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Instruction for use: Dyclonine

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Latin name:Dicloninum (genus. Diclonini)

Chemical name

1- (4-Butoxyphenyl) -3- (1-piperidinyl) -1-propanone (and as hydrochloride)

Gross formula


Pharmacological group:

Local irritants

The nosological classification (ICD-10)

J02.9 Acute pharyngitis, unspecified: Purulent pharyngitis; Acute rhinopharyngitis; Lymphonodular pharyngitis

CAS code


Characteristics of the substance Racementhol

Menthol - colorless crystals with a strong smell of peppermint and peppery and cold taste. Flying at ordinary temperature. Very little soluble in water, very easy - in ethanol, chloroform, ether, acetic acid, easily - in fatty oils, paraffin.

Menthol oil is a solution of menthol (natural or synthetic racemic) in vaseline oil. Colorless oily liquid with a weak smell of menthol.


Pharmacological action - soothing, coronarodilating, antipruritic, antiseptic, local irritating, analgesic, distracting.

The effect is mainly due to reflex reactions associated with irritation of sensitive nerve endings. Irritation of the receptors of the skin or mucous membranes stimulates the formation and release of endogenous biologically active substances (peptides, kinins, etc.) involved in the regulation of pain, vascular permeability and other processes, providing an analgesic, distracting and antipruritic effect.

Antiseptic activity is a consequence of indiscriminate action on microbial cells. Annoying (distracting) effect helps to reduce pain. Local action is accompanied by a narrowing of the vessels, a sensation of cold, resulting in mild burning and tingling. Skin-visceral reflexes (reflex arc does not affect the brain) improve trophism of tissues (respectively, the zones of innervation). Reflexively changes the tone of vessels both superficial and deep located in tissues and internal organs. Irritating the receptors of the oral mucosa, causes the expansion of spasmodic coronary vessels. It is possible to use with migraine - lubricating the skin of the temples with menthol pencil. With systemic action lowers blood pressure and has a calming effect on the central nervous system. After absorption, biotransformed in the liver and excreted in the urine and bile in the form of glucuronides.

Menthol is an integral part of a number of combined ready-made medicines.

Application of the substance Racementhol

Inflammatory diseases of the upper respiratory tract (rhinitis, pharyngitis, laryngitis, tracheitis), neuralgia, myalgia, arthralgia, itching dermatosis.


Hypersensitivity, violation of the integrity of the skin, inflammatory skin diseases at the site of the intended application; early childhood (to lubricate the nasopharynx) - possible reflex respiratory depression, up to a stop, and collapse.

Side effects of Dyclonine

Allergic reactions, contact dermatitis (with external application).

Routes of administration

External, inhalation, intranasal.

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