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Instruction for use: Acetylsalicylic acid + [Citric acid + Sodium hydrocarbonate] (Acidum acetylsalicylicum+[Acidum citricum+Natrii hydrocarbonas])

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Pharmacological groups

NSAIDs - Salicylic acid derivatives

Nosological classification (ICD-10)

F10.3 abstinence

Alcohol withdrawal syndrome. abstinence symptom, Abstinence syndrome in alcoholism, abstinence, alcohol Abstinence, alcohol withdrawal, Alcohol abstinence, Alcohol withdrawal syndrome, postabstinentnom disorder, postabstinentnom state, alcohol withdrawal syndrome, withdrawal syndrome, The syndrome of alcohol abstinence, alcohol withdrawal syndrome, Status of abstinence

G43 Migraine

The pain of migraine, Migraine, hemiplegic migraine, Migraine headache, A migraine attack, Continuous headache, hemicrania

K08.8.0 * Painful toothache

Dentinal pain, Dentinal pains, Pain pulpitis, Anesthesia in dentistry, Pain syndromes in dental practice, Pain after removal of tartar, Pain when extracting a tooth, Toothache, Pain after dental interventions

M25.5 Pain in the joint

Arthralgia, Pain syndrome in musculo-articular diseases, Pain syndrome in osteoarthritis, Pain syndrome in osteoarthritis, Pain syndrome in acute inflammatory diseases of the musculoskeletal system, Pain syndrome in chronic inflammatory diseases of the musculoskeletal system, Pain in the joints, Soreness of the joints, Soreness of joints in severe physical exertion, Painful inflammatory joint damage, Painful conditions of the musculoskeletal system, Painful joint conditions, Painful traumatic affection of joints, Pain in the musculoskeletal system, Pain in Shoulder Joints, Pain in the joints, Joint pain, Joint pain with injuries, Musculoskeletal pain, Pain with osteoarthritis, Pain in the pathology of the joints, Pain in rheumatoid arthritis, Pain in chronic degenerative bone diseases, Pain in chronic degenerative joint diseases, Bone-joint pain, Joint pain, Arthritic pain of rheumatic origin, Articular pain syndrome, Joint pain, Rheumatic pain, Rheumatic pains

M79.1 Myalgia

Myofascial pain syndromes ,Pain syndrome in musculo-articular diseases, Pain syndrome in chronic inflammatory diseases of the musculoskeletal system, Pain in the muscles, Tenderness of muscles, Muscular soreness in severe physical exertion, Painful conditions of the musculoskeletal system, Pain in the musculoskeletal system, Pain in the muscles, Pain at rest, Muscle aches, Muscle pain, Musculoskeletal pain, Myalgia, Muscle pain, Muscle pain at rest, Muscle pain, Muscular pain of non-rheumatic origin, Muscle pain of rheumatic origin, Acute muscle pain, Rheumatic pain, Rheumatic pains, Myofascial syndrome, Fibromyalgia

M79.2 Neurology and neuritis, unspecified

Pain syndrome with neuralgia, Brachialgia, Occipital and intercostal neuralgia, Neuralgia, Neuralgic pain, Neuralgia, Neuralgia of intercostal nerves,Neuralgia of the posterior tibial nerve, Neuritis, Neuritis traumatic, Neuritis, Neurological Pain Syndromes, Neurological contractures with spasms, Acute neuritis, Peripheral neuritis,Post-traumatic neuralgia,Severe pain of a neurogenic nature, Chronic neuritis, Essential neuralgia

N94.6 Dysmenorrhea Unspecified

Pain during menstruation, Functional disorders of the menstrual cycle, Menstrual cramps, Emmeniopathy, Pain during menstruation, Painful menstrual irregularities, algomenorrhea, algomenoreya, Pain smooth muscle spasm, Pain spasm of smooth muscles (renal and biliary colic, intestinal spasms, dysmenorrhea), Pain spasm of smooth muscles of internal organs (kidney and biliary colic, intestinal spasms, dysmenorrhea), Disalgomenoreya, dysmenorrhea, Dysmenorrhea (essential) (Exfoliative), menstrual disorder, menstruation painful, metrorrhagia, Violation of the menstrual cycle, Menstrual irregularities, Prolaktinzavisimoe menstrual disorders, Prolaktinzavisimoe menstrual dysfunction, Pain spasm of smooth muscles of internal organs, Spasmodic dysmenorrhea, Primary disalgomenoreya

R50 Fever of unknown origin

Malignant hyperthermia, Hyperthermia malignant

R51 Headache

Pain in the head, Cephalgia, Pain with sinusitis, Pain in the back of the head, Painful headache, Headache of vasomotor genesis, Headache of vasomotor origin, Headache with vasomotor disorders, Headache, Neurological headache, Serial headache

Characteristics of substances Acetylsalicylic acid + (Citric acid + Sodium bicarbonate)

Combined drug.


Pharmacological action - anti-inflammatory, antipyretic, analgesic, antiaggregant.

