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Cipromed (Ciprofloxacin) eye drops - is an antibacterial drug from the group of fluoroquinolones for topical application in ophthalmology. It is active against a wide range of microorganisms (bacteria and protozoa) that cause eye diseases such as conjunctivitis, keratitis, blepharoconjunctivitis. It is used in the postoperative period to prevent secondary infection. It is prescribed as part of complex therapy for viral diseases of the eyes.
Antibacterial drug from the group of fluoroquinolones for topical application in ophthalmology. Has a broad spectrum of antibacterial action, has a bactericidal effect. The mechanism of action is associated with the ability to inhibit the DNA enzyme of the bacterial DNA, which leads to a disruption in the replication of DNA and the synthesis of bacterial cell proteins. Ciprofloxacin acts both on multiplying microorganisms, and on those in rest.
It is active against gram-negative microorganisms: Escherichia coli, Salmonella spp., Shigella spp., Proteus spp. (indole-positive and indole-negative strains), Morganella morganii, Citrobacter spp., Klebsiella spp., Enterobacter spp., Vibrio spp., Campylobacter spp., Hafnia spp., Providencia stuartii, Haemophilus influenzae, Pasteurella multocida, Pseudomonas spp. , Gardnerella spp., Legionella pneumophila, Neisseria spp., Moraxella catarrhalis, Acinetobacter spp., Brucella spp., Chlamydia spp.
Ciprofloxacin is also sensitive to gram-positive microorganisms: Staphylococcus spp., Streptococcus pyogenes, Streptococcus agalactiae, Corynebacterium diphtheriae, Listeria monocitogenes.
The drug is low toxicity.
With topical application of the drug, ciprofloxacin penetrates well into the eye tissue. After a single instillation, the concentration of ciprofloxacin in the moisture of the anterior chamber of the eye is reached after 10 minutes and is 100 μg / ml. Cmax in the moisture of the anterior chamber after 1 hour is 190 μg / ml. After 2 hours the concentration of the drug begins to decrease, while its antibacterial action in the tissues of the cornea is kept up to 6 hours, in the moisture of the anterior chamber - up to 4 hours.
After instillation, systemic absorption of the drug is possible.
When treated for 7 days with application of 4 times / day in both eyes, the average concentration is less than 2 ng / ml.
With local application of T1 / 2 from the plasma is 4-5 hours. The drug is excreted by the kidneys in unchanged form - up to 50%, and in the form of metabolites - up to 10%; through the intestine - about 15%.
Some part of the drug is excreted in breast milk.
Bacterial inflammatory diseases of the eye and its appendages:
When wearing soft contact lenses, do not use eye drops Tsipromed, t. the preservative included in their composition can be deposited in soft contact lenses and have an adverse effect on the eye tissue. Rigid contact lenses should be removed before instillation of the drug and set them again after 15 minutes.
When using other ophthalmic drugs, the interval between their administration should be at least 5 minutes.
Impact on the ability to drive vehicles and manage mechanisms
Immediately after application of the drug, it is possible to reduce the clarity of vision and slow the psychomotor reactions, which can reduce the ability to engage in potentially dangerous activities that require increased attention (especially with simultaneous use of alcohol).
From the side of the organ of vision: immediately after instillation - a feeling of slight burning during 1-2 minutes, itching, soreness, hyperemia of the mucous membrane of the eye; the possibility of an allergic reaction, eyelid swelling, photophobia, lacrimation, foreign body sensation in the eye, an unpleasant aftertaste in the mouth immediately after instillation, decreased visual acuity, the appearance of white crystalline precipitate in patients with corneal ulcer, keratitis, keratopathy, staining or infiltration of the cornea, development of superinfection.
The drug is prescribed 1-2 drops in the conjunctival sac of the affected eye. The frequency of instillations depends on the severity of the inflammatory process.
With acute bacterial conjunctivitis, simple, scaly and ulcerative blepharitis, Cipromed is prescribed 4-8 times / day, depending on the severity of the inflammatory process. The course of treatment is from 5 to 14 days.
In keratitis, the drug is prescribed 1 drop at least 6 times / day. If there is a positive effect, the duration of therapy depends on the severity of the corneal lesion and is usually 2-4 weeks.
When a corneal lesion is caused by Pseudomonas aeruginosa, tsipromed is prescribed 1 drop at least 8-12 times / day. The duration of therapy depends on the course of the disease and is usually about 2-3 weeks.
With anterior uveitis, the drug is prescribed 1 drop 8-12 times a day.
With acute dacryocystitis and canaliculitis Tsipromed appoint 1 drop 6-12 times / day, for chronic - 4-8 times / day.
To prevent secondary infection in case of eye injuries and its appendages, tsipromed is prescribed 1 drop 4-8 times / day for 1-2 weeks.
For prevention of inflammatory diseases after surgery with perforation of the eyeball, tsipromed is prescribed 1 drop 4-6 times / day during the entire postoperative period (usually from 5 days to 1 month).
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Systein Ultra eye drops 15ml