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Instruction for use: Niselat

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Active substance: Amtolmetin guacil


Rheumatoid arthritis; osteoarthritis; ankylosing spondylitis; articular syndrome with exacerbation of gout; bursitis; Tendovaginitis.

Pain syndrome (weak and moderate intensity): arthralgia; myalgia; neuralgia; migraine; toothache and headache; algodismenorea; pain with injuries, burns.

It is intended for symptomatic therapy, reducing pain and inflammation at the time of use, the progression of the disease is not affected.


Hypersensitivity to amtolmethine, tolmetin; complete or incomplete combination of bronchial asthma, recurrent nasal polyposis or paranasal sinuses and intolerance to acetylsalicylic acid and other NSAIDs (including in the anamnesis); erosive and ulcerative changes in the mucous membrane of the stomach and duodenum, active gastrointestinal hemorrhage; cerebrovascular or other bleeding; inflammatory bowel disease (Crohn's disease, ulcerative colitis) in the phase of exacerbation; hemophilia and other bleeding disorders; Decompensated heart failure; hepatic insufficiency or active liver disease; marked renal failure (Cl creatinine <30 ml / min), progressive kidney disease, confirmed hyperkalemia; period after aortocoronary shunting; arterial hypertension; pregnancy; lactation period; children's age till 18 years.

Side effects

The frequency of side effects is classified according to the frequency of occurrence of the event: often - (1-10%); infrequently - (0,1-1%); rarely - (0,01-0,1%); very rarely - (<0.01%), including individual messages.

From the digestive system: often - nausea; infrequently - dyspepsia, discomfort in the stomach and intestines, bloating; rarely - abdominal pain, diarrhea, vomiting, constipation, gastritis; very rarely - a peptic ulcer, a violation of the liver.

From the urinary system: an increase in the content of urea nitrogen in the blood, urinary tract infection.

From the senses: rarely - noise in the ears, visual impairment.

From the respiratory system: rarely - bronchospasm, dyspnea, rhinitis, laryngeal edema.

From the side of the central nervous system: often - dizziness, headache, drowsiness; rarely - depression.

From the CCC: often - lifting blood pressure.

From the hemopoiesis: rarely - anemia, thrombocytopenia, agranulocytosis, leukopenia.

On the part of the skin: infrequent - skin rash (including maculopapular), purpura; rarely - exfoliative dermatitis (fever with chills or without, redness, densification or flaking of the skin, swelling and / or tenderness of the tonsils), hives, Stevens-Johnson syndrome, Lyell's syndrome.

Allergic reactions: rarely anaphylaxis or anaphylactoid reactions (skin discoloration of the face, skin rash, hives, skin itch, tachypnea or dyspnea, edema of the eyelids, periorbital edema, shortness of breath, shortness of breath, chest pain, wheezing).

Other: often - weakness; rarely - swelling (face, legs, ankles, fingers, feet, weight gain); rarely - excessive sweating, fever, lymphadenopathy; very rarely - swelling of the tongue.

Precautionary measures

During treatment, it is necessary to monitor the picture of peripheral blood and the functional state of the liver and kidneys.

Treatment should be discontinued 48 hours before the determination of 17-ketosteroids.

Influence on the ability to drive vehicles and work with machinery. During treatment, one should refrain from engaging in potentially dangerous activities that require increased attention and speed of mental and motor reactions.

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