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Instruction for use: Bystrumgel

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Active substance Ketoprofen

ATX code M02AA10Ketoprofen

Pharmacological group

NSAIDs - Propionic acid derivatives

Nosological classification (ICD-10)

G54.1 Disorders of lumbosacral plexus

Sciatica, Neurology radicular origin, spine Pathology, Sciatica lumbosacral, radiculoneuritis

I80 Phlebitis and thrombophlebitis

Diseases of peripheral vessels, Inflammation of superficial veins, Inflammatory diseases of veins, Deep venous thrombophlebitis, The disease of veins, Disease of the veins of the lower extremities, Diseases of peripheral vessels, Migrating phlebitis, Insufficiency of veins of lower extremities, Exacerbation of chronic thrombophlebitis, Acute thrombophlebitis,Acute thrombophlebitis of superficial veins, Periphlebitis, Periflebit surface, Superficial inflammation of veins, Surface thrombophlebitis, Surface phlebitis, Thrombophlebitis, Deep vein thrombophlebitis, Thrombophlebitis superficial, Phlebitis, Phlebitis of deep veins, Phlebitis of superficial veins, Phlebopathy, Chronic thrombophlebitis, Endophlebitis

M12.5 Traumatic arthropathy

Painful traumatic affection of joints

M13.9 Arthritis, unspecified

Arthritis,Purulent arthritis (non-infectious), acute Arthritis,Pain in acute inflammatory diseases of the musculoskeletal system,Pain in chronic inflammatory diseases of the musculoskeletal system,The pain in osteoarthritis, Inflammation in osteoarthritis, Inflammatory arthropathy, Inflammatory and degenerative joint diseases, Inflammatory disease of the musculoskeletal system, Inflammatory joint disease, Inflammatory diseases of the musculoskeletal system, destructive arthritis, The disease of the musculoskeletal system, Diseases of the musculoskeletal system, Diseases of the musculoskeletal system and connective tissue, Infections musculoskeletal system, monoartrit, Non-infectious arthritis, rheumatic arthritis, Osteoarthritis, Acute inflammation of the musculoskeletal tissue, Acute inflammatory diseases of the musculoskeletal system, Acute inflammatory condition of the musculoskeletal system, Acute arthritis, Acute osteoarthritis, Post-traumatic osteoarthritis, Reactive arthritis, Chronic inflammatory diseases of the joints, Chronic arthritis, Chronic inflammatory arthritis, Chronic inflammation of the inner layer of the joint capsule, Chronic inflammation of the joint capsule,Chronic inflammatory disease of the joints, Exudative arthritis

M43.6 Torticollis

Congenital torticollis

M54 Dorsalgia

Pain in the back area, Pain in the spine, Back pain, Pain in different parts of the spine, Backache, Painful pain syndrome in the spine, Pain in the musculoskeletal system

M54.3 Sciatica

Ishialgia, Neuralgia of the sciatic nerve, Sciatic neuritis

M54.4 Lumbago with sciatica

Pain in the lumbosacral spine, Lumbago, Sciatica, Lumbar syndrome

M60 Myositis

Myositis, Fibrositis Fibromyositis, Inflammatory disease of soft tissues

M71 Other bursopathies

Bursitis, Bursopathy, Diseases of soft tissues, Osteoarthritis in musculo-articular diseases, Inflammatory disease of soft tissues, Subacute bursitis

M77.9 Other unspecified

Capsule, Periarthritis, Tendonitis, Tendopathy, Periarthropathy

T14.0 Surface injury of unspecified body region

Abrasions, Scratch, Skin Wounds, Wounds of soft tissues, Hematoma, Hematoma of traumatic origin, Hematomas, Hematomas of muscles, Hematomas of soft tissues, Healing of the skin, Bruise, Bruising due to sprains and bruises, Microtrauma, External bruises, Small combing, Superficial hematoma, Superficial damage to the skin and mucous membranes, Subcutaneous hematoma, Post-traumatic hematoma, Post-traumatic disturbance of microcirculation, Skinness of the skin, Traumatic plexus lesions, Injury, Contusion of soft tissues, Joint bruise, Traumatic bruises, Traumatic injury, Primary treatment of surface contaminated wounds, Abrasion, Bruise

T14.3 Dislocation, sprain and damage to the capsular-ligamentous apparatus of the joint of the unspecified area of the body

Painful stretching of muscles, Pain and inflammation in tension, Dislocation of dislocation, Degenerative changes in the ligamentous apparatus, Edema due to sprains and bruises, Edema after interventions for sprains, Damage and rupture of ligaments, The musculoskeletal system is damaged, Damage to ligaments, Damage to the joints, Ligament ruptures, Tendon tendons,Ruptures of the tendons of muscles,Stretching, Crick, Stretching of the muscle, Sprain, Tension of the tendons, Extensions,Stretch muscles, Sprains, Tension of the tendons, Injury of the musculoskeletal system, Injuries to the joints, Injuries of capsule-articular tissues, Injuries of the osteoarticular system, Injuries to ligamentsInjuries to the joints, Joint wounds, Stretching of the ligamentous apparatus, Habitual stretching and tearing

Composition and form of release

Gel for external use 2.5% 1 g

ketoprofen 25 mg

auxiliary substances: ethyl alcohol rectified; nipagin; carbomer; trometamol; lavender oil; non-germ oil; purified water

in tubes of 30 or 50 g; in the box 1 tuba.

Description of dosage form

A colorless, almost transparent gel with a specific odor. Opalescence is allowed.

pharmachologic effect

Pharmacological action - anti-inflammatory, analgesic.


Inhibits cyclooxygenase 1 and 2, inhibits the synthesis of PG. It has anti-bradykinin activity, stabilizes lysosomal membranes. Reduces the secretion of cytokines, inhibits the activity of neutrophils. With articular syndrome, it alleviates joint pain at rest and during movement, reduces morning stiffness and swelling of the joints, contributes to an increase in the volume of movements.


With epilation of gel applications, extremely slow transdermal absorption of ketoprofen occurs, which ensures that its concentration in inflamed tissues is maintained within the therapeutic level for a long time. It penetrates well into the synovial fluid and connective tissue. Absorption into the systemic blood flow is insignificant, bioavailability is about 5%. Practically does not cumulate.


Painful inflammatory or traumatic lesions of joints, tendons, ligaments and muscles (arthritis, periarthritis, tendinitis, tendosinovitis, bursitis, bruises, ligament injuries, dislocations, knee meniscus, torticollis, lumbago); phlebitis, periphlebitis.


Hypersensitivity to ketoprofen or other components of the drug, dermatoses, eczema, infected abrasions and wounds, pregnancy and the period of breastfeeding, children's age.

Side effects

In individual patients, in all cases, allergic reactions are possible (require the abolition of therapy), photosensitization.


At present, no interaction of ketoprofen with a dermal application with other medications has been identified.

Dosing and Administration

Locally, apply to the skin, squeezing from the tube about 3-5 cm of gel or more (depending on the area of the painful area), distribute a uniform thin layer and gently rub into the inflamed and painful areas of the body until it is completely absorbed. Apply 2 times a day. In order to increase the effectiveness of therapy, it is possible to apply a dry occlusive bandage.

special instructions

Do not let the gel get on the mucous membranes and eyes. Do not apply gel to open wounds or damaged skin.

Storage conditions

In dry, the dark place at a temperature of 15-25 ° C.

Keep out of the reach of children.

Shelf life

2 years.

Do not use after the expiry date printed on the package.

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