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Semax: It improves brain function!

20 Dec 2016

Experts predict that in 5-10 years, drugs that improve mood or mental activity, will take the same vitamins as it is now. For such drugs, even came up with the name - "cosmetics for a brain." Their development is now becoming a fashionable trend in the pharmaceutical industry. I do not stay aside and Russia. Our scientists have developed some unique products that help people strengthen intelligence and overcome anxiety and fear. The foundation was laid secret military development of the 80s.

Academician Myasoedov, Semax inventor

For example, the preparation Semax has been clinically tested and, as has long been declassified, sold in pharmacies.
Its mechanism of action is that it causes an increase in bonds between the cells of the brain. And it is known to update the main principle of the nervous system: the number of nerve cells can not grow, however, some cells may assume the functions of others, thus compensating for the loss of neural tissue. And they do this by increasing the number of connections with other nerve cells.
- Students shaft felled for "Semax" before the exam, - he says the developer, Academician Myasoedov - then came and boasted of fives.


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Cigarettes: The Real Facts

20 Dec 2016

This review is about such a popular and legal drug as cigarettes. The issue promises to be the most objective, however, this is a huge topic, and perhaps many of the points will be missed.

smoking

And what in cigarettes?

There were some interesting characters, traditions are well illustrated in the chic movie "Dances with Wolves" - the Indians. That never disdain smoke that whatsoever, including tobacco. Tobacco was safely brought to Europe from the United States.

From that moment, in fact, the world has learned that such tobacco. Production and overproduction, export / import, the desire to save, globalization has played a role played until now. Do not think that only tobacco, but all smokers ala Indians smoke cigarettes in nature. Now manufacturers of cigarettes, like any normal person, interested in the difference between revenues and expenditures. How to reduce the cost production? You need to add these substances to keep our cigarettes smoke faster, easier to transport, etc. Please pay attention to Cerluten.

Thus, the cigarettes contained: Ammonia, arsenic, carbon monoxide, cyanide, and other substances. A total of 51 of the 4000 substance are carcinogenic, and we recall that a carcinogen called that causes cancer. Well smoke cyanide and not very nice, and at the level of the body, too. The girls, by the way, is much more harmful than smoking if she plans to give birth. The cigarettes may damage the egg from which child will develop, which eventually will cause anomalies 100%.

Cons of cigarettes:

The longer a person smokes, the closer to the 50% probability of approaching death from cigarettes. A huge study, begun in 1951 and completed only in 1991! Deferred suicide. Yes, you can philosophically say that once a person was born, life itself has become a long-term suicide, but there are things that slow down the process, and have that speed. Sleep in a dream)

Passive smoking also hurts! There is a statistical relationship, that those who are exposed to secondhand smoke more likely to die from cancer due to circulatory diseases compared to those who did not breathe smoke-filled air. Passive smokers also are more frequent miscarriages.

Another very interesting study, for a period of 10 years, showed a marked improvement in the fight against cardiovascular disease. The bottom line: in 1993, experimentally, in Toronto, in Canada began to gradually ban smoking in public places and absolutely banned in 1996. In parallel, in Ontario, Canada is the same, everything was allowed. In 2006, we compared the statistics of calls to the hospital because of problems with the cardiovascular system, and in Toronto, it was below 35%. It is clear that this is not the environment suddenly improved.

Addiction. So simple and not get down! Tobacco is highly addictive in 32% of cases. And talk about that, "I can quit at any time" came to nothing lead, at least 1/3 of the time, you can try) For this indicator, even alcohol and marihuana is safer.

The dependence is due to nicotine and its action on the brain. People sometimes confuse nicotine and nicotinic acid. In general, the nicotine - is the main component of cigarettes stimulating, concurrently, that is addictive. Niacin - a useful Vitamin which the body is formed from tryptophan, an amino acid present in the food. Because tryptophan is created also serotonin and melatonin, an important neurotransmitter good mood and biorhythms regulators.

