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Active substance Tiaprofenic acid

Pharmacological group

NSAIDs - Propionic acid derivatives

Nosological classification (ICD-10)

G54.1 Disorders of lumbosacral plexus

Sciatica, Neurology radicular origin, spine Pathology, Sciatica lumbosacral, radiculoneuritis

M00-M25 Arthropathy

M05 Seropositive rheumatoid arthritis

Rheumatoid arthritis seropositive

M15-M19 Osteoarthritis

M45 Ankylosing spondylitis

Ankylosing spondylarthrosis, Marie-Strumpel disease, Ankylosing spondylitis, Pain syndrome in acute inflammatory diseases of the musculoskeletal system, Pain syndrome in chronic inflammatory diseases of the musculoskeletal system, Bechterew's disease, Ankylosing spondylitis, Diseases of the spinal column, Rheumatic spondylitis, Bechterew-Marie-Strumpel disease

M54.3 Sciatica

Ishialgia, Neuralgia of the sciatic nerve, Sciatic neuritis

M65 Synovitis and tendosynovitis

Acute tenosynovitis, Tendovaginitis (tenovaginitis), Tendosinovit (tenosynovitis), Tendovaginitis, Osteoarthritis in musculo-articular diseases, Inflammatory disease of soft tissues, Nonspecific tenosynovitis, Tendosinovit

M71 Other bursopathies

Bursitis, Bursopathy, Diseases of soft tissues, Osteoarthritis in musculo-articular diseases, Inflammatory disease of soft tissues, Subacute bursitis

M77.9 Other unspecified

Capsule, Periarthritis, Tendonitis, Tendopathy, Periarthropathy

R52.2 Other constant pain

Pain syndrome, rheumatic origin, Pain at vertebral lesions, Pain in the chamber, Pain for burns, Pain syndrome weak or moderate, Perioperative pain,Moderate to severe pain, Moderately or weakly expressed pain syndrome, Moderate to severe pain, Ear pain of otitis, Neuropathic pain, neuropathic pain

Z100 * CLASS XXII Surgical practice

Abdominal surgery, adenomectomy, Amputation, Coronary angioplasty, Angioplasty of the carotid arteries, Antiseptic skin treatment for wounds, Antiseptic Hand, Appendectomy, atherectomy, Balloon coronary angioplasty, Vaginal hysterectomy, The coronary bypass, Interventions in the vagina and cervix, Interventions on the bladder, Intervention in the mouth, Restoration and reconstructive surgery, Hand hygiene of medical personnel, Gynecologic surgery, Gynecological intervention, Gynecological surgery, Hypovolemic shock during operations, Disinfection of purulent wounds, Disinfection of wounds edges, Diagnostic intervention, Diagnostic procedures, Cervical Diathermocoagulation, Long-surgery, Replacing the fistula catheters, Infection in orthopedic surgery, Artificial heart valve, cystectomy, Short-term outpatient surgery, Short-term operation, Short surgical procedures, Krikotireotomiya, Blood loss during surgery, Bleeding during surgery and in the postoperative period, Kuldotsentez, laser photocoagulation, laser coagulation, retinal laser coagulation, Laparoscopy, Laparoscopy in Gynecology, CSF fistula, Small gynecological operations, Small surgical procedures, Mastectomy and subsequent plastic, mediastinotomy, Microsurgical operations on the ear, Mukogingivalnye operation, suturing, Minor surgery, neurosurgical operation, Immobilization of the eyeball in ophthalmic surgery, testectomy, pancreatectomy, Perikardektomiya, The period of rehabilitation after surgery, The period of, convalescence after surgery, Percutaneous transluminal coronary angioplasty, Pleural thoracentesis, Pneumonia postoperative and posttraumatic, Preparation for surgical procedures, Preparation for surgery, Preparation of the surgeon's hands before surgery, Preparation of the colon for surgical procedures, Postoperative aspiration pneumonia in neurosurgical and thoracic surgery, Postoperative nausea, Postoperative bleeding, postoperative granuloma, postoperative shock, The early postoperative period, myocardial revascularization, Radiectomy, gastric Resection, bowel resection, uterine Resection, liver Resection, enterectomy, Resection of part of the stomach, Reocclusion of the operated vessel, Bonding tissues during surgical procedures, Removal of sutures, Condition after eye surgery, Condition after surgery, Condition after surgery in the nasal cavity, Condition after gastrectomy, Status after resection of the small intestine, Condition after tonsillectomy, Condition after removal of the duodenum, Condition after phlebectomy, Vascular surgery, Splenectomy, Sterilization of surgical instruments, Sterilization of surgical instruments, sternotomy, Dental surgery, Dental intervention in periodontal tissues, strumectomy, Tonsillectomy, Thoracic surgery, total gastrectomy, Transdermal intravascular coronary angioplasty, Transurethral resection, Turbinektomiya, Removal of a tooth, cataract surgery, Removal of cysts, tonsillectomy, Removal of fibroids, Removing the mobile primary teeth, Removing polyps, Removing broken tooth, Removal of the uterus body, Removal of sutures, Urethrotomy, Fistula likvoroprovodyaschih ways, Frontoetmoidogaymorotomiya, Surgical infection, Surgical treatment of chronic limb ulcersm, Surgery, The surgery in the anal area, The surgery on the colon, Surgical practice, The surgical procedure, Surgical interventions, Surgery on the gastrointestinal tract, Surgical procedures on the urinary tract, Surgical procedures on the urinary system, Surgical intervention of the genitourinary system, Surgical procedures on the heart, Surgical manipulation, surgery, Surgery on the veins, Surgical intervention, Vascular surgery, Surgical treatment of thrombosis, cholecystectomy, Partial gastric resection, transabdominal hysterectomy, Percutaneous transluminal coronary angioplasty, Percutaneous transluminal angioplasty, Coronary artery bypass, tooth Extirpation, Extirpation of milk teeth, pulpectomy, pulsative cardiopulmonary bypass, tooth Extraction, teeth Extraction, cataract extraction, Electrocoagulation, endourological intervention, episiotomy, Etmoidotomiya, Complications after tooth extraction

