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Instruction for use: Serophene

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Active substance Clomifene

ATX code G03GB02 Clomifene

Pharmacological group

Estrogens, gestagens; Their homologues and antagonists

Nosological classification (ICD-10)

N91 Lack of menstruation, meager and rare menstruation

Amenorrhea, Amenorrhea hypogonadotropic, Amenorrhea is prolactin-dependent, Oligomenorrhoea, Shortening of the secretory phase of the menstrual cycle, Menstrual disorders, Menstruation disorders, Prolactin-dependent amenorrhea without galactorrhea

N97 Female infertility

Female infertility in anovulation, Hyperprolactinemic infertility, Hyperprolactinaemia with infertility, Endocrine infertility, Infertility due to hypothalamic-pituitary dysfunction, Infertility infertility, Infertility, Infertility on the background of hyperprolactinaemia, Functional infertility, Marriage is infertile, Infertility of ovarian genesis, Stimulation of the growth of a single follicle

Composition and form of release

1 tablet contains clomiphene citrate 50 mg; In the package 10 pcs.

pharmachologic effect

The pharmacological action is antiestrogenic.

Blocks estrogen receptors, enhances the secretion of gonadotropins to stimulate the maturation and endocrine activity of follicles in the ovaries, ovulation and the development of a functioning corpus luteum (in small doses), inhibits the secretion of gonadotropins (in high doses).


Infertility, functional uterine bleeding, secondary amenorrhea, oligomenorrhea expressed, polycystic ovarian syndrome (Stein-Leventhal type) when stored ovarian function.


Dysfunction of the liver, existing or previously existing visual impairment, ovarian cysts, pregnancy.

Side effects

Hot flashes, sweating, irritability, fatigue, dizziness, insomnia, headache, increase in the size of the ovaries and ovarian cysts in the uterus pain, heavy menstruation, feeling of heaviness in the epigastric region, bloating, nausea, vomiting, impaired visual acuity, increased body weight, chest tightness, polyuria, pollakiuria, unexpressed reversible alopecia, allergic reactions: urticaria, or allergic dermatitis.

Dosing and Administration

Inside, between meals. Within 5 days to 1 table. (1 course) or 2 tablets. (2 courses) per day; The reception starts from the 5th day of the cycle.

Storage Conditions

At a temperature not exceeding 25 ° C.

Keep out of the reach of children.

Shelf life

5 years.

Do not use after the expiry date printed on the package.

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