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Instruction for use: Prostin F2-alpha

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Dosage Form: solution for injection

Active substance: Dinoprost*


G02AD01 Dinoprost

Pharmacotherapeutic group:

The generic activity of the stimulant is a preparation of PGF2α [prostaglandins, thromboxanes, leukotrienes and their antagonists]

Composition and release form

Solution for injection 1 ml

Dinoprost (in the form of dinoprost Tromethamine) 5 mg

Auxiliary substances: benzyl alcohol - 9 mg; Water for injection - q.s. Up to 1 ml

In ampoules of 1, 5 or 8 ml; In a pack of cardboard 1 ampoule.


Mode of action - stimulating generic activity.

Dosing and Administration

IV, inside the fetal bladder.

For termination of pregnancy: a deep peri-abdominal puncture of the fetal bladder is made with a suitable sized needle and an amniotic fluid of at least 1 ml is taken, then 40 mg (8 ml) is slowly introduced into the fetal bladder. The first 5 mg (1 ml) is injected very slowly and only if the liquid obtained in puncture is clear (without the admixture of blood). Such precautions allow to reduce the risk of developing anaphylaxis and the probability of a random intravascular injection of the bolus of the drug, which can cause arterial hypertension, bronchospasm and severe vomiting. If an additional 10-40 mg (2-8 ml) is administered within 24 hours after the first dose, the abortion does not begin or end (and also in the presence of an unopened bladder). Continuous administration of the drug for more than 2 days is not recommended.

For induction of labor with full term pregnancy and / or for expulsion of the fetus during its intrauterine death in the III trimester of pregnancy: a solution with a concentration of 15 μg / ml at a rate of 2.5 μg / min is injected into the infusion for 30 minutes (not less). This level can be maintained in the future if it is possible to obtain an appropriate response from the uterus, or you can increase the dose by 2.5 μg / min every hour until a satisfactory response is received from the uterus, but it should not be Exceed the level of 20 μg / min.

If the development of hypertension of the uterus with bradycardia or without fetal bradycardia, the infusion of the drug should be discontinued and assess the situation, and then resume the infusion at a lower rate. If no effect is obtained within the first 12-14 hours, then the drug should be discontinued.

Storage conditions of Prostin F2-alpha

At a temperature of 20-25 ° C.

Keep out of the reach of children.

Shelf life of Prostin F2-alpha

4 years.

Do not use beyond the expiration date printed on the package.

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