Best painkillers for Headache and Migraine

Headache (cephalalgia) is one of the most common complaints received by a physician and neurologist. The most common types are migraine and tension headache. However, most people do not consider this a symptom of something serious and prefer to solve the problem with the help of painkillers broad spectrum or specific drugs for migraine.

Causes of headache
Headache can occur for various reasons: from nervous strain, pressure changes, injuries, inflammatory diseases to sunstroke, or tumor. Experts identify primary cephalgia, which refers to the independent neurological disorders, and secondary, associated with certain pathological processes in the body. You can also like Semax.

Primary headaches. These often include migraine and tension headaches. The first type can be identified by encircling the head and compression cephalgia varying intensity. There is due to overexertion, stress or problems in the cervical spine. If the pain is localized in one half of the head, extending to the temples and forehead, as well as supplemented by symptoms such as nausea, photophobia, aggravation of smell, then it is likely a migraine - chronic neurological condition that occurs due to disturbances in the structures brain. For primary cephalgia also include cluster headaches that are characterized by piercing or burning sensation, appearing in series of attacks of intense pain, often in the eye area. But this condition is rare.

Secondary headaches. This cephalalgia may be associated with vascular disorders, such as vascular dystonia. Headache is throbbing with the character, moving in long bouts of aching. The feeling of "fullness" inside the head is typical for liquorodynamic cephalgia caused by changes in intracranial pressure. Infectious diseases can also cause headaches, which often appears a few days before the rest of the symptoms. Cephalalgia can occur due to exposure to toxins, such as drugs after administration, large amounts of alcohol, with a concentrated household cleaning products, paints and others.

Cure for headaches and migraines
If cephalalgia caught by surprise, and you need as soon as possible to cope with the pain, come to the aid of modern tablets NEXT head. This combined OTC analgesic in the form of tablets, has a marked and rapid analgesic effect by combining two proven ingredients - paracetamol and ibuprofen.

The principle of action of paracetamol is unique. It affects pain and thermoregulatory centers in the brain, but also has an effect on the spinal cord level. This allows the drug to quickly overcome the pain and have a pronounced analgesic action.

Note that paracetamol is recognized by the World Health Organization reference ratio analgesic efficacy and safety.

Also contained paracetamol ibuprofen representing NSAID in a formulation NEXT. Ibuprofen is capable of acting on the "periphery" of pain, contributing to rapid suppression of pain and inflammatory processes that cause them. Ibuprofen is included in the list of essential medicines.

NEXT preparation feature is that it combines the two elements discussed above. Pills head NEXT helps to quickly remove not only migraine but also other kinds of pain. They can become a reliable assistant for the young and dynamic people, who value every minute of their lives.

These tablets of pain in the head have directed action by two complementary components. NEXT This provides rapid and pronounced effect. Shortly after taking the medicine, you may feel relieved. The use of this drug NEXT helps to quickly get rid of the discomfort.

If the question arises, what to drink a pill for a headache, look for a proven tool - NEXT. It is necessary to take one tablet. The maximum dose of three tablets per day. Duration of treatment as an analgesic should not exceed five days. Next, take the medicine only after consulting a doctor.

Careerists often have mental disabilities

Dr. Doping shared his opinion on how to identify the signs of mental abnormalities in their loved ones and what to do in such cases.

"In this city, everyone is crazy ..." sings gaily in one of the songs. The saddest thing is that, according to my feelings, he is not far from the truth. It only seems that people with mental disorders are sitting in soft wards and consider themselves to be Napoleons. And if you do not hide the brain from the Martian rays, then with you everything is OK. In fact, headaches that affect mood, cognitive abilities and an adequate assessment of the world around them can affect everyone. Psychiatrists are sure that in European culture, fixated on achievements and victories, mental disorders manifest themselves more often. But do not be reassured by the fact that we live in Asia.
For some reason, when a patient's arm is broken, the question of going to the doctor or "dissolving himself" does not arise. I can not understand why patients with severe depression for months, or even years, are suffering, do not go to the doctor?

