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Instruction for use: Relium

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Dosage form: Solution for intravenous and intramuscular administration; Injection; Coated tablets

Active substance: Diazepam*

ATX

N05BA01 Diazepam

Pharmacological groups:

Anxiolytics

Antiepileptic drugs

The nosological classification (ICD-10)

A35 Other forms of tetanus: Tetanus local; Tetanus; Muscle spasms in tetanus; Clostridiosis wound; Tetanus; Hydrophobia (hydrophobia)

F10.2 Syndrome of alcohol dependence: Alcoholism; Alcohol addiction; posiomania; Dependence on alcohol; dipsomania; drunken state; alcohol abuse; Ideatornoy violations in alcoholism; Quarterly booze; Obsessive craving for alcohol; Neurotic symptoms of alcoholism; Craving for alcohol; Psychoorganic syndrome in chronic alcoholism; Reduced craving for alcohol; chronic alcoholism

F10.4 Abstinent state with delirium: Alcoholic delirium; White fever alcoholic; Delirium; Delirious condition with alcoholism and drug addiction

F10.5 Alcoholic alcohol: Alcoholic hallucinations; Psycho-organic syndrome in chronic alcoholism; Alcoholic psychosis; White fever alcoholic; Delirium; Delirium with alcoholism; Acute alcoholic psychosis; Delirious condition with alcoholism and drug addiction; Acute alcoholic psychosis with autonomic disorders

F41 Other anxiety disorders: Anxiety status; Anxiety; Chronic alarm; Sense of anxiety; Anxious-hypothetical states; Stopping an alarm; Nonpsychotic anxiety disorders

F48 Other neurotic disorders: Neurosis; Neurological diseases; Neurotic disorders; Neurotic condition; Psychoneurosis; Anxious-Neurotic Conditions; Chronic neurotic disorders; Emotional reactive disorders

G24 Dystonia: Violation of muscle tone

G47.0 Disorders of falling asleep and maintaining sleep [insomnia]: Insomnia; Insomnia, especially difficulty falling asleep; desynchronosis; Prolonged sleep disturbance; Difficulty falling asleep; Short-term and transient insomnia; Short-term and chronic sleep disorders; Short or shallow sleep; Violation of sleep; Disturbed sleep, especially in the phase of falling asleep; Infringements sleep; sleep disturbances; Neurotic sleep disturbance; Shallow superficial sleep; shallow sleep; Poor quality of sleep; Night awakening; sleep Pathology; Postsomnic violation; transient insomnia; Trouble falling asleep; Early awakening; Early morning awakening; Early awakening; sleep disorder; somnipathy; persistent insomnia; difficult to fall asleep; difficulty falling asleep; Difficulty falling asleep in children; persistent insomnia; Worsening sleep; Chronic insomnia; Frequent night and / or early morning awakening; Frequent nocturnal awakening and a sense of the depth of the non-sleep; Night waking

O15 Eclampsia

R25.2 Cramp and spasm: Muscle spasms in tetanus; Pain syndrome with smooth muscle spasms; Pain syndrome with smooth muscle spasms (renal and biliary colic, intestinal spasm, dysmenorrhea); Pain syndrome with spasms of smooth muscles of internal organs; Pain syndrome with spasms of smooth muscles of internal organs (renal and biliary colic, intestinal spasm, dysmenorrhea); Painful muscular spasm; Mimic spasms; Muscular spasticity; Muscle spasms; Muscular spasms of central origin; Muscular spasticity; Muscle spasm; Neurological contractures with spasms; Night cramps in the extremities; Nocturnal cramps in the legs; Night cramps calf muscles; Symptomatic convulsive state; Vesta Syndrome; Spasm of smooth muscles; Spasm of smooth vascular musculature; Spasm of muscles; Spasm of striated muscle due to organic diseases of the central nervous system; Skeletal muscle spasms; Spasms of smooth muscles of internal organs; Skeletal Muscle Cramps; Spastic states of striated musculature; Spasmodic pain syndrome; The spastic condition of smooth muscles; Spasticity of skeletal musculature; Muscle cramp; Convulsions; Cramps of the calf muscles; Convulsions of central origin; Convulsive condition; Convulsive Syndrome; Convulsive status in children; Tonic convulsions; Cerebral spasmodic syndrome; clasp knife phenomenon

