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Instructions

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Instruction for use: Navoban

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Dosage form: Capsules; Solution for intravenous administration; Injection

Active substance: Tropisetron*

ATX

A04AA03 Tropisetron

Pharmacological groups:

Antiemetic means and preparations

Serotonergic agents

The nosological classification (ICD-10)

R11 Nausea and vomiting: Postoperative vomiting; Nausea; Vomiting; Vomiting in the postoperative period; Vomiting medication; Vomiting in the background of radiation therapy; Vomiting uncontrollable; Vomiting in radiation therapy; Persistent vomiting; Indomitable vomiting; Postoperative nausea; Vomiting with chemotherapy; Vomiting of the central genesis; Vomiting with cytotoxic chemotherapy; Persistent hiccups; Repeated vomiting

Y43.1 Adverse reactions in the therapeutic use of antitumor antimetabolites: Treatment with mercaptopurine

Y43.2 Adverse reactions in the therapeutic use of antineoplastic natural preparations

Y43.3 Adverse reactions in the therapeutic use of other antitumor drugs

Composition and release form

1 ml of solution for injection contains troposisetron hydrochloride 1 mg; In ampoules of 2 and 5 ml.

1 capsule - 5 mg; In the package 5 pcs.

Pharmachologic effect

Mode of action - antiemetic.

Selectively blocks the excitation of presynaptic 5-HT3 receptors of peripheral neurons (takes part in the origin of the emetic reflex) and CNS (mediates the influence of the vagus nerve on the area postrema).

Clinical Pharmacology

The duration of action is 24 hours, which allows you to apply 1 time per day.

Indications for the Navoban

Nausea and vomiting with antitumor therapy (prevention and treatment) and in the postoperative period.

Contraindications

Hypersensitivity, children's age (up to 2 years).

Application in pregnancy and breastfeeding

In pregnancy, it is contraindicated, except in cases where the purpose of an operation is to interrupt an early pregnancy. Lactating women should stop breastfeeding.

Side effects

Abdominal pain, constipation, diarrhea, headache, dizziness, weakness, fainting, circulatory shock, cardiac arrest; Allergic reactions.

Dosing and Administration

To prevent nausea and vomiting caused by antitumor therapy, appoint courses for 6 days. The daily dose for adults is 5 mg. The first day (shortly before the start of chemotherapy) is administered iv, in the next 5 days - inside (1 capsule per day). Children older than 2 years - in a daily dose of 0.2 mg / kg, the maximum daily dose - up to 5 mg; The first day is administered iv, in the next 5 days - inside (the contents of the ampoule are mixed with orange juice or a drink of the cola type). For treatment and prevention of postoperative nausea and vomiting, adults are prescribed a dose of 2 mg IV.

Precautionary measures

Care should be taken with uncontrolled hypertension. Patients driving vehicles or working with potentially dangerous machines and mechanisms should consider that treatment reduces the reaction rate.

Storage conditions of the drug Navoban

At temperatures below 30 ° C (do not freeze).

Keep out of the reach of children.

Shelf life of the drug Navoban

5 years.

Do not use after the expiry date printed on the package.

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