It is clear that on the one hand the disease attacks the will, which is so necessary in the fight against it, and on the other hand, it is difficult for a person to assess his inner feelings, he himself is not able to see the malfunction in his behavior. But the saddest thing is that the people around him are embarrassed about saying this! Being somehow at one of the meetings, I clearly understood that something was wrong with the partner, moreover, I knew exactly what was wrong. On leaving, he asked his colleague: "Does it seem to me alone?" - "No, you, many people notice. But we do not know how to invite him to go to a specialist, sort of how we blame him for being crazy. " Excellent! Here we would "be accused of having cancer"! We sympathize with those who are sick with ARVI and silently giggle or resent those who have a broken psyche. Severe psychosis. Moreover, we make diagnoses to those who, for example, have red-blue hair, but for some reason do not pay attention to the fact that our close person still go to a restaurant, spend an evening with a loved one, lie for three days on the couch or step In the window. Do not forget take Mildronate for better results.

In order for us to begin to be more attentive to others, I will tell you a little about those disorders that are most often encountered in people in the city.

And I will start with the Asperger syndrome, which is also called "social color blindness."

Not because it is the most common. Maybe because he himself worked for a long time with the people who are most exposed to him - techies and IT-specialist. They have narrowly focused interests, it is important for them to understand the algorithm of everything, they have difficulty empathy, and they look extremely unfriendly. "What do you want, a computer expert." Some people manage to come up with a manual to work with them, but in most they avoid. And they do not hurry to you. If you are so, take a closer look at the strange surrounding - they are so curious!

But just the opposite story - creatives. They give energy as if in portions. Today he is a workaholic, tomorrow it is impossible to lift him from the sofa. Portional energy is spread to sleep, appetite, mood, sex. They need those who can get along with their strange splashes, and in return can give a wide range of sensations. And all this is called bipolar disorder.
Recently, more and more articles I see on the topic "if you are a sociopath." Here again there is a mistake from incompetence. Sociopath is not someone who does not like hanging out. The sociopath usually does not have anything against being in the team, if this can be of use to him.

This is a kind of frustration that hits not so much over the bearer as by the people around him. A symptom of sociopathy is the almost complete absence of feelings of guilt, empathy, and remorse. Turning into a maniac is not necessary, but a hard manipulator will grow out of a sociopath easily. Yes, everyone knows such superiors. It is because they achieve career heights more easily than others.

I have a friend who has everything under control, she works 16 hours a day. But lately it has become increasingly difficult for her to concentrate, her head hurts, everything sleeps worse. True, who is easy now, the crisis. And there's nothing to complain about: the business is on, the family is fine. But for some reason, more often I want to lie down on the floor and die, but first I need to concentrate and finish this report. This is the major depressive disorder. The very thing that almost everyone receives in a bad mood, and with which some individuals can live for years without asking for help. The results of neglect of the disease can be the most tragic. So stop drinking pills on the advice of a pharmacist and TV, and march to a specialist.

Somehow I looked to an old friend, to medicine, nothing to do with. We talked for half an hour, and I realized that
1) winter is close, 2) something is about to happen 3) the catastrophe is close. What happened? There was a generalized anxiety disorder (GAD).

The most terrible thing is that it is difficult to specify the source of the alarm, because it does not threaten him with an immediate catastrophe. Fears are irrational, and you can not simply turn them off by effort of will. We need help from: not to give the alarmist to lose touch with reality and to find logical inconsistencies in his catastrophic forecasts.

Employee, which will be discussed later, lives in the style of noir: black and white, romance-parting. This is not immorality. This is a throw-off between idealization and disappointment, it is a borderline personality disorder. The most interesting stories of fatal love are due to such characters, but in life they can not withstand uncontrolled stress for a long time. Therefore, it is important for someone close to us to keep in constructive relations.

