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Instructions

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Instructions / Instruction for use: Loratadine 10-SL

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Dosage form: Tablets

Active substance: Loratadinum

ATX

R06AX13 Loratadine

Pharmacological groups:

H1-antihistamines

The nosological classification (ICD-10)

H10.1 Acute atopic conjunctivitis: Allergic conjunctivitis; Allergic eye diseases; Allergic conjunctivitis; Allergic conjunctivitis caused by chemical and physical factors; Allergic rhinoconjunctivitis; Allergic inflammation of the eyes; Spring Qatar; Spring keratitis; Spring conjunctivitis; Conjunctivitis allergic; Year-round allergic conjunctivitis; Exacerbation of pollinosis in the form of rhinoconjunctival syndrome; Acute allergic keratoconjunctivitis; Acute allergic conjunctivitis; Superficial bacterial infection of the eyes; Rhinoconjunctivitis; Seasonal allergic conjunctivitis; Seasonal conjunctivitis; SENSORY; Chronic allergic keratoconjunctivitis; Chronic allergic conjunctivitis

J30 Vasomotor and allergic rhinitis: Allergic rhinopathy; Allergic rhinosinusopathy; Allergic diseases of the upper respiratory tract; Allergic rhinitis; Allergic rhinitis seasonal; Vasomotor runny nose; Prolonged allergic rhinitis; All-year-round allergic rhinitis; All-year allergic rhinitis; Year-round or seasonal allergic rhinitis; All-the-year-round rhinitis of an allergic nature; Rhinitis vasomotor allergic; Exacerbation of pollinosis in the form of rhinoconjunctival syndrome; Acute allergic rhinitis; Edema of the nasal mucosa; Edema of the nasal mucosa; Edema of the mucous membrane of the nasal cavity; Swelling of the nasal mucosa; Swelling of the nasal mucosa; Pollinosis; Permanent allergic rhinitis; Rhinoconjunctivitis; Rhinosinusitis; Rhinosinusopathy; Seasonal allergic rhinitis; Seasonal allergic rhinitis; Hay rhinitis; Chronic allergic rhinitis; Allergic diseases of the respiratory tract

L23 Allergic contact dermatitis: Allergic dermatitis;Purulent allergic dermatopathies; Contact allergic reaction; Contact allergic dermatitis; Contact allergic dermatitis; Photoallergic contact dermatitis

L30.9 Unspecified Dermatitis: Allergic dermatoses complicated by a secondary bacterial infection; Anal eczema; Bacterial maturation; Varicose Eczema; Venous dermatitis; Inflammation of the skin; Inflammation of the skin upon contact with plants; Inflammatory Skin Disease; Inflammatory Skin Diseases; Inflammatory Skin Diseases; Inflammatory skin reactions; Inflammatory processes of the skin; Hypostatic dermatitis; Fungal Eczema; Fungal dermatosis; Dermatitis; Dermatitis is stagnant; Dermatitis and eczema in the anal area; Dermatitis acute contact; Perianal dermatitis; Dermatosis; Dermatosis of the scalp; Dermatosis of psoriasis; Dermatosis with persistent itching; Dermatoses; Dermatoses itchy; Other itching dermatoses; Significant eczematous manifestations; Itching with dermatoses; Itching eczema; Itching dermatoses; Itching dermatitis; Itching dermatosis; True eczema; Skin reaction to insect bites; Skin itching with dermatosis; Constitutional eczema; Weeping eczema; Drowsing inflammatory skin disease; Dying Infectious-Inflammatory Skin Disease; Non-allergic dermatitis; Nummular eczema; Acute contact eczema; Acute inflammatory skin disease; Acute dermatosis; Acute severe dermatosis; Perianal dermatitis; Superficial dermatosis; Subacute Contact Eczema; Simple dermatitis; Occupational dermatitis; Psychogenic dermatosis; Bubble dermatitis of newborns; Pustular eruptions; Irritation and redness of the skin; Low-flammable eczema; Dry atrophic eczema; Dry eczema; Toxic dermatitis; Ear eczema like dermatitis; Chronic eczema; Chronic dermatosis; Chronic dermatosis; Chronic common dermatosis; Scaly papular dermatosis; Eczema; Eczema anal region; Eczema of the hands; Eczema Contact; Eczema lichenized; Eczema Nummular; Eczema acute; Eczema acute contact; Eczema subacute; Eczematous dermatitis; Eczema-like rashes; Ecome exogenous; Endogenous eczema; Gluteal dermatitis; Limited itching dermatitis

L50.0 Allergic urticaria: Skin reaction to medication

L50.1 Idiopathic urticaria: Idiopathic urticarial; Chronic idiopathic urticaria

Composition and release form

1 tablet contains loratadine 10 mg and excipients - lactose, MCC, calcium stearate; In a contour blister packing 10 pcs., In a box 1 or 3 packings.

Pharmachologic effect

Mode of action - anti-allergic, antihistamine.

It blocks histamine H1 receptors.

Pharmacodynamics

Does not cause drowsiness and does not affect psychomotor functions, attention, performance, mental activity.

Pharmacokinetics

Well absorbed from the digestive tract. The action begins in 30 minutes and lasts for 24 hours. It is metabolized in the liver with the participation of cytochrome P450 with the formation of an active metabolite - dexarboethoxyloratadine. Cmax of loratadine and its active metabolite in plasma are achieved after 1.3 and 2.5 hours, respectively. T1 / 2 loratadine - 8 h, dexarboethoxyloratadine - about 28 h.

Indications of the Loratadine 10-SL

Allergic rhinitis (seasonal, all-the-year-round), allergic rhinoconjunctivitis, chronic idiopathic urticaria, allergic itching dermatoses - contact allergic dermatitis, chronic eczema (as part of complex treatment).

Contraindications

Hypersensitivity (including its components), pregnancy, breast-feeding, children under 2 years.

Application in pregnancy and breastfeeding

Contraindicated in pregnancy. For the duration of treatment, breastfeeding should be stopped.

Side effects

From the nervous system and sensory organs: headache, fatigue, increased excitability.

On the part of the intestine: dryness of the oral mucosa, nausea, vomiting, gastritis.

Allergic reactions: skin rash.

Interaction

Erythromycin, cimetidine, ketoconazole increase the concentration in the plasma.

Dosing and Administration

Inside. Adults and children over 12 years of age - 10 mg once a day, daily dose - 10 mg. Children 2-12 years: body weight less than 30 kg - 5 mg once a day, daily dose - 5 mg, more than 30 kg - 10 mg once a day, daily dose - 10 mg. Against the background of violations of the liver function, the initial dose is 5 mg / day.

Overdose

Symptoms: drowsiness, tachycardia, headache.

Treatment: gastric lavage, administration of emetic and laxatives, activated charcoal.

Precautionary measures

Caution should be exercised while using drugs that inhibit the cytochrome P450 system.

Storage conditions of the drug Loratadine 10-SL

In dry, the dark place at a temperature of 15-25 ° C

Keep out of the reach of children.

Shelf life of the drug Loratadine 10-SL

5 years.

Do not use after the expiry date printed on the package.