DR. DOPING

Instructions

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Instructions / Instruction for use: Strepsils intensive

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Active substance Flurbiprofen

ATX code M01AE09 Flurbiprofen

Pharmacological group

Non-steroidal anti-inflammatory drug (NSAID) [NSAIDs - Propionic acid derivatives]

Nosological classification (ICD-10)

J06 Acute upper respiratory infections of multiple and unspecified

Frequent colds viral diseases, Infections of the upper respiratory tract, Acute respiratory disease influenza character, for colds Pain, Acute colds,Cold, respiratory infection,Seasonal colds, Pain in infectious and inflammatory diseases of the upper respiratory tract, Bacterial infections of the upper respiratory tract, Bacterial respiratory infections, Viral disease of the respiratory tract, Viral respiratory tract infections, Inflammatory disease of the upper respiratory tract, Inflammation of the upper respiratory tract disease, Inflammation of the upper respiratory tract illness with difficult sputum, Inflammatory airway disease, Secondary infections with colds, Shortness of sputum in acute and chronic respiratory diseases, Upper respiratory tract infection, Infections of the upper respiratory tract, Respiratory Tract Infections, Infections of the respiratory tract and lungs, Infectious-inflammatory diseases of the upper respiratory tract, Infectious-inflammatory diseases of the upper respiratory tract and ENT-organs, Infectious-inflammatory diseases of the upper respiratory tract in children and adults, Infectious-inflammatory diseases of the upper respiratory tract, Infectious inflammation of the airways,respiratory infection, Qatar upper respiratory tract, Catarrh of the upper respiratory tract, Catarrhal disease of the upper respiratory tract, Catarrhal symptoms of the upper respiratory tract, Coughing with a cold, SARS, ARI, ARI with rhinitis phenomena, Acute respiratory infection, Acute infectious and inflammatory disease of the upper respiratory tract, Acute respiratory disease, Sore throat or nose, Respiratory viral infections, Respiratory diseases, Respiratory infections, Recurrent respiratory infections, Secondary infection with influenza, cold in the chest, Feverish condition with flu usitis, acute sinusitis, genyantritis, purulent sinusitis

R07.0 Sore throat

A sharp pain in the throat, Sore throat

Composition

Tablets for resorption honey-lemon 1 tab.

active substance:

Flurbiprofen 8.75 mg

auxiliary substances: macrogol 300 - 5.47 mg; potassium hydroxide - 2,19 mg; lemon flavor (502904 A) - 3.6 mg; levomenthol - 2 mg; honey - 50.4 mg; sucrose liquid - 1407 mg; dextrose - 1069 mg

Description of dosage form

Round tablets from translucent caramel mass from light yellow to light brown color, with the letter "S" on both sides of the tablet. Air bubbles in the caramel mass and slight unevenness of the edges are allowed. Occurrence of a white touch is possible.

pharmachologic effect

Pharmacological action - anti-inflammatory, analgesic, inhibiting COX (cyclooxygenase).

Pharmacodynamics

The mechanism of action of flurbiprofen is associated with inhibition of the enzymes COX-1 and COX-2 followed by inhibition of the synthesis of PG mediators of pain. Has anti-inflammatory and analgesic effect. The drug has no antimicrobial effect.

The effect of the drug occurs 30 minutes after the beginning of resorption of the tablet in the oral cavity and lasts for 2-3 hours.

Pharmacokinetics

Absorption is high. Communication with plasma proteins is more than 99%. Cmax in plasma is achieved after 30-40 minutes. It is mainly metabolized through hydroxylation and excreted by the kidneys. T1 / 2 is 3-6 hours.

Indications

As a symptomatic tool for alleviating pain in the throat with infectious inflammatory diseases of the oral cavity and pharynx.

Contraindications

hypersensitivity to any of the components of the drug;

Stomach ulcer (exacerbation);

The bronchial asthma and rhinitis on the background of taking acetylsalicylic acid or other NSAIDs;

deficiency of glucose-6-phosphate dehydrogenase;

pregnancy;

lactation period;

children's age (up to 12 years).

