Instruction for use: Legalon 140

Active substance Silybi mariani fructuum extract

ATX code A05BA03 Silymarin

Pharmacological group

Hepatoprotectors

Nosological classification (ICD-10)

B19 Viral hepatitis, unspecified

Anicteric hepatitis, viral hepatitis, Viral hepatitis in children, Infection of the liver, Acute liver infection

K71 Toxic liver disease

Toxic liver damage, Hepatitis medication, Hepatitis Toxicum, Liver medication, Medicinal Hepatitis, Liver medications, Medicinal Hepatitis, , Dysfunction of the liver of toxic etiology, Toxic hepatitis, Toxic liver damage, Toxic hepatitis, Hepatotoxic effect of drugs, Toxic liver disease, Effect of drugs on the liver, The effect of toxins on the liver

K73 Chronic hepatitis, not elsewhere classified

Inflammatory liver disease, Hepatitis autoimmune, Hepatitis chronic, Infection of the liver, Chronic hepatitis with signs of cholestasis, Chronic reactive hepatitis, Chronic persistent hepatitis, Chronic infectious hepatitis, Chronic active hepatitis, Chronic inflammatory liver disease, Autoimmune Hepatitis, Chronic hepatitis is aggressive

K74 Fibrosis and cirrhosis of the liver

Otecno-ascitic syndrome with cirrhosis of the liver, Inflammatory liver disease, Precircrotic condition, Cystic fibrosis of the liver, Cirrhotic and precircotic state, Cirrhosis with portal hypertension, Cirrhosis of the liver with portal hypertension and edematous-ascitic syndrome, Cirrhosis of the liver with portal hypertension, Cirrhosis of the liver with ascites and edema, Cirrhosis of the liver with ascites, Cirrhotic ascites

K76 Other Liver Diseases

Liver disease

T51 Toxic effect of alcohol

Intoxication alcoholic, Alcohol intoxication, Intoxication with alcohol, Acute alcohol intoxication, Chronic alcohol intoxication

T56 Toxicity of metals

Intoxication with manganese, Intoxication with metals and their compounds

Composition and release form

1 tablet (Legalon 70) contains silymarin 70 mg with a minimum of 30 mg silibinin in 90 mg of milk thistle fruit extract (Cardui mariae); in a blister strip packaging 10 pcs., in a cardboard bundle 2 or 4 packs.

1 capsule (Legalon 140) contains 173–188.7 mg of dry extract from the fruits of milk thistle, or 140 mg of silymarin calculated from silibinin; in a blister strip packaging 10 pcs., in a cardboard bundle 2 packs.

pharmachologic effect

Pharmacological action - detoxification, hepatoprotective.

Neutralizes free radicals in the liver, prevents the destruction of cellular structures. It specifically stimulates RNA polymerase and activates the synthesis of structural and functional proteins and phospholipids in damaged hepatocytes. Stabilizes cell membranes, prevents the release of intracellular components (transaminases) and accelerates the regeneration of liver cells. It inhibits the penetration into the cell of certain hepatotoxic substances (poison of the toadstool).

Clinical Pharmacology

It improves the general condition of patients with liver diseases, reduces subjective complaints (weakness, feeling of heaviness in the right hypochondrium, loss of appetite, vomiting, skin itch), normalizes laboratory parameters (transaminase activity, gamma-glutamyltransferase, alkaline phosphatase, bilirubin level). With prolonged use increases the life expectancy of patients with cirrhosis of the liver.

Indications

Toxic (including medicinal) liver damage, alcoholism, intoxication with halogenated hydrocarbons, heavy metal compounds, chronic inflammatory liver diseases, liver cirrhosis (supportive therapy).

Contraindications

Hypersensitivity.

Side effects

Diarrhea (rare).

Dosage and administration

Inside, after eating, without chewing and squeezing a small amount of liquid. For the initial treatment and in severe cases - 2 tablets or 1 caps. 3 times a day; maintenance dose - 1 tablet 3 times a day or 1 caps. 2 times a day.

Storage conditions

In the dark place at a temperature of no higher than 30 ° C.

Keep out of the reach of children.

Shelf-life

5 years.

Do not use after the expiration date printed on the package.