DR. DOPING

Instructions

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Instructions / Instruction for use: Tamoxifen-Ebewe

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Active substance Tamoxifen

ATX code L02BA01 Tamoxifen

Pharmacological groups

Estrogens, gestagens; Their homologues and antagonists

Antineoplastic hormonal agents and hormone antagonists

Nosological classification (ICD-10)

C49 Malignant neoplasm of other types of connective and soft tissue

Leiomyosarcoma, Angiosarcoma, Rhabdomyosarcoma, Rabdosarcoma, Soft tissue sarcoma, Embryonic rhabdomyosarcoma, Metastatic squamous cell carcinoma of the soft tissues of the head and neck

C50 Malignant neoplasm of breast

Cancer of the nipple and areola of the breast, Breast carcinoma, The hormone-dependent form of recurrent breast cancer in women in menopause, Hormone-dependent breast cancer, Disseminated breast carcinoma, Disseminated Breast Cancer, Malignant breast cancer, Malignant neoplasm of breast, Contralateral breast cancer, Locally advanced or metastatic breast cancer,Locally-distributed breast cancer, Locally-recurring breast cancer, Metastatic breast carcinoma, Metastasis of breast tumors, Metastatic breast carcinoma, Inoperable breast carcinoma, Incompatible breast cancer, Breast cancer in women with metastases, Breast cancer in men with metastases, Breast Cancer, Breast cancer in men, Mammary cancer, Breast cancer with distant metastases, Breast cancer in postmenopausal women, Breast cancer hormone-dependent, Breast cancer with local metastases, Breast cancer with metastases, Breast cancer with regional metastases,Breast cancer with metastases, Common hormone-dependent forms of breast cancer, Common Breast Cancer, Recurrent Breast Cancer, Recurrence of breast tumors, Breast cancer, Estrogen-dependent breast cancer, Estrogen-Dependent Breast Cancer, Disseminated breast cancer with overexpression of HER2, Tumors of the mammary glands

C54 Malignant neoplasm of uterus

Uterine cancer, Cancer of the body of the uterus, Sarcoma of the uterus

C64 Malignant neoplasm of kidney, except for renal pelvis

Wilms swelling, Kidney Cancer, Metastatic Renal Cell Carcinoma, Renal carcinoma, Inoperable kidney carcinomas, Metastatic kidney carcinoma, Metastatic Renal Cell Carcinoma, Wilms tumor, Wilms swelling, Adenomyosarcoma, Adenomyocystosarcoma, Adenosarcoma of the kidney, Kidney Cancer, Common renal cell carcinoma, Nephroblastoma, Nephroma, Embryonal nephroma, Recurrent carcinoma of the kidney, Birch-Hirschfeld Tumor, Common renal cell carcinoma, Tumors of the kidney

Composition and form of release

1 tablet contains tamoxifen citrate 10, 20, 30 or 40 mg; In contour acheikova packing 10 pcs. (10, 20 mg), in a cardboard bundle 3 packages, or in a plastic container 30 pcs. (30, 40 mg), in a cardboard bundle 1 container.

pharmachologic effect

Pharmacological action - antitumor, antiestrogenic.

Competitively blocks estrogen receptors in target organs and thus inhibits tumor growth stimulated by estrogen.

indications

Breast cancer, endometrium, kidney; Soft tissue sarcoma.

Contraindications

Hypersensitivity, severe thrombocytopenia, leukopenia, hypercalcemia, pregnancy, breast-feeding.

pregnancy and lactation

Contraindicated. At the time of treatment should stop breastfeeding.

Side effects

Nausea, vomiting, redness and dryness of the skin, dizziness, headache, drowsiness, depression, pain in the bones and foci of the lesion, itching in the genital area, vaginal bleeding, swelling, alopecia, visual disturbances, thromboembolism, phlebitis. In very rare cases - changes in the picture of blood, an increase in the ovaries, violations (until the termination) of the menstrual cycle.

Interaction

Cytotoxic drugs increase the risk of thrombosis.

Dosing and Administration

Inside, washed down with water, 10-20 mg 2 times a day, for 2-3 years.

Precautionary measures

Before starting treatment, patients should undergo gynecological (to exclude pregnancy) and therapeutic examination; Women of childbearing age should use reliable contraceptives (not oral), and contraception should continue for 3 months after the end of the course. In the treatment should periodically monitor the calcium content in the blood, the picture of the blood (leukocytes, platelets). Special care and careful observation is necessary in patients with kidney pathology, diabetes mellitus, ophthalmic diseases and thromboembolic disorders (even in the anamnesis).

storage Conditions

In dry, the dark place at a temperature of no higher than 25 ° C.

Keep out of the reach of children.

Shelf life

3 years.

Do not use after the expiry date printed on the package.

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