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Instruction for use: Diclofenac + Misoprostol (Diclophenacum + Misoprostolum)

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Pharmacological groups

NSAIDs - Acetic acid derivatives and related compounds in combinations

Nosological classification (ICD-10)

M06.9 Other specified rheumatoid arthritis

Rheumatoid arthritis,Pain syndrome in rheumatic diseases, Pain in rheumatoid arthritis, Inflammation in rheumatoid arthritis, Degenerative forms of rheumatoid arthritis, Children's rheumatoid arthritis, Exacerbation of rheumatoid arthritis, Acute articular rheumatism, Rheumatic arthritis, Rheumatic polyarthritis, Rheumatoid arthritis, Rheumatic polyarthritis, Rheumatoid arthritis, Rheumatoid arthritis of active course, Rheumatoid arthritis, Rheumatoid polyarthritis, Acute rheumatoid arthritis, Acute rheumatism

M19.9 Arthrosis, unspecified

Change in brush with osteoarthritis, Osteoarthritis, Osteoarthrosis, Arthrosis of large joints, Pain syndrome in osteoarthritis, Pain syndrome in acute inflammatory diseases of the musculoskeletal system, Pain syndrome in chronic inflammatory diseases of the musculoskeletal system, Deforming arthrosis, Deforming osteoarthritis, Deforming osteoarthritis of joints, Osteoarthritis in the acute stage, Osteoarthritis of large joints, Acute pain syndrome with osteoarthritis, Post-traumatic osteoarthritis, Rheumatic osteoarthritis, Spondylarthrosis, Chronic osteoarthritis

M45 Ankylosing spondylitis

Ankylosing spondylarthrosis, Marie-Strumpel disease, Ankylosing spondylitis, Pain syndrome in acute inflammatory diseases of the musculoskeletal system, Pain syndrome in chronic inflammatory diseases of the musculoskeletal system, Bechterew's disease, Ankylosing spondylitis, Diseases of the spinal column, Rheumatic spondylitis, Bechterew-Marie-Strumpel disease

Characteristics of Diclofenac + Misoprostol

A combination drug consisting of diclofenac sodium (NSAIDs (nonsteroidal anti-inflammatory drugs)) and misoprostol (a synthetic analogue of PGE1).


Pharmacological action - anti-inflammatory, antipyretic, analgesic, gastroprotective.

Diclofenac - inhibits the synthesis of prostaglandins and has an anti-inflammatory, analgesic, antipyretic effect.

Misoprostol - suppresses basal and stimulated secretion of hydrochloric acid in the stomach, promotes the formation of bicarbonate, improves blood supply to the gastric mucosa.

Indications Diclofenac + Misoprostol

Osteoarthrosis, rheumatoid arthritis, ankylosing spondylitis.


Hypersensitivity, bleeding from the digestive tract (gastrointestinal tract).

Restrictions for use

Chronic heart failure, predisposition to fluid retention in the body, hepatic and / or renal failure.

pregnancy and lactation

Contraindicated in pregnancy and during breastfeeding.

When planning pregnancy, it should be borne in mind that misoprostol raises the tone of the uterus and can provoke a threat of miscarriage.

The use of diclofenac and other NSAIDs during pregnancy can cause premature closure of the arterial duct in the fetus, and as a consequence, hypertension in the small circulation.

The action category for the fetus by FDA is X.

Side effects of Diclofenac + Misoprostol

On the part of the intestine: nausea, diarrhea, gastralgia, dyspepsia, flatulence.

From the cardiovascular system and blood (hematopoiesis, hemostasis): reduced platelet aggregation, prolonged bleeding time, anemia (including hemolytic and aplastic), leukopenia, thrombocytopenia, eosinophilia, agranulocytosis.

From the nervous system and sensory organs: headache, dizziness.

Other: menorrhagia, metrorrhagia in women in the pre- and post-menopausal period, fluid retention, edema, skin rash.


With simultaneous use with potassium-sparing diuretics, an increase in the K + content in the plasma (due to diclofenac) is possible. Diclofenac promotes the accumulation in the plasma of methotrexate, digoxin, lithium. Acetylsalicylic acid displaces diclofenac from binding sites, accelerates elimination and reduces the concentration of diclofenac. Myelotoxic drugs (drug) increase the manifestation of hematotoxicity of the drug.

Routes of administration


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