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Instructions

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Instruction for use: Traskolan

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Dosage form: solution for infusion

Active substance: Aprotininum

ATX

B02AB01 Aprotinin

Pharmacological groups

Fibrinolysis inhibitors

Ferment and antiferments

The nosological classification (ICD-10)

K65 Peritonitis: Abdominal infection; Intra-abdominal infections; intra-abdominal infections; Diffuse peritonitis; abdominal Infections; Infections of the abdominal cavity; The infection of the abdominal cavity; The infection of the gastrointestinal tract; Spontaneous bacterial peritonitis

K85 Acute pancreatitis: Acute pancreatitis; Pancreatitis; Pancreatitis haemorrhagic; acute Pancreatitis; Sepsis pancreatogenic; Acute necrotizing pancreatitis; edematous pancreatitis

R57 Shock, not elsewhere classified: Obstructive shock

R58 Bleeding, not elsewhere classified: Abdominal apoplexy; Hemorrhagia; Haemorrhage of the esophagus; Hemorrhage; Generalized bleeding; Diffuse bleeding; Diffuse bleeding; Prolonged bleeding; Blood loss; Blood loss during surgical interventions; Bleeding during surgery and in the postoperative period; Bleeding during labor; Bleeding and haemorrhage in hemophilia B; Bleeding from the gums; Bleeding intraoperative abdominal; Bleeding against a background of coumarin anticoagulants; Hepatic hepatitis; Bleeding in hemophilia A; Bleeding at hemophilia A; Bleeding with inhibitory forms of hemophilia A and B; Bleeding due to leukemia; Bleeding in patients with leukemia; Bleeding; Bleeding due to portal hypertension; Bleeding due to hyperfibrinolysis; Drug bleeding; Local bleeding; Local bleeding due to activation of fibrinolysis; Massive blood loss; Acute blood loss; Parenchymal hemorrhage; Hepatic bleeding; Postoperative hemorrhage; Kidney bleeding; Vascular-platelet hemostasis; Traumatic bleeding; Threatening bleeding; Chronic blood loss

T79.1 Fat embolism (traumatic): Fat embolism; fat embolism

T79.4 Traumatic shock: Haemorrhagic shock; Crash Syndrome; Posthemorrhagic shock; Postoperative shock; Post-traumatic shock; Post-traumatic shock; Traumatic shock; Syndrome of hemorrhagic shock and encephalopathy

T81.1 Shock during or after the procedure, not elsewhere classified: Operating shock; Postoperative shock; Operational shock

Composition and release form

1 ml of solution for injection contains aprotinin 5000 or 10,000 IU; In ampoules of 10 ml, in the package 5 pcs.

Pharmachologic effect

Mode of action - Hemostatic, antiprotease.

It binds proteolytic enzymes (trypsin, chymotrypsin, kallikrein), incl. Activating fibrinolysis (plasmin).

Pharmacodynamics

Inactivates plasma proteinases (plasmin, kininogenase, trypsin, chymotrypsin), blood cells and tissues. Antiprotease activity determines the effectiveness of the use in acute pancreatitis. Inhibiting plasmin, reduces the fibrinolytic activity of the blood, inhibits fibrinolysis and has a hemostatic effect in coagulopathy. Blockade of kallikrein-kinin system allows to use for the prevention and treatment of various forms of shock (endotoxic, traumatic, hemolytic).

Indications of the Traskolan

Acute pancreatitis, peritonitis, hyperfibrinolytic bleeding, hemorrhagic, traumatic and toxic shock, fat embolism, postoperative bleeding, postoperative pancreatitis.

Contraindications

Hypersensitivity.

Side effects

Erythema, urticaria, bronchospasm, nausea, vomiting, myalgia, lability of AD, rarely - hallucinations, confusion, psychosis.

Interaction

Incompatible with corticosteroids, as well as with infusion solutions containing amino acids and fat emulsions.

Dosing and Administration

IV (intravenously) by stream or drop injection. The dose is selected individually, depending on the patient's condition. Acute pancreatitis: 500,000-1000000 KIE without dilution, at a rate of up to 5 ml / min, then - 100,000-500,000 KIE daily, drip. With the improvement of the general condition of the patient, the dose is gradually reduced. Treatment (if necessary) lasts up to 15 days.

Severe conditions: after bolus administration, it is recommended to continue drip treatment at a rate of 100,000 KIU / h for 8-12 h until a clinical improvement is achieved.

Fibrinolytic bleeding: drip, in a dose of 100,000-200,000 KIE, if necessary - up to 500,000 KIE, depending on the intensity of bleeding.

With the preventive purpose in surgery: 200,000-400,000 KIe before the operation, during and after it, then - for 100,000 KIE for the next 2 days.

Precautionary measures

Before use, a skin test should be performed to identify possible hypersensitivity. They are used with caution in patients who received muscle relaxants 2-3 days before.

Storage conditions of the drug Traskolan

At a temperature not higher than 15 C.

Keep out of the reach of children.

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