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Instructions

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Instruction for use: Clenbuterol (Clenbuteroli)

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Chemical name: 4-Amino-3,5-dichloro-alpha - [[(1,1-dimethylethyl) amino] methyl] benzenemethanol (as the monohydrochloride)

Pharmacotherapeutic group:

Beta-adrenergic agonist

The nosological classification (ICD-10)

J43 Emphysema

Interstitial emphysema, Emphysema, Chronic lung disease, Chronic obstructive pulmonary disease, Obstructive pulmonary emphysema, Chronic pulmonary emphysema, Chronic obstructive pulmonary emphysema

J44 Other chronic obstructive pulmonary disease

Allergic bronchitis, Bronchitis asthma, Asthmatic bronchitis, wheeze bronchitis, Bronchitis is an obstructive, bronchi disease, Shortness of sputum in acute and chronic respiratory diseases, Cough in inflammatory diseases of the lung and bronchus, Reversible airflow obstruction, Reversible obstructive airway disease, Obstructive bronchitis disease, Obstructive lung disease, Obstructive bronchitis, Spastic bronchitis, Chronic lung disease, Chronic nonspecific lung diseases, Chronic obstructive pulmonary disease, Chronic obstructive bronchitis, Chronic obstructive airway disease, Chronic obstructive pulmonary disease, Restrictive lung pathology

J45 Asthma

Asthma physical effort, status asthmaticus, Bronchial asthma, Asthma lung flow, Bronchial asthma with obstruction of sputum discharge, Bronchial asthma heavy currents, Bronchial asthma physical effort, hypersecretory asthma, Hormone-dependent form of bronchial asthma, Relief of asthma attacks in bronchial asthma, Non-allergic asthma, nocturnal asthma, Exacerbation of asthma, Asthma attacks, Endogenous forms of asthma, Night asthma, Cough with bronchial asthma

CAS Cade 37148-27-9

Characteristics

Selective beta2-agonists. Clenbuterol Hydrochloride - colorless microcrystalline powder. Very soluble in water, methanol, ethanol; slightly soluble in chloroform; insoluble in benzene.

Pharmacology

Pharmacological effect

bronchodilator.

Excited beta2-adrenergic receptors stimulates adenylate cyclase, increases the concentration of cAMP in the cells, which is affecting the protein kinase system, deprives the ability of myosin bind to actin and promotes relaxation bronchi. It stops the release from mast cells intermedianty provoking bronchoconstriction and inflammation of the bronchi. T1 / 2 of plasma -. About 3 hours Reduces swelling and congestion in the bronchi and improves mucociliary clearance. It has tocolytic effect: lowers the tone and uterine activity. When inhaled has a rapid and long-lasting bronchodilator effect (about 12 hours).

Indications

Bronchial asthma, lung disease with BOS syndrome, including chronic obstructive bronchitis, emphysema.

Contraindications

Hypersensitivity, thyrotoxicosis, arrhythmia, myocardial infarction (acute phase).

Pregnancy and breast-feeding

Contraindications I trimester of pregnancy and just before birth.

Side effects of Clenbuterol

Cardio-vascular system and blood (blood, hemostasis): tachycardia, arrythmia, reduction or (more often) increase in blood pressure.

From the nervous system and sensory organs: the tremor of fingers, anxiety, headache.

From the digestive tract: dry mouth, nausea.

Allergic reactions: skin rash, urticaria.

Other: hypokalemia.

Interaction

Beta-blockers reduce or eliminate the effect of clenbuterol. Clenbuterol reduces the effect of insulin and sulfonylureas. In combination with sympathomimetic agents clenbuterol enhanced effects. Against the background of cardiac glycosides and theophylline MAO inhibitors increases the risk of cardiac arrhythmias.

Overdose

Symptoms: tremor of the extremities, restlessness, tachycardia.

Treatment: dose reduction, symptomatic therapy.

Routes of administration

Inside.

Precautions

It should stop taking shortly before birth, because clenbuterol has a relaxing effect on the muscles of the uterus. Perhaps the development of "bounce" and resistance syndrome.

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