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Instruction for use: Diffumal 24

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Dosage form: Tablets are divided; Tablets divisible for children

Active substance: Theophyllinum


R03DA04 Theophylline

Pharmacological group

Adenosinergic agents

The nosological classification (ICD-10)

J45 Asthma: Asthma of physical effort; Asthmatic conditions; Bronchial asthma; Bronchial asthma of light course; Bronchial asthma with difficulty in sputum discharge; Bronchial asthma of severe course; Bronchial asthma physical effort; Hypersecretory asthma; The hormone-dependent form of bronchial asthma; Curbing asthma attacks with bronchial asthma; Non-allergic bronchial asthma; Night Asthma; Exacerbation of bronchial asthma; Attack of bronchial asthma; Endogenous forms of asthma; Night attacks of asthma; Cough with bronchial asthma J98.8.0 * Bronchospasm: Bronchospasm with bronchial asthma; Bronchospasm when exposed to an allergen; Bronchospastic reactions; Bronchospastic conditions; Bronchospastic syndrome; Diseases accompanied by bronchospastic syndrome; Reversible bronchospasm; Spasmodic cough

Composition and release form

1 divided tablet contains theophylline 100 or 200 mg; In the blister 10 pcs., In the box 3 blisters.


Mode of action - bronchodilating, diuretic.

Inhibits phosphodiesterase, increases the content of cAMP tissues, reduces the contractility of smooth muscles. It dilates the bronchi, vessels, mainly the brain, skin and kidneys. Reduces pulmonary vascular resistance, reduces pressure in a small circle of blood circulation. Expands peripheral veins, increases renal blood flow and has a moderate diuretic effect. Inhibits the aggregation of platelets, stimulates the respiratory center, increases the frequency and strength of the heartbeat.


Quickly absorbed. The therapeutic effect is manifested when the concentration in the blood is 10-20 μg / ml. The volume of distribution is 0.5 l / kg. 8% is excreted unchanged in the urine, the rest is metabolized to 1,3-dimethylurea and methylxanthine (excreted through the kidneys). The therapeutic effect is manifested when the concentration in the blood is 10-20 mkg / ml.

Indications of Diffumal 24

Bronchial asthma, bronchial obstructive syndrome in chronic lung diseases.


Hypersensitivity, acute period of myocardial infarction, hypotension.

Application of pregnancy and breastfeeding

During pregnancy - according to vital indications. Lactating women at the time of treatment should stop breastfeeding.

Side effects

Dyspeptic disorders, headache, insomnia, tachycardia, extrasystole, albuminuria, hyperglycemia.


Incompatible with other xanthine derivatives. Strengthens (mutually) the diuretic effect of Furosemide. A simultaneous appointment with reserpine can provoke a tachycardia. Erythromycin, lincomycin, clindamycin and cimetidine increase the concentration in the blood, nicotine (smoking) - reduces.

Dosage and Administration

Inside, 1 time per day, in the morning.

Children with a body weight of 15 to 20 kg - 200-300 mg (not more); From 20 to 25 kg - 300-400 mg (not more than); More than 25 kg - 2 tablets. On 200 mg (no more than 500 mg / day).

Adults - 2 tablets. On 350 mg (but no more than 2.5 tab.).


It is necessary to determine the amount of the drug taken and the interval of time elapsed from the moment of taking it, induce vomiting, rinse the stomach, give activated charcoal. It should monitor the heart, blood pressure, breathing, electrolyte balance. When there are seizures, benzodiazepines are prescribed.

Precautionary measures

Caution is prescribed for children, elderly people, hypertensive patients, patients with hyperthyroidism, heart, liver and kidney disease, hypoxia, patients with pulmonary heart, congestive circulatory insufficiency, peptic ulcer. When combined with ephedrine or other bronchodilator sympathomimetics, careful monitoring is necessary. Chronically smoking patients require, as a rule, a large dose of theophylline (reduced concentration in the blood, shortened T1 / 2).

Storage conditions of Diffumal 24

In a cool place protected from light.

Keep out of the reach of children.

Shelf life of the drug Diffumal 24

3 years.

Do not use after the expiry date printed on the package.

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