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Instruction for use: Dermestril

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Active substance: Estradiol

ņ“’ Code: G03CA03 Estradiol

Pharmacological groups

Estrogens, gestagens; their homologues and antagonists

Antineoplastic hormonal agents and hormone antagonists

Nosological classification (ICD-10)

M81.0 Postmenopausal osteoporosis

Menopause osteoporosis, Osteoporosis in menopause, Osteoporosis in menopause, Osteoporosis in postmenopausal women, Osteoporosis in the postmenopausal period, Postmenopausal osteoporosis, Osteoporosis in postmenopausal women, Perimenopausal osteoporosis, Postmenopausal osteoporosis, Post-menopausal osteoporosis, Postmenopausal osteoporosis, Postmenopausal demineralization of bones, Osteoporosis with estrogen deficiency, Osteoporosis in postmenopausal women, Osteoporosis in postmenopausal women and after hysterectomy

N95.1 menopausal and menopausal status of women

Atrophy of the mucosa of the lower genital tract, caused by estrogen deficiency; Vaginal dryness; Autonomic dysfunction in women; gipoestrogeniya state; Deficiency of estrogen in menopausal women; Degenerative changes of the mucous membrane in the menopause; Natural menopause; an intact uterus; climacteric; Menopause women; Menopause in women; menopausal depression; Climacteric ovarian dysfunction; Menopause; Climacteric neurosis; Menopause; Menopausal symptoms complicated psychovegetative; Climacteric syndrome; Climacteric vegetative disorders; Climacteric psychosomatic disorder; menopausal disorders; Menopausal disorders in women; menopausal condition; Climacteric vascular disorders; Menopause; Menopausal vasomotor symptoms; menopausal period; Lack of estrogen; Feeling the heat; Pathological menopause; perimenopause; menopause; postmenopausal; Premature menopause; premenopauznom period; tides; hot flashes; flushing in the Meno and postmenopausal; Hot flashes / hot flashes in menopause; Heart attack during menopause; Early menopause in women; Disorders of menopause; climacteric syndrome; Vascular complications of menopause; Physiological menopause; Estrogendefitsitnye state; premature Menopause

Composition and form of release

1, the plaster of 9, 18 or 36 cm2 contains estradiol 2, 4 or 8 mg respectively, the release rate of the active substance is 25, 50 or 100 μg per day; in the box 8 pcs. in protective bags.

pharmachologic effect

The pharmacological action is estrogenic.

It binds to estrogen receptors in target cells and replenishes the lack of estradiol in the body, prevents the development of osteoporosis, normalizes lipid metabolism.

Indications of Dermestril

Physiological or postoperative menopause (hot flashes, sleep disorders, urogenital atrophy, mental instability, mood disorders); postmenopausal osteoporosis (prophylaxis).


Breast cancer, etc. estrogen-dependent tumors (diagnosed or suspected), endometriosis, vaginal bleeding of unknown etiology; severe diseases of the kidneys, liver, cardiovascular system; thromboembolism and thrombophlebitis (including (including) in the anamnesis), pregnancy, children's age.

Side effects

Headache, breast tenderness, vaginal bleeding, sodium and water retention, swelling, vomiting, flatulence, intestinal spasm, erythema and itching at the site of application.

Dosing and Administration

On skin, impose on a clean, dry and fat-free area of intact skin on the thigh, waist or abdomen (places of applications alternate). Treatment begins with the imposition of one patch of Dermestril 50. The patch is changed 2 times a week (if possible with observance of permanent days of the week: for example, Monday and Thursday); when the patch is unfastened, it is necessary to replace it with a new one. The maximum daily dose is 100 mcg. The drug is used cyclically, for 3 weeks (week) (6 applications) followed by a weekly break. In the case of hysterectomy appoint continuously.

Precautionary measures

Caution is prescribed for heart failure, renal and hepatic dysfunction, severe hypertension, epilepsy, bronchial asthma, diabetes, edema, the elderly and hypogonadism. Regular monitoring of endocrine system parameters and gynecological examinations is recommended. Therapy should be immediately stopped when migraines appear, frequent headaches and any type of vision disorder.

storage Conditions

In a place protected from moisture, at a temperature of no higher than 25 į C.

Keep out of the reach of children.

Shelf life of Dermestril

2 years.

Do not use after the expiry date printed on the package.

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