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Sofradex eye drops - is a combined preparation for topical application in ophthalmology and otolaryngology. The composition of the drug includes two antibiotics and glucocorticosteroid, due to which the drug has anti-inflammatory, bactericidal and anti-allergic action, eliminating pain, itching and lacrimation. In ophthalmology, Sofradex is used to treat bacterial eye infections caused by microorganisms that are sensitive to the action of the drug.
Framicetin sulfate is an antibiotic from the aminoglycoside group, it acts bactericidal. It has a wide spectrum of antibacterial action, it is active against gram-positive microorganisms, including Staphylococcus aureus, and most clinically significant Gram-negative microorganisms (E. coli, Diz., Proteus, etc.). It is not effective for stethococci. Does not affect pathogenic fungi, viruses, anaerobic flora. Stability of microorganisms to framicetin sulfate develops slowly. Gramicidin - has a bactericidal and bacteriostatic effect, expands the spectrum of the antimicrobial action of Framicetin due to its activity against staphylococci, since it also has an anti-staphylococcal effect.
Dexamethasone - GCS, which has a pronounced anti-inflammatory, antiallergic and desensitizing effect. Dexamethasone suppresses inflammatory processes, inhibiting the release of inflammatory mediators, the migration of mast cells and reducing the permeability of capillaries. When instilled in the eyes reduce pain, burning, lacrimation, photophobia. When instilled in the ears reduces the symptoms of otitis externa ear (reddening of the skin, pain, itching, burning in the external auditory canal, feeling of stuffiness of the ear).
With topical application, systemic absorption is low.
Framicetin sulfate can be absorbed through inflamed skin or open wounds. When entering the systemic bloodstream, it is quickly excreted by the kidneys unchanged. T1 / 2 of framicetin sulfate is 2-3 hours.
When ingesting dexamethasone can be absorbed quickly from the digestive tract. T1 / 2 is 190 minutes.
Bacterial diseases of the anterior part of the eye:
To children of younger age (especially at purpose or appointment of a preparation in the big doses and it is long - risk of development of system effects and suppression of function of adrenals).
With long-term use of the drug, as with the long-term use of other antimicrobial agents, it is possible to develop superinfections caused by microorganisms resistant to the preparation, including fungi.
Continuous instillation of the drug in the eyes can lead to thinning of the cornea with the development of its perforation, as well as an increase in intraocular pressure.
Treatment with drugs containing corticosteroids should not be repeated or prolonged without regular monitoring of intraocular pressure, eye examination for cataracts or secondary infections.
Local corticosteroids should never be used in patients with eye hyperemia of unknown etiology; as inappropriate use of the drug may lead to a significant deterioration of vision.
Framicetin sulfate, which is part of the drug, is an antibiotic from the aminoglycoside group, which is characterized by the development of nephro- and ototoxic effects in systemic application or local application to open wounds or damaged skin.
These effects depend on the dose and increase with renal or hepatic insufficiency.
Although the development of these effects has not been observed with instillation of the drug in the eye, it should be taken into account the possibility of their occurrence in the case of topical application of high doses of the drug in children.
The duration of the drug should not exceed 7 days, except in cases of obvious positive dynamics of the disease, as long-term use of the glucocorticosteroid included in its composition can mask hidden infections, and long-term use of antimicrobial components - contribute to the emergence of a stable microflora.
Patients who, after instillation into the eye of the drug, temporarily lose visual clarity, it is not recommended immediately after the instillation of the drug to drive a car or work with complex equipment, machines or some other complex equipment that requires clear vision. The bottle must be closed after each use.
Do not touch the tip of the pipette to the eye. After opening the vial, the drug should be used within 1 month.
With eye diseases
In the light of the infectious process, 1-2 drops of the drug are instilled in the conjunctival sac of the eye every 4 hours.
In the case of a serious infectious process, the drug is instilled every hour.
As the inflammatory phenomena decrease, the frequency of instillations of the drug decreases.
In case of ear diseases
Bury 2-3 drops 3-4 times a day, in the external auditory can be put a gauze swab moistened with a solution.
The duration of the drug should not exceed 7 days, except in cases of obvious positive dynamics of the disease (glucocorticoid can mask hidden infections, and long-term use of antimicrobial components of the drug to promote the development of a stable flora).
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