Well, at last one more problem, which is already similar to a mental disorder. With his comedic special effects, forgetful and incapable of concentrating: different socks and a smartphone, forgotten in the refrigerator. From simple absent-mindedness, Attention Deficit Hyperactivity Disorder (ADHD) is characterized by the scale of the disaster and the attendant symptoms: rapid fatigue, hyperactivity and distractibility. Unfortunately, such people often look irresponsible hackers, and sometimes feel themselves to be such. But it's not that they are too lazy to concentrate.
Dear friends! Mental illnesses exist as objectively as asthma or diabetes, with them it is necessary to work without shame and superstition, and with a specialist.

Especially since the diagnosis of a psychiatrist is not a verdict, as is customary in our country. The world of mental illness is a spectrum of disorders of varying degrees of severity. Most of them really lead to persistent remission or learn to live with them if you approach systemic treatment. Remember, it's healthy to be fashionable. Take care of yourself.

Spondylosis of the lumbar spine

To a certain extent, spondylosis and spondyloarthrosis can be considered the next stage in the development of osteochondrosis, when as a result of degenerative changes in the intervertebral discs compensatory calcification begins and the subsequent sprawling of the peripheral parts of the vertebrae in their contact areas.

Spondylosis is manifested primarily in the lower parts of the spine, it can develop quite rapidly and the sprawling of the peripheral parts of the vertebrae can sometimes lead to their complete fusion.

The process of development of degenerative-dystrophic changes in the spine is associated with both physical exertion and disruption of nutrition of the tissues that form the intervertebral joints. These two effects can not be considered separately. The load leads not only to the flattening of the intervertebral disc and excessive load on the vertebral bodies, but also to the development of spasm of the adjacent muscles. As a result, the blood supply and innervation of the affected areas worsen, which further aggravates the functioning of the lumbar spine. The process is moving in a circle, the changes are increasing. The intervertebral disc becomes more and more susceptible to mechanical influence, and the fibrous ring is involved in the process of change. One of the Best Nooropic drug is Semax.

Treatment method Due to the complexity of the disease and the variety of causes that cause it, treatment of spondylosis of the lumbosacral spine is long and complex.

The combination of different types of therapy with exercise therapy can delay the development of the disease, will improve the quality of life of the patient, extend his working life.

In the early stages of the disease, physiotherapy is good. The impact of ultrasound, phonophoresis, and therapeutic mud improves the nutrition of the affected areas of the spine, delaying the dystrophic changes in it. Drug therapy is used to relieve the course of the disease. Applied as anti-inflammatory drugs (diclofenac, ibuprofen, movalis, nise, ketonal), and muscle relaxants (midokalm, flexene).

The chondroprotectors (dona, chondroxide) also have a beneficial effect, now they are sometimes treated with growth hormones (Jintropin, Somatropin) in small doses. In most cases, add Actovegin, Solcoseryl. In some cases, the appointment of sedatives, antidepressants. It is mandatory to take appropriate vitamin complexes.

Aktoveginb Mexidol and other medications contribute to better blood circulation and joint nutrition, stimulates the development of muscles. Physical exercises help to form an additional support for the spine, the spasmodic phenomenon is significantly removed, painful manifestations decrease.

In severe cases, in the presence of individual indications, surgical treatment remains the only effective method. At the same time, the patient's age status, presence of other diseases must be taken into account. Spondylosis of the lumbar spine is a severe chronic disease, difficult to treat. When diagnosing spondylosis or osteochondrosis, treatment should be started as early as possible, scrupulously fulfilling all the doctor's prescriptions. Based on special physical training in combination with medical treatment and physiotherapy, you can stop the development of the disease, avoid deterioration of well-being.

About insulin-like growth factor and insulin

The fat burning properties of IGF-1 result from the fact that it blocks the transport of insulin glucose through the cell membranes, thus forcing the body to switch to an alternative energy source - fat. However, clenbuterol (to a lesser extent) and metformin (to a greater extent - not only in relation to clenbuterol, but also to IGF-1) do the same. In my opinion, the combination of clenbuterol with metformin is superior in strength (meaning burning fat) to insulin-like growth factor. At the same time, growth hormone can significantly increase the fat burning effect of IGF-1 (most likely due to a significant prolongation of the half-life of IGF-1). You can also like Semax.

