Antidepressant: Transaminum (Transamin)
Active ingredient: Tranylcypromine (tranylcypromine)
Tranylcypromine belongs to the group of so-called MAO inhibitors. This drug has a pronounced stimulating effect, as well as a clear antidepressant effect. Despite the fact that tranylcipromine is a rather powerful drug, it does not have a toxic effect on the liver, and it also exhibits comparatively low side activity. This is due to the fact that the drug has a very short time at the MAO - about 12 hours. A noticeable effect is already on the 2nd-5th day of treatment.
First of all, Transamin (tranylcypromine) helps to overcome such unpleasant components of depression as inhibition, lack of initiative and lethargy due to a stimulating effect. Thus, the patient receives the necessary energy boost, and his mood improves significantly. With the right dosage, tranylcypromine is well tolerated, and therefore it is successfully used in the treatment of somatogenic depressions in patients suffering from somatic diseases.
Indications for use: - treatment of depressive conditions of different nosological affiliation.
Contraindications: Individual intolerance, as well as simultaneous intake of other antidepressants (including other MAO inhibitors) and stimulant drugs (such as phenamine, sydnocarb, etc.).
Dosage and administration: Tranylcypromine taken internally. The recommended initial dose is 5-10 mg / day. The dose should be divided into two doses: morning and evening. Dosage gradually increases at a rate of 5-10 mg every 2-3 days. The average therapeutic daily dose is 25-40 mg. If necessary, it can be increased to 60 mg / day and even more.
Once a distinct antidepressant effect is achieved, the dosage should be slowly reduced, taking 5 mg less every 3-5 days. In addition, a method of shock doses is possible. In this case, the drug is taken immediately in an amount of 25-30 mg / day. Then the dose should be gradually reduced (every 5-10 days).
Tranylcypromine can be prescribed together with neuroleptic drugs. So, for the treatment of schizophrenic depressions, its combination with triftazine (10 parts of tranylcypromine and 1 part of triftazine) is very effective. In addition, this combination is often used in the fight against involuntary melancholy.
Side effects: Properly dosed intake of the drug does not lead to complications and serious side effects. With individual intolerance, as well as in case of an overdose, tranylcypromine gives a side effect inherent in all MAO inhibitors.