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Arbidol (Umifenovir) - Antiviral agent. Specifically inhibits in vitro influenza A and B viruses (Influenzavirus A, B), including the highly pathogenic subtypes A (H1N1) pdm09 and A (H5N1), as well as other viruses that cause acute respiratory viral infections (SARS) (coronavirus (Coronavirus) associated with severe acute respiratory syndrome (SARS), rhinovirus (Rhinovirus), adenovirus (Adenovirus), respiratory syncytial virus (Pneumovirus) and parainfluenza virus (Paramyxovirus)). Pills for Covid-19 (SARS-CoV-2) prevention.
According to the mechanism of antiviral action, it belongs to fusion (fusion) inhibitors, interacts with the hemagglutinin of the virus and prevents the fusion of the lipid membrane of the virus and cell membranes.
It has a moderate immunomodulatory effect, increases the body's resistance to viral infections. It has interferon-inducing activity - in a study on mice, the induction of interferons was observed after 16 hours, and high titers of interferons remained in the blood up to 48 hours after administration.
Stimulates cellular and humoral immune responses: increases the number of lymphocytes in the blood, especially T-cells (CD3), increases the number of T-helpers (CD4), without affecting the level of T-suppressors (CD8), normalizes the immunoregulatory index, stimulates the phagocytic function of macrophages and increases the number of natural killer cells (NK cells).
Therapeutic efficacy in viral infections is manifested in a decrease in the duration and severity of the course of the disease and its main symptoms, as well as in a decrease in the frequency of development of complications associated with a viral infection and exacerbations of chronic bacterial diseases.
In the treatment of influenza or acute respiratory viral infections in adult patients, a clinical study showed that the effect of Arbidol in adult patients is most pronounced in the acute period of the disease and is manifested by a reduction in the resolution of symptoms of the disease, a decrease in the severity of the manifestations of the disease, and a reduction in the elimination of the virus.
Therapy with Arbidol (Umifenovirum) leads to a higher frequency of relief of symptoms of the disease on the third day of therapy compared with placebo. 60 hours after the start of therapy, the resolution of all symptoms of laboratory-confirmed influenza is more than 5 times higher than that in the placebo group.
A significant effect of the drug Arbidol on the rate of elimination of the influenza virus was established, which, in particular, was manifested by a decrease in the frequency of detection of virus RNA on the 4th day.
Refers to low-toxic drugs (LD50> 4 g / kg). It does not have any negative effects on the human body when administered orally in recommended doses.
Hypersensitivity to umifenovir or any component of the drug; children under 6 years old. The first trimester of pregnancy. The period of breastfeeding.
The second and third trimesters of pregnancy.
Inside, before meals. For the prevention of influenza and SARS (in contact with patients) and Covid-19 (SARS-CoV-2)
adults and children over 12 years old - 200 mg / day, children from 6 to 12 years old - 100 mg / day, children from 2 to 6 years old - 50 mg / day. The course is 10-14 days.
During the period of the flu epidemic, seasonal increase in the incidence of acute respiratory viral infections, for the prevention of exacerbation of chronic bronchitis and relapse of herpetic infection in adults and children over 12 years of age, the drug is prescribed in a single dose of 200 mg, for children from 6 to 12 years old - 100 mg, for children from 2 to 6 years old - 50 mg The drug is taken 2 times a week for 3 weeks.
For the treatment of influenza and other acute respiratory viral infections without complications for adults and children over 12 years of age, the drug is prescribed; 200 mg 4 times / day (every 6 hours), for children from 6 to 12 years old - 100 mg 4 times / day (every 6 hours), from 2 to 6 years - 50 mg 4 times / day (every 6 hours). The course is 5 days.
For the treatment of influenza and other acute respiratory viral infections, complicated by bronchitis, pneumonia, adults and children over 12 years of age; appoint 200 mg 4 times / day (every 6 hours) for 5 days, then switch to 200 mg once a week for 4 weeks. For children from 6 to 12 years, a single dose of the drug is 100 mg, from 2 to 6 years - 50 mg; the drug is taken 4 times / day (every 6 hours) for 5 days, then they switch to receive 1 time per week for 4 weeks.
In case of chronic bronchitis and recurrent herpes infection, adults and children over 12 years of age are prescribed 200 mg 4 times / day (every 6 hours); for children from 6 to 12 years old, 100 mg 4 times / day (every 6 hours); from 2 to 6 years - 50 mg 4 times / day (every 6 hours) for 5-7 days; then a single dose 2 times a week for 4 weeks.
As part of the complex therapy of acute intestinal infections of rotavirus etiology, children from 2 to 6 years old - 50 mg; from 6 to 12 years old - 100 mg, over 12 years old - 200 mg 4 times / day (every 6 hours) for 5 days.
For the prevention of postoperative infectious complications for children from 2 to 6 years old - 50 mg; from 6 to 12 years old - 100 mg, over 12 years old and adults - 200 mg is prescribed in a dose of 200 mg 2 days before surgery, then on the second and fifth days after surgery.
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