With caution: hyperbilirubinemia (including Gilbert syndrome, Dubin-Johnson and Rotor syndrome); chronic circulatory failure; edema; arterial hypertension; hemophilia; hypocoagulation; peptic ulcer of the stomach or duodenum (in remission, in the anamnesis); hepatic and / or renal insufficiency; decreased blood clotting; oppression of bone marrow hematopoiesis; hearing loss; pathology of the vestibular apparatus. When prescribing to the elderly, the use of the drug is possible only after consultation with the attending physician.

Side effects

Adverse reactions related to the use of Strepsils® Intensive are mainly related to distortion of taste perception and elements of paresthesia (burning, tingling or tingling). Possible ulceration of the oral mucosa. Unwanted side effects associated with NSAID drugs may occur when the drug is taken orally at a dose of 50-100 mg 2-3 times a day (12-30 tablets Strepsils® Intensive per day)

On the part of the digestive tract: dyspepsia (nausea, vomiting, heartburn, diarrhea), NSAIDs - gastropathy, abdominal pain, impaired liver function; with prolonged use in large doses - ulceration of the mucous membrane of the gastrointestinal tract, bleeding (gastrointestinal, gingival, hemorrhoidal).

From the CCC: increased blood pressure, tachycardia, heart failure.

From the hemopoiesis: rarely - anemia (iron deficiency, hemolytic, aplastic), agranulocytosis, leukopenia, thrombocytopenia.

From the side of the nervous system: headache, dizziness, drowsiness or insomnia, asthenia, depression, amnesia, tremor, agitation; rarely - ataxia, paresthesia, impaired consciousness.

From the side of the urinary system: tubulointerstitial nephritis, edematous syndrome, impaired renal function.

Allergic reactions: skin rash, itching, urticaria, bronchospasm, photosensitivity, Quincke's edema, anaphylactic shock.

Other: hearing loss, tinnitus, increased sweating.

Interaction

Inducers of microsomal oxidation in the liver (phenytoin, ethanol, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants) increase the production of hydroxylated active metabolites. Reduces the effectiveness of uricosuric drugs, enhances the effect of anticoagulants (increases the risk of bleeding), antiplatelet agents, fibrinolytics, side effects of mineralosteroids and GCS, estrogens; reduces the effectiveness of antihypertensive and diuretics; enhances the hypoglycemic effect of sulfonylurea derivatives. Increases the concentration in the blood of lithium preparations, methotrexate.

Dosing and Administration

Inside. Tablets must be resorbed in the oral cavity until complete dissolution. At resorption, the tablet should be moved all over the oral cavity to avoid damage to the mucosa at the site of absorption.

Recommended for adults and children over 12 years of age by 1 table. as needed. Do not consume more than 5 tablets. within 24 hours. Do not take the pill for more than 3 days.

Overdose

Symptoms: when taken 1 g - drowsiness; more than 1.5 g - excitation; 2,5-4 g - nausea, headache, dizziness, epigastric pain, diplopia, myosis, hypotension; more than 4 g - oppression of consciousness up to a coma. In case of an overdose, stop taking the drug.

Treatment: symptomatic.

special instructions

Patients with diabetes should take into account that the tablet contains about 2.5 g of sugar.

In the case of a combination of pain in the throat with a significant increase in body temperature, taking the drug may be recommended only by a doctor.

If it is necessary to determine 17-ketosteroids, the drug should be discontinued 48 hours before the test. If the temperature persists, headache or other undesirable phenomena occur, consult a doctor.

Do not exceed the dose specified in the instructions.

Form of issue

Tablets for resorption honey-lemon. For 8 tables. in the blister (PVC / PVDC / aluminum). By 1, 2 or 3 bl. placed in a cardboard box.

Conditions of leave from pharmacies

Without recipe.

Storage conditions

At a temperature of no higher than 25 ° C.

Keep out of the reach of children.

Shelf life

3 years.

Do not use after the expiry date printed on the package.

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