Cigarettes make a person less happy in the long run through the destruction of serotonin receptors in the brain. Serotonin - is the well-known neurotransmitter, its relatively high level of influence a pleasant chat with the people, the sun, physical and intellectual activity. The cigarettes do not reduce the production of this neurotransmitter, but destroy the protein structure interacts with the mediator. This is not good, as you can imagine. It's like talking to a serious topic with regularly drink too much man.

Pros of Cigarettes:

+ Effect on dopamine. Here dopamine that during smoking begins to be produced in the brain in a larger scale. At issue was removed dopamine. Briefly: it is responsible for the care, joy, motivation, determination, but also for schizophrenia) Cigarettes, through nicotine makes a person for smoking during and after a bit more sensitive and satisfied.

+ Cigarettes temporarily make a man a little smarter, but not smarter than other people, and themselves wiser than the former. How? Nicotinic acetylcholine receptors. Acetylcholine we help in training than his more - the better and easier to learn, the excess can kill. There are 2 types of acetylcholine receptors: nicotinic and muscarinic. Nicotine is an agonist, obviously, for the nicotine, showing the effects of acetylcholine. Genius will not become, but just think better on 15 minutes - perhaps.

From the first 2 plus the possibility and advantages such as: temporary improvement in mood, antidepressant state, relieve fatigue, etc.

Bottom line:

Cigarettes are not worth it. Cons much more than the pros, even if you do not go into details. However, it is still popular to this day in the movies cool as brutal actors smoking cigarettes and all win. Unfortunately, behind the scenes it is their way of life before the shooting.


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How I struggled with chronic fatigue syndrome

20 Dec 2016

From tips to give birth to the creation of new neural connections in the brain - how to cope with the disease, from which only 5% of cured patients

Depressiom, Meldonium, Mildronate, Semax, Afobazol

The name "chronic fatigue syndrome" is often misleading. CFS - the story is not about people who get tired quickly and often, though how it all begins. It is a state of complete exhaustion, when any movement is a man of enormous efforts. The disease can develop in different ways: some are experiencing severe headaches, others suffer because of cognitive difficulties and brain haziness, the third appears intolerant of certain colors and sounds.
Chronic fatigue syndrome have no risk. Among patients found both older people and children. However, it is believed that most CFS ill residents of large cities. Despite the fact that in Western countries recognized the disease as early as the middle of last century, Russia still does not believe in its existence. Meanwhile, the number of cases increases, and manages to recover only 5%. These results are explained by the fact that the disease is still poorly understood and generally accepted cure for it is not.

About how it all began

Some years I spent abroad: studied and worked first in Paris, then in New York and London. And two years ago, I have returned home and began to work in a think tank that advises the government. Frequent flights, stress, mental and physical stress led to the fact that in September 2015, after returning from Ibiza, I caught a cold and fell ill for two weeks with atypical for themselves weakness.

Syndrome of chronic fatigue

By the end of the month I was able to recover from a cold, but in October I began to notice that with me there is something strange. Forces of dwindled, and even in the morning I woke up tired. His eyes ached. At first, as any resident of the metropolis, I did not attach any importance to this and continued to try to live in a normal rhythm for himself. But day after day fatigue is becoming stronger. However, it was not like that which a person experiences after a long day. Rather, it seemed that I was put in the armor.

Other symptoms also becomes brighter: eye pain intensified, cognitive dysfunction appeared - sometimes I just can not understand what is written in the working papers. It seemed to me that it is necessary to relax and let it be.

On my complaints anybody especially did not react - friends and colleagues advised to drink only vitamins. But time passed and nothing helped me. At some point, a friend said that waking up tired, as though the night dragged stones on Kilimanjaro - is not that great, and I decided to go to the doctor.

About trying to diagnose

I always felt as if sick, so I decided that I have problems with immunity, and in the first place went to the immunologist. I made a few tests for immune status, and based on their results the doctor of a private clinic diagnosed me - "secondary immunodeficiency."
As treatment, she appointed me medicines, which, as I later learned, abroad have long recognized ineffective. But then I have not penetrated as it should to this topic and trusted doctor, and therefore cutting the full course.

