GRF(1-29) - Sermorelin

GRF(1-29), is issued under a trade name Sermorelin - the peptide stimulating growth hormone secretion concerns to the GHRH group. Has a short half-life period in an organism, about several minutes that isn't enough for the maximum rise in concentration of hormone of growth.

For increase in stability and the period of semi-destruction the sequence of GRF(1-29) included in addition 4 amino acids. This structural modification increased action duration up to 30 minutes that is quite enough for achievement of long effect and stimulation of peak secretion of hormone of growth. This form also often is called as the tetrareplaced GRF(1-29) or modified and is very often confused to CJC-1295. If to draw an analogy to anabolic steroids, then tetroreplaced of GRF(1-29) represents a propionate testosterone analog, and CJC-1295 - testosterone of an enantat.

Structure

GRF (1-29) or Sermorelin (Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-NH2) - biologically active part consisting of 44 GHRH amino acids = elimination half-life less than 5-10 minutes

Mod GRF (1-29) or tetrareplaced 2nd, 8th, 15th and 27th amino acid in the sequence of GRF (1-29): (Tyr-DAla-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-NH2) = period of semi-destruction of 30 minutes

Upon peptide purchase surely specify "attention", the tetrareplaced (modified) this form or not.

Often tetroreplaced GRF(1-29) is called also by CJC-1295 without DAC (Drug Affinity Complex - a special complex which increases action duration up to several days due to communication with proteins of plasma)

For creation of more convenient last long GHRH form substance under the code of CJC-1295 was created. This peptide is similar in structure to the considered tetrareplaced GRF(1-29), excluding the fact that amino acid a lysine which is connected with a molecule of so-called "Drug Affinity Complex (DAC)" was added to the sequence. This complex allows to contact to peptides albumine of blood and increases the semi-destruction period up to 1-2 weeks. By analogy with testosterone, this form can be compared to testosterone tsipionaty. Some information about Phenotropil.

Course

The modified GRF (1-29) is used most often in a dose of 100-200 mkg, intramuscularly, injections are carried out 1-3 times a day intramuscularly or hypodermically.

For achievement of the maximum synergy effect it is strongly recommended to combine with GHRP (for example, GHRP-6 or GHRP-2):

GRF (1-29) 100-200 of mkg

GHRP-6 or GHRP-2 100 mkg

Peptides are dissolved in 1-2 ml of water for injections (it is possible to use 1 syringe) and 1-3 times a day intramuscularly are entered.

The best time for injections: in 15 minutes prior to food, after the training, before going to bed.

Duration of a course is 6-12 weeks.

Storage and preparation

It is necessary to cool a bottle to room temperature then to enter the required water volume for injections (which has to flow down on a bottle wall) and to stir the rotating movements (not to shake). The solution received by means of water for injections remains stable for only 8-10 days in the refrigerator. If to use bacteriostatic water, duration of storage increases up to 30 days in the refrigerator. It is better for Mod GRF 1-29 to dissolve only by means of bacteriostatic water. The received solution can't be frozen.