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Instructions

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Instruction for use: Flexital

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Dosage form: Concentrate for solution for intravenous and intra-arterial administration, film-coated tablets of prolonged action, Coated tablets with enteric

Active substance: Pentoxyphyllinum

ATX

C04AD03 Pentoxifylline

Pharmacological group

Antiaggregants

Adenosinergic agents

Angioprotectors and microcirculation correctors

The nosological classification (ICD-10)

I70 Atherosclerosis: Atherosclerosis; Atherosclerosis of peripheral vessels; Atherosclerotic changes; Atherosclerotic vascular changes; Atherosclerotic disorders; spontaneous; Trombangioz obliterans; Frinlendera disease

I70.2 Atherosclerosis of arteries: arteriosclerosis obliterans; Arteriosclerosis peripheral arteries; Atherosclerosis of the arteries of the lower extremities; Atherosclerosis of peripheral arteries; Atherosclerosis limbs; Occlusive disease of the lower extremities; arteriosclerosis obliterans; Arteriosclerosis obliterans of lower limb arteries; Atherosclerosis obliterans of the upper limbs; Arteriosclerosis obliterans of lower extremities; Atherosclerosis of arteries; limb arteriopathy; Arteriosclerosis obliterans limbs; arteriosclerosis obliterans

I73 Other peripheral vascular disease: peripheral angiopathy; limb arteriopathy; The disease of arteries; Violations of peripheral arterial circulation; Lack of blood flow arteriovenous; Obliterating diseases of arteries; occlusive disease; Occlusive disease with severe intermittent claudication; obliterating diseases of arteries; Chronic obliterating peripheral arterial disease; endarteritis obliterans; Ischemic lesions stop

I73.0 Raynaud's Syndrome: Raynaud's syndrome Leriche; Raynaud's disease; Raynaud's phenomenon; RaynaudLeriche syndrome; Raynaud's disease; Raynaud's syndrome with trophic disorders; Peripheral angiopathy

Composition and release form

1 tablet, coated with enteric coating, contains pentoxifylline 100 mg; In a contour acheive box 10 pcs., In a cardboard bundle 6 packages.

1 ml of solution for injection - 20 mg; In ampoules of 5 ml, in a cardboard pack of 5 ampoules.

Pharmacology

Mode of action - Antiaggregational, angioprotective, vasodilating.

It blocks adenosine receptors, inhibits phosphodiesterase, promotes the accumulation of cAMP in cells. Increases the flexibility of red blood cells, reduces their adhesion, reduces platelet aggregation. Improves microcirculation and rheological properties, lowers the viscosity of the blood.

Indications of Flexital

Violations of peripheral arterial and arteriovenous blood circulation (obliterating endarteritis, Raynaud's disease, atherosclerosis).

Contraindications

Hypersensitivity, acute myocardial infarction, massive bleeding.

Side effects

Dyspepsia, dizziness, headache, insomnia or drowsiness, tachycardia, allergic reactions.

Interaction

Enhances the effect of anticoagulants.

Dosage and Administration

Inside, after or during a meal, without chewing and drinking with a small amount of liquid - 400 mg 2-3 times a day (if side effects occur, the dose is reduced to 400 mg twice a day); Course - not less than 8 weeks.

I.V., lying down, for at least 5 minutes, the initial single dose - 100 mg, with good tolerability dose increase to 200-300 mg / day (100 mg 2-3 times a day). The solution is applied at the beginning of the course treatment or if it is necessary to obtain a faster therapeutic effect when taking the drug inside.

I.V., drip, the contents of 1 ampoule are diluted in 250-500 ml infusion solution (0.9% sodium chloride solution, 5% glucose solution (dextrose), Ringer's solution, low molecular weight dextran solution), infusion duration is 2-3 hours. The initial infusion dose is 100 mg; If necessary, increase to 400 mg / day (infusion rate 2 times a day).

The daily dose should not exceed 1200 mg, the individual dose is calculated by the formula: 0.6 mg per 1 kg of body weight per hour.

Storage conditions of Flexital

In a dry place, at a temperature of no higher than 25 ° C.

Keep out of the reach of children.

Shelf life of Flexital

Concentrate for the preparation of a solution for intravenous and intra-arterial administration of 20 mg / ml - 2 years.

Coates tablets, with enteric100 mg - 4 years.

Do not use after the expiry date printed on the package.

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