From prescription medication does not become easier. In the New Year I went to Perm, where my parents live. There I got worse: all the holidays I just lay there, as could not sleep or walk. My mother asked why I was so tired, and I believed that if I shall sleep, everything goes. In desperation, I went to an appointment with a local neurologist. The doctor said I was perfectly healthy. And then he asked me if I had a man, and advised as soon as possible to give birth.

Back in Moscow, I went to the Federal Institute for Immunology. There I was again sent for tests and found the sixth type of herpes virus. By the way, it is a great many - either in the active form, or as passive. And its effect on fatigue is not fully studied. But then I had hoped to cure for herpes, and finally to death. I was prescribed Meldonium buy and antiviral drugs, from which it was neither hot nor cold. I remember, for all the work of a colleague laughed that Sharapova this medication helped, but I do not.

On the advice of the chief, I went to another immunologist at the same center. Female doctor appointed the new drugs, but the disease has progressed only. One day I woke up and swam around me and circled. This went on for a week or two longer remember the bad. In addition, I have always something to hurt: the head, the body, the eyes (they all wanted to get it and put it on the shelf). Get up out of bed in the morning was worth the hardest efforts. In the evening, I did not even stand the forces, so I washed, sitting on the basin. I began to torment insomnia: I either just could not get to sleep, or waking up constantly.

Another female immunologist suggested that I contracted parasites of irregular migrants in Ibiza, and gave common medical advice - to give birth. Then there was a neurologist, who advised me to move abroad. There was a paramedic who thought I was undermined health, swallowing psychotropic substances in Ibiza. There was a quack doctor of a private clinic, which is simply feeling the patient and make the diagnosis. I, for example, he said, that all my problems - because of the "non-reduced sleep stage", and suggested that antidepressants are abroad as a prohibited narcotic. I drink them, of course, I did not. I also tried to go to the optometrist complaining of pain in his eyes. They advised various drops, which, however, turned out to be useless.

About depression

Doctors were so many that I have all, and I do not remember. My ordeal lasted almost a year. During this time I have tried all kinds of medicines (from tablets against parasites to anti-virus anti-herpes infections) and collected the whole set of diseases that do not exist in the International Classification of Diseases: from vascular dystonia simply to fatigue. I also tried to go to psychotherapists to prevent masked depression.

In fact, I would have learned with pleasure that I have depression. So at least there was a treat. I had a couple of depressive episodes. But they passed quickly and soon became not cause but the consequence of my illness. After all, I actually lost my life with numerous travel, parties, surfing, lost many friends and relatives. In addition, it weighed on me that I could not plan anything and everything is constantly missed.

First the therapist after a couple of sessions has refused to work with me.
According to him, I was mentally normal any physically healthy person. The second therapist tried very hard to help me, but was unable to. So I just came to her to complain about the way I feel bad, and how awful to lose because of this that so love. Another thought that I grew up in a dysfunctional family, and so fascinated by the charity as a means of escape from the real problems. I have a wonderful family, and how this nonsense could be attributed to my well-being, still do not understand.

Sometimes I returned to immunologists and said that I did not help to prescription drugs. And they said something unintelligible or hinted that I had problems with the head, referring to the depression. When I say that psychotherapists refuse to work with me because of the fact that a mentally unhealthy person I have too much, and genuinely laugh, conversation ended.

About trying to activity

In the beginning, I thought that perhaps the reason for my fatigue became a bad physical shape. So I start walking on fitness twice a week. I only lasted for a month, because after class forces no choice at all. Then the doctor told me to do exercises in the morning. Once I tried and barely reached the subway, where the crying - it was so bad. After that I gave up sports until one of immunologists not imagine that I suffer because of problems with the vascular system. Then I went to the swimming pool - there are sessions given me incredibly hard. But I did not know what was happening to me, and was ready to try by all means, just to get back to normal.

