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Instructions

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Instruction for use: Proproten-100

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Trade name of the drug – Proproten-100

Active substance: Antibodies to S-100 brain-specific proteins (Anticorpora ad proteino S-100 cerebrospecifico)

Dosage Form: Tablets
Composition:
Active components: antibodies to S-100 affinity-purified brain-specific proteins - 0,003 g
Excipients: lactose, microcrystalline cellulose, magnesium stearate.

Description
Tablets plano-cylindrical shape White to nearly white. On the flat side with the mark applied inscription MATERIA MEDICA, on the other flat side of the inscription PROPROTEN 100 applied.
Pharmacotherapeutic group:

Alcoholism treatments.

ATX Code

N07BB Drugs used in alcohol dependence

The nosological classification (ICD-10)

F10.1 Harmful use of alcohol: Posiomania, binge drinking, drunken state, abuse of alcohol, excessive alcohol consumption, obsessive craving for alcohol, the craving for alcohol.

F10.2 Alcohol dependence syndrome: Alcoholism, Alcohol addiction, posiomania, dependence on alcohol, binge drinking, drunken state, abuse of alcohol, violations in alcoholism, Quarterly binge, compulsive craving for alcohol, neurotic symptoms of alcoholism, pathological attraction to alcohol, Psychoorganic syndrome in chronic alcoholism, Reduced craving for alcohol, alcoholism
F10.3 Abstinence:
Alcohol withdrawal syndrome, abstinence syndrome, abstinence syndrome in alcoholism, abstinence, abstinence Alcohol, Alcohol withdrawal, alcohol withdrawal state, alcohol withdrawal syndrome, post-abstinent disorder, post-abstinent state, Hangover, withdrawal syndrome, alcohol withdrawal, withdrawal of alcohol, withdrawal state

Pharmacological PropertiesPharmachologic effect

Mode of action - alcohol withdrawal, neuroprotective, anti-hypoxic.

The drug modifies the functional activity of the protein S-100, carrying information in the brain interfacing and metabolic processes. Sensitizing neuronal membrane modulates neuronal synaptic plasticity. It has a modifying effect on the functional state of the brain structures involved in the formation of alcohol dependence: the hypothalamus, hippocampus, and others.When alcohol dependence has a normalizing effect on the positive emotional reinforcement system, which reduces the frequency of self-stimulation of the lateral hypothalamus. Reduces the bursting activity of hippocampal neurons; reduces the number of circulating immune complexes in the peripheral blood, which correlates with reduced ethanol consumption. It helps strengthen the inhibitory effects of GABA in the CNS. It was established experimentally that the drug restores the neurotransmitter balance and conditioned reflex activity. Increases resistance to cerebral hypoxia and toxic effects.

Indications for Ğroproten-100
Exhibits anti-alcohol effect, reducing the craving for alcohol, and reducing the likelihood of relapse.Monotherapy with alcohol withdrawal syndrome mild to moderate severity. The product facilitates both psychiatric disorders (anxiety, mental stress, insomnia, irritability, anxiety, depressed mood, intense craving for alcohol), and somatic vegetative disorders (weakness, sweating, headache, tremors, tachycardia, dyspepsia) alcohol "hangover" syndrome .

Contraindications for Ğroproten-100

Individual hypersensitivity to the drug, pregnancy and lactation.

Ğroproten-100 Dosage and Administration
At one time - one to hold the tablet in the mouth until complete dissolution of the - (not during a meal).In the state of hangover the first 2 hours of drug taking 1 tablet every 30 minutes; next 8 - 10 watches - 1 tablet per hour. In the event of acceptance of sleep resumed after waking.
In the future, while improving the state of the drug take 1 tablet every 2 to 3 hours (4 to 6 tablets per day) for 2-3 days.
When weighting alcohol withdrawal symptoms must attach drugs traditionally used in detoxification.
To prevent a recurrence, drug taking 1-2 tablets a day for 2 to 3 months; after accidentally drinking to take an additional 2 tablets of the drug 2 times - day and night.

Side effect of Ğroproten-100
Possible reactions of individual hypersensitivity to the drug.

Overdose

In case of accidental overdose possible dyspeptic symptoms caused by members of the excipients of the drug.

Interaction
Cases of incompatibility with other drugs has not yet been revealed.

SPECIAL INSTRUCTIONS
The product contains lactose, and therefore it is not recommended for patients with congenital galactosemia, glucose malabsorption syndrome or congenital lactase deficiency.

Release Form

Lozenges. On 20 tablets in blisters of PVC film and aluminum foil. 20 or 50 tablets in a jar with a screw neck of a polymer and a screw-cap for vitamins and drugs with a polymer or jar lid and tensioned damper to control the first opening for vitamins and drugs. In each jar adhesive label paper label.
At 1, 2 or 5 contour cell packages or each jar along with instructions for use are placed in a pile of cardboard.

Storage conditions
In a dry place at room temperature.
Keep out of the reach of children.
Shelf life
3 years. Do not use beyond the expiration date printed on the package.

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