Blocking the transport of glucose through the membranes of muscle fibers also has a downside - glycogen stores in muscles quickly run out and do not replenish, which ultimately leads to a visual reduction in muscle size and a very specific loss of endurance. In order to eliminate these unpleasant consequences, in parallel with injections of IGF-1 injections of insulin are made. In the "every other day" scheme (insulin injections are made simultaneously with IGF-1 injections every second day), there is no decrease in endurance, and with daily injections, endurance is even increased (which, however, is largely to "write off" the action of insulin). In these cases, there is no visual reduction in the size of the muscles (their mass), injections "every other day" even gave a slight increase in muscle mass, although not as significant as one would expect.

It is also believed that insulin somewhat prolongs the half-life of IGF-1, but I do not think that it is so significant to talk about it seriously. It would be interesting to experiment with daily injections of insulin-like growth factor and insulin injections 1-2 times a week. It would be possible to include in this scheme also growth hormone (injections according to the scheme "every other day" or 3 times a week). We will definitely conduct such an experiment.

Growth Hormone and Other Doping in UFC

It's no secret that people from different spheres of life and different sports used these or other drugs that improved their strength / endurance and other characteristics in order to defeat their competitors. Everyone who has a brain understands that the athlete will do anything to win. In this article, we will discuss with you aspects of this issue in the field of UFC, while dispelling unnecessary myths and facts.

What is UFC?
Ultimate Fighting Championship (Russian Absolute Fighting Championship) is a sports organization based in Las Vegas, USA, and conducting fights under mixed rules (also known as MMA - from English MixedMartialArts) in North America, Europe, Asia. Any MMA fighter dreams of getting into this organization one day, as the best fighters participate in it, get the most money and open many doors before the fighter.

In the UFC there are 9 weight categories (starting from 115 pounds and reaching up to 265 pounds), and the rules correspond to the "United Rules of MMA". This organization was born in 1993, and the headquarters is in Lag Vegas.

When you watch the UFC, you can see that there are different disciplines, for example: boxing, karate, judo, muay thai, sambo, wrestling and Brazilian jujutsu. So this sport has been growing for many years and now many halls have in their arsenal the possibility of training and performances in the style of MMA. You can try Phenotropil.

Complicated UFC rules (short description)
The match may end when the fighter demands it, when the fighter is off, or the judge / doctor / coach decides to stop the fight. Also, a fighter can be disqualified for improper reception and so on. When the match is over, three judges announce their points for each round, so the winner is determined.

Check for the presence of doping.
Media resources and politicians are talking a lot about the topic of steroids, and most sports organizations are not behind them, that's why the methods of testing the athlete for the use of pharmacology were invented.

By the way, in 2014, reforms were carried out and, as a result, banned athletes from using HRT, so as a result, some athletes could not even take the medications prescribed to them by the doctor.

However, there were cases of unsuccessful checks on the consumption of steroids, because the organization decided to tighten the rules that were introduced in July 2015. All 585 UFC fighters are subject to random testing. In addition, strict penalties have been imposed, and those who re-burn on the test will be permanently excluded from this organization. There is even a chance of losing titles. Moreover, to make sure that such tests work well, athletes must still pass the third test, so that the organization knows where the fighter lives at any given time, so if the tests are not observed the fighters, then he will be punished / excluded.

Basic doping application
According to former champion UFC Renzo Gracie: "almost every MMA fighter uses steroids, because to be at the level that now and to win, their consumption is simply necessary."

However, not only anabolic steroids are used. Fighters still take estrogen blockers, diuretics, erythropoietin and growth hormone. Moreover, some of the fighters discovered Winstrol and Masteron. But anyway, these two substances are not the only ones used by UFC athletes, as well as positive tests for nandrolone, testosterone, trenbolone and even oral steroids, for example, the superdrill.

Advantages of doping
It's no secret that the fighters want to deftly manipulate their weight. Collect more meat, but do not skip to the next weight category to have a weight advantage in your category. Then it becomes clear why the master and Winstrol are used, as they will help to inhibit estrogen and reduce water retention, while they do not forget about DHT and increase their aggression. Among other things, estrogen blockers and diuretics help a fighter stay in his weight category, so that their use, in this case, is justified. However, the incorrect use of diuretics can greatly dehydrate the body, which will greatly deplete the athlete.