Despite his illness, I continued to go to work. I was incredibly lucky with the director and colleagues who not only reacted to the situation with understanding and reduced my workload, but also helped in the search for doctors. Of course, when I was the weakest link in the team, but my partner always tried to help cheer. I am sure that, if not for my colleagues, I would have gone mad. Sometimes I thought of resignation, but just lie at home - not an option for me.

Previously, I led a very active life, which was not ready to give up. So the first time attended a Spanish course. Sometimes I went to recreational activities near your home or work. occupied homes were few, since due to the helplessness and pain in the eyes, I could only lie there and talk on the phone. Shout was especially not with someone, and to do something like, so after my work has become part of the entertainment ironing. Fortunately I have a lot of skirts.

On the relation of society

In our society we do not talk about diseases. If you do something wrong, there is a risk becoming an outcast. I do not know how to explain this phenomenon, but many face with him. Ill, I decided to go the other way and start to sound right and left that I need help. Because it was I really needed. But in response to receiving any comments on Dmitry Medvedev's style - "Well, you hold on! Health to you! "- Or empty promises. For example, I wrote: "Oh, Pauline, because you feel sorry! How did it happened? Be sure'll come on Saturday. " But neither on Saturday nor then about this man I did not hear.

It is not just about the little-known, but also close friends. It would be more understandable if they have ceased to communicate with me because of the constant whining. But I was not discouraged and did not complain. From friends I wanted to communicate and minimal assistance. Since I badly hurt my eyes, I asked for help in finding doctors and information about possible diseases of the Internet. Many agreed, but then, referring to employment and work, disappeared from my life. This happened quite often, and I'm still hard to live with it.

But there were also heroes who have supported me, looking for doctors around the world, introduced with the right people, passing my analyzes and the conclusion that I could make an atlas of illness and recovery. With some of them to the disease, I almost did not communicate. Most of all living abroad.

Yet, oddly enough, helped Tinder. In the days when my eyes hurt not so much, this application was a major time killer. During the year I talked with so many people - although with none of them, of course, are not met. About his health, I told only once for the sake of the experiment, more than the man I did not write. Actually, I think that Tinder came up for girls sick: and time you can spend, and feel normal.

About acquainted with other patients

In the summer I went to the reception to the immunologist one of the most popular private clinics.
By the time I had on hand was already a huge pack with the results of the various tests. Was late more than an hour, the doctor glanced at my papers and said that they are worthless, but because better to hand it all over again in the laboratory, which it trusts. At that moment I thought, "Fuck you all to hell with their analyzes and useless drugs!" Almost a year, I went through all the circles of hell the Russian state and private medicine, spent about half a million, but beyond knowing that this match is not only difficult, but also wildly expensive, I got nothing. So I decided myself to understand what's going on with me.

At the beginning of the disease, I tried to find an answer to the question, what it is with me, on the Internet. The most common result of the search for my symptoms had a disease called "chronic fatigue syndrome". In this disease there is no risk, and it is still poorly understood. While in the west have long recognized a serious problem in our CFS nobody believes. Accordingly, there are no doctors who could help. On the Internet, in addition to the advice to wear more red (he gives the power), I found many forums of patients with this very weariness.

Forums - depressing place, because basically sitting there are those who do not help. According to research, only 5% of patients with CFS can be cured. Many people spend their entire lives confined to bed, and someone even dares to commit suicide. I confess that sometimes I do think about it, but only as a last resort method - in case of disease transmission will be very difficult. The fact that patients with fatigue to live in complete uncertainty: no one knows how to treat you, and it is unclear how long your suffering. This means that you can not plan for the future, to start a relationship, change jobs. Awareness of this is killing.

As to the disease I for some time lived abroad and traveled a lot, I had a lot of contacts. Friends and acquaintances have helped me to contact the CFS patients from around the world. Those often painted the horrors awaiting me in the future: "What, you do not have problems with digestion? Wait, will start soon, "" Do not know what brain fog? Soon you learn. " Some eventually developed intolerance to certain sounds and colors. Others have raised the temperature, and they simply could not get out of bed. Recognizing it was hellish burden on the psyche.

