DR. DOPING

Instructions

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Instructions / Instruction for use: Pamol

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Active substance Paracetamol

ņ“’ N02BE01 Paracetamol

Pharmacological group

Anilides

Nosological classification (ICD-10)

M25.5 Pain in the joint

Arthralgia, Pain syndrome in musculo-articular diseases, Pain syndrome in osteoarthritis, Pain syndrome in osteoarthritis, Pain syndrome in acute inflammatory diseases of the musculoskeletal system, Pain syndrome in chronic inflammatory diseases of the musculoskeletal system, Pain in the joints, Soreness of the joints, Soreness of joints in severe physical exertion, Painful inflammatory joint damage, Painful conditions of the musculoskeletal system, Painful joint conditions, Painful traumatic affection of joints, Pain in the musculoskeletal system, Pain in Shoulder Joints, Pain in the joints, Joint pain, Joint pain with injuries, Musculoskeletal pain, Pain with osteoarthritis, Pain in the pathology of the joints, Pain in rheumatoid arthritis, Pain in chronic degenerative bone diseases, Pain in chronic degenerative joint diseases, Bone-joint pain, Joint pain, Arthritic pain of rheumatic origin, Articular pain syndrome, Joint pain, Rheumatic pain, Rheumatic pains

M79.1 Myalgia

Myofascial pain syndromes ,Pain syndrome in musculo-articular diseases, Pain syndrome in chronic inflammatory diseases of the musculoskeletal system, Pain in the muscles, Tenderness of muscles, Muscular soreness in severe physical exertion, Painful conditions of the musculoskeletal system, Pain in the musculoskeletal system, Pain in the muscles, Pain at rest, Muscle aches, Muscle pain, Musculoskeletal pain, Myalgia, Muscle pain, Muscle pain at rest, Muscle pain, Muscular pain of non-rheumatic origin, Muscle pain of rheumatic origin, Acute muscle pain, Rheumatic pain, Rheumatic pains, Myofascial syndrome, Fibromyalgia

N94.0 Pain in the middle of the menstrual cycle

Algomenorea, Painful menstruation, Menalgia, Pain in menstruation

N94.3 Premenstrual tension syndrome

Pronounced premenstrual syndrome, Menstrual psychosomatic disorder, Menstrual syndrome, Premenstrual tension, Premenstrual status, Premenstrual period, Premenstrual syndrome, Menstruation syndrome

R50 Fever of unknown origin

Malignant hyperthermia, Hyperthermia malignant

R51 Headache

Pain in the head, Cephalgia, Pain with sinusitis, Pain in the back of the head, Painful headache, Headache of vasomotor genesis, Headache of vasomotor origin, Headache with vasomotor disorders, Headache, Neurological headache, Serial headache

R52.0 Acute pain

Acute pain syndrome, Acute pain syndrome with osteoarthritis, Acute pain syndrome of traumatic origin, Severe pain of a neurogenic nature, Severe pain, Pain syndrome at delivery

Composition and form of release

1 tablet with a fracture line contains 125 or 500 mg of paracetamol, in a package of 20; 1 effervescent tablet - 500 mg, in a package of 20 pieces; 1 ml of medicine - 24 mg, in a bottle of 100 ml; candles - 125 or 500 mg, in the package 10 pcs.

pharmachologic effect

Pharmacological action - antipyretic, analgesic.

Pharmacokinetics

Absorbed almost completely when injected into the stomach and by 60% with rectal administration (suppositories). The maximum concentration in the plasma is achieved in the first variant after 0.5-1 h (after the application of effervescent tablets is faster) and in 2-3 hours in the second variant. The action lasts 4-6 hours after ingestion (a little longer after rectal administration). The degree of binding to plasma proteins is negligible. Metabolised in the liver. Metabolites of paracetamol have a certain hepatotoxicity, but in normal concentrations it does not appear (glucuronides and sulfates are formed). About 80% is excreted by the kidneys.

Indications for Pamol

Fever, pain: headache, dental, muscular, articular, with menstruation.

Contraindications

Severe hepatic and renal insufficiency.

pregnancy and lactation

Can be used in therapeutic doses.

Side effects

Dyspepsia, impaired renal and hepatic function (with prolonged use in large doses), swelling (due to sodium in the composition of effervescent tablets), hypoglycemia, thrombocytopenia, agranulocytosis, allergic reactions.

Interaction

Zidovudine increases (especially with prolonged use) the risk of neutropenia. Barbiturates, alcoholism, malnutrition increase the hepatotoxicity. Against the background of paracetamol, the concentration of chloramphenicol in the blood plasma increases.

Dosing and Administration

Adults: 0.5-1 g 3-4 times a day; Children: 50 mg / kg of body weight per day (3-4 sessions). Effervescent tablets should be dissolved in 0.5 glasses of water.

Overdose

Symptoms are similar to those of hepatitis, which appear after a 24-72-hour latent period in the form of loss of appetite, nausea, vomiting, pain under the right costal arch, jaundice, changes in the color of urine and feces. The cases of toxic liver damage with a lethal outcome after taking paracetamol in a dose of 15-20 g are described. Severe dysfunction of the liver was noted after using moderate doses (up to 10 g / day) of paracetamol in patients with alcoholism. An effective antidote for overdose of paracetamol is N-acetylcysteine, which should be used even after 12 hours or more after taking the drug.

storage Conditions

At room temperature.

Keep out of the reach of children.

Shelf life

tablets effervescent 500 mg - 2 years.

tablets 125 mg - 5 years.

suppositories rectal 125 mg - 3 years.

suppositories rectal 500 mg - 3 years.

solution for oral administration of 24 mg / ml - 3 years.

Do not use after the expiry date printed on the package.

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