Composition and form of release

1 tablet or adult suppository contains tiaprofenic acid 300 mg; in the blister 10 pcs., in the box 4 blisters (table) and in the blistere 6 pcs., in the box 1 blister (supp.).

1 bottle with powder for injection - 200 mg; complete with a solvent (benzyl alcohol and water for injection) in ampoules of 3 ml.

pharmachologic effect

Pharmacological action - anti-inflammatory, antipyretic, analgesic.

Oppresses the activity of cyclooxygenase, reducing the synthesis of PG.


After applying 1 supp. (300 mg) Cmax is achieved after 4 hours, after 1 hour it ranges from 19 to 26 μg / ml. 98% binds to plasma proteins (mainly with albumins). With the / m and / in the introduction of assimilated by 100%. 60% is excreted by the kidneys in the form of glucuronide.

Cmax after taking 1 table. (300 mg) reaches after 1 hour and is 49 μg / ml. T1 / 2 - 1-2.5 h. 98% binds to plasma proteins. 60% is excreted through the kidneys in the form of glucuronide.


Rheumatoid arthritis, ankylosing spondylitis, osteoarthritis, diseases and injuries of the periarticular soft tissues (capsulitis, bursitis, tendonitis, humeroscapular periarthritis, epicondylitis, fibrositis, etc.), lower back pain, radicular syndrome, orthopedic surgery (postoperative pain syndrome and inflammation) .


Hypersensitivity, peptic ulcer of the stomach and duodenum (including in the anamnesis), bronchial asthma (provoked by drugs suppressing the synthesis of PG), pronounced violations of the kidney and / or liver, children's age (up to 3 years).

pregnancy and lactation

Not recommended in I and III trimesters.

Side effects

Nausea, vomiting, epigastric pain, diarrhea, erosive and ulcerative gastrointestinal disorders, gastrointestinal bleeding, changes in functional liver samples, bronchospasm, tinnitus, dizziness, hypotension, sodium and water retention, dysuric phenomena, cystitis, hematuria, thrombocytopenia, photosensitivity, itching, rash.


Reduces the effect of antagonists of vitamin K, hypoglycemic (sulfonylurea derivatives), phenytoin, diuretics.

Dosing and Administration

Tablets: Inside, adults - 300 mg 2 times a day during meals; children (over 3 years) - 10 mg / kg / day in 2-3 hours.

Suppositories: rectally, adults - 1 supp. (300 mg) 2 times (morning and evening) or once a night; children - 1 soup. (150 mg) 2-3 times a day. The course is from 3 to 5 days.

Powder for injection: in / m, with severe pain, the initial dose is 400 mg, then - 200 mg every 8 hours for 2 days maximum, then inject 200 mg for 4-6 days. Later on they switch to oral intake.

Storage Conditions

In the dark place at a temperature of 8-25 ° C.

Keep out of the reach of children.

Shelf life of the preparation

tablets 300 mg - 5 years.

suppositories 300 mg - 2 years.

Powder for solution for injection 200 mg - 2 years.

Do not use after the expiry date printed on the package.

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