Instructions / Instruction for use: TropisetronI want this, give me price
The Latin name of the substance Tropisetron
Tropisetronum (genus. Tropisetroni)
Antiemetic means and preparations
The nosological classification (ICD-10)
R11 Nausea and vomiting: Postoperative vomiting; Nausea; Vomiting; Vomiting in the postoperative period; Vomiting medication; Vomiting in the background of radiation therapy; Vomiting uncontrollable; Vomiting in radiation therapy; Persistent vomiting; Indomitable vomiting; Postoperative nausea; Vomiting with chemotherapy; Vomiting of the central genesis; Vomiting with cytotoxic chemotherapy; Persistent hiccups; Repeated vomiting
Y84.2 Abnormal reaction or late complication of the patient without mentioning accidental harm to him during the performance of the radiological procedure and radiation therapy: Radiation therapy of tumors
Z51.0 Radiotherapy course: Supplement to external radiation therapy; Local X-Ray Irradiation; Radiation therapy; Brain edema associated with radiation therapy; Lesion in radiation therapy; Radiotherapy
Z51.1 Chemotherapy for neoplasm: Cystitis hemorrhagic, caused by cytostatics; Urotoxicity of cytostatics
Z98.8 Other specified post-surgical conditions: Purulent complications in the postoperative period; Suppurative complications of surgery; Postoperative liver dysfunction; Postoperative vomiting; Postoperative complications; Postoperative period; Early postoperative period
Pharmacological action - Antiemetic.
Selectively blocks the presynaptic 5-HT3 receptors of peripheral neurons and the central nervous system, thereby inhibiting the gag reflex.
Fast (on average for 20 minutes) and almost completely (more than 95%) is absorbed from the digestive tract. After ingestion, Cmax is reached within 3 hours. Absolute bioavailability is dose dependent. Binding to plasma proteins - 71%. Undergoes biotransformation in the liver by hydroxylation followed by conjugation (glucuronides), while the metabolites formed are inactive. It is excreted slowly from the body. The duration of action is about 24 hours.
Application of substance Tropisetron
Nausea and vomiting during antitumor therapy (prophylaxis) and in the postoperative period (prevention and treatment).
Hypersensitivity, pregnancy, breast-feeding, children's age (up to 2 years).
Restrictions on the use
Side effects of the substance Tropisetron
Abdominal pain, constipation, diarrhea, headache, dizziness, weakness, allergic reactions; Extremely rare - fainting, collapse, cardiac arrest.
Inducers of microsomal liver enzymes (phenobarbital, rifampicin) reduce the concentration in the blood.
Symptoms: increased blood pressure, visual hallucinations.
Routes of administration
Precautions for the substance Tropisetron
Care should be taken when prescribing against uncontrolled hypertension and to consider the possibility of reducing the reaction rate.