T08-T14 Injuries to the unspecified part of the trunk, limb or body region

Z100 * CLASS XXII Surgical practice: Abdominal surgery; adenomectomy; Amputation; Coronary angioplasty; Angioplasty of the carotid arteries; Antiseptic skin treatment for wounds; Antiseptic Hand; Appendectomy; atherectomy; Balloon coronary angioplasty; Vaginal hysterectomy; The coronary bypass; Interventions in the vagina and cervix; Interventions on the bladder; Intervention in the mouth; Restoration and reconstructive surgery; Hand hygiene of medical personnel; Gynecologic surgery; Gynecological intervention; Gynecological surgery; Hypovolemic shock during operations; Disinfection of purulent wounds; Disinfection of wounds edges; Diagnostic intervention; Diagnostic procedures; Cervical Diathermocoagulation; Long-surgery; Replacing the fistula catheters; Infection in orthopedic surgery; Artificial heart valve; cystectomy; Short-term outpatient surgery; Short-term operation; Short surgical procedures; Krikotireotomiya; Blood loss during surgery; Bleeding during surgery and in the postoperative period; Kuldotsentez; laser photocoagulation; laser coagulation; retinal laser coagulation; Laparoscopy; Laparoscopy in Gynecology; CSF fistula; Small gynecological operations; Small surgical procedures; Mastectomy and subsequent plastic; mediastinotomy; Microsurgical operations on the ear; Mukogingivalnye operation; suturing; Minor surgery; neurosurgical operation; Immobilization of the eyeball in ophthalmic surgery; testectomy; pancreatectomy; Perikardektomiya; The period of rehabilitation after surgery; The period of convalescence after surgery; Percutaneous transluminal coronary angioplasty; Pleural thoracentesis; Pneumonia postoperative and posttraumatic; Preparation for surgical procedures; Preparation for surgery; Preparation of the surgeon's hands before surgery; Preparation of the colon for surgical procedures; Postoperative aspiration pneumonia in neurosurgical and thoracic surgery; Postoperative nausea; Postoperative bleeding; postoperative granuloma; postoperative shock; The early postoperative period; myocardial revascularization; Radiectomy; gastric Resection; bowel resection; uterine Resection; liver Resection; enterectomy; Resection of part of the stomach; Reocclusion of the operated vessel; Bonding tissues during surgical procedures; Removal of sutures; Condition after eye surgery; Condition after surgery; Condition after surgery in the nasal cavity; Condition after gastrectomy; Status after resection of the small intestine; Condition after tonsillectomy; Condition after removal of the duodenum; Condition after phlebectomy; Vascular surgery; Splenectomy; Sterilization of surgical instruments; Sterilization of surgical instruments; sternotomy; Dental surgery; Dental intervention in periodontal tissues; strumectomy; Tonsillectomy; Thoracic surgery; Thoracic surgery; total gastrectomy; Transdermal intravascular coronary angioplasty; Transurethral resection; Turbinektomiya; Removal of a tooth; cataract surgery; Removal of cysts; tonsillectomy; Removal of fibroids; Removing the mobile primary teeth; Removing polyps; Removing broken tooth; Removal of the uterus body; Removal of sutures; Fistula likvoroprovodyaschih ways; Frontoetmoidogaymorotomiya; Surgical infection; Surgical treatment of chronic limb ulcers; Surgery; The surgery in the anal area; The surgery on the colon; Surgical practice; The surgical procedure; Surgical interventions; Surgery on the gastrointestinal tract; Surgical procedures on the urinary tract; Surgical procedures on the urinary system; Surgical intervention of the genitourinary system; Surgical procedures on the heart; Surgical manipulation; surgery; Surgery on the veins; Surgical intervention; Vascular surgery; Surgical treatment of thrombosis; Surgery; cholecystectomy; Partial gastric resection; hysterectomy; Percutaneous transluminal coronary angioplasty; Percutaneous transluminal angioplasty; Coronary artery bypass; tooth Extirpation; Extirpation of milk teeth; pulpectomy; pulsative cardiopulmonary bypass; tooth Extraction; teeth Extraction; cataract extraction; Electrocoagulation; endourological intervention; episiotomy; Etmoidotomiya; Complications after tooth extraction

Composition and release form

1 tablet coated with diazepam contains 5 mg; In a blister of 20 pcs., In a cardboard box 1 blister.

1 ml solution for injection - 5 mg; In ampoules of 2 ml, in a cardboard box 50 pcs.

Pharmachologic effect

Mode of action - anticonvulsant, anxiolytic, myorelaxing, sleeping pills.

Interacts with benzodiazepine receptors of the brain and spinal cord, the cerebellum; And increases the inhibitory effect of GABA on the central nervous system.

Indications for the Relium

Neuroses, anxiety states, incl. At somatic diseases (cancer, heart failure, arterial hypertension, peptic ulcer of the stomach and duodenum); Anxiety, sleep disorders, alcoholism abstinence, epilepsy, epileptic status, central muscle spasms, post-traumatic states and motor rehabilitation (for reducing skeletal muscle tension), tetanus, eclampsia, indomitable vomiting, premedication.

