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Instruction for use: Apo-Clorazepate

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Dosage form: capsules

Active substance: Dipotassium clorazepate*


N05BA05 Dicatia clorazepate

Pharmacological group:


The nosological classification (ICD-10)

F41 Other anxiety disorders: Anxiety status; Anxiety; Chronic alarm; Sense of anxiety; Anxious-hypothetical states; Stopping an alarm; Nonpsychotic anxiety disorders

F48 Other neurotic disorders: Neurosis; Neurological diseases; Neurotic disorders; Neurotic condition; Psychoneurosis; Anxious-Neurotic Conditions; Chronic neurotic disorders; Emotional reactive disorders

R45.1 Anxiety and agitation: Agitation; Anxiety; Explosive excitability; Internal stimulation; Excitability; Excitation; Excitation acute; Psychomotor agitation; Hyperexcitability; Motor excitement; Cessation of psychomotor agitation; Nervous excitement; Restlessness; Night trouble; Acute stage of schizophrenia with excitation; Acute mental agitation; Paroxysm of excitation; Overexcitation; Increased excitability; Increased nervous excitability; Increased emotional and cardiac excitability; Increased agitation; Mental arousal; Psychomotor agitation; Psychomotor agitation in psychoses; Psychomotor agitation of an epileptic nature; Psychomotor paroxysm; Psychomotor fit; Symptoms of excitation; Symptoms of psychomotor agitation; The state of agitation; A state of anxiety; Excitation status; A state of heightened concern; The state of psychomotor agitation; Conditions of anxiety; Excitation conditions; The state of excitement in somatic diseases; Excitation level; Feelings of anxiety; Emotional arousal

R45.7 Condition of emotional shock and stress, unspecified: Exposure to stress factors; Exposure to extreme situations; Neuropsychic stresses; Professional stress; Psychoemotional overload and stress; Psychoemotional stress; Stressful condition; Stress; Stress loading; Stressful condition; Stressful situations; Stress of everyday life; Chronic stress; Long-term emotional stress; Psychological stress in air flights; Psychoemotional stress in stressful situations

T51 Toxic effect of alcohol: Intoxication alcoholic; Alcohol intoxication; Intoxication with alcohol; Acute alcohol intoxication; Chronic alcohol intoxication

Composition and release form

1 capsule contains clorazepate dikal of 7.5, 15 or 3.75 mg; In bottles of 30, 100, 1000 or 30, 100 and 500 pieces. respectively.

Pharmachologic effect

Mode of action - anxiolytic, myorelaxing, sleeping, sedative.

Excites benzodiazepine receptors, increases the sensitivity of GABA-receptors to the mediator.

Clinical Pharmacology

Reduces or eliminates anxiety, restlessness, muscle tension (leads to their relaxation), stops psychomotor agitation.

Indications for the Apo-Clorazepate

Neuroses, accompanied by a sense of anxiety, fear, anxiety, excitement, tension, including in patients with somatic complaints; acute alcohol intoxication (as part of combination therapy).


Hypersensitivity, myasthenia gravis, depressive neuroses, psychotic reactions, children and adolescence (up to 18 years).

Application in pregnancy and breastfeeding

Not recommended.

Side effects

Drowsiness (or insomnia), dizziness, headache, irritability, weakness, confusion, impaired coordination of movements, diplopia, dry mouth, dyspeptic disorders, arterial hypotension, rash.


Enhances the effect of deprimir drugs, alcohol.

Dosing and Administration

Inside. With neuroses, the average therapeutic dose for adults is 30 mg / day (with variations ranging from 15 to 60 mg) for one week. For elderly and debilitated patients - the initial dose of 3.75 mg, at night. In acute alcohol intoxication begin with 30-90 mg in the first 24 hours in several doses, reducing to 15-30 mg on the 4th day, with the subsequent cessation of treatment as early as possible.


Symptoms: CNS depression, respiratory and cardiovascular failure, in severe cases - coma. Treatment: gastric lavage, if necessary - symptomatic therapy.

Precautionary measures

Precautions are prescribed for elderly patients with closed-angle glaucoma, debility, and during occupations requiring increased attention and rapid mental and motor reactions.

Storage conditions of the drug Apo-Clorazepate

In the dark place at a temperature of 15-30 ° C.

Keep out of the reach of children.

Shelf life of the drug Apo-Clorazepate

2 years.

Do not use after the expiry date printed on the package.

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