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Instructions

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Instruction for use: Ethisterone (Aethisteronum)

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Pharmacological groups

Estrogens, gestagens; their homologues and antagonists

Nosological classification (ICD-10)

E28.3 Primary ovarian failure

Hypogonadism of the ovary (primary), Hypofunction of the ovaries, Estrogen deficiency, Insufficient estrogen content in the body, Insufficiency estrogenic, Insufficiency of estrogens, Primary dysfunction of the ovaries, Estrogen-deficient conditions

N91 Lack of menstruation, meager and rare menstruation

Amenorrhea, Amenorrhea hypogonadotropic, Amenorrhea is prolactin-dependent, Oligomenorrhoea, Shortening of the secretory phase of the menstrual cycle, Menstrual disorders, Menstruation disorders, Prolactin-dependent amenorrhea without galactorrhea

N93 Other abnormal bleeding from the uterus and vagina

Atonic uterine bleeding, Prolonged menstruation, Blood loss during menstruation, Bleeding from the genitourinary system, Bleeding uterine dysfunctional, Bleeding from the genital tract of organic etiology, Uterine bleeding, Menorrhagia with fibroids, Functional uterine bleeding, Abnormal bleeding from the genitals in women

N94.6 Dysmenorrhea Unspecified

Pain during menstruation, Functional disorders of the menstrual cycle, Menstrual cramps, Emmeniopathy, Pain during menstruation, Painful menstrual irregularities, algomenorrhea, algomenoreya, Pain smooth muscle spasm, Pain spasm of smooth muscles (renal and biliary colic, intestinal spasms, dysmenorrhea), Pain spasm of smooth muscles of internal organs (kidney and biliary colic, intestinal spasms, dysmenorrhea), Disalgomenoreya, dysmenorrhea, Dysmenorrhea (essential) (Exfoliative), menstrual disorder, menstruation painful, metrorrhagia, Violation of the menstrual cycle, Menstrual irregularities, Prolaktinzavisimoe menstrual disorders, Prolaktinzavisimoe menstrual dysfunction, Pain spasm of smooth muscles of internal organs, Spasmodic dysmenorrhea, Primary disalgomenoreya

Code CAS 434-03-7

Characteristics of Ethisterone

White or white with a yellowish hue of crystalline powder. Almost nerastvorim in water, very little soluble in alcohol, soluble in oils.

Pharmacology

Pharmacological action - progestagenic.

As a synthetic analogue of progesterone (5-6 times weaker) binds to specific receptors on the surface of cells of target organs, penetrates into the nucleus and increases the synthesis of RNA (ribonucleic acid). Stimulates the transition of the mucous membrane of the uterus from the proliferative phase to the secretion phase, reduces the contractility and excitability of the uterus and fallopian tubes, their sensitivity to oxytocin, creates the necessary conditions for the development of a fertilized egg in the uterus, promotes the proliferation and secretion of the terminal sections of the mammary glands, inhibits the synthesis and release of luteinizing hormone from the anterior lobe of the pituitary gland. It is not destroyed by enzymes of saliva and gastrointestinal tract, therefore it can be applied enterally and sublingually. After absorption, rapid biotransformation in the liver undergoes the formation of pregnanediol and pregnenolone. Excreted by the kidneys.

Application of Ethisterone

Insufficiency of the yellow body, dysfunctional uterine bleeding, amenorrhea, dyslagomenorrhea.

Contraindications

Hypersensitivity, breast and genital tumors, impaired liver and kidney function, incomplete abortion, bloody discharge from the vagina, bronchial asthma, heart failure, epilepsy, migraine, diabetes, ectopic pregnancy, hyperlipidemia, thrombophlebitis, thromboembolic complications, cerebral circulation.

Side effects of Ethisterone

Weakness, drowsiness, sleep disturbance, dyspeptic phenomena, hepatitis, calculous cholecystitis, visual impairment, thromboembolic complications, virilism, weight gain, galactorrhea, spotting from the vagina, dysmenorrhea, amenorrhea, enlargement and thickening of the mammary glands, acne, alopecia, allergic reaction.

Interaction

Reduces the effects of antiplatelet agents, anticoagulants, bromocriptine.

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