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Instruction for use: Hydrotalcite (Hydrotalcitum)

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Pharmacological group


Nosological classification (ICD-10)

K21.0 Gastro-oesophageal reflux with oesophagitis

Reflux gastritis, Reflux esophagitis, Erosive and ulcerative esophagitis

K25 Gastric ulcer

Helicobacter pylori, Pain syndrome in gastric ulcer, Pain syndrome in gastric ulcer and duodenal ulcer, Inflammation of the gastric mucosa, Inflammation of the gastrointestinal mucosa, Benign gastric ulcer, The disease of the stomach and duodenum, asotsiirovannoe with Helicobacter pylori, Aggravation gastroduodenita on the background of peptic ulcer, Exacerbation of peptic ulcer, The aggravation of gastric ulcer, The organic gastrointestinal disease, Peptic ulcer of the stomach and duodenum, Postoperative gastric ulcer, Recurrent ulcers, Symptomatic gastric ulcers, Chronic inflammatory disease of the upper gastrointestinal tract, associated with Helicobacter pylori, Helicobacter pylori eradication, Erosive and ulcerative lesions of the stomach, Erosive lesions of the stomach, The erosion of the gastric mucosa, Peptic ulcer disease, Stomach ulcer, Gastric lesion, Ulcerative lesions of the stomach, Symptomatic ulcers of the stomach and duodenum

K26 Duodenal Ulcer

Pain with duodenal ulcer, Pain syndrome in gastric ulcer and duodenal ulcer, The disease of the stomach and duodenum, asotsiirovannoe with Helicobacter pylori, Exacerbation of peptic ulcer, The worsening of duodenal ulcer, Peptic ulcer of the stomach and duodenum, Relapse of duodenal ulcers, Symptomatic ulcers of the stomach and duodenum, Helicobacter pylori eradication, Erosive and ulcerative lesions of the duodenum, Erosive-ulcerative lesions of duodenal ulcers associated with Helicobacter pylori, Erosive lesions of the duodenum, Duodenal ulcer, Ulcerative lesions of the duodenum]

K29.7 Unspecified gastritis

Gastritis with low acidityá Gastritisá Gastritis with a normal secretory functionáGastritisá Erosive gastritis

K30 Dyspepsia

Fermentation dyspepsia, Hyperacid indigestion, Putrefactive indigestion, Dyspepsia, Dyspepsia, Dyspepsia of nervous origin, Dyspepsia in pregnant women, Dyspepsia fermentation, Dyspepsia putrefactive, Dyspepsia medication, Dyspepsia due to diseases of the digestive system, Dyspepsia due to impaired motility of the gastrointestinal tract, Dyspepsia due to unusual food or overeating, Dyspeptic phenomena during pregnancy, Dyspeptic Syndrome, Gastric indigestion, Delayed emptying of the stomach, Delayed digestion, Idiopathic indigestion, Acid dyspepsia, Disturbance of the upper GI tract motility, Indigestion, Nervous indigestion, Non-ulcer dyspepsia, The feeling of heaviness in the stomach after eating, Postprandial functional dyspepsia, The processes of fermentation in the intestine, Stomach upset, Gastrointestinal disorders, Digestive disorders, Disorders from the digestive tract, Stomach upset, Indigestion disorder, Indigestion in infants, Symptoms of dyspepsia, The syndrome of putrefactive dyspepsia, Syndrome of putrefactive dyspepsia in infants, Syndrome of insufficiency of digestion, Syndrome of nonulcer dyspepsia, Toxic indigestion, Functional dyspepsia, Functional indigestion, Chronic indigestion, Chronic episodes of dyspepsia, Essential dyspepsia, Dyspeptic disorder

K31.8.0 * Atony of the stomach

Diabetic gastroparesis, Atony of the gastrointestinal tract, Hypotension of the stomach, Idiopathic gastroparesis, Medication Gastroparesis, Stomach paresis, Postoperative atony of the stomach, Postoperative hypotension of the stomach, Paresis of the stomach and intestines

R12 Heartburn

CAS 12304-65-3

Characteristics of substance Hydrotalcite

An antacid.


Pharmacological action - antacid, gastroprotective.

Has an astringent and moderate laxative effect. Quickly and continuously (for several hours) neutralizes the hydrochloric acid of gastric juice; maintains the pH at a level close to normal; binds pepsin and increases the activity of the protective factors of the gastric mucosa.

The release of Mg2 + and Al3 + occurs in the stomach gradually, depending on the pH value. Absorbed slightly, mainly in the small intestine. After ingestion, the content of Mg2 + and Al3 + in the plasma temporarily increases, but penetration into the nerve and bone tissue does not occur (with normal kidney function). The absorbed part is excreted by the kidneys.

The effect develops 30 minutes after ingestion and lasts 4-5 hours.

Application of Hydrotalcite

Giperacidnost gastric juice, heartburn, gastritis, peptic ulcer of the stomach and duodenum, reflux-esophagitis, dyspeptic phenomena.


Hypersensitivity, violation of excretory function of the kidneys, children's age (up to 6 years).

Side effects

Belching, constipation; when taken in high doses, diarrhea may occur.


Hydrotalcite reduces the absorption of tetracyclines, fluoroquinolones (ciprofloxacin, ofloxacin), iron preparations, coumarin derivatives, chenodeoxycholic acid, cimetidine and digoxin (the interval between doses should be 1-2 h). Reduces the toxic effect of NSAIDs on the digestive tract.

Routes of administration


Precautions for Substance Hydrotalcite

To achieve high effectiveness of treatment, it is necessary to combine the reception of hydrotalcite with drugs blocking acid production.

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