Acetylsalicylic acid inhibits COX-1 and COX-2, disrupts the synthesis of PG, has anti-inflammatory, antipyretic and analgesic effect, inhibits platelet aggregation. Sodium bicarbonate neutralizes free hydrochloric acid in the stomach, which reduces the risk of ulcerogenic action of acetylsalicylic acid. Citric acid promotes a faster absorption of the drug.

Application of Acetylsalicylic acid + (Citric acid + Sodium bicarbonate)

Feverish syndrome with infectious and inflammatory diseases, pain syndrome of mild and moderate severity: headache (including associated with alcohol withdrawal syndrome), migraine, toothache, neuralgia, myalgia, arthralgia, algodismenorea.


Hypersensitivity, erosive-ulcerative lesions of the gastrointestinal tract (in the phase of exacerbation), gastrointestinal bleeding, aspirin asthma, hemophilia, hemorrhagic diathesis, hypoprothrombinemia, portal hypertension, avitaminosis K, renal and / or hepatic insufficiency, glucose-6-phosphate dehydrogenase deficiency, Children's age (under 15 years - the risk of developing Reye's syndrome in children with hyperthermia in the background of viral diseases).

Restrictions for use

Hyperuricemia, gout, urate nephrolithiasis, liver disease, heart failure.

pregnancy and lactation

Contraindicated in pregnancy (I and III trimesters). Acetylsalicylic acid has a teratogenic effect: when applied in the first trimester, it leads to the formation of a developmental disorder such as cleavage of the upper palate, in the third trimester - to inhibition of labor (inhibition of PG synthesis), premature closure of the arterial duct in the fetus, which causes hyperplasia of the pulmonary vessels and hypertension in the vessels of the small circle of blood circulation.

Contraindicated during lactation. Isolated with breast milk, which increases the risk of bleeding in the child due to impaired platelet function.

Side effects of Acetylsalicylic acid + (Citric acid + Sodium bicarbonate)

Nausea, decreased appetite, gastralgia, diarrhea, erosive and ulcerative gastrointestinal lesions, bleeding from the gastrointestinal tract, allergic reactions (skin rash, angioedema, bronchospasm), increased hepatic transaminase activity, hepatic and / or renal insufficiency, hematopoiesis (thrombocytopenia, aplastic anemia , agranulocytosis, pancytopenia), aspirin asthma (including recurrent polyposis of the nasal mucosa and paranasal sinuses); long-term use - dizziness, headache (when used in high doses), visual impairment, tinnitus, vomiting, reduced platelet aggregation, hypocoagulation, bleeding, prerenal azotemia, hypercreatininaemia, hypercalcemia, kidney damage with papillary necrosis, nephrotic syndrome, deafness , malignant exudative erythema (Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell syndrome), Reye syndrome in children, aseptic meningitis, aggravation of chronic cardiac insufficiency and.


Strengthens the effect of other NSAIDs, oral anticoagulants, glucocorticoids, narcotic analgesics. NSAIDs, methotrexate, antihistamines drugs increase the risk of side effects. Reduces the effectiveness of spironolactone, furosemide, hypotensive, uricosuric drugs. Glucocorticoids and ethanol increase the adverse effect on the gastrointestinal mucosa, increase the risk of developing gastrointestinal bleeding. Antatsida, containing magnesium and aluminum hydroxide, slow down and worsen the absorption of acetylsalicylic acid.


Symptoms: with mild intoxication - nausea, vomiting, gastralgia, dizziness, ringing in the ears. With a severe overdose - inhibition, drowsiness, collapse, convulsions, difficulty breathing, anuria, bleeding, hyperthermia, coma. Initially, central hyperventilation of the lungs leads to respiratory alkalosis (dyspnea, suffocation, cyanosis, sweating), as the intoxication intensifies, progressive respiratory paralysis and dissociation of oxidative phosphorylation cause respiratory acidosis. In chronic overdose, the concentration of the drug in the plasma does not correlate well with the severity of intoxication.

Treatment: with acute overdose, induction of vomiting, the appointment of activated carbon, laxatives, monitoring of acid-base state and electrolyte balance; depending on the state of metabolism - the introduction of sodium bicarbonate, sodium citrate or sodium lactate. The increase in reserve alkalinity increases the excretion of acetylsalicylic acid by alkalinizing urine.

Precautions for Acetylsalicylic acid + (Citric acid + Sodium bicarbonate)

It should be taken into account that drugs containing acetylsalicylic acid increase the risk of Reye's syndrome in the presence of a viral infection (symptoms of Reye syndrome: prolonged vomiting, acute encephalopathy, enlargement of the liver).

With prolonged use of the drug, control of peripheral blood and the functional state of the liver, as well as examination of feces for latent blood, is necessary. Since acetylsalicylic acid slows blood clotting, in the case of an impending surgery, it is necessary to stop taking the drug 5-7 days before the operation.

Patients with hypersensitivity, or with asthmatic reactions to salicylates or their derivatives, acetylsalicylic acid can be prescribed only with special precautions (in an emergency care setting).

Acetylsalicylic acid in low doses reduces the excretion of uric acid. In patients with a corresponding predisposition, this can in some cases provoke a gout attack.

During treatment should be abandoned the use of ethanol (increased risk of gastrointestinal bleeding).

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