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Instruction for use: Proxibarbal

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The Latin name of the substance Proxibarbal

Proxibarbalum (genus. Proxibarbali)

Chemical name

5- (2-Hydroxypropyl) -5- (2-propenyl) -2,4,6 (1H, 3H, 5H) -pyrimidinetrione

Gross formula


Pharmacological group


The nosological classification (ICD-10)

G43 Migraine: The pain of migraine; Migraine; hemiplegic migraine; Migraine headache; A migraine attack; Continuous headache; hemicranias

K25 Stomach ulcer: Helicobacter pylori; Pain syndrome with gastric ulcer; Pain syndrome with peptic ulcer of stomach and duodenum; Inflammation of the gastric mucosa; Inflammation of the mucosa of the gastrointestinal tract; Benign ulcer of the stomach; Disease of the stomach and duodenum, associated with Helicobacter pylori; Exacerbation of gastroduodenitis against ulcer disease; Exacerbation of peptic ulcer; Exacerbation of gastric ulcer; Organic GI disease; Peptic ulcer of the stomach and duodenum; Postoperative Stomach Ulcer; Recovering ulcers; Symptomatic Stomach Ulcers; Chronic inflammatory disease of the upper gastrointestinal tract associated with Helicobacter pylori; Helicobacter pylori eradication; Erosive-ulcerative lesions of the stomach; Erosive lesions of the stomach; Erosion of the gastric mucosa; Peptic Ulcer; Stomach ulcer; Stomach ulcer; Ulcerative lesions of the stomach; Symptomatic ulcers of the stomach and duodenum

K26 Ulcer of duodenum: Pain syndrome with duodenal ulcer; Pain syndrome with peptic ulcer of stomach and duodenum; Disease of the stomach and duodenum, associated with Helicobacter pylori; Exacerbation of peptic ulcer; Exacerbation of duodenal ulcer; Peptic ulcer of the stomach and duodenum; Recurrence of duodenal ulcer; Symptomatic ulcers of the stomach and duodenum; Helicobacter pylori eradication; Erosive-ulcerative lesions of the duodenum; Erosion-ulcerative duodenal lesions associated with Helicobacter pylori; Erosive lesions of the duodenum; Peptic ulcer disease of the duodenum; Ulcerative duodenal lesions

N94.3 Premenstrual tension syndrome: Pronounced premenstrual syndrome; Menstrual psychosomatic disorder; Menstrual syndrome; Premenstrual tension; Premenstrual status; Premenstrual period; Premenstrual syndrome; Menstruation syndrome

N95.1 menopausal and menopausal status of women: Atrophy of the mucosa of the lower genital tract, caused by estrogen deficiency; Vaginal dryness; Autonomic dysfunction in women; gipoestrogeniya state; Deficiency of estrogen in menopausal women; Degenerative changes of the mucous membrane in the menopause; Natural menopause; an intact uterus; climacteric; Menopause women; Menopause in women; menopausal depression; Climacteric ovarian dysfunction; Menopause; Climacteric neurosis; Menopause; Menopausal symptoms complicated psychovegetative; Climacteric syndrome; Climacteric vegetative disorders; Climacteric psychosomatic disorder; menopausal disorders; Menopausal disorders in women; menopausal condition; Climacteric vascular disorders; Menopause; Menopausal vasomotor symptoms; menopausal period; Lack of estrogen; Feeling the heat; Pathological menopause; perimenopause; menopause; postmenopausal; Premature menopause; premenopauznom period; tides; hot flashes; flushing in the Meno and postmenopausal; Hot flashes / hot flashes in menopause; Heart attack during menopause; Early menopause in women; Disorders of menopause; climacteric syndrome; Vascular complications of menopause; Physiological menopause; Estrogendefitsitnye state; premature Menopause

R51 Headache: pain in the head; cephalgia; Pain in sinusitis; Pain in the neck; Pain headache; Headache vasomotor origin; Headache vasomotor origin; Headache with vasomotor disturbances; Headache; Neurological Headache; Continuous headache

CAS Code


Characteristics of the substance Proxibarbal

White crystalline powder odorless. Slightly soluble in water, soluble in alcohol, ether, chloroform and methylene chloride.


Pharmacological action - tranquilizing, sedative.

Regulates the functions of the reticular formation, the hypothalamus and the autonomic nervous system. Inhibits the action of neurotransmitters of excitation, intensifies the intensity of GABA effects. Reduces neurovegetative disorders that accompany psychosomatic disorders. Eliminates anxiety, anxiety, increased excitability, vasomotor headache (including migraine). Has a regulatory effect in vegetative dysfunctions. The effect on the central nervous system is stabilized 4-10 days after the initiation of therapy.

When ingested quickly and completely absorbed from the digestive tract. C max is achieved in 30 minutes. Easily passes through the histohematological barriers, including the BBB. Metabolised in the liver. It is excreted mainly by the kidneys.

Application of substance Proxibarbal

Headache of vasomotor genesis, migraine, neurosis, psychopathy, vegetative lability in somatic diseases, premenstrual syndrome, climacteric disorders, peptic ulcer of stomach and duodenum (as part of complex therapy).


Hypersensitivity, renal and hepatic insufficiency, pregnancy, breast-feeding.

Application in pregnancy and lactation

Contraindicated in pregnancy. For the duration of treatment, breastfeeding should be stopped.

Side effects of Proxibarbal

Dizziness, drowsiness, dyspeptic phenomena, allergic reactions; with prolonged use - addiction and drug dependence.


Strengthens the effects (mutually) of other deprimants (including alcohol).

Routes of administration


Precautions for the substance Proxibarbal

With caution appoint elderly and debilitated patients, children, with depression. Do not use in combination with other deprimiruyuschimi medicines.

Do not use during work drivers of vehicles and people whose profession is associated with increased concentration of attention.

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