On the search for a way

Realizing that if I do not take the disease into their own hands, no I will not save, I read almost everything that could be found on the Internet about chronic fatigue syndrome, and treatment plan.

The forums periodically information appeared that from the disease helps to something called the Lightning Process and The Gupta Programme. At first I thought it was for those who believe in esoteric and stuff. But realizing that traditional medicine can not help me, she decided to read about these programs. They were based on a study of neuroplasticity connections in the brain, and argued that the CFS and a number of other diseases occur due to malfunction of the brain, and if you get it back to normal, then everything goes.

Independent reviews have been difficult to find, but they all talked about the amazing healing. For example, one woman wrote that 22 years lain in bed, and after passing through the three-day training ran the London Marathon. Of course, I was skeptical, but after the panic attacks and depression, when it seemed that my soul sucked Dementors, I decided to trust non-traditional methods and enrolled in a Lightning Process training in London. It was my plan A.

Then I signed up to the doctor of the Institute in San Francisco, but the reception he had to wait for about six months. Like most American doctors, he explained the occurrence of CFS by the presence of viruses or parasites in the body and offered medical treatment. If it did not work, I would start to take the medicine called LDN (Low-dose naltrexone). In the US, it prescribed to patients with alcoholism, but one of my friend with CFS small doses of the drug helped to cope with the disease. But I did not want to start with LDN, because she was afraid to stuff themselves incomprehensible pills. I still had something to lose.

About training

I was interviewed and got to the training Lightning Process. The program not only helps with CFS, and in anxiety disorder, chronic pain, depression and other autoimmune diseases. Therefore, apart from me, in the group were people with various problems: woman with CFS from South Africa, 12-year-old boy with CFS in the UK, two women from New Zealand (in one has depression, and the second it supported) and the Briton, who lived Cyprus, with an anxiety disorder.

In the classroom we talked about the neuroplasticity of the brain and gave the instrument - about this can be described as a system of exercises - with which supposedly can convert it to a job. In fact, it is a mechanism to run again and create new neural connections. For three days my condition has not changed, while the girl, who for five years was afraid to leave the house due to an anxiety disorder, on the second day of the training, one went to the bar.

I returned to Moscow distressed, but, gathering the remnants of willpower in a fist, continued to apply the technique Lightning Process. I explained that often the higher the human intellect, the more difficult it lends itself to retrain the brain. Five days after my first return for a long time suddenly I felt relieved - it has given me an insight into what the instrument is. By the end of next week, I was able to recover up to 70%.

The first days I just could not believe his good fortune, and constantly crying. In the subway, on the bus, at work. The idea that this nightmare is finally over, did not fit in my head. However, I still sometimes cry with happiness.


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Swimmer Efimova require compensation for meldonium scandal

20 Dec 2016

World champion and Olympic medalist, celebrated swimmer Yuliya Efimova is going to require compensation for non-pecuniary damage.

Agent of Yuliya Efimova said that the swimmer will file a lawsuit to get compensation for non-pecuniary damage, resulting in stories with Meldonium buy.

According Efimova agent, no organization has apologized athlete.

- The claim in the court to help make foreign lawyers - said agent Efimova

Recall that because of the scandal with Meldonium Yuliya Efimova was barred from participating in the Olympic Games in Rio, allegedly due to the use of Meldonium for sale. But, later it was made. Despite all the discontent on the part of the press and other participants, Yuliya Efimova won two silver medals.


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FEI has updated the list of banned drugs

20 Dec 2016

The Fédération Equestre Internationale (FEI) approved amendments to the lists of prohibited substances and preparations for limited use. The updated document will come into force on January 1, 2017. The first list have been excluded substances such as adrenaline, brinzolamide, Calcium dobesilat, dobutamine, loperamide, midazolam, naloxone, phenylephrine, tiletamine and zolazepam. All of them will go into the category of limited therapeutic use of substances.

List of "doping" supplemented AICAR, GW1516, andarin, cobalt (substance increases the number of red blood cells and thus increases the hemoglobin), meldonium, osterin and thymosin.


