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Instruction for use: Fluxonil

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Dosage form: tablets

Active substance: Fluoxetine*


N06AB03 Fluoxetin

Pharmacological groups:


The nosological classification (ICD-10)

F32 Depressive episode: Adynamic subdepression; Astheno-adynamic subdepressive states; Asthenoadressive disorder; Astheno-depressive disorder; Asthenodepressive state; Astheno-depressive state; Major Depressive Disorder; Vyaloapatichesky depression with retardation; Double Depression; Depressive pseudodement; Depressive illness; Depressive mood disorder; Depressive disorder; Depressive mood disorder; Depressive state; Depressive disorders; Depressive syndrome; Depressive syndrome larviated; Depressive syndrome in psychoses; Depressed masks; Depression; Depression Depletion; Depression with the phenomena of inhibition within the framework of cyclothymia; Depression is smiling; Involutional depression; Involutionary melancholy; Involutional depression; Manic-depressive disorder; Masked Depression; Melancholic Attack; Neurotic depression; Neurotic depression; Shallow Depression; Organic depression; Organic depressive syndrome; Simple depression; Simple melancholic syndrome; Psychogenic depression; Reactive depression; Reactive depression with moderate psychopathological symptoms; Reactive depressive states; Reactive depression; Recurrent depression; Seasonal depressive syndrome; Severostatic depression; Senile Depression; Symptomatic Depression; Somatogenic depression; Cyclotymic depression; Exogenous depression; Endogenous depression; Endogenous Depressive Conditions; Endogenous Depression; Endogenous depressive syndrome

Composition and release form

1 tablet contains fluoxetine hydrochloride 10 mg; in the package of 100 pcs. or in a blister 10 pcs., in the package 3 blisters.

1 capsule - 20 mg; in the package of 100 pcs. or in a blister 10 pcs., in the box 3 blisters.

Pharmachologic effect

Pharmacological action - antidepressant.

Selectively inhibits the reuptake of serotonin.


It relieves depression of various genesis, weakly affects cholinergic, adrenergic and histamine receptors.


When ingested quickly absorbed, bioavailability - 60%; T1 / 2 of the drug - 2-3 days, and its main metabolite - 7-9 days; metabolized in the liver, excreted by the kidneys.

Clinical Pharmacology

The effect develops after 3-4 weeks of constant reception.

Indications for the Fluxonil

Depression of various etiologies.


Hypersensitivity, convulsive syndrome, severe renal dysfunction, simultaneous administration of MAO inhibitors, pregnancy, children's age.

Side effects

Side-effects are extremely rare and occur at doses exceeding 20 mg / day. Headache, dizziness, nervousness, asthenia, sleep disturbance, drowsiness, anxiety, tremor, weakness, dry mouth, loss of appetite, indigestion, nausea, vomiting, diarrhea, increased sweating, weakening of sexual desire, anorgasmia, hyponatremia, allergic reactions skin rash, serum sickness, thrombocytopenia, thrombocytopenic purpura).


The effect on the central nervous system is intensified by hypnotics, anticonvulsants, neuroleptics, analgesics (including narcotics), anesthetics, ethanol. When taken with MAO inhibitors - increased body temperature, muscle stiffness, cramps, agitation, impaired consciousness (before delirium and coma); when used with tryptophan - agitation, anxiety, gastrointestinal symptoms.

Dosing and Administration

Inside, once, in the morning - 20 mg (maximum - 80 mg), then gradually increase the dose (with an interval of one week); daily dose of more than 20 mg taken in 2 divided doses. With bulimia - 60 mg per day (divided into 3 doses).

Precautionary measures

Be wary appoint patients with cardiovascular diseases, as well as persons engaged in activities that require increased attention (driving, etc.). For the duration of treatment, nursing mothers should stop breastfeeding.

Storage conditions for Fluxonil

At room temperature.

Keep out of the reach of children.

Shelf life of Fluxonil

3 years.

Do not use after the expiry date printed on the package.

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