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Instructions

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Instructions / Instruction for use: Apo-Lorazepam

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Dosage form: tablets

Active substance: Lorazepam*

ATX

N05BA06 Lorazepam

Pharmacological group:

Anxiolytics

The nosological classification (ICD-10)

F41 Other anxiety disorders: Anxiety status; Anxiety; Chronic alarm; Sense of anxiety; Anxious-hypothetical states; Stopping an alarm; Nonpsychotic anxiety disorders

F48 Other neurotic disorders: Neurosis; Neurological diseases; Neurotic disorders; Neurotic condition; Psychoneurosis; Anxious-Neurotic Conditions; Chronic neurotic disorders; Emotional reactive disorders

R45.7 Condition of emotional shock and stress, unspecified: Exposure to stress factors; Exposure to extreme situations; Neuropsychic stresses; Professional stress; Psychoemotional overload and stress; Psychoemotional stress; Stressful condition; Stress; Stress loading; Stressful condition; Stressful situations; Stress of everyday life; Chronic stress; Long-term emotional stress; Psychological stress in air flights; Psychoemotional stress in stressful situations

Composition and release form

1 tablet contains lorazepam 0.5; 1 or 2 mg; in bottles of 20 and 500 pcs., 20 and 1000 pcs. And 100 and 1000 pcs. respectively.

Pharmachologic effect

Mode of action - anticonvulsant, miorelaxing, tranquilizing, central.

Stimulates benzodiazepine receptors in the limbic system, reticular formation, intercalary neurons of the lateral horns of the spinal cord, increases the sensitivity of GABA receptors to the mediator (enhances its inhibitory effect).

Pharmacodynamics

It causes anxiolytic action, reduces emotional tension, reduces feelings of fear, anxiety, has muscle relaxant and anticonvulsant properties.

Pharmacokinetics

Quickly and completely absorbed. Cmax is reached within 2 hours. 88% of the accepted dose is excreted from the body mainly with urine, of which 75% - in the form of glucuronides. T1 / 2 - 16-20 hours.

Indications for the Apo-lorazepam

Anxious neuroses; Anxiety and stress associated with the stresses of everyday life.

Contraindications

Hypersensitivity (including to other benzodiazepines), myasthenia gravis, angle-closure glaucoma.

Side effects

Drowsiness, inhibition, disorientation, depression, itching.

Dosing and Administration

Inside. The dosage regimen is strictly individual. The initial dose is 2 mg (in 2-3 doses), then it is increased (with caution) to 6 mg (not more) or reduced; For the elderly and weakened patients, the daily dose should not exceed 0.5 mg. The duration of the initial course is no more than 1 week.

Precautionary measures

It is not recommended to use during pregnancy and lactation, with depressive neuroses, to appoint patients younger than 18 years. With caution combine with drugs that depress the central nervous system. The use of alcohol is excluded. With prolonged admission, you need to periodically monitor the picture of peripheral blood, with liver or kidney disease - carefully monitor their function.

Storage conditions of the drug Apo-Lorazepam

In dry, the dark place at room temperature.

Keep out of the reach of children.

Shelf life of the drug Apo-Lorazepam

3 years.

Do not use after the expiry date printed on the package.