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Abramova disqualified for one year for the use of Meldonium

20 Dec 2016

Ukrainian biathlete Olga Abramova disqualified for one year for the use of Meldonium for sale.

The concentration of the prohibited substance Meldonium buy in a sample of athletes of 10 January 2016, 7.3 times higher than the permissible value.

Abramova disqualification period will be counted from November 14, 2016, however, given its suspension last season, the athlete will be allowed to act as early as February 4, 2017.

All results Abramova from January 10 to February 3, 2016 will be canceled. Also, an athlete will pay a fine of 2,000 euros.


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The ninth game of the match for the world chess crown ended in a draw

20 Dec 2016

The game lasted five and a half hours. Sergey Karjakin and Magnus Carlsen agreed to a draw on move 74. As a result, after the ninth installment of a Russian leader with a score of 5: 4.

He defeated the Norwegian in the previous match, playing with black pieces. Both players admitted that last game was very tense.

After the game players have undergone the procedure of doping control, including on the infamous Meldonium buy. Pretenders to the crown will play the next game tonight: Karjakin with black pieces. Team Magnus Carlsen has filed an appeal against the penalty for non-participation in the last press conference. Recall, after the defeat in the eighth installment of the Norwegian lost his temper and did not communicate with journalists, for which he was punished - deprived of 10% of the prize money.


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In doping sample of Famous Russian Motor Racer was Found Meldonium for Sale

20 Dec 2016

The doping sample moto-racer Russian Anastasia Nifontova was found banned drug Meldonium. As reported on the official website of the Fédération Internationale de Motocyclisme (FIM), the athlete is suspended from participation in the competition.

The decision was made after receiving a report from an accredited World Anti-Doping Agency (WADA) lab in Cologne. According to official data, illegal drug has been identified on the basis of the analysis of the Russian athletes urine, taken October 3, 2016 in the rally-raid in Morocco at the World Cup.

For Russian woman left to right to be present at the opening of the sample "B". If it is positive, it will decide on the disqualification of the athlete. Anastasia Nifontova a silver medalist FIM World Championship for Cross Country Rally in the women's standings.


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Modafinil: Supremacy of Reason

20 Dec 2016

It’s time to see a very unusual drug that can safely make a list of the most vigorous cognitive activators that exist in the still young world of nootropics. In some countries it is on the list of banned substances to spread, in other not what sells "prescription", but is on a par with conventional biological supplements, such as Gingko biloba or green tea extract.

amphetamine, modafinil

It's about Modafinil(Adrafinil)! It can be said, the most popular smart-drag among students and scholars in the West, Western Phenotropil.

Today will be another interesting study, thus, an important amendment, the power is not safe, as it would not be in any. In Russia it is forbidden, we will not say how and how much to drink, and google will find all. In Western countries, it is used in military and medical purposes, by appointment (combating sleepiness).

Modafinil, Adrafinil buy

How does Modafinil act

Most of all modafinil is sold in tablet form. So a desperate subject, in the hope of achieving their selfish ends lowland consumes 300 mg of material, which is then inflated with a book and a film series about a pill for the brain. In the stomach / intestine is a magical substance is absorbed into the blood stream. Blood from this desperate subject circulates through the body. Modafinil passes brain protection and, once it begins its dark action which lasts about 12 hours. There are several isomers of modafinil, and the duration of changes

modafinil amphetamine

The action itself is not fully understood. And some of the effects of this drug remains unclear. Like the butterfly effect, for Research, we see the action here and here, but why more and then something works.

neurotransmitters, modafinil, adderall

What is well known by almost 100%:

  • 1.Partially blocked the reuptake of dopamine, norepinephrine, and glutamate, increasing their production. Who does not know these substances, we read the corresponding article. Action-style drugs such as cocaine / amphetamine. In the short term, the combination of production and blocking the reuptake of catecholamines suggests a furious drive, stimulation, Tunnel vision, when you easily focus on any one thing, even when everything is moving / jumping / flashes. Simply put, such a person is difficult to draw, it is collected and concentrated. However, because you can become paranoid and concentrate, at least believe in Pokemon.
  • 2.It increases the level of histamine. No sleep. Perhaps few people know that the majority of drug allergies, rashes - antihistamines. Histamine develops, strengthens the body's response to a stimulus, he seems to be saying: "You are nothing is eaten or sniffed - here's a rash on the hands and a couple of spots on the back. Your great-grandfather of this garbage almost died, this information has been encoded in a particular gene, so that you - fool not to repeat the mistakes. Nothing personal!". Antihistamines, as the name implies, suppress it. And Modafinil, on the contrary, increases its production, making the body more sensitive and irritable. But elevated levels of histamine completely destroys all sleepy. Because it is believed that modafinil primarily for narcoleptics who constantly want to sleep.
  • 3.Increase IQ. This is one of those effects that are underexplored. IQ associated with acetylcholine, acetylcholine modafinil but no effect or no effect. Perhaps there is a substance that changes under the current drug, causing an indirect improvement of the functioning of the brain and its cognitive functions. It is difficult to say what it might come back to haunt in 30-40 years. Particularly strong increases in IQ of people with a low coefficient of brain development.
  • 4.Improve short-term memory. At this point, most likely, the truth lies in the influence of the dopaminergic system. After all, the dopamine and its receptors are responsible for the so-called "focus", concentration, attentiveness.
  • 5.Inhibition of GABA secretion. This feature is designed to completely kill all the tranquility, serenity and peace

Harm of modafinil, its danger

  • Side effects of Modafinil. Do you remember the old axiom: "The stronger the effects - the more side effects". In modafinil side effects show themselves relatively more often than most other nootropics, however, he is stronger on the action of the majority. The most common side effect - headache, approximately 34% of all the side effects of modafinil.
  • Depletion of the body. Regular sleep deprivation and relief modafinil can not only lead to an imbalance of the body, but also to a variety of depression and psychosis. We know that everything is relative, and so, research was carried out, I would have called it "the addict's dream." The essence of the 3 groups of people, the 1st received placebo, group 2 - modafinil in a dosage of 300 mg 3-I - amphetamine (d-isomer) at a dosage of 20 mg.
  • Under our present substance with amphetamine and noticeably improved short-term memory, logical thinking and reaction as compared to placebo. Frequency of side effects same was the highest among amphetamine (so it does not smell that stuff), much more often than that of modafinil. But modafinil tolerated more painful than placebo. And an important note! All the components for this study were created in normal laboratories, normal pharmacology.

Bottom line:

  • Modafinil - a controversial drug. Strong nootropics with frequent side effects.
  • The basis of its action, its effects - an increase in dopamine, norepinephrine, histamine + strange effects are understudied.The most frequent side effects headache and decreased resistance to allergies. It is much safer narcotic stimulant, but is not "glycine".

In matters of nootropics difficult to be "not romantic", I want to try everything, but maybe sometimes you should choose "blue" pill and quietly move on. If the "red", the responsibility for yourself at your own!


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Ephedrine

20 Dec 2016

Ephedrine - is a once-popular stimulant and fat burner. The basis of its application in the past - it is a sport and medicine. Ephedrine can help in intellectual activity expense of increased tone and composure. In sports, this additive has proved almost as the most powerful in terms of stimulation and fat burning in medicine - to treat a number of diseases, such as asthma or sleepiness.

ephedrine, methamphetamine, 1

However, some have started to do addicts of ephedrine, amphetamine, as a result, its sales had to restrict, and in some countries and ban completely. In Russia, by the way, it is in the first list of prohibited substances.

However, some people manage his purchased in pharmacies in conjunction with other substances, for example, "Bronholitin". Well we deal with ephedrine ...

