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Instruction for use: Alprazolam

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Trade name of the drug – Alprazolam

Active substance: Alprazolam (Alprazolamum)

Dosage Form: Tablets

The active substance - alprazolam. Tablets of 0.25, 0.5, 1.0 mg to 10, 20, 30, 50 and 100 units. packaged.
Pharmacotherapeutic group:

Anxiolytic (tranquilizer)

ATX CodeN05BA12 Alprazolam

The nosological classification (ICD-10)

F41.0 Panic disorder [episodic paroxysmal anxiety]: Panic; Panic attack; Panic disorder; Panic disorder; Panic condition.
F41.2 Mixed anxiety and depressive disorder: Depression with anxiety and depressive components;
Mixed anxiety-depressive states; Anxious depression; Anxious, depressed mood; Anxiety and depression; Anxiety and depression; Anxiety-depressive syndrome; Anxious-neurotic state.
F41.9 Anxiety disorder, unspecified: Severe anxiety; neurosis-like symptoms; neurosis-like disorder;
neurosis-like state; Neurosis with anxiety symptoms; Neurosis with anxiety; Neurotic disorders with anxiety syndrome; The acute situational stress and anxiety; The acute situational stress anxiety; Acute anxiety attack; Depressed mood with anxiety elements; Psychopathy with a predominance of anxiety and worry; Sudden anxiety; Situational Anxiety Disorder; An alarm condition; Soest; Anxious-delirium;
Disturbingly delusional component; anxiety; Anxiety; anxiety disorder; Anxiety disorders; Anxiety disorders in neurotic and neurosis-like states; Anxiety Disorders; Alarm syndrome; Chronic neurotic anxiety; Sense of anxiety.
F48.9 Neurotic disorder, unspecified: Secondary neurotic symptom; Other neurotic state; Neurosis
Neurosis with increased irritability; Neuroses; Neuroses of all kinds; Neuroses with inhibition; neuroses of the heart; Neurotic disorders in alcoholism; Neurotic disorders with inhibition; Neurotic disorders with anxiety syndrome; Neurotic reactions; Neurotic symptoms of alcoholism; Neurotic state; The neurotic syndrome; neurotic disorders; The attack of neurological dysfunction; School neurosis;
Emotional stress.
Pharmacological Properties

Tranquilizer from the group of benzodiazepines. It reduces anxiety, causing muscle relaxation, has anticonvulsant activity, a mild sedative effect. Under the influence of the drug shortens the sleep period, with an increase in sleep duration, reduced the number of nighttime awakenings. It does not cause changes in the cardiovascular and respiratory systems.


Neuroses, psychopathy, accompanied by anxiety, restlessness. Reactive depression (in particular, against systemic diseases).

Contraindications for Alprazolam

Acute pulmonary insufficiency expressed by the human liver and kidneys, acute attack of glaucoma, pregnancy, lactation, hypersensitivity to benzodiazepines.

Alprazolam Dosage and Administration

Inside, 2-3 times a day, regardless of meals. Doses are selected depending on the severity of the syndrome, the individual sensitivity of the patient and response to the drug. Begin with the minimum use of the drug doses (0.25-0.5 mg / day) followed by an increase in the first night and then in the daytime within several days or weeks. Elderly or debilitated patients administered 0.25 mg 2-3 times a day. A further increase in the dose up to 0.5-0.75 mg / day is carried out with caution, with good tolerability.

When anxiety states, anxiety initial daily dose is 0.75-1.5 mg and may be increased to 3-4.5 mg / day. When panic disorders and depressive states, the daily dose can reach 3-6 mg; the highest daily dose - 10 mg.

The course of treatment alprazolam - from a few days (in acute state of fear) to 3 months. Discontinuation of treatment should be carried out during 2-6 weeks, reducing the daily dose is no more than 500 micrograms every 3 days, in order to prevent the development of withdrawal syndrome (abrupt cessation therapy can cause anxiety and fear of worsening) may sometimes require even slower cancellation.

Side effect of Alprazolam

Drowsiness, dizziness, impaired concentration, mental retardation and motor responses; rarely - blurred vision, headache, insomnia, depression, nervousness, anxiety, tremor, change in weight, memory impairment, coordination of the various manifestations of the autonomic nervous system, gastrointestinal tract, timoleptic action, agitation, irritability, difficulty concentrating , confusion, hallucinations, dystonia, anorexia, weakness, appearance of "slurred" speech, jaundice, muscle weakness, changes in libido, menstrual disorders, urinary incontinence, urinary retention, renal dysfunction. Perhaps getting used to the drug and the development of drug dependence.

Symptoms: irritability, disturbance of nighttime sleep. Treatment: gastric lavage, activated charcoal, if necessary - symptomatic therapy should reduce the dose or stop taking the drug.

Must not be used concurrently with other drugs sedative. Patients taking alprazolam, must refrain from all activities that require attention, rapid physical and mental reactions. The efficacy and safety of the drug in patients younger than 18 years have not been established.


Algol (Alzolam) Sun Pharmaceutical, India; Alpraks (Alprax) Torrent, India; Zenaks (Zenax) Dr.Reddys Laboratories, India; Zoldak (Zoldak) Cadila, India; Kassadan (Kassadan) AWD, Germany; Xanax (Xanax) Upjohn, USA; Neurol (Neurol) Lechiiva, Czech Republic.
Storage conditions

In the dark place at a temperature no higher than 30 ° C. Schedule III of the list of narcotic drugs, psychotropic substances and their precursors subject to control in the Russian Federation.
Shelf life
5 years. Do not use beyond the expiration date printed on the package.
Conditions of supply of pharmacies
On prescription.

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