Erythropoietin is used to improve endurance, the reason, I think, is clear, since the fighter wants to defeat the opponent. GH also helps with recovery and trauma. And oral steroids have their own advantage, they quickly leave the human body.

Also there are fighters who were caught with a large concentration of testosterone in the blood. The ratio of testosterone to epitestosterone allows to be 6k1. Anything higher is forbidden. Testosterone is a male sex hormone that can give an advantage to a fighter in the form of strength and aggression.

You can guess about the use of other substances, drops and unesterified hormones that can be used just before the fight, but they are practically impossible to detect.

The history of the captured fighters
Commentator UFC Joe Rogan said that more than half of the fighters use AAS. Interestingly, if we take into account all of the above in this article, it becomes clear that Joe slightly understated consumption among athletes.

Recently, one of the greatest fighters of all time, Anderson Silva, was detained for using masteron and androsterone. The reason for their application, he said, was to recover after a leg injury, but we then understand the real purpose of using them.

At the end of 2014, fighters Keith Berry, Nick Moghaddam and Robert Drysdale were detained for using testosterone and, interestingly, it was not the first shoe of Drysdale.

Peter Halman, Brian Ortega, Kevin Casey and Herman Terrado were caught using the master in 2014. Casey said then that he just wanted to reduce the weight slightly.

It is impossible not to mention women fighters, for example, Christian Santos, who was caught using Winstrol. As a result, she was fined, and the right to speak was frozen for a certain time. Her statement on the use of testosterone was that she wanted to adjust the weight.

In general, there were 5 more arrests in 2014 (not taking into account the increased testosterone in humans), and each year there is at least one detection for the use of an athlete of something. Record year was 2007, then revealed the use of pharmacology as much as 14 athletes. The irony is that those who discovered the use of AAS, they lost their fights. This should make you realize that steroids will not do anything for you, they are not the most important factor during a fight. Although, perhaps, the opponents of these people were more intelligent and lucky, that they did not get caught and that they won the fight.

Endure pain is barbarism

Why suffer pain is barbarism, what are the top 3 reasons for referring to doctors, and why do people eventually have to just "eat tablets" .

Here is a comment I had in one of the social networks: "Mom's strong exhausting headaches. Three years to which only doctors she was born: neurologists, therapists; MRI, ultrasound, etc. No one offered a coherent treatment regimen, unfortunately! I will be glad of any recommendation. "

What kind of recommendation can there be? Of course, we must go to the doctor. And after all this, I will not be surprised at the sarcastic grin on the faces of many. Well, they deserve it. Now let's understand.

Pain in the back, head, joints - this is the top 3 reasons why people turn to doctors. At us the problem of pain of the doctor is engaged for a long time, for this theme groups of enthusiasts are taken, and for some reason there is still no nation-wide approach. Please pay attention to Phenotropil.

There is nothing to be surprised at. After all, we usually have every specialist looking for a patient "his". I call this "psychotherapy". The patient with pain in the chest, for example, from the neurologist moves to the cardiologist, thence to the pulmonologist. It can go on for a long time. At this time the patient stops believing in medicine, the pain does not stop, he gets it, and he does not know what to do with it. When you can not tolerate pain, he begins to heal independently.

And here it is important to understand that the pain itself is not a disease, but a symptom of a disease. That is, we must go from the opposite. Do not stifle the pain with pills and injections, and pain assess and build assumptions about what kind of character it is. And it happens that pain is the only symptom.

How meticulously the doctor will conduct the examinations, will reveal the causes of the pain, determine the disease, the health depends, and sometimes the life of the patient. It is impossible to fully anesthetize a person until we determine the cause of the pain, their localization and type. Therefore, before you fight pain, recommend anesthesia, you need to find out what the body is trying to tell you.
The strangest pain in Russia is the headache. No one takes it seriously. It is not a cause for concern and an excuse for leaving work. Even a joke such is "what is there to hurt, there is also a bone".