Contraindications

Hypersensitivity, respiratory disorders of central origin, severe respiratory failure, dizziness, impaired consciousness, glaucoma, myasthenia gravis, depressive states with suicidal tendencies, balance disorders.

Application in pregnancy and breastfeeding

Contraindicated (especially in the first trimester of pregnancy). For the period of treatment should stop breastfeeding.

Side effects

Drowsiness, fatigue, weakness, dizziness, locomotor ataxia, weakened memory, reduced ability to concentrate and speed of reaction, decreased skeletal muscle tone, weakened libido, hypotension, bradycardia, collapse, speech, vision, confusion and disorientation, loss of consciousness, Paradoxical reactions (psychomotor agitation, convulsions, anxiety, restlessness, insomnia, muscle tremor, aggressiveness), skin allergic reactions, after intravenous administration: thrombosis, phlebitis, symptoms of Raynaud's disease.

Interaction

The effect is enhanced by anti-epileptic, antihistamines, narcotic analgesics, antipsychotics, tricyclic antidepressants, sympatho- and cholinolytics, alcohol, muscle relaxants (d-tubocurarine, etc.), weaken - nicotine. Cimetidine, disulfiram, isoniazid - prolonged (slow down elimination); Rifampicin, phenobarbital - reduce the effect (stimulate biotransformation).

Dosing and Administration

Tablets: Inside, 5-20 mg in divided doses for a short time.

Alcohol withdrawal: 10 mg 3 times a day. If necessary, the dose can be increased to 60 mg / day.

Insomnia: 5-10 mg for half an hour before bedtime, for a short time.

Spastic states of the muscles: 5-15 mg / day in several receptions. If necessary, the dose can be increased to 60 mg.

Children: 2-3 years - 2-5 mg / day in 2-3 doses, 4-7 years - 4-6 mg in 2-3 doses, 8-18 years - 5-8 mg in 2 divided doses.

Solution for injection: IM (deep into large muscles) or IV, adults - 2-20 mg.

Acute cases of anxiety and anxiety: IM or IV, - 2-5 mg, if necessary again after 3-4 hours.

Severe phobic disorders: IM or IV, - 5-10 mg, if necessary, repeat after 3-4 hours.

Alcohol abstinence syndrome: IM or IV, - 10 mg once, then, if necessary, 5-10 mg after 3-4 hours.

Premedication: IO slowly, usually 10 mg (maximum - 20 mg, provided that the patient does not receive narcotic analgesics at the same time) or IM, 30 minutes before the procedure - 5-10 mg.

Tetanus, athetosis, muscle spasms: IM or IV, - 5-10 mg (with tetanus, an increase in the dose is possible);

Epileptic status and severe recurrent convulsive seizures: IV or IM, first - 5-10 mg once, possibly again 10-15 minutes and 2-4 hours, maximum - 30 mg.

Electropulse therapy: iv, 5-10 minutes before the procedure, 5-10 mg.

Children. Tetanus: IM or IV (slowly), with 5 weeks of life - 1-2 mg, from 5 years and older - 5-10 mg, if necessary again after 3-4 hours.

Epileptic status and severe, recurrent convulsive seizures: IV slowly, under the control of respiratory function, with 5 weeks of life and up to 5 years - 0.2-0.5 mg for 2-5 minutes (maximum to 5 mg); From 5 years and older, intravenously slowly, 1 mg for 2-5 minutes (maximum to 10 mg). If necessary, the administration is repeated after 2-4 hours.

To prepare the solution for intravenous administration, the contents of the ampoule are diluted to 10 ml with saline or 5% glucose solution and injected at a rate of up to 4 ml (4 mg) per minute; For iv drip infusion - the contents of 10 ampoules (100 mg) are diluted in 500 ml of saline or 5% glucose solution and injected iv at a rate of 40 ml / h (8 mg of active substance).

Precautionary measures

Do not administer parenterally in conditions of shock, coma, acute alcohol poisoning and after head injuries. When violations of the liver and kidneys need to reduce the dose. Elderly or debilitated patients are recommended 1/2 of the usual dose. With caution appoint people with an increased risk of drug dependence, with extreme caution - to young children (possibly a respiratory function disorder). During the treatment period and before 5 days after the end of the day, you should not drive a car, serve a moving mechanical device, or consume alcohol.

Storage conditions of the drug Relium

In a dry, the dark place at a temperature below 25 ° C.

Keep out of the reach of children.

Shelf life of the drug Relium

3 years.

Do not use after the expiry date printed on the package.

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