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Luxfen (Luxphen) eye drops - to treat open-angle glaucoma, decrease in intraocular pressure. The drug can be used as a monotherapeutic agent by patients who have contraindications to the use of local beta-adrenoreceptor blockers.
Luxfen eye drops - antiglaucoma preparation. Brimonidine is a selective α 2 -adrenoreceptor agonist.
When instillation 0.2% solution of brimonidine, the decrease in intraocular pressure is 10-12 mm Hg. The maximum effect is observed after 2 hours, the duration of the action is 12 hours.
Brimonidine has a dual mechanism of action: it lowers the intraocular pressure by decreasing the synthesis of the intraocular fluid and enhancing the uveoscleral outflow.
Suction and distribution
When instillation of eye drops Cmax drug in blood plasma is achieved after 0.5-2.5 h. Binding to blood proteins with topical application is 29%. The systemic absorption of brimonidine is slowed down. After applying the drug 2 times / day for 10 days, the concentration of brimonidine in the plasma remains low (an average of 0.06 ng / ml).
Metabolism and distribution
The drug is metabolized primarily in the liver. Brimonidine and its metabolites are excreted by the kidneys. T1 / 2 is about 2 hours.
Open angle glaucoma, ophthalmic hypertension (in monotherapy and in combination with other drugs that reduce intraocular pressure).
With caution: when using the drug in patients with severe, unstable and uncontrolled form of cardiovascular disease, with cerebral or coronary insufficiency, depression, orthostatic hypotension, Raynaud's disease, obliterating thromboangiitis; if the liver or kidney function is impaired; children age from 2 to 18 years.
Before using the drug, contact lenses should be removed. The time interval between use of the drug and the re-installation of contact lenses should be at least 15 minutes.
Impact on the ability to drive vehicles and other mechanisms that require increased concentration
The drug can cause fatigue or drowsiness, reduced vision, so during drug treatment should refrain from driving vehicles and servicing moving mechanisms.
Bury 1 drop of the drug 2 times a day.
The duration of treatment is determined by the doctor.
Important notice- the outer box design may vary before prior notice!
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