Instruction for use: Loperamide-Akri

Active substance Loperamide

ATX code A07DA03 Loperamide

Pharmacological group

Antidiarrheal drugs

Nosological classification (ICD-10)

A04.9 Bacterial intestinal infection, unspecified

Bacterial intestinal infections, GI tract infections, Infections of intestinal bacterial, Digestive tract infections, Infectious-inflammatory diseases of the digestive tract, Infectious Disease of the GI tract, Infection of the intestine, Intestinal infection, Acute infectious disease of the digestive tract, Acute intestinal disease with colon lesions, Acute intestinal infection

K59.1 Functional diarrhea

Diarrheal syndrome, Diarrhea, Diarrhea with prolonged enteral feeding through the probem, Prolonged diarrheam Nonspecific diarrhea, Acute diarrhea, Diarrhea, Syndrome of diarrhea, Functional diarrhea, Chronic diarrhea, Diarrhea with an electrolyte balance disorder, Chronic diarrhea, Diarrhea of non-infectious genesis, Diarrhea after a gastroectomy, Diarrhea in children, Persistent diarrhea, Diarrhea (diarrhea), Enterocolitis of non-infectious origin

Composition and release form

Capsules 1 caps.

loperamide 2 mg

in a blister strip package 10 pcs .; in a pack of cardboard 1 or 2 packs.

pharmachologic effect

Pharmacological action - antidiarrheal.

Interacts with opiate receptors of the intestinal wall and inhibits the release of acetylcholine and PG.

Pharmacodynamics

It lowers the motility and tone of the intestinal smooth muscle, spasms the anal sphincter, inhibits the secretion of fluid and electrolytes and / or stimulates the absorption of salts and water from the intestine. The action comes quickly and lasts 4-6 hours.

Pharmacokinetics

Absorbed from the gastrointestinal tract less than half (40%) of the administered dose. Cmax - after 5 h. Binds to plasma proteins by 97%. Does not penetrate the BBB. Almost completely metabolized in the liver by conjugation. T1 / 2 - 9-14 hours. Excreted in the feces and kidneys.

Indications

Diarrhea of various origins (acute and chronic), regulation of stool in patients with ileostomy.

Contraindications

Hypersensitivity, intestinal obstruction, acute ulcerative or pseudomembranous colitis, I trimester of pregnancy, child age (up to 5 years).

pregnancy and lactation

Contraindicated in the first trimester of pregnancy. At the time of treatment should stop breastfeeding.

Side effects

Dizziness, drowsiness, fatigue, constipation, nausea, intestinal obstruction, toxic megacolon.

Interaction

Opioid analgesics increase the risk of developing severe constipation.

Dosage and administration

Inside Acute diarrhea. Adults: the initial dose is 4 mg, then 2 mg after each bowel movement with liquid stools. Children older than 5 years: the initial dose is 2 mg, then 2 mg after each bowel movement act with a liquid stool.

Chronic diarrhea. Adults: the initial dose is 4 mg, then 2 mg 1–6 times a day. Children over 5 years: 2 mg 1–5 times a day.

Overdose

A specific antidote is naloxone.

Precautionary measures

With caution prescribed for dehydration, infectious diarrhea, abnormal liver function, in the elderly (risk of loss of fluid and electrolytes).

special instructions

In the absence of the effect of the drug for 2 days, it is necessary to clarify the diagnosis and exclude infectious genesis of diarrhea.

Storage conditions

In a dry, dark place at a temperature of no higher than 25 ° C.

Keep out of the reach of children.

Shelf life

4 years.

Do not use after the expiration date printed on the package.