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DR. DOPING

Instructions

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Instruction for use: Dinaton

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Dosage form: Solution for intravenous and intramuscular administration

Active substance: Serotonin

Dosage form

Solution for intravenous and intramuscular administration

Composition

Active substance: Serotonin adipate 10 mg.

Excipients: unitiol - 1.5 mg, water for injection - up to 1 ml.

Description of dosage form

A colorless or slightly colored transparent solution with a faint smell of hydrogen sulphide.

Pharmacological group

Hemostatic, serotonergic

Pharmacodynamics

Hemostatic and serotonergic. The haemostatic effect of serotonin is due to its ability to increase platelet aggregation and capillary resistance, as well as a reduction in bleeding time. Serotonin causes constriction of the kidney vessels and has an antidiuretic effect. It binds to serotonin receptors of smooth muscles of internal organs and normalizes its contractile activity (endogenous vasomotorics, peristalsis). The manifestation of the normalization of the function of smooth muscles is the stabilization of hemodynamics, restoration of motor-evacuation function of the gastrointestinal tract, reduction of local hypoxia.

Pharmacokinetics

In blood plasma quickly deaminated and loses its activity. Does not possess a cumulative effect.

Indications

Functional intestinal obstruction (PKN)

Hemorrhagic syndrome:

With Werlhof's disease

On the background of cytostatics treatment

With acute, subacute and chronic radiation sickness

In malignant neoplasms

Anemia hypo- and aplastic

Thrombocytopenia

Hemorrhagic vasculitis

Contraindications

Hypersensitivity to any component of the drug, glomerulonephritis (acute and chronic), kidney disease, oligo- and anuria, arterial hypertension, acute thrombosis, angioedema, bronchial asthma, diseases accompanied by hypercoagulability.

If you have any of these diseases, always consult a doctor before taking the drug.

Application in pregnancy and breastfeeding

In pregnancy, the effect of the drug has not been studied, since the drug is rapidly deaminated in the bloodstream. Breastfeeding is not a contraindication for its use.

Dosing and Administration

For the prevention and treatment of functional intestinal obstruction (PKN): intravenously into the central vein at a rate of 5-10 mg / h, previously dissolving the contents of the ampule (10 mg) in 100-200 ml of physiological saline. When introduced into the peripheral vein, 10-20 mg should be dissolved in 200-400 ml of saline. The maximum daily dose can reach 360 mg and above.

Intravenous: 20 to 50 mg are diluted in 200-400 ml of 0.9% sodium chloride solution; Injected drip (30 cap / min) 2-3 times a day before the appearance or strengthening of weakened peristalsis and clinical manifestations of recovery of motor and evacuation function of the gastrointestinal tract.

For the prevention and treatment of hemorrhagic syndrome associated with Verlhof disease. Treatment with cytostatics. Radiation sickness, malignant neoplasms. Hypo- and aplastic anemia, thrombocytopenia, hemorrhagic vasculitis begin with an intravenous injection, and then switch to intramuscular injections. The initial dose is 5 mg; In the absence of side effects, the dose is increased to 10 mg, not more than 15-20 mg / day. The course of treatment - an average of 10 days.

Intravenous: 5-10 mg of the drug is diluted in 100-150 ml of a 0.9% solution of sodium chloride or in 5-10 ml of 0.9% sodium chloride solution, followed by dilution in 100-150 ml of 5% dextrose (plasma, canned Blood) and injected drip (no more than 30 cap / min) no more than 2 times a day.

Intramuscularly: 5-10 mg is diluted in 5 ml of a 0.5% solution of lidocaine; Enter 2 times a day at intervals of at least 4 hours.

Side effects

From the urinary system: a decrease in diuresis.

On the part of the digestive system: abdominal pain, nausea, diarrhea.

On the part of the respiratory system: difficulty breathing.

From the cardiovascular system: cardialgia, increased blood pressure.

Other: pain along the vein (with rapid administration), with intramuscular injection - soreness in the injection site, a feeling of heaviness in the occipital region

If any of the side effects indicated in the manual are aggravated or you notice any other side effects not listed in the instructions, tell your doctor.

Overdose

Symptoms: hyperemia of the skin, tachypnea.

Treatment: no specific treatment is required. It is necessary to suspend the introduction of the drug for 5-10 minutes and continue again at a slower rate.

Interaction

Serotonin potentiates the effect of narcotic, hypnotics and analgesic drugs. It is not recommended to co-administer with calcium chloride preparations.

In the event that you are taking other medicines, be sure to consult a doctor before taking the drug.

Precautionary measures

When side effects occur, it is necessary to suspend the drug for 2-3 minutes and continue again at a slower rate.

Special instructions

The effect of the drug on the ability to drive vehicles, mechanisms

Information on the adverse effects of serotonin on the ability to control vehicles and mechanisms are absent.

Release form

Solution for intravenous and intramuscular injection 10 mg / ml. 1 or 5 ml into neutral glass ampoules.

5 ampoules of 1 ml or 1 ampoule of 5 ml, or 5 ampoules of 5 ml in a contiguous cell pack of a polyvinyl chloride film.

One contour mesh package together with instructions for use in a pack of cardboard.

Storage conditions

In a dry, protected from light place at a temperature of no higher than 25 į C.

Keep out of the reach of children.

Shelf life

3 years.

The drug should not be used after the expiry date indicated on the package.

Terms of leave from pharmacies

On prescription.

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