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Metaprot (Metaprote, Bemitil) - is an adaptogenic drug with nootropic, antihypoxic, antioxidant and immunomodulatory activity. Metaprot is effective in restoring and enhancing physical and mental performances. It increases resistance to extreme factors such as stress, hypoxia, hyperthermia and physical activity without increasing oxygen consumption or heat production. Metaprot is used to treat asthenic disorders of various nature (in neurasthenia, somatic disorders). Also used in a combination therapy in cerebral circulation dysfunction and cognitive disorders.
The drug has nootropic, regenerative, antigipoksicheskoy, antioxidant and immunomodulatory activities. The mechanism of action is to activate the synthesis of RNA, and then proteins, including enzyme and related to the immune system. The activation of the synthesis of enzymes of gluconeogenesis, which provide disposal of lactate (factor limiting performance) and resynthesis of carbohydrates - a source of energy during intense stress - which leads to increased physical performance. Increased synthesis of mitochondrial enzymes and structural proteins of the mitochondria provides an increase in energy production and maintaining a high degree of coupling of oxidation and phosphorylation. Keeping a high level of ATP synthesis with the oxygen deficiency contributes expressed antigipoksicheskoy and antiischemic activity. It enhances the synthesis of antioxidant enzymes, and has a pronounced antioxidant activity. It increases the body's resistance to the effects of extreme factors: physical activity, stress, hypoxia, hyperthermia. Increases performance during physical exertion. It possesses strong antiastenicheskim action accelerates the recovery processes after extreme impacts.
After oral administration, is well absorbed from the gastrointestinal tract, it is extensively metabolised in the liver. After a single dose is found in the blood after 30 minutes, the maximum effect is achieved in 1-2 hours, duration -. 4-6 hours Amid course taking effect usually increases during the first 3-5 days, then steadily maintained at current levels. Prolonged kursovom continuous reception, especially at high doses, there may be a tendency to accumulation of the drug with an increase in its concentration in the blood by 10-12 th day of application.
Metaprot (Metaprote, Bemitil) is the first widely used actoprotectors ekonomiziruyuschego type of action. Analysis of the results of its experimental and clinical application show that the drug is promising in terms of prevention and correction of various pathological conditions caused by extreme influences. Optimization of power supply cells of the nervous, immune and endocrine systems in the unfavorable conditions of hypoxia allows metaprote provide a wide range of protective effects.
In extreme conditions metaprot not only ensures a high survival rate of animals and humans, but also contributes to the restoration and maintenance of mental and physical performance. It improves the processes of cellular respiration, it helps to optimize the hormonal regulation of stress response, mobilizes immune defenses and improves hemodynamics. It restores and maintains a high level of operating activity, enhances portability changing time zones, and the stability of the sleep-wake rhythm with a replacement or a rotational production. Thanks gepato- nephroprotective action it improves the tolerability of being in areas of high pollution of various toxicants.
Profile metabolic action metaprote unique and complements the effect of different antihypoxants and antioxidants on metabolic processes. It contributes to the resumption of stocks not only ATP and creatine phosphate energy-intensive materials, but also a wide range of enzymes of the respiratory chain enzymes to liver detoxifying systems. Clinically proven its potentiating effect on the basic therapy a variety of diseases.
The incidence of side effects: Very common (more than 10%); frequently (10.1%); infrequently (0.1-1%); rare (0.01-0.1%); very rare (<0.01%, including isolated cases with unknown frequency).
On the part of the central nervous system: very often - headache, facial flushing, insomnia, anxiety; very rarely - paresthesia, convulsions.
From the CCC: rarely - increased blood pressure, tachycardia.
From the digestive system: rarely - nausea, vomiting, discomfort in the stomach and liver.
Allergic reactions: often - urticaria, allergic conjunctivitis, allergic rhinitis.
In the event of adverse reactions, including not listed above, you should reduce the dose or stop taking the drug and notify your doctor.
250 mg (1 capsule. 250 mg or 2 capsules. 125 mg), 2 times a day. If necessary, the daily dose is increased to 750 mg (500 mg - 250 mg in the morning and - after lunch), patients weighing over 80 kg - 1000 mg (500 mg 2 times a day). The course of treatment - 5 days. Depending on the effect of treatment on average spend 2-3 courses (at least - 1 and 4-6), in order to avoid accumulation of the drug, it is advisable to do a two-day break between courses.
To improve performance in extreme conditions take medication for 40-60 minutes before the upcoming activity at a dose of 500-750 mg. With continued work readmission produce in 6-8 hours at a dose of 250 mg. The maximum daily dose - 1500 mg, and the next day - 1000 mg.
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