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Instructions

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Instruction for use: Polio Sabin Vero

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Dosage form: solution for oral administration

Active substance: Vaccinum ad prophylaxim poliomyelitidis

ATX

J07BF03 Three-valent inactivated whole-genome virus

Pharmacological group:

Vaccines, serums, phages and toxoids

The nosological classification (ICD-10)

B91 Consequences of poliomyelitis: Poliomyelitis consequences; Post-poliomyelitis syndrome

Composition and release form

Solution for oral administration. 1 dose of the vaccine (2 drops or 0.5 ml) in the multidose package contains poliomyelitis viruses: type 1 (strain LS-c 2 ab) - not less than 1 million CPD50, type 2 (strain P 712, Ch, 2 Ab) - not less than 100000 CPD50, type 3 (strain Leon 12 a 1b) - not less than 600,000 CPD50. The composition of the vaccine also includes: human albumin - 1%, phenol red - q.s. To provide color, a single-buffered solution of magnesium chloride - q.s. 1 vaccine dose. The vaccine is released in ampoules of 1 dose and in vials of 10 and 20 doses; In the box 1 ampoule or 10 bottles.

Characteristic

Live vaccine for the prevention of poliomyelitis. It is made of 3 types of attenuated live poliovirus, cultivated on the BERO cell line.

Pharmachologic effect

Mode of action - Immunostimulating.

Formation of specific immunity against polioviruses.

Clinical Pharmacology

Immunity is acquired after the first oral dose and is increased after the introduction of the subsequent 2 doses. Seroconversion is observed in 98-100% of the vaccinated. There are data indicating the formation of local immunity by stimulating the production of IgA in the mucous membranes of the nasopharynx and intestines in grafted, which prevents the fecal-oral route of transmission of wild poliovirus. One of the advantages of the vaccine is the possibility of creating collective immunity due to transmission of the vaccine strain to unvaccinated individuals.

Indication of the drug Polio Sabin Vero

Prevention of poliomyelitis.

Contraindications

Congenital and acquired immunodeficiencies. Pregnancy (the first 5 months).

Application of pregnancy and breastfeeding

Use in pregnant women is contraindicated. However, its use in women in the early stages of pregnancy (when they did not know that they are pregnant) is not an indication for the interruption of this pregnancy.

Dosing and Administration

Inside (either - directly, or - on sugar or in syrup). Vaccine dose: 0.5 ml (when using monodose package) or 2 drops (using a multi-dose package). In doubtful cases (for example, with diarrhea) after recuperation, a repeated dose is recommended. Vaccination is carried out by at least 3 vaccine doses administered at intervals of not less than 4 weeks (except for the epidemic period). In endemic areas, a newborn child should receive an additional dose as soon as possible after birth. Revaccination is carried out 1 year after the end of the vaccination course, then every 5 years. Any opened packaging should be used within the same day.

Precautionary measures

Vaccination should be done orally. Use with caution in individuals with allergies to neomycin.

Storage conditions of the drug Polio Sabin Vero

In the dark place at a temperature of 2-8 ° C.

Keep out of the reach of children.

Shelf life of the drug Polio Sabin Vero

6 moths.

Do not use after the expiry date printed on the package.

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