This material comes to us from Chinese medicine, from herbs Ephedra, they used it for millennia and as a stimulant for the treatment of asthma. Mass production started in China in 1926 and in just 2 years the export volume has increased as much as 54 times. Supplement become popular abroad.

ephedrine, methamphetamine, broncholitine

Adrenoreceptor agonist is ephedrine, which means that it reacts with them, increasing their activity. And therefore, it stimulates the production of adrenaline and noradrenaline. To a large extent produced by norepinephrine. And we still focus on specific measurable data, and how does ephedrine with the brain and body. You can also like Ovagen.

ephedrine, methamphetamine

How does ephedrine act

  • 1.Quickens the heartbeat. Noradrenaline stimulation, there is no precise data on how many and at what dosage increases the heart rate, but this effect is present.
  • 2.It reduces weight. On this subject was carried out a great many studies, but most used the classic bodybuilding fat-burning bundle, in which not only ephedrine and caffeine. And they work synergistically. Nevertheless, there are some studies which used only ephedrine, and weight loss also attended. And the results are really very cool, if you observe even a diet.
  • 3.This fat burning effect. There was a slight increase in temperature and improves circulation in the adipose tissue. This generally is not dangerous, because our organism is struggling with the virus in vivo.
  • 4.Presumably, the increased levels of dopamine. Here the action is a veiled way, not because we are used to that, "ephedrine through the BBB into the brain and doing their dirty little business", and after a certain receptor in the GABA system, GABA-B. Its activity is reduced, and it is already beginning to swing action of dopamine. Dopamine is responsible for the attraction, concentration, very important things in learning. By the way, there is an assumption that the effect of intoxication - activation of the receptor GABA-B. We extend this logic and get a result that may ephedrine makes people even more sober than in the normal state.
  • 5.It accelerates metabolism through the action of T3, T4. The toilet will go, but slightly reduces the noradrenaline peristalsis, in short, only "in the small" is often wanting. This effect is valuable in sports, ie per unit of time, such as the day, the body will be able to quickly process the proteins, fats, carbohydrates
  • 6.As an agonist of beta-adrenergic receptors, ephedrine shifts the nitrogen balance in a positive way. This leads eventually to anabolism or at least a decreased catabolism of skeletal muscle.

The danger (harm) of ephedrine

Thus, all ephedrine danger lies in its effects, this substance is not directly destroys the organism, as do dangerous drugs. Ephedrine is harmful to people with unstable mentality, nervous, short-tempered. With regard to the physical condition of the person, it is possible to draw parallels with the DMAC. And here and there, there noradrenaline stimulation, vasoconstriction, high blood pressure, heart beat more often.

ephedrine

If the above described factors, and so you are present, you receive ephedrine can actually harm the body. It's like to pump greatly inflated tire.

There may be individual features: dizziness, euphoria, nausea, pimples, etc.

It is also important to mention that ephedrine is dangerous to take a monoamine oxidase inhibitor (MAOI), antidepressants, yohimbine, as it may cause hyperstimulation may sausage so that sleep is not an option. This is due to the production of noradrenaline and dopamine, they by MAO inhibitor run too long, though they should timely exit from the circulation.

epinephrine, Norepinephrine, Phenylephrine, Methoxamine

Also there is a danger with ephedrine - legal ephedrine, as it were in the same list with marijuana and amphetamine. And the project once again remind that in Russia every 5th sitting of banned substances. For this reason, today we will not talk about the courses and dosages. But! Previously, it took approximately 0.8-1.2 mg per kg of body weight per day in combination with caffeine 200-300 mg / day optional courses or small (1-2 months).

And a little bit of dependence, it is possible to say no. A study was conducted where a group of people taking 60 mg ephedrine every day for attention! 6 months in a row, and then abruptly discontinued, so, serious signs of withdrawal were recorded.

Bottom line:

  • Ephedrine is really dangerous, but rather as a powerful stimulant and fat burner that can deplete the body, increase nervousness, sleeplessness, and so contribute In addition, he began to wear the stigma of the drug in 2013.
  • Ephedrine acts through norepinephrine and thyroid hormones.
  • Effects on the brain: all around very slowly, thoughts fly, has poor concentration, easy, small excitement.
  • It took either alone or with other stimulants.


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