People treat the headache themselves. Kilograms drink antispasmodics. A friend of mine says "now we'll eat pills and feel better."

Spasmolytics help someone, some do not. As a result, pain occurs time after time, becomes chronic. If you compare acute pain and chronic pain, then acute pain is a brochure, and chronic is a multi-volume, such as "War and Peace".

Such pain is increasingly manifested, more worried and people begin to drink painkillers more often. As a result, the pain develops into a medicamentally induced: a person takes an anesthetic every day, and the headache arises from the use of drugs. Five tablets of aspirin and ten tablets of citramone, ketanov per day - this is the largest dose in my memory. At the same time, people do not understand that they drink tablets, which already cause a headache.

Some people say: "I do not even consider it". I took a pill - passed, after two hours my head got sick - I took it again. And so for years: we treat ourselves, we earn medication-induced pain. Regarding the reception of tablets, everything is individual, but the general norm, not dangerous for health, is as follows: two tablets of anesthetic per day no more than twice a week.

Or another very common reason for contacting doctors in Russia is chest pain. It can be caused by intercostal neuropathy. Unhappily sighed or turned, there was a mechanical trauma, inflammation and edema, because of this a pain arose. There are many reasons for the pain in the back. Take painkillers or not - today the issue is debatable. But to endure the pain today, I believe, barbarism. How is this possible with a huge arsenal of drugs and an anesthetic technique? Anesthesia, of course, is a personal choice of each: this or that drug has side effects.

Interesting attitude to human pain. It can be formed by three components: perception through the nerve endings, carrying out and interpreting the pain impulse in the brain. All of them are individual, respectively, and the feeling of pain is individual.
There are people who can abstract from suffering, but there are those who focus on them, and thereby strengthen them. If a person wants to experience pain, he will experience it.

These patients are in the competence of psychiatrists. I can assume that we are talking about the reception of pain: if a person is pleased, the perception of pain should provoke endorphins in the brain. That is, an association arises: you get pain - you get pleasure. Violation of the perception of pain, usually associated with a genetic or social factor. It can be an anxiety disorder, stress. The brain does not correctly perceive the pain impulses. Nothing happened to the man, but it hurts.

But they are not crazy, they are unfortunate people, and nobody understands them seriously. Everyone says that they invent illnesses and they need a psychiatrist. But pain is never imagined, pain is a fact.

One of the main problems today is an overestimated expectation of drug therapy. We will eat tablets and all will pass or take place? Not true. Treatment is necessary. And only complex treatment. On the one hand, the doctor must find and eliminate the cause of the ailment, and even surgical intervention is not ruled out. On the other hand, he should strive to reduce the patient's discomfort after the first admission. But for this, of course, you need a doctor.

Jintropin - Myths and reality

Any successful and popular product in our time of global Internetization very quickly overgrew with myths and legends. The product is attributed to both qualities that it does not possess, and absolutely fantastic properties / side effects, which can lead to the use of this product. Myths and legends have not been bypassed by recombinant growth hormone. So, for example, the most horrible of all that happened to hear is the alleged property of growth hormone causing a person to have diabetes.

This is completely untrue, because growth hormone does not have any direct effect on the pancreas. Another fantastic property attributed to Jintropin is the stimulation of the production of antibodies to its endogenous growth hormone. This statement also does not correspond to reality, because the highest level of purification of "Jintropin " (99%) indicates that it is 99% identical to the natural human growth hormone, and in a healthy person, antibodies are not produced on its growth hormone. You can also like Semax.

This indicates that this product could not get into any foreign matter that could cause the appearance of antibodies. Almost all people who are first beginning to be interested in the growth hormone are afraid that the use of the hormone "from the outside" (exogenous hormone) will cause the hormone to cease to stand out and the person will become dependent on the exogenous hormone. This is also a misconception, because a person's development of his growth hormone is largely dependent on his lifestyle.

