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Instruction for use: Sinemet SR

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Dosage form: Controlled release tablets

Active substance: Levodopa + Carbidopa*


N04BA02 Levodopa and a decarboxylase inhibitor

Pharmacological groups:

Dopaminomimetics in combination

Antiparkinsonics in combination

The nosological classification (ICD-10)

G20 Parkinson's disease: A trembling paralysis; Idiopathic Parkinsonism; Parkinson's disease; Symptomatic Parkinsonism

G21 Secondary Parkinsonism: Medicinal Parkinsonism; Parkinsonism; Parkinsonism symptomatic; Disorders of extrapyramidal system; Parkinson's Syndrome

Composition and release form

1 tablet Sinemet contains carbidopa 25 mg and levodopa 250 mg; In a blister 10 pcs., In a box of 10 blisters.

1 tablet Sinemet SR - carbidopa 50 mg and levodopa 200 mg; In a blister 10 pcs., In a box of 10 blisters.

Pharmachologic effect

Mode of action - antiparkinsonian, dopaminergic.

Inhibits decarboxylase.

Indications of the drug Sinemet SR

Disease and Parkinson's syndrome: rigidity, bradykinesia, tremor, dysphagia, sialoreya, postural body sway.


Hypersensitivity undiagnosed skin disease, a history of melanoma, angle-closure glaucoma, pregnancy, lactation, age (18 years).

Side effects

Dyskinesia (blepharospasm, muscle twitching, choreiform, dystonic, and others. Involuntary movements), transient psychosis, depression, dementia, dizziness, drowsiness, lack of appetite, nausea, vomiting, bleeding from the gastrointestinal tract, development of duodenal ulcer, palpitations, orthostatic hypotension, pain Behind the sternum, shortness of breath, anemia, thrombocytopenia, agranulocytosis, paresthesia.


Incompatible with MAO inhibitors. Combination with antihypertensive drugs can potentiate orthostatic hypotension. Phenothiazines, butyrophenones can reduce the therapeutic effect, phenytoin and papaverine - level it. With a high-protein diet, absorption of levodopa may be impaired.

Dosing and Administration

Inside. Individual dose selection is recommended. The initial dose is 1/2 table. 1-2 times a day; If necessary add to 1/2 table. Every day or every other day (until the optimal effect is obtained); The maximum daily dose is 8 tablets.

Precautionary measures

Carefully prescribed to patients with serious diseases of the cardiovascular system, lungs (including asthma), kidney, liver and endocrine system, peptic ulcer history, convulsions, chronic open-angle glaucoma. It is recommended to periodically monitor the functions of the liver, hematopoietic and cardiovascular systems, kidneys. Cancel should be gradual.

Storage conditions of the drug Sinemet SR

In a dry, the dark place at a temperature of 2-30 ° C.

Keep out of the reach of children.

Shelf life of the drug Sinemet SR

3 years.

Do not use after the expiry date printed on the package.

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