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Instruction for use: Azelaic acid (Acidi azelaici)

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Pharmacological group

dermotropic means

Antiseptics and disinfectants

Nosological classification (ICD-10)

L70.0 Acne vulgaris

Ugropodobnye rashes, Congenital youthful acne, Acne vulgaris, Acne vulgaris, Common Acne, Acne draining, Youthful pimples, Youthful Acne, Acne youthful

L71 Rosacea

Pink acne, Acne Red, Acne pink, Redheads

L81.1 Chloasma

Mask of pregnant women (chloasma), Melasma (Chloasma)

L81.8.0 * Hyperpigmentation

Cronkheta-Canada syndrome, Melasma, Pathological hyperpigmentation

Code CAS123-99-9

Characteristics of Azelaic acid

White crystalline substance. It is poorly soluble in water at 20 ° C (0.24%), easily soluble in boiling water and ethanol. Molecular weight 188.22.


Pharmacological action - anti-inflammatory, antibacterial, keratolytic.

Has bacteriostatic activity against Propionibacterium acnes and Staphylococcus epidermidis. Reduces the fraction of free fatty acids in the skin's superficial lipids. It inhibits the proliferation of keratinocytes and the growth of abnormal melanocytes. Clinical improvement occurs on average after 2-4 weeks of treatment.

After application to the skin of the cream, azelaic acid penetrates the epidermis and dermis, and 3.6% is absorbed into the systemic bloodstream. Excreted urine mainly in unchanged form, and part - in the form of shorter dicarboxylic acids formed as a result of oxidation.

Application of Azelaic acid

Cream. Ordinary acne (acne vulgaris), hyperpigmentation of the melasma type (eg, chloasma).

Gel. Ordinary acne (acne vulgaris), rosacea.


Hypersensitivity, incl. to the components of the drug (propylene glycol).

pregnancy and lactation

The action category for fetus by FDA is B.

Side effects

In rare cases (in the first 1-2 weeks of therapy) skin irritation, burning sensation is possible.

Routes of administration

Routes of administration. Locally.

Precautions for Azelaic acid

Avoid contact with the eyes, mucous membranes of the nose, lips and mouth. In cases of severe skin irritation in the first weeks of treatment, you can apply 1 time per day or briefly cancel the drug.

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