A person who sleeps a little, poorly eats and leads a sedentary lifestyle (do you recognize the average office worker?), The development of his growth hormone will occur irregularly and in completely different amounts. As soon as a person allows himself to sleep - at this point he will be recorded the highest concentration of growth hormone. It has been repeatedly proved that after application of " Jintropin " the allocation of its growth hormone will be restored by the body in full in the first few days after the last injection. So there is no question of any dependence and hormone replacement.

How to understand that growth hormone works?

Recombinant growth hormone in the first days of reception is not felt at all. It's about the highest, unique degree of purification of Jintropin. Thanks to which our body reacts to it, as to its own growth hormone produced by the pituitary gland.

Also, this degree of purification ensures that the body does not develop antibodies to the drug, which completely eliminates the addictive effect. A few days later, you will most likely experience a "tunnel" or rehimost of joints. Those. Your fingers and knuckles are felt like strangers. In fact, most of those who use growth hormone in dosages of up to 10 units. The day it does not feel. You can try Phenotropil.

The main effects you will see in the mirror and feel during work with the training weights in the hall. They will increase significantly, and old injuries will stop worrying. The very same form will begin to improve significantly due to fat loss and increased muscle fullness, this will be noticeable in the mirror. All this suggests that growth hormone works.

What you not know about peptide hormones?

What you did not know about peptide hormones

When the amino acids are combined into a chain, a linear protein macromolecule is formed. In any living organism, there are thousands of proteins that perform a variety of functions. In order to give an idea of the variety of proteins, a general view of molecules (with respect to the shape and size) of a number of extracellular and intracellular proteins is given in the scheme with an increase of about 1 x 1500000. The functions performed by proteins are distributed approximately as follows:

- Structure-forming functions.
Structural proteins are responsible for maintaining the shape and stability of cells and tissues. As an example of a structural protein, a fragment of the collagen molecule is presented on the diagram. At a given scale, an entire collagen molecule measuring 1500000-300 nm would occupy three pages. Structural proteins can also include histones, the function of which is the organization of DNA packing in chromatin. Chromatin structural units, nucleosomes, consist of an octameric complex of histones on which a DNA molecule (DNA) is wound.

- Transport functions.
The most well-known transport protein is hemoglobin of erythrocytes (left bottom), responsible for the transfer of oxygen and carbon dioxide between the lungs and tissues. The blood plasma contains many other proteins that perform transport functions. Thus, prealbumin tolerates thyroid hormones - thyroxine and triiodothyronine. Ionic channels and other integral membrane proteins transport ions and metabolites through biological membranes.

- Protective functions.
The immune system protects the body from pathogens and foreign substances. The key component of this system is immunoglobulin G, which forms a complex with membrane glycolipids on erythrocytes.

- Regulatory functions.
In biochemical signal chains, proteins function as signaling substances (hormones) and hormonal receptors. As an example, a growth hormone (somatotropin) complex with an appropriate receptor is provided herein. In this case, the extracellular domains of two receptor molecules bind one molecule of the hormone. Binding to the receptor activates the cytoplasmic domains of the complex and thereby provides for further signal transmission. In the regulation of metabolism and the processes of differentiation, DNA-associating proteins (transcription factors) play a decisive role. The structure and functions of protein-activators of catabolism and other bacterial factors of transcription have been studied in detail.

- Catalysis.
Among the 2000 known proteins, the most numerous group is made up of enzymes. The lowest molecular weight of them are mol. Weight 10-15 kDa. Proteins of medium size, such as those listed on the alcohol dehydrogenase scheme, have a molecular mass of 100-200 kDa. The molecular weight of high molecular weight enzymes, which includes glutamine synthetase, built from 12 monomers, can reach 500 kDa.

- Motor functions.
The interaction of actin with myosin is responsible for muscle contraction and other forms of biological mobility. The myosin hexamer (left), 150 nm long, is one of the largest proteins. Filament actin (F-actin) is formed by polymerizing relatively small molecules of globular actin (G-actin). The reduction process is controlled by the associated with F-actin tropomyosin and other regulatory proteins.

- Spare functions. The plants contain spare proteins, which are valuable nutrients. In animal organisms, muscle proteins serve as reserve nutrients that are mobilized when absolutely necessary.

