Instruction for use: Clopamide + Pindolol (Clopamidum+ Pindololum)

Pharmacotherapeutic group:

Beta-blockers in combination

Pharmacological action

Combined preparation has a long hypotensive effect. It contains 2 active substances, complementary antihypertensive effect each other. Pindolol is a nonselective beta-blocker with its own MCA, lowers high blood pressure in the patient's position "standing" and in the "lying"; It does not cause orthostatic hypotension. Klopamid - saluretikami average potency, promotes the excretion of Na +, Cl-, K + and water; duration - 12 to 24 hours.

Indications

Arterial hypertension.

Contraindications

Hypersensitivity, AV block; CHF (resistant to treatment with cardiac glycosides); bradycardia; cardiogenic shock; liver and / or kidney failure; bronchial asthma; bronhospastichesky syndrome, hypokalemia, hypercalcemia, Addison's disease, pregnancy; lactation.

Dosing

Inside, the initial dose of 1 / 2-1 tablet 1 time per day during breakfast. If after 2-3 weeks, there is no sufficient reduction in blood pressure, the dose should be increased to 2-3 tablets a day. In this case, the multiplicity of purposes - 2 times a day (morning and afternoon).

Side effect

Dizziness, fatigue, indigestion, insomnia, depression, hallucination, thrombocytopenia, leukopenia, allergic reactions.

Interaction

With salt Li + - increase in blood concentration of Li +, Reduction - adrenostimulyatorov and sympathomimetics, tricyclic antidepressants and MAO inhibitors; strengthening effect - with sympatholytic drugs, peripheral vasodilators drugs; strengthening of hypoglycemic effect - with oral hypoglycemic drugs and insulin (pindolol mask symptoms of hypoglycemia).

Special instructions

It should not be administered concurrently with corticosteroids and NSAIDs. When the need for surgery under general anesthesia, the drug should be discontinued for 2 days prior to surgery.