Instruction for use: Isofan-Insulin HM

ATX Code A10AB01 Human insulin

Active substance: Insulin-isophan [human semisynthetic]

Pharmacological group

Insulins

Nosological classification (ICD-10)

E10 Insulin-dependent diabetes mellitus

Decompensation of carbohydrate metabolism, Diabetes mellitus, Diabetes insulin sugar, Diabetes mellitus type 1, Diabetic ketoacidosis, Insulin-dependent diabetes, Insulin-dependent diabetes mellitus, Coma hyperosmolar non-ketoacidotic, Labile form of diabetes mellitus, Violation of carbohydrate metabolism, Type 1 diabetes mellitus, Type I diabetes mellitus, Insulin-dependent diabetes mellitus, Type 1 diabetes mellitus

E11 Non-insulin-dependent diabetes mellitus

Acetonuric diabetes, Decompensation of carbohydrate metabolism, Diabetes insulin-independent sugar, Diabetes sugar type 2, Type 2 Diabetes, Non-insulin-dependent diabetes, Non-insulin dependent diabetes mellitus, Non-insulin-dependent diabetes mellitus, Insulin resistance, Insulin resistant diabetes mellitus, Coma lactobacillus diabetic, Violation of carbohydrate metabolism, Type 2 diabetes mellitus, Diabetes mellitus type II, Diabetes mellitus in adulthood, Diabetes mellitus in old age, Diabetes insulin-independent, Diabetes mellitus type 2, Sugar insulin-independent diabetes type II

Composition and form of release

1 ml of the suspension for injection contains human insulin (biosynthetic origin) 40 IU (international unit); In bottles of 10 ml.

Characteristic

Neutral suspension of human insulin of medium duration.

pharmachologic effect

Pharmacological action - hypoglycemic.

Activates the system of phosphatidylinositol, changes the membrane transport of glucose and ions, normalizes the polarization of membranes (increases the intake of potassium in the cell), activates hexokinase and glycogen synthetase, promotes the uptake of amino acids by cells.

Clinical Pharmacology

The effect develops 1-2 hours after administration, reaches a maximum of 6-12 hours and lasts 18-24 hours.

Indications

Insulin-dependent diabetes mellitus: for allergy to other types of insulin, for intensified insulin therapy (needleless injectors, standard and PEN syringes, etc.), in patients with severe vascular complications of diabetes, for devices with special purposes (artificial pancreas, etc.) ; Insulin-independent diabetes (combination therapy with oral hypoglycemic drugs, temporary insulin therapy).

Contraindications

Hypoglycemic conditions, coma.

Side effects

Hypoglycemia (sensation of hunger, overwork, tremor); Allergic reactions; Lipodystrophy in places of administration.

Dosing and Administration

Subcutaneously, intramuscularly (intramuscularly), the contents of the vial before use are shaken well and injected immediately after filling the syringe. Dosage is determined individually.

Precautionary measures

Do not enter in the same place. At simultaneous reception with a high-speed insulin solution of a person in the syringe first dial Inutral XM. They are used with caution in renal failure, against infections, hypopituitarism, pregnancy, in persons over 65 years of age.

storage Conditions

In the refrigerator, at a temperature of 2-8 ° C (do not freeze).

Keep out of the reach of children.

Shelf life

2 years.

Do not use after the expiry date printed on the package.