2) A significant increase in growth hormone is found during sleep (regardless of the time of sleep, be it at night or in the daytime).

3) As soon as a person falls asleep, the growth of production of this hormone is fixed.

4) During sleep, the greatest release of growth hormone is observed in the first 2 hours. On the basis of the second, third and fourth thesis, we can conclude that the recommendation to sleep at least 2 times a day has a serious biological justification. Daytime sleep (1-2 hours) leads to a marked increase in the secretion of growth hormone. The more once a day you sleep, the higher the hormonal background. You can also like Honluten.

5) Myth is the opinion that at night the muscles are destroyed allegedly due to catabolism. This myth gave birth to the following fiction about the need for a night snack. In fact, at night, the secretion of growth hormone at a height, which increases muscle anabolism (as well as body length growth in young years). At the same time, under the influence of the secretion of growth hormone, the main energy exchange is carried out at the expense of fats, and not carbohydrates and proteins (as in the day). Therefore, nocturnal catabolism is observed only in adipose tissue, but not muscular. At night, muscles feed on fatty acids from fat stores that do not allow muscle fibers to break down, and no night snack is needed for this. For the same reason, there is not much point in snacks before going to bed. This need has been established in the minds of athletes thanks to marketers who have untwisted casein protein. Moreover, food before bedtime, as a rule, prevents timely sleep and a good sleep.

6) Growth hormone is stimulated by protein nutrition. The more proteins, the higher the production of the hormone. The secretion of growth hormone is higher the faster the protein products enter the blood. We are talking about the so-called fast proteins - powdered proteins, boiled egg whites, lean fish, low-fat cottage cheese, skim milk. The production of growth hormone is inhibited, the more in the diet of fast carbohydrates (confectionery, sweets, fresh white bread, etc.) and saturated fatty acids (bad fats). Therefore, do not use fast carbohydrates and fatty foods before bedtime, when a surge of this hormone is expected. This is what is known to date reliably. However, the influence of nutrition on the production of growth hormone also has conflicting facts. In particular, according to one scientific study, the daily secretion of growth hormone is lower with rare meals (2-3 times a day) compared with frequent fractional meals. According to other scientists, a long period between meals (we are talking about periodic starvation) is a powerful stimulant for the release of growth hormone. In general, this issue remains open.

7) The synthesis of growth hormone is enhanced by training with weights. In principle, any intensive physical work - sprinting, fast cycling, swimming, etc. - can increase the release of this hormone. If we talk about bodybuilding, then the so-called anaerobic training (heavy weights for 8-12 repetitions) surpasses the aerobic power (relatively light weights by 15 and higher repetitions) and pure power (maximum and submaximal weights by 1-5 repetitions) to stimulate the release of the hormone Growth. On the contrary, strength training best activates the production of testosterone, the most important anabolic hormone. One should not forget that prolonged training inhibits the secretion of any anabolic hormones, including growth hormone. Therefore, do not exercise for more than an hour, especially if you have a lower level of this hormone.

8) The secretion of growth hormone depends on age. At the age of 20-25 years it is maximal. Then there is a gradual decrease in the secretion of this hormone. The lowered level of growth hormone in middle and older age is one of the reasons for the appearance of excess weight and the gradual degeneration of muscle fibers. For the same reason, to fight excess weight and to grow muscle is more difficult than the older person.
Conclusion. Sleep, nutrition and exercise are the most important factors in the active secretion of growth hormone. The raised hormonal background is a pledge of a muscle anabolism and absence of muscular catabolism.

Grindeks is working to create new combinations Mildronate. What's Meldonium

The manufacturer of the drug Mildronate company "Grindeks" is working on the creation of new Mildronate - Meldonium combinations, as well as on the development of another 20 products.

According to the "Grindeks" strategy, new products will be placed on the market gradually, so that annually replenish the portfolio at least 4 new medicines.

Clearly, the new original products, we need to bring to the market as soon as possible, to their term of patent protection has been as long as possible; in turn, bringing generic drugs, we need to be on the market one of the first to be able to use all the competitive advantages.