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DR. DOPING

Instructions

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Instruction for use: Megace

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Active substance Megestrol

ATX code G03DB02 Megestrol

Pharmacological groups

Estrogens, gestagens; Their homologues and antagonists

Antineoplastic hormonal agents and hormone antagonists

Composition and form of release

1 tablet contains megestrol acetate 40 or 160 mg; In bottles of 100 pcs., In the box 1 bottle.

pharmachologic effect

The pharmacological action is gestagenic, antitumoral.

Suppresses the production of estradiol and androstenedione by the adrenal glands, has a cytotoxic effect on hormone-sensitive cells of tumors and suppresses the liberalization of a number of factors of their growth. It blocks the formation of cachectin and interleukin-1 or their effect.

Pharmacokinetics

After oral administration, it is rapidly absorbed from the digestive tract. Cmax is achieved in 2-3 hours. T1 / 2 - 2-3 days. It is excreted in urine (57-78%) and with feces (8-30%).

Indications

Disseminated breast cancer, endometrial cancer, anorexia and cachexia in cancer patients and AIDS patients.

Contraindications

The first 4 months of pregnancy.

Side effects

Bloody discharge from the vagina; Very rarely - fluid retention, thrombophlebitis, Itenko-Cushing syndrome (iatrogenic).

Dosing and Administration

Inside, once or in several (2-4) receptions. With disseminated breast cancer - 160 mg per day; With anorexia and cachexia in cancer patients and AIDS patients - 480 mg (and more) per day.

Precautionary measures

Do not use in pregnancy diagnosis. Cautiously appoint at a thrombophlebitis, even in the anamnesis. Megace does not exclude surgical, chemotherapeutic or radiotherapy for cancer.

storage Conditions

At a temperature not exceeding 25 ° C. Avoid storage at temperatures above 40 ° C.

Keep out of the reach of children.

Shelf life

3 years.

Do not use after the expiry date printed on the package.

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