ipamorelin with Tesamorelin'om. Combining Ipa with other ghrelin mimetics is also possible, but from a practical point of view it is better not to do it at the same time, but at different times of the day, for example, morning, GHRP day, and Ipamorelin evening.
Also, because of the lack of influence on the secretion of insulin, Ipamorelin can be used during the application of HGH Frag 176-191 without risking "suppressing" the action of the latter with undesirable insulin. With MGF (and its more advanced forms), as well as with Peg MGF (simple, pegellated and Long form), Ipamorelin is also normally combined without suppressing (as in principle and without amplifying) the effects of these growth factors.
If you want to choose what to be stabbed by the time of "AAS homeopathy" and PCT, then the most normal option is Ipamorelin (and on PCT so even more), as, as you already remember, Ipa does not stimulate cortisol and prolactin, and also increases Concentration of IGFBP-3, thereby maximizing the benefits of IGF-1.
This question is increasingly worried about the minds of athletes who turned their attention to peptides. The answer is that the peptides on the DK are "scorching or not burning" is very simple - "scorching" but in the case of mass spectrometry after separation of the sample by liquid chromatography. And in this regard, there is a counter question, "but do you apply this method to the DC of your competitions?". If "yes", then it is desirable for an athlete to stop using both Ipamorelin and other releasing peptides and somatoliberin analogs at least one day before DC.
Here is such a selective ghrelin mimetic, releasing growth hormone peptide Ipamorelin. As you can see, this is quite a promising product. But, as we have, any budding project can be ruined by poor quality, and even by an absolutely inadequate price. Absolutely absurd solution is also the sale of Ipamorelin weighing 10 mg, because the degradation is quite fast, and besides, to measure the normal dosage in a solution with a large concentration of peptide (after the liquid in the bottle is placed a maximum of 3.5 ml) is not very easy . It turns out some strange savings. In general, discarding these ridiculous misunderstandings, in my opinion, Ipamorelin deserves attention, and has to be in the arsenal of many athletes. As a safe, but very effective tool for improving physical performance.